Intranasal Delivery of Exendin
Abstract Exendin-4 is now considered as a promising drug for the treatment of cerebral ischemia. To determine the neuroprotective effects of intranasal exendin-4, C57BL/6J mice were intranasally administered with exendin-4 daily for 7 days before middle cerebral artery occlusion (MCAO) surgery. Intranasally administered exendin-4 produced higher brain concentrations and lower plasma ...
Exendin-4 is now considered as a promising drug for the treatment of cerebral ischemia. To determine the neuroprotective effects of intranasal exendin-4, C57BL/6J mice were intranasally administered with exendin-4 daily for 7 days before middle cerebral artery occlusion (MCAO) surgery. Intranasally administered exendin-4 produced higher brain concentrations and lower plasma concentrations when ...
Intranasal administration of Exendin
This particular example perfectly highlights why Intranasally Administered Exendin is so captivating.
The study showed that intranasally administered Exendin-4 passed through the blood-brain barrier. Aβ31-35 given by intrahippocampal injection disrupted circadian rhythm and impaired learning and memory in C57BL/6 mice, and Exendin-4 given by nasal cavity or hippocampal administration ameliorated Aβ31-35-induced circadian rhythm ...
The day after the last trial of the MWM test, the mice were anesthetized by i.p. injection of sodium pentobarbital (50 mg/kg), and then exendin-4 with or without l - or d -penetratin insulin was administered intranasally (30 th administration) as described above.
Intranasal Delivery of Exendin
To determine the neuroprotective effects of intranasal exendin-4, C57BL/6J mice were intranasally administered with exendin-4 daily for 7 days before middle cerebral artery occlusion (MCAO) surgery.
Because some I-Ex administered intranasally enters the blood, we evaluated the relative contribution of the vascular versus the intranasal route in olfactory bulb, whole brain, and C-node uptake by comparing tissue/serum ratios after i.v. versus intranasal delivery (n = 2-4 mice/time point).
PDF Recent Advances in Intranasal Delivery of Therapeutic Peptides
This particular example perfectly highlights why Intranasally Administered Exendin is so captivating.
Because some I-Ex administered intranasally enters the blood, we evaluated the relative contribution of the vascular versus the intranasal route in olfactory bulb, whole brain, and C-node uptake by comparing tissue/serum ratios after i.v. versus intranasal delivery (n = 2-4 mice/time point).
Intranasal Exendin
EX4 was administered intranasally alone or preceded by RAPA, which was also solely given to male Sprague-Dawley rats subjected to CLP. First, opposite to the SE effect, RAPA inhibited mTORC1 and blunted TNF-α-induced necroptosis and Drp1, a mitochondrial fission marker.
We previously found that coadministering peptides and proteins with the cell-penetrating peptide L-penetratin intranasally significantly increased transport to the brain and enhanced pharmacological effects. The present study aimed to clarify the mechanisms of nose-to-brain drug delivery enhancement by L-penetratin coadministration. First, we compared the concentrations of Exendin-4 in plasma ...
