Methoprene. Causes of Advantage Flea Medication Allergy in Cats. Advantage flea treatment is generally considered to be safe for cats; however, some cats may develop a reaction to the active ingredient.
Flea Allergy Dermatitis (FAD) is a common and severe allergic reaction in dogs and cats triggered by flea bites. The reaction is not to the bite itself but to the flea's saliva.

The key to protecting flea allergic cats is using highly effective anti-flea treatments and ensuring that there is no break in the protection. One option we have for this is the Seresto UK Flea and Tick Control Collar For Cats, not only does it protect brilliantly against fleas, it also gives...

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Flea-allergic dermatitis: Thats when your cat has severe allergies from the saliva of a flea, resulting in excessive grooming, hair loss, and red, raised, crusty bumps all over the bodyits torturous to your cat, as this allergy is excruciatingly uncomfortable.

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If your cat is allergic to fleas, your vet may recommend flea treatment for your cat and your home. They may also prescribe medication, such as a topical treatment, oral corticosteroids, Oclacitinib (Apoquel), or allergy shots.
Fleas cause itch and allergy dermatitis can result from just one flea bite. Find out how to control a flea infestation and dermatitis in your dog or cat.Flea allergies are allergic reactions to flea saliva, which pets are exposed to when a flea bites them.