Alza 27 vs Adderall: A Comprehensive Comparison
Alza 27 and Adderall are both stimulant medications commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD) and Narcolepsy. While they share some similarities, they also have distinct differences. This article will delve into the details of Alza 27 vs Adderall, helping you understand each medication's unique features, effects, and considerations.
Understanding Alza 27 and Adderall
Alza 27, also known as mixed amphetamine salts extended-release (MAS XR), is a once-daily, extended-release formulation of a combination of four amphetamine salts. It's designed to release medication gradually throughout the day, providing a consistent level of stimulation.
Adderall, on the other hand, is a combination of two amphetamine salts: amphetamine aspartate and amphetamine sulfate. It's available in both immediate-release (Adderall IR) and extended-release (Adderall XR) formulations. Adderall IR is typically taken two to three times a day, while Adderall XR is taken once daily.

Active Ingredients and Formulations
| Medication | Active Ingredients | Formulations |
|---|---|---|
| Alza 27 | Mixed amphetamine salts (amphetamine aspartate monohydrate, amphetamine sulfate, amphetamine succinate, and amphetamine saccharate) | Extended-release capsules |
| Adderall | Amphetamine aspartate and amphetamine sulfate | Immediate-release tablets, extended-release capsules |
Effects and Duration of Action
Both Alza 27 and Adderall work by increasing the levels of dopamine and norepinephrine in the brain, which helps improve focus, attention, and reduce impulsivity. However, due to their different formulations, they have distinct onsets and durations of action.
- Alza 27 starts working within a few hours after administration and provides a consistent level of stimulation for about 12 hours.
- Adderall IR begins working within 30-60 minutes and lasts for about 4-6 hours.
- Adderall XR starts working within 1-2 hours and provides a consistent level of stimulation for about 12 hours.
Efficacy and Side Effects
Both medications have been shown to be effective in managing ADHD symptoms, with similar rates of improvement in clinical trials. However, individual responses can vary, and some people may find one medication works better than the other.
In terms of side effects, both Alza 27 and Adderall can cause similar issues such as insomnia, decreased appetite, anxiety, and cardiovascular problems. However, Alza 27 may have a lower incidence of some side effects due to its extended-release formulation, which can help reduce peak plasma concentrations of the drug.

Cost and Availability
The cost of Alza 27 vs Adderall can vary depending on your location, insurance coverage, and the pharmacy you use. Generally, both medications are covered by most insurance plans, but some plans may require prior authorization. It's always a good idea to check with your insurance provider to understand your specific coverage and out-of-pocket costs.
Both medications are widely available at most pharmacies, but you may need a prescription from a healthcare provider to obtain them.
Which is Right for You?
Choosing between Alza 27 and Adderall ultimately depends on your individual needs, preferences, and how your body responds to the medication. It's essential to discuss the potential benefits and drawbacks of each medication with your healthcare provider to make an informed decision.
In some cases, your healthcare provider may recommend trying one medication first and then switching to the other if it's not effective or well-tolerated. They may also adjust the dosage or add additional medications to help manage your symptoms effectively and safely.