Integrative network analysis workflow overview. GLP
Integrative network analysis workflow overview . GLP-1 stimulated insulin secretion GWAS SNP P-values were converted to gene significance scores, which were then mapped onto a beta-cell specific ...
Integrative network analysis workflow overview . GLP-1 stimulated insulin secretion GWAS SNP P-values were converted to gene significance scores, which were then mapped onto a beta-cell specific PPI network created by pruning the global network using beta-cell gene expression data.
Integrative network analysis workflow overview.
GLP-1 stimulated insulin secretion GWAS SNP P-values were converted to gene significance scores, which were then mapped onto a beta-cell specific PPI network created by pruning the global network using beta-cell gene expression data. The jActiveModules algorithm was used to identify network modules that were enriched for association signal. The top scoring network modules were used to ...
A The discovery analysis consisted of an integrative network analysis where GLP-1 stimulated insulin secretion GWAS P-values were combined with a beta-cell specific PPI network to identify enriched network modules or 'network hotspots'.
Integrative network analysis highlights biological processes ...
A The discovery analysis consisted of an integrative network analysis where GLP-1 stimulated insulin secretion GWAS P-values were combined with a beta-cell specific PPI network to identify enriched network modules or 'network hotspots'.
A The discovery analysis consisted of an integrative network analysis where GLP-1 stimulated insulin secretion GWAS P-values were combined with a beta-cell specific PPI network to identify enriched network modules or 'network hotspots'.
(PDF) Integrative network analysis highlights biological processes ...
Recently, using an untargeted integrative genomics approach, a set of genes that contained variants associated with GLP-1-stimulated insulin secretion were described, which at the same time have ...
The findings provide biological insight into the mechanisms through which the effects of GLP-1 may be modulated and highlight a potential role of the beta-cell expressed genes RYR2, GDI2, KIAA0232, COL4A1 and COL4A2 in GLP-1 stimulated insulin secretion.
Integrative network analysis highlights biological processes underlying ...
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