Oxidative Phosphorylation

Biology Pathways Complexity: high

Description

Oxidative phosphorylation: electrons from NADH/FADH2 pass through respiratory complexes to O2 while protons are pumped across the inner membrane, and the resulting proton-motive force drives ATP synthase, with respiratory control by ADP availability.

Process Flowchart

graph TD N1["NADH / FADH2 fuel"] N2["Complex I/II oxidize"] N3["Ubiquinone shuttle"] N4["Complex III -> cyt c"] N5["Complex IV reduces O2"] N6["Protons pumped out"] N7["Proton-motive force"] N8["ATP synthase rotates"] N9{"ADP available?"} N10["ATP synthesized"] N11["Backpressure slows ETC"] N1 --> N2 N2 --> N3 N3 --> N4 N4 --> N5 N2 --> N6 N4 --> N6 N5 --> N6 N6 --> N7 N7 --> N8 N8 --> N9 N9 -->|yes| N10 N9 -->|no ADP| N11 N11 -->|respiratory con…| N2 style N1 fill:#ff6b6b,color:#fff style N2 fill:#51cf66,color:#fff style N3 fill:#51cf66,color:#fff style N4 fill:#51cf66,color:#fff style N5 fill:#51cf66,color:#fff style N6 fill:#74c0fc,color:#fff style N7 fill:#74c0fc,color:#fff style N8 fill:#51cf66,color:#fff style N9 fill:#74c0fc,color:#fff style N10 fill:#b197fc,color:#fff style N11 fill:#51cf66,color:#fff

Node provenance

Each step below is grounded in a cited source (hover a citation for the full title).

StepRoleSource
NADH / FADH2 fuelTriggers & InputsBerg, J. M. et al. 2002
Complex I/II oxidizeProcessing & OperationsBerg, J. M. et al. 2002
Ubiquinone shuttleProcessing & OperationsBerg, J. M. et al. 2002
Complex III -> cyt cProcessing & OperationsBerg, J. M. et al. 2002
Complex IV reduces O2Processing & OperationsBerg, J. M. et al. 2002
Protons pumped outIntermediates & StatesMitchell, P. 1961
Proton-motive forceIntermediates & StatesMitchell, P. 1961
ATP synthase rotatesProcessing & OperationsBerg, J. M. et al. 2002
ADP available?Intermediates & StatesSaraste, M. 1999
ATP synthesizedProducts & OutputsBerg, J. M. et al. 2002
Backpressure slows ETCProcessing & OperationsSaraste, M. 1999

🎨 Color Scheme (5-Color System)

Red
Triggers & Inputs
Yellow
Structures & Objects
Green
Processing & Operations
Blue
Intermediates & States
Violet
Products & Outputs

Process Statistics

  • Nodes: 11
  • Edges: 13
  • Conditionals: 1
  • AND Gates: 2
  • OR Gates: 3
  • Total Gates: 5

Keywords

  • oxidative phosphorylation
  • electron transport chain
  • proton gradient
  • atp synthase
  • chemiosmosis

Sources & References

  • Biochemistry, 5th ed. — Oxidative Phosphorylation
    Berg, J. M.; Tymoczko, J. L.; Stryer, L. , W. H. Freeman (NCBI Bookshelf, Chapter 18) (2002)
    View Source
  • Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism
    Mitchell, P. , Nature (1961)
    DOI: 10.1038/191144a0
  • Oxidative phosphorylation at the fin de siècle
    Saraste, M. , Science (1999)
    DOI: 10.1126/science.283.5407.1488