Autophagic cell death
Autophagic cell death (ACD) is a controversial form of programmed cell death that is morphologically distinct from apoptosis and necrosis. [1][2] While autophagy is generally considered a cellular survival mechanism, ACD occurs when excessive or dysregulated autophagy leads to the cell's demise. [3]
In this chapter we discuss methods to study autophagic cell death . A large body of evidence demonstrates that autophagy is a cell survival mechanism in response to starvation. The role of autophagy in cell death , however, has long been ...

Autophagy in Cell Life and Cell Death
Such autophagic cell death was seen in several studies, such as in cell death induced by various chemotherapy drugs and in Drosophila tissue cell death during the developmental transition from a larva to an adult, also known as metamorphosis.

This mechanical stress on lysosomal membranes triggered autophagic cell death through the Galectin-3 (Gal3)-Trim16 signaling axis, establishing a direct mechanobiological link between nanostructure geometry and cell fate.
Additional Notes on Autophagic Cell Death
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