Description
Oxidative phosphorylation: electrons from NADH/FADH2 pass through respiratory complexes to O2 while protons are pumped across the inner membrane, and the resulting proton-motive force drives ATP synthase, with respiratory control by ADP availability.
Process Flowchart
graph TD
N1["NADH / FADH2 fuel"]
N2["Complex I/II oxidize"]
N3["Ubiquinone shuttle"]
N4["Complex III -> cyt c"]
N5["Complex IV reduces O2"]
N6["Protons pumped out"]
N7["Proton-motive force"]
N8["ATP synthase rotates"]
N9{"ADP available?"}
N10["ATP synthesized"]
N11["Backpressure slows ETC"]
N1 --> N2
N2 --> N3
N3 --> N4
N4 --> N5
N2 --> N6
N4 --> N6
N5 --> N6
N6 --> N7
N7 --> N8
N8 --> N9
N9 -->|yes| N10
N9 -->|no ADP| N11
N11 -->|respiratory con…| N2
style N1 fill:#ff6b6b,color:#fff
style N2 fill:#51cf66,color:#fff
style N3 fill:#51cf66,color:#fff
style N4 fill:#51cf66,color:#fff
style N5 fill:#51cf66,color:#fff
style N6 fill:#74c0fc,color:#fff
style N7 fill:#74c0fc,color:#fff
style N8 fill:#51cf66,color:#fff
style N9 fill:#74c0fc,color:#fff
style N10 fill:#b197fc,color:#fff
style N11 fill:#51cf66,color:#fff
Node provenance
Each step below is grounded in a cited source (hover a citation for the full title).
| Step | Role | Source |
|---|---|---|
| NADH / FADH2 fuel | Triggers & Inputs | Berg, J. M. et al. 2002 |
| Complex I/II oxidize | Processing & Operations | Berg, J. M. et al. 2002 |
| Ubiquinone shuttle | Processing & Operations | Berg, J. M. et al. 2002 |
| Complex III -> cyt c | Processing & Operations | Berg, J. M. et al. 2002 |
| Complex IV reduces O2 | Processing & Operations | Berg, J. M. et al. 2002 |
| Protons pumped out | Intermediates & States | Mitchell, P. 1961 |
| Proton-motive force | Intermediates & States | Mitchell, P. 1961 |
| ATP synthase rotates | Processing & Operations | Berg, J. M. et al. 2002 |
| ADP available? | Intermediates & States | Saraste, M. 1999 |
| ATP synthesized | Products & Outputs | Berg, J. M. et al. 2002 |
| Backpressure slows ETC | Processing & Operations | Saraste, M. 1999 |
🎨 Color Scheme (5-Color System)
Red
Triggers & Inputs
Triggers & Inputs
Yellow
Structures & Objects
Structures & Objects
Green
Processing & Operations
Processing & Operations
Blue
Intermediates & States
Intermediates & States
Violet
Products & Outputs
Products & Outputs
Process Statistics
- Nodes: 11
- Edges: 13
- Conditionals: 1
- AND Gates: 2
- OR Gates: 3
- Total Gates: 5
Keywords
- oxidative phosphorylation
- electron transport chain
- proton gradient
- atp synthase
- chemiosmosis
Sources & References
-
Biochemistry, 5th ed. — Oxidative Phosphorylation
Berg, J. M.; Tymoczko, J. L.; Stryer, L. , W. H. Freeman (NCBI Bookshelf, Chapter 18) (2002)
View Source -
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism
Mitchell, P. , Nature (1961)
DOI: 10.1038/191144a0 -
Oxidative phosphorylation at the fin de siècle
Saraste, M. , Science (1999)
DOI: 10.1126/science.283.5407.1488