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Tolerance results from the brain's gradual adaptation towards the additional dopamine. This reduces the amount of high that the user experienced before they started taking the medication. You could use more medication to get the same dopamine high.

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Long-term drug use can also cause brain chemical changes and circuits. This affects functions such as learning, judgment, decision making, stress, memory, and behavior. Many people continue to use drugs despite knowing these negative outcomes. This is what addiction looks like.
Why are some people addicted to drugs and others not? There are many factors that can influence whether someone will become addicted to drugs. Risk of addiction is affected by a combination of many factors. A person's risk factors can influence the likelihood of becoming addicted to drugs.

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Drugs that can lead you to addiction target your brain's reward system. Dopamine, a neurotransmitter is released in high quantities into your brain. This causes a state of pure joy. You continue taking the drug to recreate the high.
Your brain will soon adjust to the high levels of dopamine. For the same effect you will likely need to take more dopamine. Other things that used bring joy to you, such food and time spent with your family, may not be as effective.
Use of drugs for prolonged periods can cause brain chemical and circuit changes. They can affect your decision-making and judgement as well as memory and learning abilities. This combination can lead to brain changes that make it hard to resist the urge for drugs to be used in ways that are out of your control.

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Why is it that some people become addicted while others do not? One factor cannot predict if someone will become addicted. There are many factors that influence the risk of developing addiction. A person is more likely to become addicted to drugs if they have a higher risk factor.
Biology. A person's chances of becoming addicted to drugs and alcohol are about half the problem. The risk of drug addiction and use may be affected by gender, race, and mental health conditions.
Environment. The environment can influence many aspects of a person's life, such as their family and friends, financial status, and overall quality of his/her life. Factors such a peer pressure, emotional and sexual abuse, early exposure and parental guidance, as well as stress levels and early exposure can significantly impact a person's risk of becoming addicted to drugs.

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The brain becomes more used to the dopamine and the person feels less high after a while. This is called tolerance. In an effort to feel the same dopamine rush, they may take more medication.
There is no single factor that can predict if someone will become dependent on drugs. It is possible for many factors to influence whether or not someone will become addicted. A person is more likely to use drugs if they have more risk factors.

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Is it possible to stop being addicted to drugs or get over it?
Most of the time, therapy for drug addiction doesn't lead to a full recovery. This is similar to what happens when someone has a long-term illness like diabetes, asthma, or heart disease. On the other hand, addiction may be treated, and its symptoms can be effectively managed. People who are trying to beat an addiction will have a chance of relapsing for a long time, maybe even for the rest of their lives. Combining medication and behavioural therapy to treat addiction has been shown to work best for most people. Continued sobriety is possible with the help of treatment methods that are tailored to each patient's drug use history and any other medical, mental, or social problems they may have.
Another piece of good news is that people can avoid both using drugs and becoming addicted to them. Research funded by the National Institute on Drug Abuse (NIDA) found that drug abuse prevention programmes that included families, schools, communities, and the media helped prevent or reduce drug abuse and addiction. Even though both personal experiences and social factors play a role in how people use drugs, it has been shown that when young people think that drug use is dangerous, they tend to cut back on it. So, education and outreach are important parts of helping people understand the risks of using drugs. Parents, teachers, and doctors all have a role to play in educating young people, especially about how to avoid using drugs and becoming addicted to them.

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Relapse is not uncommon, but it does not mean that treatment has failed. Like with all chronic diseases, therapy must be continuous and dependent on the patient’s response. Patients' needs must be reflected on and treated accordingly.
What effects can drug use have upon the brain?