Hepatic Immune Response

Why Hepatic Immune Response Continues to Amaze Us

From Traditional to Trained Immunity

A key mechanism underpinning this duality involves neutrophil-derived microRNA-223 (miR-223), which modulates hepatic immune responses by silencing the NLRP3 inflammasome in macrophages and promoting their transition toward a restorative phenotype [76].

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Hepatic Immune Response

Immune System and Hepatic Stellate Cells' Crosstalk in Liver Fibrosis ...

Illustration of Hepatic Immune Response
Hepatic Immune Response

Liver fibrosis, characterized by the excessive deposition of extracellular matrix (ECM) driven by hepatic stellate cells (HSCs) activation, remains a critical challenge due to its progression to cirrhosis and hepatocellular carcinoma (HCC). This review clarifies the complex crosstalk between the immune system and HSCs, highlighting key cellular players including macrophages, natural killer (NK ...

The optimal management strategy for adults with immune -tolerant (IT) chronic hepatitis B infection remains undefined. A new study aimed to investigate the efficacy and predictive factors of a pegylated interferon (Peg-IFN)-based treatment strategy in IT patients with chronic HBV infection.

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