Delta Cells Are Ideally Positioned Within

The Difference

Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β- cells that determines the blood glucose set point and suggest that local δ- cell -mediated feedback stabilizes glycemic control.

Delta Cell

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Introduction The mammalian pancreas contains both exocrine and endocrine compartments. The endocrine cells (representing ~1-2% of the organ) are organized within the islets of Langerhans, endocrine "mini-organ" clusters scattered throughout the pancreas. Islets contain five hormone-producing cell types: alpha cells secrete glucagon, beta cells secrete insulin, delta cells secrete ...

Abstract Simple Summary Pancreatic islets are micro-organs composed of several endocrine cell types, including α- cells (secreting glucose-elevating glucagon), β- cells (releasing glucose-lowering insulin) and δ- cells (producing somatostatin, a potent inhibitor of insulin and glucagon secretion). Despite their low percentage within the islets (~5%), δ- cells play an important role in ...

Delta cell

Delta cells (δ- cells or D cells ) are somatostatin -producing cells . They can be found in the stomach, intestine and the pancreatic islets. Delta cells comprise ca 5% of the cells in the islets [1] but may interact with many more islet cells than suggested by their low numbers. In rodents, delta-cells are located in the periphery of the islets; in humans the islet architecture is generally ...