Insulin Resistance in Dogs
In diabetic dogs , many concurrent diseases can cause resistance to exogenous insulin . The most common concurrent disorders in diabetic dogs are hyperadrenocorticism, urinary tract infection, acute pancreatitis, neoplasia, and hypothyroidism. When a concurrent disorder is treated, the insulin dose should be decreased to avoid possible hypoglycemia when an underlying cause of insulin resistance ...
Diabetes Mellitus in Cats and Dogs Edited by Chen Gilor DVM, PhD - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA Thomas K. Graves DVM, PhD, DACVIM - College of Veterinary Medicine, Midwestern University, Glendale, AZ, USA
Diabetes Mellitus in Dogs and Cats
Insulin resistance and secondary diabetes mellitus also occur in many dogs that have spontaneous hyperadrenocorticism or that have been chronically administered glucocorticoids or progestins. Pregnancy and diestrus also can predispose an animal to diabetes mellitus.
The most common causes of insulin resistance in diabetic dogs are Cushing syndrome, diestrus, and obesity. Cushing-associated effects include insulin resistance , excessive postprandial hyperglycemia, perceived short duration of insulin action, and/or substantial within-day and/or day-to-day glycemic variability. Successful strategies to manage excessive glycemic variability include basal ...
Insulin Resistance
The most common disorders causing insulin resistance in dogs include severe obesity, use of diabetogenic drugs (glucocorticoids), hyperadrenocorticism, diestrus, chronic pancreatitis, renal insufficiency, oral and urinary tract infections, hyperlipidemia, and anti- insulin antibodies in dogs receiving beef source insulin .
The most common disorders causing insulin resistance in dogs include severe obesity, use of diabetogenic drugs (glucocorticoids), hyperadrenocorticism, diestrus, chronic pancreatitis, renal insufficiency, oral and urinary tract infections, hyperlipidemia, and anti- insulin antibodies in dogs receiving beef source insulin .
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Treatment for dogs
As with cats, a clinically sick, diabetic, ketotic dog should be admitted for 24 hr care for aggressive therapy of the ketosis and other underlying illnesses. In dogs with subclinical DM, investigate and address causes of insulin resistance , including obesity, medications, hyperadrenocorticism and diestrus in intact females.
Davison LJ, Walding B, Herrtage ME, Catchpole B. Anti- insulin antibodies in diabetic dogs before and after treatment with different insulin preparations. J Vet Intern Med. 2008;22:1317-1325.
Hard to Regulate Diabetic Dogs
Struggling to manage your diabetic dog's glucose levels? Discover why insulin resistance happens and how to troubleshoot with this 2025 vet guide. 🩺🐶
The guidelines provide rec- ommendations for each insulin formulation currently available for use in dogs and cats, the choice of which is generally based on efficacy and duration of effect in the respective species. Also discussed are non- insulin therapeutic medications and dietary management.