Feline cutaneous lymphoma. Figure 1. Diffuse anaplastic large B
Feline primary cutaneous lymphoma is a rare malignancy seen predominately in older cats, representing 0.2-3% of all feline lymphomas . 1 This malignancy can present as epitheliotropic T-cell ...
Feline cutaneous lymphoma . Figure 1 . Diffuse anaplastic large B-cell lymphoma , cat No. 10. Prominent angiocentrism: neoplastic cells tightly surround vessels in the deep dermis. Hematoxylin and ...
The Treatment of Feline Cutaneous Lymphoma
Cutaneous non-epitheliotropic lymphoma (CNEL) is the more common condition in cats and includes indolent T-cell lymphoma (or cutaneous lymphocytosis), diffuse T-cell lymphoma , T- cell -rich large B-cell lymphoma , and lymphoplasmacytic lymphoma [ 1 ].
Intermediate to large B-cell LSAs, including diffuse large B-cell lymphoma (DLBCL), also occur with slightly less frequency (Figure1C). Cats are often presented with a palpable mass and more acute and severe clinical signs. 1
Feline lymphoma
Certain classifications to highlight include intestinal T cell lymphomas , which are the most commonly seen category of lymphoma in cats (Vezzali and others 2010), and diffuse large B cell lymphoma (DLBCL), which is the most common form of B cell lymphoma in cats.
Anaplastic large cell lymphomas were diagnosed in 4 cats when a T-cell (3 cases) or natural killer (NK)-like cell ( 1 case) phenotype was associated with large size, severe pleomorph- Clinical Follow-up ism with presence of C-shaped nuclei (Hallmark cells ), and fre- Clinical follow-up was available in 15 of 17 cats and is listed in quent bi ...
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Cutaneous , non-epitheliotropic lymphomas seem more frequent in cats 10 than dogs and include indolent T cell lymphoma , also referred to as cutaneous lymphocytosis, 6,7 diffuse T cell lymphoma , T cell rich large B cell lymphoma , and lymphoplasmacytic lymphoma .
The primary goal of this study was to characterize the clinical presentation of feline cutaneous lymphoma . The secondary aims included determining if treatment or initial response to treatment affected the overall survival of patients, and understanding if disease characteristics such as immunophenotype, cell size or the presence of epitheliotropism influenced response to treatment.
Feline cutaneous lymphoma
The varied presentation of cutaneous lymphoma likely contributes to delays in appropriate diagnosis and Figure 1 Alopecia and scaling. Image courtesy of University of Minnesota under-diagnosis, which may inhibit timely appropriate treatment. Gold standard treatment for cutaneous lym-phoma in veterinary patients has yet to be defined.
The cause is unknown in most cases. Feline leukemia virus and feline immunodeficiency virus can cause lymphoma in cats, but don't seem to be involved in most cases of cutaneous lymphoma . Lymphoma in cats can rarely happen at a vaccine site, but most vaccine-associated tumors are other kinds of cancer, not lymphoma .