Pancreatic Beta Cell Cycle Regulation By Glp-1

Localized GLP1 receptor pre

Pancreatic alpha cells modulate beta cell function in a paracrine manner through the release of glucagon. However, the detailed molecular architecture underlying alpha-to- beta cell regulation remains poorly characterized. Here, we show that the glucagon-like peptide-1 receptor (GLP1R) is enriched as nanodomains on beta cell membranes that contact alpha cells , in keeping with increased single ...

Thus, although the pancreatic beta-cell secretory actions of GLP-1 and GLP-2 are distinct, parallels in terms of their beneficial effects on beta-cell signalling and turnover, as well as glucose homeostasis and appetite regulation , provide an attractive avenue for therapeutic application.

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This review outlines our knowledge of the actions of GLP-1 on insulin secretion and biosynthesis, beta-cell proliferation and regeneration, and protection against beta-cell damage, as well as the involvement of recently discovered signaling pathways of GLP-1 action, mainly focusing on pancreatic beta-cells .