Glucose Sensing In The Pancreatic Beta Cell A Computational Systems

"Glucose-sensing mechanisms in pancreatic beta-cells". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences.

Pancreatic -cells respond to rising blood glucose by increasing oxidative metabolism, leading to an increased ATP/ADP ratio in the cytoplasm with a subsequent influx of calcium and the eventual secretion of insulin.

Abstract. Background Pancreatic beta-cells respond to rising blood glucose by increasing oxidative metabolism, leading to an increased ATP/ADP ratio in the cytoplasm.

A mathematical model to describe the oscillatory bursting activity of pancreatic beta-cells is combined with a model of glucose regulation system in this work to study the bursting pattern under regulated extracellular glucose stimulation.

Glucose is a primary stimulator of insulin secretion in pancreatic -cells. High concentration of glucose has been thought to exert its action solely through its metabolism.

Furthermore, visual representations like the one above help us fully grasp the concept of Glucose Sensing In The Pancreatic Beta Cell A Computational Systems.

This invention relates to systems for treatment of non-insulin-dependent diabetes mellitus and, in particular, systems for stimulating the pancreas to enhance sensing of beta-cell electrical activity, from which a measure of patient blood glucose level is obtained.

Glucose sensing in the pancreatic beta cell: a computational systems analysis.A mathematical model of beta-cell sensitivity to glucose is described and predicts a special role for mitochondrial control mechanisms in insulin secretion and ROS generation in the beta cell.