Growth Plate Bone Tissue Engineering

Advances in tissue engineering for the repair of growth plate injuries

The growth plate is a cartilage tissue located between the epiphysis and diaphysis of long bones , responsible for the longitudinal growth of the skeleton. Due to its limited regenerative capacity, when the growth plate is damaged, it is typically replaced by inappropriate bone tissue , leading to the ...

Emerging strategies such as cell-based therapies, tissue engineering scaffolds, gene therapies, growth factor delivery, and exosome-based therapies are discussed for their potential to promote cartilage regeneration and prevent bone bridge formation.

Advancesintissueengineeringfor the repair of growth plate injuries

Cartilage tissue engineering for growth plate injury primarily relies on three key components: seed cells, growth factors, and scaffoldmaterials.Seedcellsprovidethebasisforcartilageregeneration,typically using autologous or allogeneic chondrocytes, mesenchymal stem cells, etc.,; growth factors such as bone morphogenetic proteins (BMPs) and ...

The growth plate (GP) is a highly organized hyaline cartilage tissue located at the metaphysis of growing bones , playing a critical role in bone development and growth through the process of endochondral ossification (ECO) (Mackie et al., 2011).

Thus, a comprehensive understanding of the underlying biomechanical, biochemical, structural and biomolecular mechanisms involved in the polarized mineralization patterns at the GP- bone interfaces is of great significance in fields such as controlled mineral assembly, bone growth and development studies, and bone tissue engineering .

Tissue engineering in growth plate cartilage regeneration

The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has ...

Introduction A significant distinction between pediatric and adult bones is the presence of growth plate structures, which facilitate continuous bone growth and development. The growth plate cartilage perpetually generates healthy bone through chondrogenesis [1, 2], increasing bone length. However, the growth plate cartilage is non-renewable and will be replaced by bone tissue rather than ...

Physical and chemical niche of human growth plate for polarized bone ...

Growth plate (GP), a critical cartilaginous structure in amniotes, underpins longitudinal bone growth , yet the intricate mechanisms behind its polarized mineralization during evolution remain ...

Serious injury to the growth plate often leads to bony bridge formation, resulting in halted long bone growth , angular deformities, and limb length discrepancies. These problems persist unaddressed in the clinic. In this study, we engineered a four-layered growth plate organoid by integrating three-dimensional culture with layer-specific induction techniques. A gelatin/alginate hydrogel ...