Glp-1 Mediated Satiety Effects

Intestinal glucagon

This review first recapitulates early findings indicating that intestinal GLP-1 is an endogenous satiation signal, whose eating effects are primarily mediated by vagal afferents. Second, on the basis of recent findings challenging a paracrine action of intestinal GLP-1 , a new model for the mediation of GLP-1 effects on eating by two discrete vagal afferent subsets will be proposed. The central ...

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Scientists were chasing an incretin hormone, and when GLP-1 was nally discovered, we found that it had a pronounced satiety fi effect , slowed down gastric emptying, and actually reduced ...