Understanding Nuclear Antigen Ki Role Function And Clinical Significance

Overview of Nuclear Antigen Ki

Antigen KI -67 is a nuclear protein that is associated with cellular proliferation and ribosomal RNA transcription. [7] Inactivation of antigen KI -67 leads to inhibition of ribosomal RNA synthesis, [8] but does not significantly affect cell proliferation in vivo: Ki -67 mutant mice developed normally and cells lacking Ki -67 proliferated efficiently.

Nuclear antigen Ki -67 is widely accepted as a cell proliferation marker in both research and cancer diagnostic settings. Despite its extensive use and clinical value, very little is still known about the biological function of Ki -67. A recent work published in Cell Reports has revealed important novel aspects of Ki -67 regulation that could provide new and extended prognostic and therapeutic value.

Key Details About Nuclear Antigen Ki

Nuclear antigen Ki -67 is widely accepted as a cell proliferation marker in both research and cancer diagnostic settings. Despite its extensive use and clinical value, very little is still known about the biological function of Ki -67. A recent work published in Cell Reports has revealed important novel aspects of Ki -67 regulation that could provide new and extended prognostic and therapeutic value.

Ki -67 is a well characterized proliferation-associated nuclear antigen with great utility in histopathology. It can be used to identify proliferating cells in healthy tissues, but is most often used as a diagnostic tool in various cancers ranging from breast to thyroid.

Epitope analysis of antibodies recognising the cell proliferation ...

The cell proliferation-associated antigen of antibody Ki -67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

The antigen was not initially characterised and hence the name Ki -67. Ki -67, a nuclear DNA binding protein which is expressed in all the vertebrates is a widely used marker of proliferation used for grading tumours [4].

Overview of Nuclear Antigen Ki

Ki -67 is a nuclear antigen present only in the nuclei of cycling cells. Entry Term (s) Antigen Ki -67 Antigen Ki67 MIB-1 Antigen Registry Numbers 0 Previous Indexing Antigens , Surface (1988-1991) Neoplasm Proteins (1994-1996) Nuclear Proteins (1992-1996) Public MeSH Note

In these studies, the combination of flow cytometry and microscopy permitted visualization and quantitative multi-parameter characterization of T cells in different phases of the cell cycle, as identified by Ki -67/DNA dual staining: thus antigen -induced T cell cycle progression corresponded to quantitative increases in SSC, nuclear size (DNA ...

The intrinsically disorderly story of Ki

The original Ki -67 monoclonal antibody was found to stain a specific nuclear sub-structure (subsequently shown to be the nucleolus). This staining was observed in nuclei of cells during G 1, S and G 2 phases of the cell cycle but not in cells in G 0 phase [5]. Given this staining pattern, it was proposed that Ki -67 antibody and protein might be good candidates for evaluating the proliferative ...

The Ki -67 protein is a prominent proliferation marker used in pathology [1, 2]. Ki -67 was first identified as an antigen for a monoclonal antibody detected in the nuclei of proliferating cells [1, 3].