Agonistic vs Antagonistic Olfactory Molecules Scent Secrets

Antagonistic odor interactions in olfactory sensory neurons are ...

Odor blends contain molecules that activate unique, overlapping populations of sensory neurons (OSNs). Here, by imaging OSN axon terminals, as well as their cell bodies within the olfactory ...

Therefore, antagonism is a common feature of odor mixture encoding in OSNs and helps in normalizing activity to reduce saturation and increase information transfer. Subject terms: Olfactory receptors, Sensory processing Odor blends contain molecules that activate unique, overlapping populations of sensory neurons (OSNs).

Antagonistic interactions between odorants alter human odor perception ...

If antagonists inhibit the response of all receptors that respond to particular VSCs, it is expected that inhibition of olfactory perception will occur. To test whether the antagonistic interactions affect olfactory perception, we designed a set of human sensory evaluation tests aimed at distinguishing antagonistic effects and central ...

Keywords: olfaction, olfactory receptor, chemical senses, chemosensory, antagonist, inverse agonist, deodorant, cAMP, olfactory psychophysics Graphical Abstract eTOC Blurb Fukutani et al. identified β-ionone as an antagonist of odorant receptors responding to potent sulfur malodors using heterologous expression.

(PDF) Antagonistic interactions between odorants alter human odor ...

The olfactory system detects a vast number of odorants using hundreds of olfactory receptors (ORs), the largest group of the G protein-coupled receptor (GPCR) superfamily. Each OR is activated by ...

Fukutani et al. identified β-ionone as an antagonist of odorant receptors responding to potent sulfur malodors using heterologous expression. Human sensory evaluations confirmed β-ionone effectively reduced malodor intensity and unpleasantness, highlighting the importance of antagonistic interactions at the odorant receptor level in odor sensation.

Odor mixtures

The olfactory world is one of complex mixtures and blends containing up to hundreds of molecules . Many of those molecules can act as agonists, antagonists or enhancers at different receptors. This complicates the mechanism by which higher centers construct perceptions of complex mixtures. We propose ...

Olfactory receptors (ORs) form the largest subfamily of class A G protein-coupled receptors (GPCRs); however, only a few 3D structures of ORs have been determined. Structure-based virtual screening and improved structural insights are required to effectively identify novel odor molecules and elucidate their binding modes along with mechanisms of activation and inactivation. Herein, we propose ...

Olfactory GPCRs through the lens of structural bioinformatics

The molecular receptive range is the set of chemical compounds (odorants) that bind to and stimulate a specific olfactory receptor. With their extensive repertoire of olfactory GPCRs, humans can distinguish numerous odorant molecules , estimated to be 10,000, or even over one trillion (Bushdid et al. 2014; Crocker and Henderson 2002).

Mechanisms of ligand-receptor interactions at olfactory receptors (ORs), particularly those of antagonists, remain largely unclear. Here, we investigated how ethanol—empirically known to suppress human olfactory perception—modulates OR activity using a heterologous assay system. Ethanol did not activate OR1A1 or OR2W1 but significantly suppressed agonist-induced responses in a ...