Overview of Exendin 4
A component of the Gila monster's venom—a peptide known as exendin-4—is being explored for new treatments for Alzheimer's disease, diabetes, and other diseases.
Exendin-4 is defined as a 39-amino acid peptide derived from the venom of the lizard Heloderma suspectum, functioning as a long-acting agonist of GLP-1 that enhances insulin secretion and promotes β-cell mass through increased replication and neogenesis. It possesses a longer half-life and greater insulinotropic efficacy compared to GLP-1, while also potentially engaging different peripheral ...
Key Details About Exendin 4
Here, we provides significant evidences on the effect of exendin-4 on synaptic plasticity, long-term potentiation, and neural structure.
Exendin-4 | C184H282N50O60S | CID 56927919 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Useful Notes on Exendin 4
Taken together, these results suggested that exendin-4 could inhibit HG-mediated cellular stresses by attenuating oxidative stress, apoptosis, and mitochondrial dysfunction in H9c2 cardiomyoblasts. In addition, the cardioprotective impact of exendin-4 is dependent on GLP-1 receptor signaling.
Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. - Mechanism of Action & Protocol.
