Overview of Pancreatic Beta Cell Cycle Regulation By Glp-1 Analogs
In this review, we provide an overview of various strategies, such as the development of GLP -1R agonists (e.g., exendin-4), and GLP-1 sequence modifications for GLP -1R targeting for the diagnosis and treatment of pancreatic beta cell disorders.
Abstract Glucagon-like peptide-1 ( GLP-1 ) is a potent gluco-incretin hormone, which plays a central role on pancreatic beta cell proliferation, survival and insulin secreting activity and whose analogs are used for treating hyperglycemia in type 2 diabetes mellitus. Notably, abnormal insulin signaling affects all the above-mentioned aspects on pancreatic beta cells . The aim of our study was to ...
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Determining how GLP-1 analogs influence serotonin synthesis, receptor activation, and uptake across different β- cell models will be impor-tant to defining the contribution of serotonin- GLP -1 in-teractions to the regulation of insulin secretion.
Glucagon-like peptide 1 ( GLP-1 ) exerts many actions that improve glycemic control. GLP-1 stimulates glucose-stimulated insulin secretion and protects β cells , while its extrapancreatic effects include cardioprotection, reduction of hepatic glucose production, and regulation of satiety. Although an appealing antidiabetic drug candidate, the rapid degradation of GLP-1 by dipeptidyl peptidase 4 ...
Request PDF | GLP-1 peptide analogs for targeting pancreatic beta cells | Loss or dysfunction of the pancreatic beta cells or insulin receptors leads to diabetes mellitus (DM). This usually occurs ...
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The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.
Overview of Pancreatic Beta Cell Cycle Regulation By Glp-1 Analogs
GLP-1 and its analogs enhance insulin secretion, but the specific intracellular mechanisms in β- cells remain unclear. Key intracellular mediators including calcium, glutamate, γ-aminobutyric acid, serotonin, and urocortin-3 are modulated by GLP-1 signaling with variable and sometimes contradictory effects.
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Conclusions: GLP -1RAs demonstrate a robust anti-apoptotic effect on pancreatic beta cells in preclinical models, supporting their role in preserving beta cell mass. However, extreme heterogeneity and unresolved questions about long-term functional exhaustion warrant cautious interpretation.
Key Details About Pancreatic Beta Cell Cycle Regulation By Glp-1 Analogs
While their anorexigenic effects are well characterized, the mechanisms by which GLP-1 modulates pancreatic β- cell function remain only partially understood. In this article, we argue that GLP-1 receptor agonists should be viewed as integrative regulators of β- cell function and explore the multifaceted actions of GLP-1 analogs on β- cell ...
