Mixing Zoloft With Levothyroxine

Editorial Team May 08, 2026
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A moderate drug interaction exists between Levothyroxine and Zoloft. View detailed information regarding this drug interaction. Levothyroxine + Zoloft The following applies to the ingredients: Levothyroxine and Sertraline (found in Zoloft) Using sertraline together with levothyroxine may decrease the effects of sertraline.

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This can cause fatigue, weight gain, constipation, and low blood pressure. Sertraline (brand name Zoloft) has interactions with many types of medications, including other antidepressants, amphetamines, blood thinners, and more. I always took my Zoloft before bed because one of the side effects was sleepiness, so that seemed the natural time.

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Then when I started taking levothyroxine I was told to take it first thing, which is what I've kept doing. Your prescriber may recommend medication changes to avoid this Zoloft interaction. They may also OK the combination and check your heart rhythm at follow-up visits.

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When a medication works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another... The phase IV clinical study analyzes what interactions people have when they take Levothyroxine sodium and Zoloft.

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It is created by eHealthMe based on reports of 1,827 people who take the same drugs from the FDA, and is updated regularly. Understand if you can take levothyroxine with sertraline. Learn about the potential drug interaction, proper timing for dosing, and what monitoring is needed for safety.

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Spacing these medications allows levothyroxine to be absorbed effectively without competition. Always follow your healthcare providers instructions and inform them about all medications you take to optimize treatment and avoid interactions. In our latest question and answer, that pharmacist discusses options of how to take levothyroxine when you take multiple other medications.

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