Systematic Characterisation of GLP1R in Human Enteric Nervous System ...
ABSTRACT Glucagon-like peptide-1 ( GLP-1 ) regulates glucose homeostasis, satiety and gastrointestinal (GI) motility through interaction with its receptor ( GLP -1R). While central GLP-1 pathways are well studied, the distribution and functional role of GLP -1R within the human enteric nervous system (ENS) remain unclear.
The gut hormone glucagon-like peptide-1 ( GLP-1 ) holds significant therapeutic interest for glycaemic and appetite control, but an endocrine role has been questioned, since GLP-1 is broken down rapidly in the bloodstream. A major new study by Zhang et al., identifies that a unique neuronal population within the enteric nervous system , whose axons leave the gut wall and activate sympathetic ...
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The enteric nervous system (ENS) controls digestion autonomously via a complex neural network within the gut wall. Enteric neurons expressing glutamate have been identified by transcriptomic studies as a distinct subpopulation, and glutamate can affect intestinal motility by modulating enteric neuron activity.
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