Kallman's syndrome is a disorder of hypogonadotropic hypogonadism, delayed puberty, and anosmia (the inability to smell). Kallman's syndrome is a birth defect in the brain that prevents release of hormones and appears as failure of male puberty. Some boys have adequate amounts of androgen in their system but fail to respond to them, a condition known as androgen resistance. Hypogonadotropic hypogonadism (hh) occurs when the body does not produce enough of two important hormones, luteinizing hormone (lh) and follicle stimulating hormone (fsh). This results in underdeveloped gonads and often infertility. Anosmia, the inability to smell, was first described with hypogonadotropic hypogonadism in 1856, but it was not until 1944 that an instance of kallman's reported the inheritance of the two symptoms together in three separate families. Last week, we started a topic on male hypogonadism. We discussed the definition, types andsomecauses. This week, we will continue with some of the primary and secondary causes of male hypogonadism and few signs and symptoms. Hemochromatosis:this condition is characterized by excess of iron in the bloodstream. Hemoglobin, which is composed of both the heme (iron) and the globulin (protein) parts, is often the main component of the red blood cell.