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Does Glucagon

This review discusses the presently available knowledge from experimental and clinical studies on the effects of GLP-1 on oxidative stress in diabetes and diabetes-related complications. Keywords: Glucagon-like peptide-1, oxidative stress , diabetes, diabetic complications

Nrf2 is a master regulator of cellular stress responses, induces the expression of antioxidant and detoxification enzymes, and protects against oxidative stress -induced cell damage. Glucagon-like peptide-1 ( GLP-1 ) is an incretin hormone, which was originally found to increase insulin synthesis and secretion.

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Effect of GLP

We evaluate the effects of GLP-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on oxidative stress biomarkers in adults with type 2 diabetes mellitus, a meta-analysis of randomized controlled trials was conducted.

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In this review, we summarize the current knowledge regarding the role of GLP-1 in the protection against oxidative damage and the activation of the Nrf2 signaling pathway.

Effect of GLP

To evaluate the effects of GLP-1 receptor agonists ( GLP-1 RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2Is) on oxidative stress biomarkers in adults (＞18 years) with type 2 diabetes mellitus (T2DM), a meta-analysis of randomized controlled trials (RCTs) was conducted.

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