A specific collagen hydrolysate improves postprandial glucose tolerance
As hydrolyzed proteins can directly affect the enteroendocrine system, targeting the natural secretion of native GLP-1 by food or dietary supplements represents a promising strategy.
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Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial ...
In conclusion, ingestion of collagen hydrolysates increases postprandial plasma concentrations of AAs over a period of 240 min, and an enzymatic hydrolysis increases the absorption rate and bioavailability of the collagen -rich AAs glycine, proline and hydroxyproline.
Overall, the data indicate that the specific collagen hydrolysate, H80, has significant GLP-1-mediated effects on oral glucose tolerance in lean and prediabetic mice. Furthermore, effects on postprandial glucose tolerance were evaluated in a small, human, proof of concept study.
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