There is a jar with 3409.0 pieces of candy.  There are also 145.0 secret eggs with a prize in them.  How many items in total are in the jar? Answer:

John is three times younger than his father, but two times older than his brother Jim. How old is John if Jim is 40 years younger than his father?
Answer: John is 16 years old.
Let X be John’s age, F be father’s age, and J be Jim’s age. Then, 3X=F, X/2 =J, and J+40=F. Solving this system of three equations for X, we get X=16.
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How might your mail be arriving in the future?
How might your mail be arriving in the future?
Answer: in a self-driving mail truck.
But don’t worry, there will still be a person in the truck for your dog to bark their head off at.
The United States Postal Service (USPS) released a report last week stating that the agency plans to integrate self-driving tech into its fleet of 228,000 vehicles. In partnership with the University of Michigan, USPS plans to build an Autonomous Rural Delivery Vehicle and start using it on 28,000 rural routes as early as 2025.

Joe’s code has 20 bugs. If Joe fixes 2 bugs per hour for 8 hours, how many bugs does Joe’s code have now? Answer: 27.

Practice the questions given in the worksheet on word problems on minuend and subtrahend.
1. Jack deposited $341256 in his bank account. He withdrew $100368. How much is left in his account?
2. Pat bought a house for $682396. He sold it for $765000. How much did he earn?
3. The sum of two numbers are 963562. One number is 493098. Find the other number?
4. A factory manufactured 432368 toys and sold 296431 out of them. How many toys were left unsold?
5. Kelly had $535426 with her. She spent $420228 to purchase different items. How much is left with her?
6. The total population of men and women in a city is 842579. If the population of men is 594025, find the population of women in the city?
Answers for the worksheet on word problems on minuend and subtrahend are given below to check the exact answers of the above questions.

An ant has six legs, a spider has eight legs and a mouse has four legs.
In my zoo, I recently counted 612 legs which came from an equal number of each of these animals.
Can you identify how many animals there are in my zoo?
Hint: Remember that there are an equal number of each animal.
Answer: 102 animals: 34 of each.
As there are the same number of each animal, for every ant, spider and mouse we have 18 legs.
612 ÷ 18 = 34 of each animal.
Which gives a total of 34 x 3 = 102 animals.

What are the Monomers that make up Proteins?
What are the Monomers that make up Proteins?
Answer : 1 Amino acids Explanation : Answer: A) Amino acids Explanation: Proteins are long chains of Amino acids. That is in brief, Amino acids are the monomers of Proteins. Amino acids are compounds which contain both an amino group and a carboxylic group. Proteins are made up of 20 essential amino acids.Monomer means a small molecule of an organic substance i.e, building block in general.

A nurse put 100 gloves into 4 containers. She puts gloves in the containers in such a way that each container has two more gloves than the one before. How many gloves are in each container?
Answer: 22, 24, 26, and 28 gloves.
Let X be the number of gloves in the first container. Then there are X+2 gloves in the 2-nd container, X+4 gloves in the 3-rd container, and X+6 gloves in the 4-th container. Hence, we have X+X+2+X+4+X+6=100. Solving for X, we get X=22 gloves in the first container, 24 gloves in the 2-nd container, 26 gloves in the 3-rd container and 28 gloves in the 4-th container.
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Subtraction is the method by which we know the remaining after taken away some quantity from a certain quantity.
Step 1: Arrange the digits of the numerals as per the place value chart.
Step 2: Now subtract ones from ones, tens from tens and so on.
Minuend: The number from which other number is subtracted.
Subtrahend: The number which is subtracted from the other number.
Difference: When a number is subtracted from other, the product is called difference.
Subtract 15 lakhs from 12 crores.
The sum of two numbers is 7894562. If one of the numbers is 564897 then find the other.
A water tank contains 9800365 litre water. 456876 litre water is replaced by 9864 cubic stones. Find the remaining amount of water in the tank?
There are two boxes, first box contains only red balls whereas second box contains blue and white balls. Number of red, blue and white balls are 456456, 745879, and 25463 respectively. Jack threw all the white balls out of box. Find the remaining number of balls in the second box.
Second box contains two types of coloured balls blue and white. Jack threw all the white coloured balls out of box.
A and B represents two different villages. Population of the village A is 758945 in which 548796 are educated. Population of the village B is 879456 in which 256456 are educated. Find the total number of uneducated people.
Therefore, total number of uneducated people = 210149 + 623000 = 833149 .
Addition is the operation to know the total quantity when two or more than two quantities are taken together.
The numbers which are added together called addend and the problems is called sum.
When two or more than two numbers are added, the product is called sum.
Subtraction is the method by which we know the remaining after taken away some quantity from a certain quantity.
The sum of a number and 0 is equal to the number itself.
The result of subtractions is called the difference between the numbers.
Plus and minus are Latin words. In Latin plus means more and minus means less.
In the USA, -7 is pronounced as negative seven instead of minus seven.
Choose correct option for the expression 12 crores - 12 thousands.
Cody goes 45607 km north and returns back then he goes 84659 km east and returns back. Find the total distance covered by him.
Total distance covered by Cody = 45607 km + 45607 km + 84659 km + 84659 km = 260532 km.
Difference of the two numbers is 5648 less than 908564. If one of the numbers is 789006, find the other number from the following.
P = 454658, Q = 400085, R = 408789. Which one of the following is the greatest?
A + B is greater than C + D. Choose the correct option.
(a) If C is greater than A, B must be greater than D.
(b) If A is greater than C, D must be greater than B.
(c) If A is greater than D, B must be greater than D.
(d) If D is greater than A, B must be equal to D.

Hemavathi cut a cake into two halves and cuts one half into smaller pieces of equal size. Each of the small pieces is fifteen grams in weight. If she has nine pieces of the cake in all with her, how heavy was the original cake ?
Hemavathi cut a cake into two halves and cuts one half into smaller pieces of equal size. Each of the small pieces is fifteen grams in weight. If she has nine pieces of the cake in all with her, how heavy was the original cake ?
Answer : 1 240 gms Explanation : Answer: A) 240 gms Explanation: The nine pieces consist of 8 smaller equal pieces and one half cake piece.Weight of each small piece = 15 g.So, total weight of the cake = [2 x (15 x 8)]g = 240 g.

The integer 14424 is an even number.
The integer 14424 is a Composite number.
21696 is greater than 14424, so 14424 is an abundant number.

It is 37.7 miles according to Google Maps.
How far is Santa Barbara California from Oxnard California?
Answer: Santa Barbara is about a 45-50 minute drive from Oxnard.

What famous TV show did the mask of Michael Myers (the face of Halloween) come from?
Answer: Back in 1978, the makers of Halloween had such a limited budget that they were forced to buy the cheapest one they could find. It turned out to be a William Shatner Star Trek mask. When Shatner found out, he said he was honored.

When I watch videos of people practicing kendo I often hear them make weird sounds. What is that sound for?
Answer: Thanks for your question. I am not sure what kinds of sounds you are referring to. Can you be more specific?

What were the total hospital costs of treating injuries caused by the atomic bomb dropped on Hiroshima?
Answer: Of more than 200 doctors in Hiroshima before the attack, over 90 percent were casualties and only about 30 physicians were able to perform their normal duties a month after the raid. Out of 1,780 nurses, 1,654 were killed or injured. Through some stocks of supplies had been dispersed, many were destroyed .Only three out of 45 civilian hospitals could be used, and two large Army hospitals were rendered unusable. Exact casualty figures for medical personnel are unknown, but the city seems to have fared better than Hiroshima: 120 doctors were at work on 1 November.
Can a guardian be sued for injuries caused by minor?
What makes sports injuries different from other types of injuries?
Answer: Sports injuries are injuries that occur in an athletic setting whether it be a game, workout, or practice for a sporting event. In many cases these are injuries from overuse of a muscle or joint which is what makes it unique to other injuries that are usually just strain or caused by impact.
What are some common injuries?
What are the common injuries in a laboratory?
What are the top 3 most common sport injuries?
What are the most common skateboarding injuries?
What are some common injuries to teenager?
Answer: Wrestling Pro Answer I know this from experience. The most common injuries are sprains and strains. Things like the arm chop can cause sprained elbows and throws and pulls cause strained and pulled muscles. Though most happen when you wrestle with a neophyte or you are simply playing around and not paying attention. In rare ocations dislocations and fractures occur.
Though in case you want to know the most common infections in wrestling are herpes simplex and ringworm.
These happen because either you or your contender dont have proper hygene and infect each other while in contact. Be clean and safe, be sure you know what you are doing.
What are the most common injuries to the bone?
Answer: The most common injury done to a bone is either spraining or braking a bone. I once fractured my ankle. All of these injuries are very painful but the worst of all is breaking it because your bone snaps into more than one piece. Spraining a bone is less painful than breaking or fracturing a bone because it is not in more than one piece. It depends on what you did to the bone like if you slide on concrete then that is probably a fracture or a break in the bone. Be careful with whatever you do your body is not made of metal or titanium!
What is the most common knee injuries?
What sport is the most common cause of eye injuries in US?
What are most common injuries to bones?
Answer: particularly the longer bones of the arms and legs is a fracture, or a break in the bone. (A fractured bone and a broken bone are the same thing; one is notworse than the other.) Other common places for fractures are thebones of the wrist, ankle, and kneecap.
What are common firefighting injuries?
Answer: Some common firefighting injuries would be knee/ankle problems, back problems, and shoulder problems.
A common method of treating minor sports injuries is the?
A common method of treating minor sports injuries is the what principle?
A common method of treating minor sports injuries is the?
Answer: A common method of treating minor sports injuries is the what principle?
What is a common method of treating minor sports injuries?
Answer: Однажды JR. бежал исключением того, что одна Ugly Kid, которая пахнет, как старое пиво и утки ленты, но любом случае, что ребенок был мертв.
What principle is a common method of treating minor sport injuries?
Overuse injuries are minor tissue injuries that have not been given time to heal true or false?
The RICE procedure is useful for A hypothermia B major injuries C hot-weather health problems D minor injuries?
Answer: RICE (Rest, Ice, Compression, Elevation) is used to treat minor injuries such as sprains or strains, usually to the arms or legs.
What is the most common injuries in sports?
Answer: The most common sports injuries are Achilles injuries, groin injuries, hamstring injuries, sprained ankles, wrist injuries, shoulder tendon inflammation and a tennis elbow.
How are common sports injuries treated?
Drugs - Most popular way, but not always most effective is to take some form of painkiller to help subside the pain, but this is often a way of making an injury worse by making the person feel fine and possibly making the injury worse.
How Physiological responses common to most sports injuries?
What types of injuries occur largely in the feet and legs and are in common in sports that require repetitive impact?
What type of injuries occur largely in the feet and legs and are common in sports that require repetitive impact?
Answer: Ankle and knee injuries are the most common injuries in sports thatrequire repetitive impact. Other injuries that may occur includefractures and breaks in leg bones.
What types of injuries occur largely in the feet and legs and are common in sports that require repetitive impact?
What is the best method for treating burns and lacerations?
Answer: The best method is to keep the area clean. When the area is clean it will heal faster. Peroxide is a great way to keep a wound clean.
What does RICE a procedure for treating minor sprains and strains stand for?
Compress: wrap the injury, apply compression.
What is the R.I.C.E procedures for minor injuries?

After a local art theft, six suspects were being interviewed.
Police know that exactly four of them told one lie each and all of the other statements are true.
Hint: If Alex had committed the crime, how many lies would there be?
Answer: Chris committed the crime.
If any other person had committed the crime there would not be exactly 4 lies told.

Need a sweet, yet savory side dish for your next meal? These rosemary honey ginger glazed carrots are sure to please, any time of year!
Baby carrots make an easy side dish. They can go from a cold bar with dips, in a lunch bag for on the go, to a hot side dish with ease. There’s not much to dislike about them, truly. Carrots are a good source of vitamins and minerals, and are a favorite for many. What could be better than little sticks of orangey goodness?
Adding in rosemary, honey and ginger.
Rosemary honey ginger glazed carrots bring out the sweetness of the carrots with just the right amount of zing. Normally, I don’t enjoy cooked carrots. Maybe it’s the texture, or some off memory from my childhood. I can’t be sure, to be honest. My mother used to coat them in brown sugar and butter and cook them until they were a pile of sugary mush.
Sweet, yes. Mushy gross texture definitely.
However, the texture of these carrots is not mushy at all. They are still lightly crisp with a delicate flavor balance. Cooking them on the stove top for a few minutes allows the honey to carmelize and blend with the carrot’s own sweetness, while the ginger and rosemary work together to set off a balance in sweetness.
The Frenchman approves of these as his favorite side dish, and hubby and the boy are in agreement. They are sure to be a hit in your home, too!
Wash the baby carrots, and pat dry with a paper towel.
Heat the butter or coconut oil in a large skillet to melt.
Add the baby carrots and stir to coat with melted oil.
Drizzle honey over the carrots and stir again.
Roast on the stove top for 5 minutes, stirring occasionally to cook evenly.
Scatter the ginger and rosemary over the carrots and stir.
Cook an additional 3 minutes.
What’s your favorite side dish? Will you try these rosemary honey ginger glazed carrots? Be sure to pin this for later!
Wash the baby carrots, and pat dry with a paper towel.
Heat the butter or coconut oil in a large skillet to melt.
Add the baby carrots and stir to coat with melted oil.
Drizzle honey over the carrots and stir again.
Roast on the stove top for 5 minutes, stirring occasionally to cook evenly.
Scatter the ginger and rosemary over the carrots and stir. Cook an additional 3 minutes.

Question: How many words constitute a fictional short story? Not a short, short story but a short story.
Answer: Generally, a short story is any story under 7,500 words. Anything under 1,000 words is often termed flash fiction.
However, these definitions are not fixed. Sometimes works up to 20,000 words have been called short stories. You have to check with individual publishers (such as literary magazines, websites, contests, etc.) to see what length of stories they are looking for and what terms they are using to describe them (e.g. micro-fiction, novelette, novella, postcard fiction).
At the extreme lower end there are also "six word memoirs," such as this famous one attributed to Hemingway: "For sale: baby shoes. Never worn."

putting the jars into "shared/lib".
that one ought to put it into "shared/lib".
I've tried both CATALINA_HOME/shared/lib and CATALINA_BASE/shared/lib.
Any ideas what might be going awry?

How many X are there in one Y?
How many X are there in one Y? For example, how many teaspoons are there in a gallon?
Answer: Use our calculator to convert from 1 gallon to teaspoons, and it will give you the answer you seek.
Another example: How many glasses of water are there in 109 ounces of water? If each glass is 2 cups, then you can find out how many 2-cup glasses are in 109 ounces of water by converting from 109/2 floz/cups and leave the "Convert To" box blank. This basically divides 109 fluid ounces by 2 cups, giving the result as the number of 2-cup glasses in 109 fluid ounces. If the glasses were each 7 fluid ounces, then you would convert from 109/7 floz/floz and again leave the "Convert To" box blank.

As we explained in our recent article “The Fed Steps On Middle America Again,” whether there is a political motive, or simply a Wall Street over Main Street bias one thing is certain: In the alternative universe where Wall Street’s Masters of the Universe and the mandarins who control America’s Federal Reserve Bank live, it seems good economic news for America’s middle-income families is something to be feared.
The Fed’s projected growth rate or target is 2 percent, half of President trump’s stated goal of 4 percent and less than half of the best quarter achieved during the Trump economic boom, and the central bank’s interest rate increases are already hitting working families in their most important investment; their home.
The S&P CoreLogic Case-Shiller 20-city home price index rose 5 percent from a year earlier, down from an annual gain of 5.2 percent in September, reported our friends at NewsMax.
Home prices have dropped as would-be buyers are struggling to afford homes. Prices have consistently climbed faster than wages, a challenge that was overcome until last year by historically low mortgage rates, reported NewsMax. But borrowing costs began to rise last year after President Donald Trump cut taxes and the Federal Reserve hiked interest rates.
While Las Vegas, San Francisco and Phoenix were bright spots in the housing index, nationally sales have generally stagnated or fallen.
The National Association of Realtors reported earlier this month that sales of existing homes tumbled 7 percent in November from a year ago.
Consumers may get some temporary relief as mortgage rates have declined in recent weeks amid the stock market sell-off. The average rate on the benchmark 30-year, fixed-rate mortgage fell to 4.62 percent last week from nearly 5 percent in early November, according to mortgage buyer Freddie Mac.
Still, average rates are up from 3.94 percent a year ago reported NewsMax.
Housing remains the largest expense for the average American family.
And while many investment professionals will argue that a home is not an “investment” it is the single largest investment most families will make, and it is the largest repository of family wealth for many working families.
According to real estate market watcher Zillow, the cumulative value of all homes in the U.S. declined by $6.4 trillion from 2006 to 2012 as the housing market collapsed.
The total value of all U.S. homes in 2017 was estimated by Zillow at $31.8 trillion. The total value of all the housing stock in the United States has never been worth more than it is right now, meaning the housing market has fully recovered value lost in the crash of 2008.
Meaning that the largest investment held by many working families had finally recovered from the grim days of the Great Recession.
What does this mean for the U.S. economy?
As Svenja Gudell of Zillow wrote for Forbes, it means that individual homeowners hold 1.5 times the Gross Domestic Product of the United States and approaching three times that of China. Total U.S. home values have grown $1.95 trillion over the past year — more than all of Canada’s GDP or two companies the size of Apple.
Gudell, chief economist for Zillow, observed that in the New York City metro area alone, total home values equal $2.6 trillion, more than the French economy — and enough money to buy 8,494 Boeing 787-10 Dreamliners.
Among the 35 largest U.S. markets, says Gundell, the greatest total home value growth happened in Columbus, Ohio, which gained 15.1 percent to $152.3 billion — enough to buy 634 million club seats at last year’s Cotton Bowl game between Ohio State and USC.
So why would the Fed want to do anything to slow the record-breaking run in housing values, slow wage growth and encourage a Bear market that will strip more wealth from the retirement accounts and college funds of America’s working families?


Third-grade students went to a concert in 8.0 buses. There were 45.0 students total. How many students went in each bus? Answer:

What is Square Root of 38 ?
38 is the sum of the squares of first three prime numbers 22 + 32 + 52 and the square root of 38 is 6.16441.
38 is the sum of the squares of first three prime numbers 22 + 32 + 52 and the square root of 38 is 6.16441.

What is Square Root of 29 ?
29 is formed by the sum of three consecutive squares 22 + 32 + 42 and the square root of 29 is 5.38516.
29 is formed by the sum of three consecutive squares 22 + 32 + 42 and the square root of 29 is 5.38516.

How many pulgada in 1 foot [iraq]? The answer is 12.44094488189.
We assume you are converting between pulgada and foot [iraq].
1 metre is equal to 39.370078740157 pulgada, or 3.1645569620253 foot [iraq].
Use this page to learn how to convert between pulgadas and feet [iraq].

Find the square root of 6.0516.
Q 1: Find the square root of the number 11.9716.
Q 2: Find the square root of the number 3.4969.
Q 3: Find the square root of the number 13.4689.
Q 4: Find the square root of the number 38.5641.
Q 5: Find the square root of the number 13.3225.
Q 6: Find the square root of the number 4.9729.

Out of sixty students, there are 14 who are taking Economics and 29 who are taking Calculus. What is the probability that a randomly chosen student from this group is taking only the Calculus class ?
Out of sixty students, there are 14 who are taking Economics and 29 who are taking Calculus. What is the probability that a randomly chosen student from this group is taking only the Calculus class ?
Answer : 2 7/15 Explanation : Answer: B) 7/15 Explanation: Given total students in the class = 60Students who are taking Economics = 24 andStudents who are taking Calculus = 32Students who are taking both subjects = 60-(24 32) = 60 - 56 = 4Students who are taking calculus only = 32 - 4 = 28probability that a randomly chosen student from this group is taking only the Calculus class = 28/60 = 7/15.

How many ml of soft cheese, grated in 4 ounces?
How many ml of soft cheese, grated in 4 ounces?
(*) or precisely 268.08 milliliters. All values are approximate.

What is the value of d? answer in units of seconds.
find 2 solutions of tan θ=.6524 in both degrees and radians. I know the answer are 33.12 degrees/.578 radians and 213.12 degrees/3.72 radians, but how do you find this? Thanks!!!!

(a) Find the potential difference between points a and b. = The answer is 5.61 volts.
(b) Find the current in the 20.0-Ω resistor. = ??????

How many pulgada in 1 wah [Thailand]? The answer is 78.740157480315.
We assume you are converting between pulgada and wah [Thailand].
1 metre is equal to 39.370078740157 pulgada, or 0.5 wah [Thailand].
Use this page to learn how to convert between pulgadas and wah [Thailand].

Can you please tell me if I have the correct answer?
Find the diameter of a circle whose circumference is 18.85m.
Yes, 6.000 is correct, to four significant figures.
6.00014 is more accurate, but since they only quoted four significant figures for the circumference, stick with 6.000 m for the answer.

View question - If you went to the store and the store is 108 Inches how many feet is that?
108 divided by 12 would be 9.
108 divided by 12 would be 9.

How many ml in 1 gram [water]? The answer is 1.
We assume you are converting between milliliter and gram [water].
1 cubic meter is equal to 1000000 ml, or 1000000 gram [water].
Use this page to learn how to convert between milliliters and grams.

In last week’s edition of APW’s Rate My Ride Wednesdays, we featured four photos of awesome all-American trucks and asked our Facebook fans to rate them on a scale of 1 to 10 (1 = Unimpressive, 10 = Extremely Hot). Here’s how they fared. Grabbing the top spot is Tony’s silver Dodge Ram with an average score of 8.9. In second place is Billy’s impressive 1995 Dodge Ram with a score of 6. Coming in at third and fourth place are Evan’s outstanding orange Dodge Ram 1500 with a rating of 4 and Chris’s Ford F-150 with a score of 3.

3 iron bars of dimensions 1.25 m × 1.25 m × 5 m are melted to mould conical pieces of base radius 10 cm and height 20 cm. Find out the number of pieces that can be made taking π = 3.
Rate of loading the sand = 4500 c.c/min.
Time taken to load = 972000 / 4500= 216 min.
A tent is in the form of a square pyramid with a base length of 21 m. The slant height of the pyramid is 16 m. If the rate of making the tent is $60 per cubicmeter, then what is the cost of making the tent?
Slant height = 16 m.
A cone has a base radius of r and height h. If x is the measure of the height of a similar cone with half the volume of the original cone, then what is the relation between x and h?
AB = r, OB = h, OD = x, CD = rxh.
Volume of first cone = 2 (Volume of the second cone).
The relation between h and x is h 3 = 2 x3.
The height of 3 ounces of liquid in a conical cup is half of the height of the cup. How many ounces of the liquid will be required to fill the entire conical cup?
A metallic cone of radius 8 cm and height 18 cm is melted and made into identical spheres each of radius 2 cm. How many spheres can be made?
Therefore, 36 spheres can be made.
how to find the volume of a rectangular pyramid?

The signs have been pointing this way for a while, but it was still a wee bit unsettling to read the obituary of a church that Wendy & I had once pastored in.
We were part of the church-planting team for the first five years, and it was a wild and woolly ride at times, believe you me.
"(Eastgate) Vineyard Christian Fellowship, worshipping in and serving from several different locations since 1992, held its last service April 29 (2007). The church’s administrator announced the closing on behalf of the congregation of 50, in a letter widely distributed in May. Several pastor couples have served the church, including... Robby and Wendy McAlpine.
"...The letter did not specify reasons for the closure – suggesting, rather, that 'we trust that as [God] has produced good seed in each of us... that He will plant these seeds in new places and bring growth and life through its members.'"
It was also this church that eventually launched us, in 1997, into our season of Detoxing From Church.
But I also remember that, unlike many churches that go through tough times, the leadership did some things right. Of special significance was their decision, on the 10th anniversary of the church, to reach out and reconcile broken relationships with several former pastors, six years after Wendy & I had left.
Several people have privately commented that it's for the best that the steadily-shrinking and struggling fellowship shut down, and they're probably right in saying so. But it's still a very strange feeling in my gut, when I think about a church that Wendy & I were once pastors in, and had helped get off the ground in its early years, which simply doesn't exist anymore.
Maybe that's for the better, but it still feels weird.

Last night, I took a break from writing and watched a TV program on the history of a young man named Alexander Graham Bell. Bell had just patented his telephone, and was having growing pains because the demand for his new invention was so strong. Needing a bigger company, he then went to the giant at that time, Western Union, and asked them if they would buy his patent and his tiny company. He wanted $100,000 for the whole package. The president of Western Union scoffed at him and turned him down, saying the price was ridiculous. The rest is history. A multi-billion-dollar industry emerged, and AT&T was born.
The evening news came on right after the story of Alexander Graham Bell ended. On the news was a story of another downsizing at a local company. The workers were angry and complained that the company ownership was unfair. A terminated manager of about 45 years of age had his wife and two babies at the plant and was begging the guards to let him talk to the owners to ask if they would reconsider his termination. He had just bought a house and was afraid of losing it. The camera focused in on his pleading for all the world to see. Needless to say, it held my attention.
I have been teaching professionally since 1984. It has been a great experience and rewarding. It is also a disturbing profession, for I have taught thousands of individuals and I see one thing in common in all of us, myself included. We all have tremendous potential, and we all are blessed with gifts. Yet, the one thing that holds all of us back is some degree of self-doubt. It is not so much the lack of technical information that holds us back, but more the lack of self-confidence. Some are more affected than others.
Once we leave school, most of us know that it is not as much a matter of college degrees or good grades that count. In the real world outside of academics, something more than just grades is required. I have heard it called "guts," "chutzpah," "balls," "audacity," "bravado," "cunning," "daring," "tenacity" and "brilliance." This factor, whatever it is labeled, ultimately decides one's future much more than school grades.
Inside each of us is one of these brave, brilliant and daring characters. There is also the flip side of that character: people who could get down on their knees and beg if necessary. After a year in Vietnam, as a Marine Corps pilot, I intimately got to know both of those characters-inside of me. One is not better than the other.
Yet, as a teacher, I recognized that it was excessive fear and self-doubt that were the greatest detractors of personal genius. It broke my heart to see students know the answers, yet lack the courage to act on the answer. Often in the real world, it's not the smart that get ahead but the bold.
In my personal experience, your financial genius requires both technical knowledge as well as courage. If fear is too strong, the genius is suppressed. In my classes I strongly urge students to learn to take • risks, to be bold, to let their genius convert that fear into power and brilliance. It works for some and just terrifies others. I have come to realize that for most people, when it comes to the subject of money, they would rather play it safe. I have had to field questions such as: Why take risks? Why should I bother developing my financial IQ? Why should I become financially literate?
And I answer, "Just to have more options."
There are huge changes up head. Just as I started with the story of the young inventor Alexander Graham Bell, in the coming years there will be more people just like him. There will be a hundred people like Bill Gates and hugely successful companies like Microsoft created every year, all over the world. And there also will be many more bankruptcies, layoffs and downsizing.
So why bother developing your financial IQ? No one can answer that but you. Yet, I can tell you why I myself do it. I do it because it is the most exciting time to be alive. I'd rather be welcoming change than dreading change. I'd rather be excited about making millions than worrying about not getting a raise. This period we are in now is a most exciting time, unprecedented in our world's history. Generations from now, people will look back at this period of time and remark at what an exciting era it must have been. It was the death of the old and birth of the new. It was full of turmoil and it was exciting.
So why bother developing your financial IQ? Because if you do, you will prosper greatly. And if you don't, this period of time will be a frightening one. It will be a time of watching people move boldly forward while others cling to decaying life rings.
Land was wealth 300 years ago. So the person who owned the land owned the wealth. Then, it was factories and production, and America rose to dominance. The industrialist owned the wealth. Today, it is information. And the person who has the most timely information owns the wealth. The problem is, information flies all around the world at the speed of light. The new wealth cannot be contained by boundaries and borders as land and factories were. The changes will be faster and more dramatic. There will be a dramatic increase in the number of new multimillionaires. There also will be those who are left behind.
Today, I find so many people struggling, often working harder, simply because they cling to old ideas. They want things to be the way they were; they resist change. I know people who are losing their jobs or their houses, and they blame technology or the economy or their boss. Sadly they fail to realize that they might be the problem. Old ideas are their biggest liability. It is a liability simply because they fail to realize that while that idea or way of doing something was an asset yesterday, yesterday is gone.
One afternoon I was teaching investing using a board game I had invented, CASHFLOW, as a teaching tool. A friend had brought someone along to attend the class. This friend of a friend was recently divorced, had been badly burned in the divorce settlement, and was now searching for some answers. Her friend thought the class might help.
The game was designed to help people learn how money works. In playing the game, they learn about the interaction of the income statement with the balance sheet. They learn how "cash flows" between the two and how the road to wealth is through striving to increase your monthly cash flow from the asset column to the point that it exceeds your j monthly expenses. Once you accomplish this, you are able to get out of the "Rat Race" and out onto the "Fast Track".
As I have said, some people hate the game, some love it, and others miss the point. This woman missed a valuable opportunity to learn something. In the opening round, she drew a "doodad" card with the boat on it. At first she was happy. "Oh, I've got a boat." Then, as her friend tried to explain how the numbers worked on her income statement and balance sheet, she got frustrated because she "had never liked math. The rest of her table waited while her friend continued explaining the relationship between the income statement, balance sheet and monthly cash flow. Suddenly, when she realized how the numbers worked, it dawned on her that her boat was eating her alive. Later on in the game, she was also "downsized" and had a child. It was a horrible game for her.
After the class, her friend came by and told me that she was upset. She had come to the class to learn about investing and did not like the idea that it took so long to play a silly game.
Her friend attempted to tell her to look within herself to see if the game "reflected" on herself in any way. With that suggestion, the woman demanded her money back. She said that the very idea that a game could be a reflection of her was ridiculous. Her money was promptly refunded and she left.
Since 1984, I have made millions simply by doing what the school system does not. In school, most teachers lecture. I hated lectures as a student; I was soon bored and my mind would drift.
In 1984,I began teaching via games and simulations. I always encouraged adult students to look at games as reflecting back to what they know, and what they needed to learn. Most importantly, a game reflects back on one's behavior. It's an instant feedback system. Instead of the teacher lecturing you, the game is feeding back a personalized lecture, custom made just for you.
The friend of the woman who left later called to give me an update. She said her friend was fine and had calmed down. In her cooling-off period, she could see some slight relationship between the game and her life.
Although she and her husband did not own a boat, they did own everything else imaginable. She was angry after their divorce, both because he had run off with a younger woman and because after twenty years of marriage, they had accumulated little in the way of assets. There was virtually nothing for them to split. Their twenty years of married life had been incredible fun, but all they had accumulated was a ton of doodads.
She realized that her anger at doing the numbers-the income statement and balance sheet-came from her embarrassment of not understanding them. She had believed that finances were the man's job. She maintained the house and did the entertaining, and he handled the finances. She was now quite certain that in the last five years of their marriage, he had hidden money from her. She was angry at herself for not being more aware of where the money was going, as well as for not knowing about the other woman.
Just like a board game, the world is always providing us with instant feedback. We could learn a lot if we tuned in more. One day not long ago, I complained to my wife that the cleaners must have shrunk my pants. My wife gently smiled and poked me in the stomach to inform me that the pants had not shrunk, something else had expanded me!
The game CASHFLOW was designed to give every player personal feedback. Its purpose is to give you options. If you draw the boat card and it puts you into debt, the question is, "Now what can you do?" How many different financial options can you come up with? That is the purpose of the game: to teach players to think and create new and various financial options.
I have watched this game played by more than 1,000 people. The people who get out of the "Rat Race" in the game the quickest are the people who understand numbers and have creative financial minds. They recognize different financial options. People who take the longest are people who are not familiar with numbers and often do not understand the power of investing. Rich people are often creative and take calculated risks.
There have been people playing CASHFLOW who gain lots of money in the game, but they don't know what to do with it. Most of them have not been financially successful in real life either. Everyone else seems to be getting ahead of them, even though they have money. And that is true in real life. There are a lot of people who have a lot of money and do not get ahead financially.

TRIPS is Rockland County’s paratransit bus service for residents with physical, mental, developmental or intellectual disabilities or senior citizens who are aged 60 or over. In each of these cases, TRIPS service is reserved for individuals who are unable to use municipal, fixed-route bus service.
TRIPS provides curbside-to-curbside service by appointment. TRIPS passengers may or may not go directly to their destinations and there may be several pick-ups and drop-offs along the way. TRIPS operates only within Rockland County. TRIPS stands for Transportation Resources, Intra-county, for Physically disabled and Senior citizens.

Congratulations to investigators at the Research Institute of the McGill University Health Centre (RI-MUHC) who were successful in the inaugural Canadian Institutes of Health Research (CIHR) Foundation Scheme "live pilot" competition and at the Fonds de recherche du Québec – Santé (FRQS).
Congratulations, as well, to our investigators with new grants and bursaries from other important funding sources. These achievements are all the more extraordinary in a year marked by physical and structural transitions for the RI-MUHC research community.

Neuronal hypoxia in vitro: investigation of therapeutic principles of HUCB-MNC and CD133+ stem cells.
Neuronal hypoxia in vitro: investigation of therapeutic principles of HUCB-MNC and CD133+ stem cells.
BACKGROUND: The therapeutic capacity of human umbilical cord blood mononuclear cells (HUCB-MNC) and stem cells derived thereof is documented in animal models of focal cerebral ischemia, while mechanisms behind the reduction of lesion size and the observed improvement of behavioral skills still remain poorly understood. METHODS: A human in vitro model of neuronal hypoxia was used to address the impact of total HUCB-MNC (tMNC), a stem cell enriched fraction (CD133+, 97.38% CD133-positive cells) and a stem cell depleted fraction (CD133-, 0.06% CD133-positive cells) of HUCB-MNC by either direct or indirect co-cultivation with post-hypoxic neuronal cells (differentiated SH-SY5Y). Over three days, development of apoptosis and necrosis of neuronal cells, chemotaxis of MNC and production of chemokines (CCL2, CCL3, CCL5, CXCL8, CXCL9) and growth factors (G-CSF, GM-CSF, VEGF, bFGF) were analyzed using fluorescence microscopy, FACS and cytometric bead array. RESULTS: tMNC, CD133+ and surprisingly CD133- reduced neuronal apoptosis in direct co-cultivations significantly to levels in the range of normoxic controls (7% +/- 3%). Untreated post-hypoxic control cultures showed apoptosis rates of 85% +/- 11%. tMNC actively migrated towards injured neuronal cells. Both co-cultivation types using tMNC or CD133- reduced apoptosis comparably. CD133- produced high concentrations of CCL3 and neuroprotective G-CSF within indirect co-cultures. Soluble factors produced by CD133+ cells were not detectable in direct co-cultures. CONCLUSION: Our data show that heterogeneous tMNC and even CD133-depleted fractions have the capability not only to reduce apoptosis in neuronal cells but also to trigger the retaining of neuronal phenotypes.
17267246 - Signals from both sides: control of cardiac development by the endocardium and epicardium.
Copyright ? 2008 Reich et al; licensee BioMed Central Ltd.
Transplantation of adult stem cells has been shown to be an auspicious and effective treatment for degenerative and traumatic neurological diseases . Among degenerative neurological disorders acute ischemic stroke is the leading cause of disability and death in industrial nations [2-4].
Acute stroke leads to an increased release of hematopoietic stem and progenitor cells from bone marrow into peripheral blood . It is assumed that these cells take part in self-healing processes occurring after neuronal injury. They are supposed to promote the survival of the injured brain tissue by producing neurotrophic factors , to enhance endogenous angiogenesis  and neurogenesis  or even to transdifferentiate into neuronal cells . However, the stroke induced endogenous release of hematopoietic stem and progenitor cells seems not to be sufficient to compensate massive loss of brain tissue after extended ischemic stroke. Therefore, external application of hematopoietic stem and progenitor cells is expected to complement current treatment of acute stroke based on thrombolytic therapy. An appropriate source of hematopoietic stem cells is the mononuclear cell (MNC) fraction of human umbilical cord blood (HUCB) [10-12]. Transplantation of HUCB-MNC as well as enriched HUCB hematopoietic stem cells into animals which were subjected to focal stroke caused by middle cerebral artery occlusion (MCAO) ameliorated the animals' functional outcome and reduced the lesion size . However, there are still manifold unanswered questions addressing the beneficial influence of such grafts on injured neuronal cells.
It has been documented that there is no neuronal transdifferentiation of hematopoietic stem cells in vitro [14-16]. Though so far there is no convincing proof that locally administered hematopoietic stem cells transdifferentiate into functionally neuronal cells forming the basis of the animals' behavioral progression .
It has recently been shown that there is no need for MNC to enter the brain for neuroprotection. Soluble factors like GDNF, NGF, BDNF or G-CSF are known to promote neuroprotection over long-distances [18,19]. This raises many questions about the cellular mechanisms causing the functional improvement after grafting . Prevention of neurons from apoptotic cell death  is considered to be supported by the transplantation and could be directly connected to improved tissue conservation, lesion size reduction and superior functional outcome .
Cell culture models of neuronal hypoxia complement the exploration of particular interactions between grafts and neuronal tissue. Our study is based on a well established post-hypoxic neuronal cell culture model (SH-SY5Y). This model was used to address (i) the neuroprotective potential of stem cell enriched and -depleted HUCB derived cell fractions, (ii) the impact of these cells especially on apoptotic status of oxygen-deprived neurons, and (iii) the mediation of cell-derived survival signals (soluble or cell-attached).
Hypoxic cultivation (48 hours) of fully matured neuronal SH-SY5Y cells resulted in an initial rate of apoptosis of 26% ? 13%. Within the following three days rate of apoptosis increased to 85% ? 11%. By contrast, normoxic control cultures showed a stable amount of apoptotic cells (7% ? 3%) over the whole observation time (data not shown). Direct co-cultivation with tMNC and CD133-showed pronounced reduction of neuronal apoptosis. Similar results were obtained after application of CD133+. By application of 4.5 ? 103 CD133+ they were given in equal amounts as they exist in tMNC. Though the whole cell amount of CD133+ was 100 times less then tMNC administered (Fig. 1A).
Levels of necrosis in post-hypoxic control cultures remained nearly stable (approximately 25%) over three days. tMNC and CD133-cell application also induced a significant reduction of necrosis. CD133+ cells did not influence the level of necrosis (Fig. 1B).
Over the entire observation period, direct as well as indirect co-cultivation with tMNC or CD133-exhibited a significant reduction of apoptosis. In all co-culture set-ups percentage of annexin-V positive cells was significantly lower (p ? 0.001) than in post-hypoxic control cultures (Fig. 2A, B). Direct and indirect co-cultivation of CD133-resulted in similar rates of apoptosis continuously below 5% of annexin-V positive cells (Fig. 2B). However, still generating strong neuroprotective effects, the number of apoptotic neuronal cells in indirect tMNC co-cultures was significantly higher than in direct co-cultures at Day 2 and Day 3 (p ? 0.001) as shown in figure 2A. Direct co-cultivation with tMNC resulted in a stable level of 6% ? 1% neuronal apoptosis and was therefore significantly lower than in post-hypoxic control cultures (Day 2: 46% ? 20%; Day 3: 85% ? 11%).
When tMNC were indirectly co-cultured neuroprotection was as pronounced as in direct co-cultures on the first day after hypoxia. Two and three days after application there was still a significant, but compared to control cultures reduced, protective effect in the indirect co-cultures while protection in direct co-cultures was as distinct as on Day 1 (7% ? 8%).
The comparison of both application types using tMNC and CD133-showed that soluble factors seem to have strong therapeutic potential (Fig. 2A).
The positive influence of indirect co-cultivation on the amount of apoptotic cells, revealed by annexin-V detection, was also confirmed by typical patterns in the cleavage of PARP, a late marker of apoptosis (Fig. 3). In indirect co-cultures with tMNC and CD133-quantities of cleaved PARP were nearly at the same level on Day 1 post-hypoxia. On Day 2 and Day 3 neuroprotection by CD133-resulted in concentrations of cleaved PARP ranging in the level of the normoxic control (Fig. 3).
Only direct co-cultures of tMNC and CD133-displayed improved protection from necrosis/late apoptosis as revealed by Propidium Iodide labeling of post-hypoxic neuronal cells (Fig. 2C, D). Indirect co-cultivation did not reduce the percentage of necrotic/late apoptotic neuronal cells.
In direct co-cultures many tMNC were found in close spatial relation with post-hypoxic neuronal cells already at Day 1 (Fig. 4B). This became even more evident at later time points (Fig. 4D, F). At Day 3, the vast majority of tMNC was found adjacent to neuronal somata and processes (Fig. 4F). Interestingly, co-cultivation with tMNC seemed to have strong positive effects on the preservation of typical neuronal cell morphology as the formation of branched processes.
In contrast, in normoxic control cultures tMNC were evenly spread throughout the culture dish (Fig. 4A, C, E).
In supernatants of direct co-cultures and corresponding mono-cultures we assessed concentrations of CCL2, CCL5, CXCL8, VEGF and bFGF (Fig. 5).
Post-hypoxic neuronal cells secreted the chemokines CXCL8 and CCL2 and the growth factor VEGF. Low amounts of CCL5 and bFGF were detectable, as well. Mono-cultures of tMNC and CD133-displayed similar growth factor and chemokine secretion patterns: CXCL8 and CCL2 were produced in considerable amounts while CCL5 and bFGF were secreted at low levels. VEGF was not present. None of the investigated soluble factors was detected in supernatants of purified CD133+ mono-cultures.
In direct co-cultures with tMNC or CD133-secretion of cytokines was regulated very similar: reduction of CXCL8 (p ? 0.001) and VEGF (p ? 0.001) and increase of CCL5 (Fig. 5). CD133+ co-cultivation only influenced VEGF levels, which decreased significantly (Fig. 5).
In a second set of experiments we investigated different effects of direct and indirect co-culturing on cytokine secretion. Therefore, concentrations of CXCL9, CCL3, VEGF, G-CSF and GM-CSF were measured in normoxic and post-hypoxic mono-cultures, and co-cultures with tMNC and CD133-.
Except VEGF neuronal cells did not secret detectable amounts of either CXCL9, CCL3, G-CSF nor GM-CSF in mono-cultures. Both, tMNC and CD133-cells expressed CCL3 and G-CSF but only CD133-produced GM-CSF (Fig. 6).
In co-cultures with tMNC direct co-cultivation generated more pronounced effects than indirect co-cultivation, as seen for the relative up-regulation of CXCL9, GM-CSF (both, p ? 0.05) and CCL3 and the relative down-regulation of VEGF.
Only direct CD133-co-cultivation had an impact on regulation of CCL3, VEGF and GM-CSF. Secretion of all three cytokines was markedly decreased compared to controls whereas indirect co-cultivation with CD133-had no effect. In contrast, the secretion of CXCL9 and G-CSF (p ? 0.01) was markedly induced by indirect co-cultivation with CD133-. For these cytokines direct co-cultivation showed no effect (G-CSF) or resulted in a remarkably reduced production (CXCL9) as compared to indirect co-cultivation with CD133-(Fig. 6).
The experiment also revealed the influence of different HUCB-MNC-derived cell preparations on the cytokine secretion.
Most prominent, direct co-cultivation with tMNC significantly increased expression of CCL3 (p ? 0.05) whereas direct co-cultivation with CD133-resulted in a relative reduction of this chemokine (p ? 0.01).
It has been previously shown that HUCB derived MNC as well as nearly pure stem cell populations obtained from MNC are able to improve the clinical outcome of animals after MCAO . In an in vitro model of neuronal hypoxia we discern cell populations within MNC being able to improve neuronal survival and disclose potential neuroprotective mechanisms.
First we studied the effects of tMNC application on the apoptotic status of post-hypoxic neurons. We found that direct application of tMNC results in preservation of neuronal morphology based on a constant protection from apoptosis (Fig. 2A).
For in vivo experiments it has been described that none or only a minority of systemically administrated cells were detected in the brain while large quantities were found in the spleen, in the lungs and in the blood of the animals. Nevertheless, some studies showed that cell-treatment improved behavioral deficits [18,23,24]. This indicates the importance of soluble factors for neuroprotection. Our data obtained from indirect co-cultures strongly support this hypothesis. tMNC application was highly protective, although the anti-apoptotic effect was slightly weakened after two days (Fig. 2A). Probably, soluble factors act as "first aid" messengers while longer protection seems to demand close proximity between tMNC and neuronal cells. The comparison of direct application of tMNC to normoxic and post-hypoxic neuronal cells revealed that only post-hypoxic neuronal cells attracted tMNC (Fig. 4). The clustering of tMNC around neuronal cells could explain the enhanced protection from apoptosis in direct co-cultures with tMNC at Day 2 and Day 3 (Fig. 4, Fig. 2A). Spatial contiguity is possibly associated with higher concentrations of neuroprotective mediators in the micro-environment of injured neuronal cells. Post-hypoxic neuronal cells were shown to significantly up-regulate the adhesion molecule ICAM-1 following hypoxia . Hence, ICAM-1 (CD54) expression could underlay the observed co-localization via binding of LFA-1 (CD11) . Besides adhesion molecules, chemotaxis could mediate this cellular co-localization. VEGF, known to exert chemotactic effects on monocytes , was produced by post-hypoxic SH-SY5Y cells (Fig. 6).
To focus the neuroprotective effects of stem cells we enriched or depleted CD133+ cells from HUCB-MNC. Purities of 97.38% for the stem cell preparation and a reduction of CD133+ up to 0.06% for the stem cell depleted fraction were achieved. In direct co-cultures CD133+ were applied to neuronal cells in quantities of 4.5 ? 103 resembling 1% of the applied tMNC, since CD133+ account for about 1% of total cell number in tMNC preparations. Neuroprotective capacity of nearly pure CD133+ cells was comparable to tMNC (Fig. 1A). According to our analyses of cytokine production CD133+ cells did not secrete measureable cytokines neither in mono-cultures nor in co-cultures with injured neuronal cells (Fig. 5). Additional experiments using even tenfold elevated numbers of stem cells (4.5 ? 104) also revealed no detectable cytokine concentrations and did not result in an increased neuroprotective capacity (data not shown). Neuroprotection by the absence of measurable soluble mediators argues for a stem cell specific therapeutic mechanism through contiguity. Due to this assumption we did not include CD133+ in the investigation of indirect co-cultures in this study.
Surprisingly, CD133-cell fractions were also highly sufficient in protection from apoptosis. Therefore, the observed anti-apoptotic neuroprotective effects of tMNC in our experiments do not only relay on hematopoietic stem cell-specific mechanisms. This assumption is supported by the missing significance in the effect of CD133+ on necrotic/late apoptotic loss of post-hypoxic neuronal cells (Fig. 1B). tMNC and CD133-significantly reduced the percentage of PI-positive neuronal cells, whereas CD133+ did not. Since CD133-in indirect co-cultures were superior to tMNC in protection from apoptosis and because of very low amounts of CD133+ in this preparation, CD133-seem to mediate additional neuroprotective effects. Possibly, the separation process influenced the functionality of CD133-cells. FACS analyses of the activation markers CD25, CD38, CD71 and HLA-DR on tMNC and on the separated CD133-fraction did not reveal an increased population of activated cells in our preparations (data not shown). However, the expression of other activation molecules cannot be excluded, since this cell population displayed an enhanced secretion of cytokines like G-CSF, GM-CSF and CCL-3 (Fig. 6). We also cannot rule out that remaining CD34+ cells could account for the neuroprotective activity of the CD133-fraction, since depletion did only reduce the number of CD34+ cells to 77% (Tab. 1).
The investigation of soluble mediators exhibited that hypoxia induced a significant increase of VEGF in neuronal cells (Fig. 6, ). VEGF is documented to inhibit pro-apoptotic signaling by Bad (BCL2 antagonist of cell death), and cleavage of caspase-3, and caspase-9  and therefore can be claimed as an autocrine self-protection mechanism of damaged neuronal cells. The neuroprotective impact of tMNC and CD133-cells in direct applications was accompanied by prevention of VEGF production which is typically induced in post-hypoxic neuronal cells (Fig. 5).
Neuroprotective effects of cell application could be mediated by G-CSF that was found only in mono-cultures of CD133-but not in mono-cultures of post-hypoxic SH-SY5Y cells. Schneider et al., 2005  pointed out that human SH-SY5Y neuroblastoma cells express the G-CSF receptor and that activation by the neurotrophic G-CSF reduced NO-induced poly-ADP ribose polymerase (PARP) and caspase-3 cleavage. Our data support these observations. At Day 3 in indirect co-cultures supply of G-CSF by CD133-was associated with cleaved PARP levels in the range of normoxic cultures (Fig. 3, Fig. 6). G-CSF levels in mono-cultures of tMNC were only slightly above detection limit and could not provide this anti-apoptotic effect (Fig. 6).
The decrease of cleaved PARP observed in post-hypoxic neuronal mono-cultures at Day 3 (Fig. 3) was probably induced by rising lack of energy due to increased rate of apoptosis (Fig. 1).
Noticeably, there are application-specific differences in the regulation of cytokine secretion in co-cultures with CD133-fractions. Concentrations of CCL3 and G-CSF were significantly higher in indirect co-cultures than in direct co-cultures. Possibly these enhanced concentrations are responsible for a protection from apoptosis in indirect co-cultures similar to that in direct co-cultures at Day 3. Indirect co-cultivation with tMNC did not induce enhanced cytokine levels (Fig. 6) and at the same time did not exert the same neuroprotective effect on post-hypoxic SH-SY5Y neurons. This could be explained by spatial effects: paracrine released cytokines could be more effective than action of cytokines over a longer distance.
In this study we investigated human umbilical cord blood derived cell populations (tMNC, CD133+, and CD133-) according to their ability to protect post-hypoxic neuronal cells.
So, since purified CD133+ fractions are not superior to total HUCB-MNC in mediating neuroprotective anti-apoptotic effects, expensive and time consuming stem cell separations are not necessarily needed to yield neuroprotective cell populations. Furthermore, our study underlines the importance of MNC derived soluble factors for the mediation of neuroprotective effects visible as prevention of neuronal cells from apoptosis. Therefore, future therapeutic approaches should focus on the sufficient supply of soluble anti-apoptotic mediators, to reduce post-hypoxic brain damage.
HUCB samples of healthy full-term neonates were obtained in accordance with ethical prescripts immediately after delivery. Samples were processed and analyzed as described previously . The total MNC (tMNC) fraction gained from Ficoll density gradient (Tab. 1) was stored in the gaseous phase of liquid nitrogen. Cellular sub-fractions of tMNC were characterized using CD3-Phycoerythrin (PE, Immunotech, Hamburg, Germany), CD14-Fluorescein isothiocyanate (FITC), CD16+56-PE (both, Becton-Dickinson, Franklin Lakes, NJ, USA), CD19-Allophycocyanin (APC) and CD45-FITC, (both, Beckman Coulter, Krefeld, Germany). Prior to use tMNC were thawed and stained with carboxy fluoresceindiacetate succinimidyl ester (CFSE, Invitrogen, Karlsruhe, Germany).
CD133 positive cells (CD133+) were isolated from HUCB-MNC using the MACS? immunomagnetic positive selection protocol (Miltenyi Biotech, Bergisch Gladbach, Germany). The flow-through fraction was collected as negative fraction (CD133-) depleted of CD133+. Final populations were analyzed using a FACSCalibur flow cytometer equipped with the CellQuest? software (both Becton-Dickinson, Franklin Lakes, NJ, USA) and characterized by the use of the following antibodies: CD133/2-PE, Miltenyi Biotech Bergisch Gladbach, Germany), CD45-FITC and CD34-APC (both Beckman Coulter, Krefeld, Germany). Isotype-identical monoclonal antibodies served as controls. CD133+ and CD133-fractions contained 97.38% and 0.06% CD133 positive cells, respectively.
Status of activation of tMNC and CD133-was analyzed via FACS using the antibodies CD25-PE, HLA-DR (Major Histocompatibility Complex, class II, cell surface receptor)-APC (both Becton-Dickinson, Franklin Lakes, NJ, USA), CD38-PE and CD71-FITC (both Beckman Coulter, Krefeld, Germany).
For differentiation 0.9 ? 104/cm2 SH-SY5Y cells were seeded in 16-mm-diameter wells (Greiner Bio-One, Frickenhausen, Germany). After 5 days Dulbecco's Modified Eagle Medium (DMEM)/10 ?M all-trans retinoic acid (Sigma-Aldrich, Steinheim, Germany)/15% fetal calf serum (PAN-Biotech, Aidenbach, Germany) media was changed into DMEM-Ham's F12/10 ?M RA/5 ng/ml Brain Derived Neuronal Factor [BDNF, Immunotools Biolance GmbH, Hanover, Germany]/0.1% Human Serum Albumine [HSA, PAN Biotech GmbH, Aidenbach, Germany] for another 11 days. Media were exchanged every third day. Afterwards fully matured neuronal cells were cultured under a hypoxic atmosphere (< 1% O2) for 48 hours . Number of viable cells remained stable between Day 16 and Day 21.
Subsequent to hypoxia, direct and indirect co-cultivation with tMNC, CD133+ or CD133-was carried out under normoxic conditions over a period of three days. Added tMNC, CD133-(4.5 ? 105 cells, both) and CD133+ (4.5 ? 103 cells) were dissolved in 500 ?l co-culture medium (DMEM-Ham's F12, 5 ng/ml BDNF and 0.1% HSA) and added to differentiated post-hypoxic neuronal SH-SY5Y cells cultivated in adequate volume of post-hypoxic medium. Cell ratio of post-hypoxic neuronal cells to MNC was 1:15 and to CD133+ 1:0.15. For indirect co-cultivation tMNC or CD133-were added in cell impassable cell culture inserts with a pore size of 0.4 ?m (Greiner Bio-One GmbH, Frickenhausen, Germany).
Prior to co-cultivation with post-hypoxic neuronal cells, tMNC as well as CD133+ and CD133-were labeled with CFSE.
Within direct and indirect co-cultures and control cultures the influence of tMNC, CD133+ and CD133-on neuronal viability was detected via i) Propidium Iodide (PI, Invitrogen, Karlsruhe, Germany) assay for necrosis and late apoptosis and ii) annexin-V assay (Becton-Dickinson, Heidelberg, Germany) for apoptosis. The PI- and annexin-V assays were performed in cell culture plates as described previously . tMNC, CD133+ and CD133-were distinguished from annexin-V-PE or PI positive neuronal cells by the green CFSE staining.
Cytometric Bead Array for human apoptosis (CBA, Becton Dickinson, Erembodegem, Belgium) was used to quantify the apoptosis specific parameter cleaved Poly-ADP-Ribose-Polymerase I (PARP) in lysates of post-hypoxic neuronal cells after indirect co-cultivation with tMNC and CD133-. For cell lyses adherent neuronal cells were rinsed with PBS and incubated on ice in the supplied buffer for 20 minutes. For analyses pooled samples obtained from three independent experiments were used.
For cytokine profiling supernatants of direct and indirect co-cultures were analyzed on Day 3. Supernatants of tMNC, CD133+ and CD133-mono-cultures and those of post-hypoxic neuronal cells were also investigated on Day 3. Cytokines were simultaneously measured using CBA for human soluble proteins (Becton Dickinson, Erembodegem, Belgium). Supernatants were screened for the following cytokines: CCL2, CCL3, CCL5, CXCL8, CXCL9 and for the growth factors basic Fibroblast Growth Factor (bFGF), Granulocyte Colony-Stimulating Factor (G-CSF), Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Vascular Endothelial Growth Factor (VEGF). The detection limit was 20 pg/ml, except for CCL2 and VEGF (40 pg/ml).
Except for apoptosis and necrosis rates all results have been reported as mean ? SD. Statistical differences were analyzed by Student's t-test or Mann-Whitney rank sum-test. P values of ? 0.05 were considered statistically significant (* p ? 0.05, ** p ? 0.01, *** p ? 0.001). Apoptosis and necrosis rates were logit-transformed to obtain normally distributed quantities. The effects of time, experimental setting (post-hypoxia), experimental run and the investigated well were determined univariately, and, finally multivariately using a mixed-model approach with time and experimental setting as fixed effects and well and experimental run as random effects.
Cytokine concentrations of indirect and direct co-cultures with tMNC, CD133-and CD133+ were compared with the sum of the concentrations obtained after post-hypoxia of neuronal cells and corresponding tMNC, CD133+ and CD133-mono-cultures using a bootstrapping algorithm. Therefore, we added concentrations which were resampled from e.g. the experiment post-hypoxia and the tMNC mono-culture and compared the results with concentrations obtained from e.g. the experiment of indirect co-culture with tMNC. Results were compared with Student's t-test or Mann-Whitney rank sum test. P-values reported are based on 10,000 bootstrapping simulations.
Box plots (if applicable) and univariate analyses were determined using the software package SPSS (SPSS Inc., Chicago IL, USA). Mixed Model analyses were performed using PROC MIXED of the statistical software package SAS 9.1 (SAS Institute Inc., Cary, NC, USA). Bootstrapping analysis was performed using the statistical software package "R" .
DMR and SH coordinated and conducted all experimental work and wrote the manuscript. MK and TS helped to interpret the data and supported writing the manuscript. MS performed the statistical analysis. JB, WN and FE critically revised the manuscript.
This work was supported by grants from the Development Bank of Saxony (SAB). The authors further want to thank Dr. Heike Opitz and Dr. Dietmar Egger from VITA 34 AG, Leipzig, for technical support.
Time course of apoptosis and necrosis of post-hypoxic neuronal cells in direct co-cultures with tMNC, CD133+ and CD133-. Box plots showing time course of apoptosis (A) and necrosis/late apoptosis (B) in direct co-cultures of post-hypoxic neuronal cells with tMNC, CD133-or CD133+ (colored plots). Grey boxes display the development of cell death in post-hypoxic neuronal cells directly after hypoxic pre-cultivation of SH-SY5Y cells (Day 0) and 1?3 days post-hypoxia. The ordinate represents the percentage of apoptotic and necrotic cells, respectively. Rates of apoptosis and necrosis were calculated in relation to the total number of SH-SY5Y cells.
Effects of direct and indirect application of tMNC and CD133-on apoptosis and necrosis of post-hypoxic neuronal cells. Box plots represent the percentage of annexin-V positive post-hypoxic neuronal cells (A, B) and of PI positive post-hypoxic neuronal cells (C, D) in direct and indirect co-cultures. Co-cultures were performed with tMNC (A, C) and CD133-(B, D). The extents of apoptosis (annexin-V-binding) and necrosis (PI) were analyzed for three days after hypoxia.
Direct comparison of effects of tMNC and CD133-on late apoptosis (PARP cleavage). Bar chart showing concentrations of cleaved PARP in lysates of post-hypoxic neuronal cells which were indirectly co-cultivated with tMNC (grey shaded bars) or CD133-(black bars). Controls are post-hypoxic mono-cultures (grey bars) and normoxic cultures (white bars). Each bar visualizes pooled samples obtained from three independent experiments.
Distribution of tMNC in direct co-cultures. Phase contrast fluorescence micrographs of co-cultures of neuronal cells (unstained) and tMNC (green). Representative images show post-hypoxic neuronal cultures (B, D, F) in contrast to normoxic control cultures (A, C, E) over a time course of three days. Images illustrate the distribution of tMNC in relation to neuronal cells. White arrows point at spatial accumulation of tMNC which are clustered around neuronal somata and processes in post-hypoxic cultures (B, D, F). In normoxic cultures no clustering of tMNC was observed (A, C, E). The black arrow points at a conserved neuronal morphology including branched processes. Scale bars indicate 100 ?m.
Cytokine profile in direct co-cultures with tMNC, CD133+and CD133-on Day 3. Control: sum of cytokine concentration from single cultured (grey) post-hypoxic SH-SY5Y cells and HUCB-MNC (light green = tMNC, light red = CD133-, not detectable = CD133+). Co-culture: direct co-culture of post-hypoxic SH-SY5Y cells and HUCB-MNC (dark green = tMNC, dark red = CD133-, dark yellow = CD133+). Data are derived from four independent experiments and are expressed as pg/ml. * significant differences in cytokine concentrations of co-cultures compared to control cultures. Note different axis scaling.
Effect of co-cultivation system (direct v. indirect) on cytokine secretion during co-cultivation of post-hypoxic neuronal cells with tMNC and CD133-. Control: sum of cytokine concentration from single cultured (grey) post-hypoxic SH-SY5Y cells and HUCB-MNC (light green = tMNC, light red = CD133-). Co-cultures: co-culture of post-hypoxic SH-SY5Y cells and tMNC (direct: dark green, filled; indirect: dark green, striped), co-culture of post-hypoxic SH-SY5Y cells and CD133-(direct: dark red, filled; indirect: dark red, striped). Effects are displayed in percent as relative changes to control. Mono-cultures: absolute cytokine concentrations in supernatants of SH-SY5Y normoxic and post-hypoxic mono-cultures (white or grey bars, respectively) and tMNC (light green bars) or CD133-(light red bars). * significant changes to control. + significant differences between co-cultivation systems.
Cellular fractions of HUCB-MNC after thawing of cryopreservated cells.
Subpopulations of lymphocytes and stem/progenitor cells are expressed as percent of total lymphocytes.

The Advanced Search featured in the locator software allows you to provide more search criteria for your customers and design the look and feel of your dealer search process.
Form Code – The default contents of this field contain our standard advanced search form code. You can customize the form here to meet your needs.
Message – You can enter descriptive text in this area and format with html if desired. Entries in this area will display above the search form.
Text – Provides text results with Map-It link to open location map in popup window.
Text & Map – Provides text results with thumbnail map on result page.
Text block width – Specifies the width of the text portion of the search results.
Text block height – Specifies the height of the text portion of the search results.
Map width – Specifies the width of the map for Text & Map results type and specifies the width of the popup map for Text results type.
Map height – Specifies the height of the map for Text & Map results type and specifies the height of the popup map for Text results type.
Map layout – Specifies the location of the map in Text & Map results type.
Locations per page – Specifies the number of locations to be displayed on each results page.
Location columns – Specifies the number of columns of locations in the results page.
Location Detail Page Setup – The location detail page provides a dedicated page for each location. You can specify more fields to display on the location detail page than you show on the results page and can select a different layout for this page, as well.
Text – Provides text results with Map-It link to open location map in popup window.
Text & Map – Provides text results with thumbnail map on result page.
Text block width – Specifies the width of the text portion of the search results.
Text block height – Specifies the height of the text portion of the search results.
Map width – Specifies the width of the map for Text & Map results type and specifies the width of the popup map for Text results type.
Map height – Specifies the height of the map for Text & Map results type and specifies the height of the popup map for Text results type.
Map layout – Specifies the location of the map in Text & Map results type.
Field Control – Field control allows you to choose which fields will be displayed and in what order. You can also chose to show the field title or to hide it an only show the field value. Control is further separated for display of fields on your Results Page and your Location Detail page.
Detail Link – Click the radio button for the field you want users to click to see the Location Detail page or click “No Link” if you do not want to use a location detail page.
Visible – If checkbox is checked, field will display on page, if unchecked, field will not be displayed.
Show title – If checkbox is checked, the field title will display, if unchecked, field title will not be displayed.
Order – Enter a numerical value to set the order in which the fields will display and click Save or Apply to save the order.
Show advance search link – If yes, link to advanced search form will be displayed below the search button.
Show all location link – If yes, link to list of all locations will be displayed below the search button.


There are 3.0 stars for 124.0 students.  How many students need to share each star? Answer:

This entry was posted on Thursday, March 3rd, 2011 at 7:18 pm	and is filed under 100 Pastel Challenge, Color, Landscapes, Paintings, Pastels. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
I love that you put in a third, just to be accurate about it!
Well, it should be 33.3333333333333333333333333 repeating to infinity, but that would be harder to draw. And take, you know, longer.
Lovely work, great number accomplished! You are a wonder!
Thanks, Thom & Leila. That was pretty left-brain of me, wasn’t it?

As he reminded me with a wall post earlier, Jacob and I have been dating for 1.3333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333333 months now, intense huh? I told him that I wasn’t counting our positive anniversaries so much as our negative ones. It’s funny how important our anniversaries were about 4-8 mo. Then we got engaged and there were more days to celebrate but the only one that “really” matters (at least monthly) is that day coming up in January 😀 And that one is less than 3 months away, yay!

1333.3333333333333333333 as a decimal - solution and the full explanation with calculations.
What is 1333.3333333333333333333 as a decimal?
To write 1333.3333333333333333333 as a decimal you have to divide numerator by the denominator of the fraction.
1333.3333333333333333333 is not a fraction so it is a decimal already.

- So that motor [Z-Axis] is a 7.5°, 48 step motor as I just listed. Since the motor is attached to a M4 rod, which has a 0.7 mm thread pitch, then in one revolution makes the Z-Axis travel up or down 0.7 mm. Since it took 48 steps to turn that rev, each step is 0.00145833333333333333333333333333 etc etc mm. To avoid rounding errors, you can use multiple of 3 of this number, which is a nice and pretty 0.04375 mm. That is a nice and handy number that effectively represents the layer heights that mathematically work the best for layer heights for this printer. + So that motor [Z-Axis] is a 7.5°, 48 step motor as I just listed. Since the motor is attached to a M4 rod, which has a 0.7 mm thread pitch, then in one revolution makes the Z-Axis travel up or down 0.7 mm. Since it took 48 steps to turn that rev, each step is 0.0145833333333333333333333333333 etc etc mm. To avoid rounding errors, you can use multiple of 3 of this number, which is a nice and pretty 0.04375 mm. That is a nice and handy number that effectively represents the layer heights that mathematically work the best for layer heights for this printer.

A variable is a quantity that has a changing value; the value can vary from one example to the next. A continuous variable is a variable that has an infinite number of possible values. In other words, any value is possible for the variable.
A continuous variable is the opposite of a discrete variable, which can only take on a certain number of values.
Time it takes a computer to complete a task. You might think you can count it, but time is often rounded up to convenient intervals, like seconds or milliseconds. Time is actually a continuum: it could take 1.3 seconds or it could take 1.333333333333333… seconds.
A person’s weight. Someone could weigh 180 pounds, they could weigh 180.10 pounds or they could weigh 180.1110 pounds. The number of possibilities for weight are limitless.
Age. So, you’re 25 years-old. Are you sure? How about 25 years, 19 days and a millisecond or two? Like time, age can take on an infinite number of possibilities and so it’s a continuous variable.
Heights and weights are both examples of quantities that are continuous variables.
Next: Discrete vs continuous variables.
← What is a Discrete Variable in Statistics?

Elections should belong to people, not parties. Support the Open Our Democracy Act to give power back to the voters.
We're 45.83333333333333% of the way to our goal, help us get there!

Convert 176 Minutes to Hours (min to h) with our conversion calculator and conversion tables. To convert 176 min to h use direct conversion formula below.
176 min = 2.9333333333333 h.
You also can convert 176 Minutes to other Time (popular) units.

Convert 4070 Minutes to Hours (min to h) with our conversion calculator and conversion tables. To convert 4070 min to h use direct conversion formula below.
4070 min = 67.833333333333 h.
You also can convert 4070 Minutes to other time units.

So that motor [Z-Axis] is a 7.5°, 48 step motor as I just listed. Since the motor is attached to a M4 rod, which has a 0.7 mm thread pitch, then in one revolution makes the Z-Axis travel up or down 0.7 mm. Since it took 48 steps to turn that rev, each step is 0.0145833333333333333333333333333 etc etc mm. To avoid rounding errors, you can use multiple of 3 of this number, which is a nice and pretty 0.04375 mm. That is a nice and handy number that effectively represents the layer heights that mathematically work the best for layer heights for this printer.
Using the information above we can put together a list of optimal layer heights ranging from 0.04375mm to 0.30625mm. We stop at 0.30625mm because with a nozzle diameter of 0.40mm, the maximum recommended layer height is 0.32mm.
* There have been a few reports of printing the same model at 0.04375 and 0.0875, with the 0.0875 version looking better. This is probably a settings issue and the reports could be outliers. Don't let this discourage you from trying to use 0.04375, you could and probably will have better results if you are patient enough to wait the extra time for higher resolution.

1.133333334 as a fraction - solution and the full explanation with calculations.
What is 1.133333334 as a fraction?
To write 1.133333334 as a fraction you have to write 1.133333334 as numerator and put 1 as the denominator. Now you multiply numerator and denominator by 10 as long as you get in numerator the whole number.

7.3333333333... years to 4/15/26 in MM/DD/YY.
7.3333333333... years to 4/15/26 in MM/DD/YY.
7.25 years to 4/15/26 in MM/DD/YY.
7.25 years to 4/15/26 in MM/DD/YY.
7 years & 2 months to 4/15/26 in MM/DD/YY.
7 years & 2 months to 4/15/26 in MM/DD/YY.
7 years & 1 month to 4/15/26 in MM/DD/YY, an arithmetical progression.
7 years & 1 month to 4/15/26 in MM/DD/YY, an arithmetical progression.

333333 has not yet been in a debate.
Post a comment to 333333's profile.
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If you are logged in, you will also see green or red bullets next to each issue, which indicate whether you agree or disagree with 333333 on that particular issue.
You can also click each issue to find other members that agree with 333333's position on the issue.

Please enter square foot (ft²) value of area unit to convert square foot to square yard.
How Many Square Yard in a Square Foot?
There are 0.1111111111 square yard in a square foot.
1 Square Foot is equal to 0.1111111111 Square Yard.
This is a very easy to use square foot to square yard converter. First of all just type the square foot (ft²) value in the text field of the conversion form to start converting ft² to yd², then select the decimals value and finally hit convert button if auto calculation didn't work. Square Yard value will be converted automatically as you type.
The decimals value is the number of digits to be calculated or rounded of the result of square foot to square yard conversion.
You can also check the square foot to square yard conversion chart below, or go back to square foot to square yard converter to top.

Convert 238.7 Inches to Miles (in to mile) with our conversion calculator and conversion tables. To convert 238.7 in to mile use direct conversion formula below.
238.7 in = 0.0037673611111111 mile.
You also can convert 238.7 Inches to other Length (popular) units.

With this tool you can convert inches to feet easily and free. Discover how many feet are a number of inches.
1 in is 0.0833333 feet.
To calculate how to convert inches to feet you can multiply the number 0.0833333 times. For example, 25 inches would be 25 x 0.0833333 = 2.0833325 feet.

In this plot, we can see the lifelines of the slowest 10% of pull requests. For this project, the cutoff is 3.3333333 × 10-4 days. 46 pull requests where processed slower than that, while 413 were faster. The line represents the time between opening and closing the pull request. Pull requests whose end time aligns at the right edge of the plot are still open at the time of building this report. Generally, it is considered good practice to avoid having pull requests open for long.

Convert 7.03 Inches to Miles (in to mile) with our conversion calculator and conversion tables. To convert 7.03 in to mile use direct conversion formula below.
7.03 in = 0.00011095328282828 mile.
You also can convert 7.03 Inches to other Length (popular) units.

To find hotels near Woodford airport, paste in search form the name of the city of (Woodford), then select the dates of Check In and Check Out, select the number of guests and click Search.
WFD airport Woodford transcript or WFD which airport?
The name of the airport: Woodford. The airport is located in the country: United Kingdom. The city location of the airport in Woodford. IATA airport code Woodford: WFD. The IATA airport code is a 3 letter unique identifier, assigned airports world International air transport Association (IATA).
The geographic coordinates of the airport Woodford.
The latitude at which the airport is located: 51.116666666667, the longitude of airport: -1.833333333333. Geographic coordinates of latitude and longitude define the position of the airport on the earth's surface. The airport is located in the time zone: +0.0 GMT. The airline always indicates local time of departure and arrival airport according to the time zones.

32.3333333 as a fraction - solution and the full explanation with calculations.
What is 32.3333333 as a fraction?
To write 32.3333333 as a fraction you have to write 32.3333333 as numerator and put 1 as the denominator. Now you multiply numerator and denominator by 10 as long as you get in numerator the whole number.


6.0 students were sitting at each table in the lunchroom. There are 34.0 tables. How many students should sit at each table, if divided evenly? Answer:

I'm currently using this function to get Total and Average scores.
How can I make the average a 1 decimal place? I'm getting something like 51.666666666667.

Welcome to the Oxpower Calculator!!!
Why do we use horsepower to measure instead of oxpower? Fear not! You can calculate horsepower to oxpower here, and you will soon see you have more oxpower compared to horsepower! What!?! For instance, I have an 18.5 horsepower motor on my riding lawnmower, but it is actually a 24.666666666666668 oxpower motor!!! Now that will impress someone! Oxpower calculators unite! Enjoy!
Visit Hokanson's Instructional Technology @ neilhokanson.com!!!

Your homework for monday Feb 6th is Worksheet 3.12, the entire page.
10. you need to solve inside the brackets first (6 x 7) and then multiply it by 1/2.
26. 12.3 would equal 11.3 + 1. Is there a way to get this?
27. What is 18 x 2 = ? Can you somehow get this number with 19 - 7 x 3 ?
MY COMPUTER WAS DOWN. MY TOWER CRASHED. PLEASE DON'T TAKE OFF MARKS FOR MY MISTAKE. SIGNED JANNA K.
You play basketball for Sargent Park. You've scored 24 baskets over the 5 home games and 28 points over the past 7 away games. Now figure out your average points per game at home, your average points per game on the road, and your total average points.Do you score more baskets per game at home or away?
For the away games the average is (28 ÷ 7 = 4). There is no estamate average because there is no decimal in the answer.
The total estimate average is (80 ÷ 12 = 6.66666666666666666666666666666667. The real average is (76 ÷ 12 = 6.3(repeated)). If you wanted to use 24 instead of 48 the your equation would look like this. (52 ÷ 12 = 4.3(repeated)).
If you wanted to know whether you scored more baskets per game at home or away and you were using the number 48 points for home and 28 points for away, then you would have scored more baskets per game for the home games. If you were using the number 24 points for home and 28 points for away then you would have scored more baskets per game for the home games.
What does a scribe do?

> Algorithm Initialization Error: Execution Security Error: Operation timed out - 0.166666666666667 minutes max. Check for recursive loops.
Thanks for letting us know AMP2. In future please use support@quantconnect.com to report issues.

1 min. = 60 sec.
Conversion base : 1 min. = 60 sec.
Conversion base : 1 sec. = 0.016666666666667 min.

Re: POLL -- Student to computer support person ratio!
25th decimal place: 466.666666666666666666666666 users to each techie.
a real pain and he takes more than his share of support.
> What is your school's student to techie ratio ?
> Ours is roughly 400:1, counting myself and a part-time assistant.
> That puts us at about 450:1.
> numbers are looking statewide.

10 ft. of 550 paracord to make 13 "ranger beads"
First, it should be understood that pace count beads are not an exact way to measure distance. Pace beads use the length of your stride to determine how far you have walked. Factors such as terrain, weather, and weight of gear you are carrying will all change the length of your stride. There are ways to take these variable into account, but just know that it is not an exact science.
There are two methods to measuring distance with pace count beads. Both require that you know the length of your stride by walking a preset distance. (Usually 100 yards in the U.S.) The best way to do this is by finding a nearby football field and walking from one end zone line to the other, keeping track of how many times your left foot hits the ground. To make your measurement a little more accurate, wear a fully loaded pack—or whatever gear you think you will be wearing out in the wilderness—for this distance measurement. Walk the distance 3 times. If the number of steps differ, take the average of all 3.
Let's say that you ended up with exactly 60 paces in 100 yards. The pace counter works like an abacus. The 9 lower beads are the one's place; the 4 upper beads are the ten's place.
Measure by Distance. After your left foot hits the ground 60 times, move one of the lower beads down. Continue doing this until all 9 are pulled. On the tenth time, pull down one top bead and raise all the lower beads back up. You have now walked 1,000 yards. By the time you pull all the top beads down, you would have walked 5,000 yards—or a little less than 3 miles. This is probably the more useful method to using pace count beads, as you are then dealing with real measurements.
Measure by Paces. Instead of counting yards, you can count paces and do the calculation afterward. You will need to know your individual pace length for this method. If 60 paces equaled 100 yards, divide it by 60 to get the length of one pace. You would get 1.66666666666666666666666666666666666666666. You are beginning to see the problem with this method. Every 10 paces, pull a bead down. When all beads are down, you will have walked 1,000 paces. Either divide 1,000 by your 100 yard pace count (1,000/60 = 16.7 x1,000 paces walked = 1,670 yards total) or by multiplying it by your individual pace length (1,000yd x 1.67 =1,670 yards).

Possibly because the formulas are not really that accurate and so some just round 2/3 to 0.7 since 2/3 is 0.6666666666. As far as the 0.01 or 0.085 constant on the front that is a bigger difference but again maybe the accuracy is not great. Don't know if I helped or not gorgeous.

Narayana was the son of Nrsimha (sometimes written Narasimha). We know that he wrote his most famous work Ganita Kaumudi on arithmetic in 1356 but little else is known of him. His mathematical writings show that he was strongly influenced by Bhaskara II and he wrote a commentary on the Lilavati of Bhaskara II called Karmapradipika. Some historians dispute that Narayana is the author of this commentary which they attribute to Madhava.
In the Ganita Kaumudi Narayana considers the mathematical operation on numbers. Like many other Indian writers of arithmetics before him he considered an algorithm for multiplying numbers and he then looked at the special case of squaring numbers. One of the unusual features of Narayana's work Karmapradipika is that he gave seven methods of squaring numbers which are not found in the work of other Indian mathematicians.
... derived his rule for a segment of a circle from Mahavira's rule for an 'elongated circle' or an ellipse-like figure.
Narayana also gave a rule to calculate approximate values of a square root. He did this by using an indeterminate equation of the second order, Nx2 + 1 = y2, where N is the number whose square root is to be calculated. If x and y are a pair of roots of this equation with x < y then √N is approximately equal to y/x. To illustrate this method Narayana takes N = 10. He then finds the solutions x = 6, y = 19 which give the approximation 19/6 = 3.1666666666666666667, which is correct to 2 decimal places. Narayana then gives the solutions x = 228, y = 721 which give the approximation 721/228 = 3.1622807017543859649, correct to four places. Finally Narayana gives the pair of solutions x = 8658, y = 227379 which give the approximation 227379/8658 = 3.1622776622776622777, correct to eight decimal places. Note for comparison that √10 is, correct to 20 places, 3.1622776601683793320. See  for more information.
The thirteenth chapter of Ganita Kaumudi was called Net of Numbers and was devoted to number sequences. For example, he discussed some problems concerning arithmetic progressions.
The fourteenth chapter (which is the last one) of Naryana's Ganita Kaumudi contains a detailed discussion of magic squares and similar figures. Narayana gave the rules for the formation of doubly even, even and odd perfect magic squares along with magic triangles, rectangles and circles. He used formulae and rules for the relations between magic squares and arithmetic series. He gave methods for finding "the horizontal difference" and the first term of a magic square whose square's constant and the number of terms are given and he also gave rules for finding "the vertical difference" in the case where this information is given.

Find out what games are how much done!
Screenshots, videos, playtests... screw all that! What we all really want is an easy-to-understand number explaining how far along a game is in development. And so we turn to the legendary "percent completion," a number assigned to a game by a developer in order to indicate how close a game is to being complete.
So it looks like the big winner in the percent completion challenge is PictoChat with its amazing 100% completion! But that doesn't mean development is done! Aim for 110%, developers. Aim for 110%!
Looking closely at this list, we can learn a few more things. Games that start with an "S" have an average percent completion of 85%. This compares favorably to games that begin with a "T," which have an average percentage completion of 61.66666666666666666%. Additionally, games from Nintendo have an average percent completion of 81.42857%, far above the 60% percent average completion of 3rd party games. This means Nintendo's DS games are more percent complete than games from the other guys. Good job, Nintendo!
We expect these percentages to go towards 100% as launch approaches.

14 years & 11 months since 12/06/03.
14 years & 11 months since 12/06/03.
15.5 years since 12/06/03 in DD/MM/YY.
15.5 years since 12/06/03 in DD/MM/YY.
15.66666.. years since 12/06/03 in DD/MM/YY.
15.66666.. years since 12/06/03 in DD/MM/YY.

To find hotels near Torembi Airport airport, paste in search form the name of the city of (Torembi), then select the dates of Check In and Check Out, select the number of guests and click Search.
TCJ airport Torembi transcript or TCJ which airport?
The name of the airport: Torembi Airport. The airport is located in the country: Papua New Guinea. The city location of the airport in Torembi. IATA airport code Torembi Airport: TCJ. The IATA airport code is a 3 letter unique identifier, assigned airports world International air transport Association (IATA). ICAO airport code Torembi Airport: DAAJ. The ICAO airport code is a 4 letter unique identifier that is assigned to the airports by the International civil aviation organization (ICAO).
The geographic coordinates of the airport Torembi Airport.
The latitude at which the airport is located: -4.016666666667, the longitude of airport: 143.133333333330. Geographic coordinates of latitude and longitude define the position of the airport on the earth's surface. The airport is located in the time zone: +10.0 GMT. The airline always indicates local time of departure and arrival airport according to the time zones.

To find hotels near West Malling airport, paste in search form the name of the city of (West Malling), then select the dates of Check In and Check Out, select the number of guests and click Search.
WEM airport West Malling transcript or WEM which airport?
The name of the airport: West Malling. The airport is located in the country: United Kingdom. The city location of the airport in West Malling. IATA airport code West Malling: WEM. The IATA airport code is a 3 letter unique identifier, assigned airports world International air transport Association (IATA).
The geographic coordinates of the airport West Malling.
The latitude at which the airport is located: 51.300000000000, the longitude of airport: 0.416666666667. Geographic coordinates of latitude and longitude define the position of the airport on the earth's surface. To fully define the position of the airport in three-dimensional space, we should also know the third coordinate is the height. The height of the airport above sea level is 99 meters. The airport is located in the time zone: +0.0 GMT. The airline always indicates local time of departure and arrival airport according to the time zones.

+ Shared exp. 30% (2 vocs) - 19500 Exp.
+ Shared exp. 60% (3 vocs) - 16000 Exp.
+ Shared exp. 100% (4 vocs) - 15000 Exp.
+ Shared exp. 30% (2 vocs) - 13000 Exp.
+ Shared exp. 60% (3 vocs) - 10666.666666667 Exp.
+ Shared exp. 100% (4 vocs) - 10000 Exp.
Limited to players of 70+, this boss can be taken down with a small team, however it does have strong attacks.
Killing or doing a large amount of damage will earn you the Slayer of Chikhaton achievement.
If you were unable to gain the achievement during the event, you can also reface this boss during Devovorga's Essence world change in exchange for 12 [We do not have this item].
Edron , Rise of Devovorga boss.

1.79166667 as a fraction - solution and the full explanation with calculations.
What is 1.79166667 as a fraction?
To write 1.79166667 as a fraction you have to write 1.79166667 as numerator and put 1 as the denominator. Now you multiply numerator and denominator by 10 as long as you get in numerator the whole number.

7.4166666666 as a fraction - solution and the full explanation with calculations.
What is 7.4166666666 as a fraction?
To write 7.4166666666 as a fraction you have to write 7.4166666666 as numerator and put 1 as the denominator. Now you multiply numerator and denominator by 10 as long as you get in numerator the whole number.

9.6666666 as a percent - solution and the full explanation with calculations.
What is 9.6666666 as a percent?
To write 9.6666666 as a percent have to remember that 1 equal 100% and that what you need to do is just to multiply the number by 100 and add at the end symbol % .

Please enter minutes (min) value of time unit to convert minutes to hours.
How Many Hours in a Minute?
There are 0.016666666666667 hours in a minute.
1 Minute is equal to 0.016666666666667 Hours.
This is a very easy to use minutes to hours converter. First of all just type the minutes (min) value in the text field of the conversion form to start converting min to h, then select the decimals value and finally hit convert button if auto calculation didn't work. Hours value will be converted automatically as you type.
The decimals value is the number of digits to be calculated or rounded of the result of minutes to hours conversion.
You can also check the minutes to hours conversion chart below, or go back to minutes to hours converter to top.

+ Shared exp. 30% (2 vocs) - 42900 Exp.
+ Shared exp. 60% (3 vocs) - 35200 Exp.
+ Shared exp. 100% (4 vocs) - 33000 Exp.
+ Shared exp. 30% (2 vocs) - 28600 Exp.
+ Shared exp. 60% (3 vocs) - 23466.666666667 Exp.
+ Shared exp. 100% (4 vocs) - 22000 Exp.
Nothing is stronger than my pure hatred!
My rancour will devour you.
The strongest of Devovorga incarnations.
Located at the Ghostlands portal, limited to players of 70+, this boss can be taken down with a small team, however it does have strong attacks, and alot of health.
Killing or doing a large amount of damage will earn you the "Slayer of Phrodomo" achievement.
If you were unable to gain the achievement during the event, you can also reface this boss during Devovorga's Essence world change in exchange for 16 [We do not have this item].