Multifaceted Roles of GLP
Several lines of evidence have revealed that GLP-1 and its analogs possess cardioprotective effects by various mechanisms related to cardiac contractility, myocardial glucose uptake, cardiac oxidative stress and ischemia/reperfusion injury, and mitochondrial homeostasis.
Glucagon-like peptide-1 receptor ( GLP -1R) is a versatile therapeutic target that regulates glucose homeostasis, cardiovascular function, neuroprotection, and immune responses. Native GLP-1 undergoes rapid enzymatic degradation, limiting its clinical utility. To overcome these challenges, engineered GLP-1 analogues and nanotechnology-enabled delivery systems have emerged. This review summarizes ...
Mitochondrial protein IF1 is a potential regulator of glucagon
As we can see from the illustration, Mitochondrial Targeted Glp 1 Analog has many fascinating aspects to explore.
Graphical abstract IF1 is a new target in the induction of GLP-1 secretion in the intestinal L-cells, which exhibit decreased apoptosis and increased mitophagy from ANT2 reduction in the If1 -KO mice.
Glucagon-like peptide-1 receptor agonists ( GLP -1RAs) are emerging as potential neuroprotective drugs in neurodegenerative diseases. These drugs were initially developed to manage type 2 diabetes (T2D) and obesity. In addition to GLP -1RAs having an impact on metabolic pathways, growing evidences suggests that GLP -1RAs also positively regulate mitochondrial homeostasis in several neuronal cell ...
Designing GLP
GLP-1 and its synthetic analogs have emerged as significant therapeutic agents for the management of metabolic disorders, merging glycemic control with weight loss through innovative structural ...
Consequently, GLP-1 analogs with extended half-lives and resistance to DPP-4 enzyme have been developed for therapeutic applications through judicious modification of peptide sequences or secondary structures.
Our study is the first work demonstrating a novel signaling pathway for cardioprotective effects of GLP -1R agonist on inhibition of oxidative stress and prevention of mitochondrial dysfunction. Thus, GLP -1R agonist represents a potential therapeutic target for inhibition of oxidative stress and modulation of mitochondrial functions ...
This review summarizes the physiological functions of GLP-1 , systematically explores diverse structural modifications, delves into the realm of unimolecular multi-agonists, and provides a nuanced portrayal of the developmental prospects that lie ahead for GLP-1 analogs .
The glucagon-like peptide-1 ( GLP-1 ) receptor, known as GLP -1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types ...
A paradigm shifts in glucagon-like peptide-1 receptor ( GLP -1R) signaling from diffuse events to spatiotemporally organized signalosomes offer insightful mechanisms into these conditions. The localization of internalized GLP -1Rs at the Mitochondria-ER interface supports a contactomics framework for understanding bioenergetic restoration.
