Introduction and Data files

This dataset contains nine tissues (heart, hippocampus, hypothalamus, kidney, liver, prefrontal cortex, skeletal muscle, small intestine, and spleen) from C57BL/6J mice that were fed 2-deoxyglucose (6g/L) through their drinking water for 96hrs or 4wks. 96hr mice were given their 2DG treatment 2 weeks after the other cohort started the 4 week treatment. The organs from the mice were harvested and processed for metabolomics and transcriptomics. The data in this document pertains to the transcriptomics data only. The counts that were used were FPKM normalized before being log transformed. It was determined that sample A113 had low RNAseq quality and through further analyses with PCA, MA plots, and clustering was an outlier and will be removed for the rest of the analyses performed. This document will determine the contribution of each main effect or their combination to each module identified, as well as the relationship of each gene within the module and its significance.

needed.packages <- c("tidyverse", "here", "functional", "gplots", "dplyr", "GeneOverlap", "R.utils", "reshape2","magrittr","data.table", "RColorBrewer","preprocessCore", "ARTool","emmeans", "phia", "gProfileR", "WGCNA","plotly", "pheatmap", "ppcor","pander","downloadthis")
for(i in 1:length(needed.packages)){library(needed.packages[i], character.only = TRUE)}

source(here("source_files","WGCNA_source.R"))
source(here("source_files","WGCNA_contribution_source.R"))
tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))

tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))

log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)

log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])

log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5] 

log.tdata.FPKM.subset <- log.tdata.FPKM.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

WGCNA.pathway <-readRDS(here("Data","Chang_B6_96hr_4wk_gprofiler_pathway_annotation_list_WGCNA.RData"))

Matched<-readRDS(here("Data","Annotated_genes_in_WGCNA_Chang_B6_96hr_4wk.RData"))

module.names <- Matched$X..Module.
name <- str_split(module.names,"_")
samples <-c()
for(i in 1:length(name)){
samples[[i]] <- name[[i]][2]
}  
name <- str_split(samples,"\"")
name <- unlist(name)

Treatment <- unclass(as.factor(log.tdata.FPKM.sample.info[,27238]))
Tissue <- unclass(as.factor(log.tdata.FPKM.sample.info[,27239]))
Time <- unclass(as.factor(log.tdata.FPKM.sample.info[,27237]))
Treat.Tissue <- paste0(Treatment,Tissue)
Treat.Time <- paste0(Treatment, Time)
Tissue.Time <- paste0(Tissue, Time)
Treat.Tissue.Time <- paste0(Treatment,Tissue, Time)
phenotype <- data.frame(cbind(Tissue, Treatment, Time, Treat.Tissue, Treat.Time, Tissue.Time, Treat.Tissue.Time))

nSamples <- nrow(log.tdata.FPKM.sample.info)

MEs0 <- read.csv(here("Data","log.tdata.FPKM.sample.info.subset.WGCNA.module.eigens.csv"),header = T, row.names = 1)
name <- str_split(names(MEs0),"_")
samples <-c()
for(i in 1:length(name)){
samples[[i]] <- name[[i]][2]
}  
name <- str_split(samples,"\"")
name <- unlist(name)
colnames(MEs0) <-name
MEs <- orderMEs(MEs0)
moduleTraitCor <- cor(MEs, phenotype, use = "p");
moduleTraitPvalue <- corPvalueStudent(moduleTraitCor, nSamples)

Relationship between Modules and Traits

#sizeGrWindow(10,6)
# Will display correlations and their p-values
textMatrix = paste(signif(moduleTraitCor, 2), "\n(",
                        signif(moduleTraitPvalue, 1), ")", sep = "");
dim(textMatrix) = dim(moduleTraitCor)

# Display the correlation values within a heatmap plot
heat <- pheatmap(moduleTraitCor, main = paste("Module-trait relationships"), color=colorRampPalette(brewer.pal(n = 12, name = "Paired"))(10), cluster_rows = F, cluster_cols = F, fontsize_number = 4, angle_col = 45, number_color = "black", border_color = "white")
heat

DT::datatable(moduleTraitPvalue, extensions = 'Buttons',
                  rownames = TRUE, 
                  filter="top",
                  options = list(dom = 'Blfrtip',
                                 buttons = c('copy', 'csv', 'excel'),
                                 lengthMenu = list(c(10,25,50,-1),
                                                   c(10,25,50,"All")), 
                                 scrollX= TRUE), class = "display")

Partial Correlation

phenotype$Tissue <- as.numeric(phenotype$Tissue)
phenotype$Treatment <- as.numeric(phenotype$Treatment)
phenotype$Time <- as.numeric(phenotype$Time)
phenotype$Treat.Tissue <- as.numeric(phenotype$Treat.Tissue)
phenotype$Treat.Time <- as.numeric(phenotype$Treat.Time)
phenotype$Tissue.Time <- as.numeric(phenotype$Tissue.Time)
phenotype$Treat.Tissue.Time <- as.numeric(phenotype$Treat.Tissue.Time)

Sigmodules <- as.data.frame(cbind(MEs$floralwhite,MEs$darkgreen,MEs$darkolivegreen,MEs$darkorange2,MEs$lightcyan1,MEs$lightyellow,MEs$midnightblue,MEs$orangered4,MEs$royalblue,MEs$skyblue)) #MEs$ivory,MEs$skyblue3,MEs$turquoise,MEs$violet # These have a computationally singular error need to fix
colnames(Sigmodules) <- c("floralwhite","darkgreen","darkolivegreen","darkorange2","lightcyan1","lightyellow","midnightblue","orangered4","royalblue","skyblue") #"ivory","skyblue3","turquoise","violet"

for(i in 1:length(Sigmodules)){
   cat("\n##",colnames(Sigmodules[i]),"{.tabset .tabset-fade .tabset-pills}","\n")
   for(j in 1:length(phenotype)){
      cat("\n###", colnames(phenotype[j]), "{.tabset .tabset-fade .tabset-pills}", "\n")
      for(k in 1:length(phenotype)){
         cat("\n####", "Partial Correlation", colnames(phenotype[k]),"\n")
         partial <- pcor.test(Sigmodules[,i], phenotype[,j],phenotype[,k])
         panderOptions('knitr.auto.asis', FALSE)
         print(pander(partial))
         cat("\n \n")
      }
      cat("\n \n")
   }
   cat("\n \n")
}

floralwhite

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.702 2.193e-22 -11.66 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.7021 2.168e-22 -11.66 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.7021 2.161e-22 -11.67 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.6568 6.928e-19 -10.31 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.7021 2.162e-22 -11.67 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.002633 0.9752 -0.03116 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.6568 6.955e-19 -10.31 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01421 0.8668 -0.1681 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.006292 0.9408 -0.07445 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.006348 0.9402 -0.07511 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.6568 6.928e-19 10.31 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.007255 0.9317 0.08585 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.01434 0.8655 -0.1697 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.6569 6.828e-19 10.31 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01643 0.8461 -0.1944 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.007921 0.9255 -0.09373 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.007877 0.9259 -0.0932 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.0114 0.8929 -0.1349 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.007255 0.9317 -0.08585 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.002633 0.9752 0.03116 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.008297 0.9219 -0.09817 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01421 0.8668 -0.1681 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.7021 2.168e-22 -11.66 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.3289 6.441e-05 -4.12 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.3288 6.473e-05 -4.119 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.6874 3.478e-21 -11.2 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.01437 0.8653 -0.17 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.008297 0.9219 0.09817 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01578 0.8521 -0.1867 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.007921 0.9255 -0.09373 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.006348 0.9402 -0.07511 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.6392 1.117e-17 9.836 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.00705 0.9336 -0.08342 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.01402 0.8685 -0.1659 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.6423 7.005e-18 9.915 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01643 0.8461 -0.1944 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.7022 2.127e-22 -11.67 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.7021 2.161e-22 -11.67 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.657 6.798e-19 -10.31 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.7021 2.13e-22 -11.67 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.7021 2.152e-22 -11.67 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.6569 6.828e-19 -10.31 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01437 0.8652 -0.17 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.7022 2.127e-22 -11.67 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.3289 6.441e-05 -4.12 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.0114 0.8929 -0.1349 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.69 2.174e-21 -11.28 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.01434 0.8655 -0.1697 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.3289 6.444e-05 -4.12 143 1 pearson

NULL

darkgreen

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.6418 7.499e-18 9.903 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.642 7.298e-18 9.908 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.6418 7.505e-18 9.903 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.5916 8.97e-15 8.683 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.642 7.312e-18 9.908 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02947 0.7277 0.3489 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.5917 8.927e-15 8.684 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02523 0.7657 0.2986 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.01585 0.8515 0.1875 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01575 0.8524 0.1864 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.5916 8.97e-15 -8.683 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.0151 0.8585 0.1787 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02533 0.7648 0.2998 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.5913 9.368e-15 -8.676 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.0133 0.8751 -0.1574 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.01359 0.8725 -0.1608 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.0137 0.8715 -0.1621 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.01155 0.8915 -0.1366 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.0151 0.8585 -0.1787 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.02947 0.7277 -0.3489 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.01445 0.8645 -0.1709 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02523 0.7657 0.2986 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.642 7.298e-18 9.908 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.3095 0.0001782 3.851 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.3096 0.0001775 3.852 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.6327 3.001e-17 9.667 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02562 0.7622 0.3032 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.01445 0.8645 0.1709 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02379 0.7787 0.2816 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.01359 0.8725 -0.1608 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01575 0.8524 0.1864 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.5804 3.716e-14 -8.433 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.01442 0.8648 0.1706 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02229 0.7924 0.2638 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.5828 2.767e-14 -8.485 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.0133 0.8751 -0.1574 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.6417 7.661e-18 9.9 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.6418 7.505e-18 9.903 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.5913 9.408e-15 8.675 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.6417 7.716e-18 9.899 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.6415 7.875e-18 9.895 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.5913 9.368e-15 8.676 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02509 0.7669 0.297 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.6417 7.661e-18 9.9 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.3095 0.0001782 3.851 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.01155 0.8915 -0.1366 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.6346 2.249e-17 9.716 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02533 0.7648 0.2998 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.3095 0.0001785 3.851 143 1 pearson

NULL

darkolivegreen

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.4072 4.91e-07 5.276 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.4073 4.878e-07 5.277 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.4072 4.92e-07 5.276 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.3636 8.654e-06 4.619 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.4073 4.882e-07 5.277 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02404 0.7764 0.2846 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.3637 8.621e-06 4.62 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01453 0.8637 0.172 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.01105 0.8961 0.1308 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01094 0.8972 0.1295 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.3636 8.654e-06 -4.619 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.01725 0.8385 0.2042 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01459 0.8632 0.1726 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.3633 8.834e-06 -4.614 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01543 0.8554 -0.1826 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.01623 0.8479 -0.1921 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.01631 0.8472 -0.193 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.01487 0.8606 -0.176 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.01725 0.8385 -0.2042 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.02404 0.7764 -0.2846 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.01666 0.844 -0.1972 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01453 0.8637 0.172 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.4073 4.878e-07 5.277 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.1972 0.01865 2.38 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1973 0.01858 2.382 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.4029 6.671e-07 5.208 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01483 0.861 0.1754 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.01666 0.844 0.1972 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01293 0.8786 0.153 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.01623 0.8479 -0.1921 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01094 0.8972 0.1295 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.3584 1.19e-05 -4.542 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.009382 0.9118 0.111 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01213 0.8861 0.1435 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.3597 1.098e-05 -4.562 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.01543 0.8554 -0.1826 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.407 4.999e-07 5.272 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.4072 4.92e-07 5.276 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.3633 8.866e-06 4.613 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.407 5.011e-07 5.271 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.4069 5.032e-07 5.271 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.3633 8.834e-06 4.614 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01438 0.8652 0.1701 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.407 4.999e-07 5.272 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.1972 0.01865 2.38 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.01487 0.8606 -0.176 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.404 6.186e-07 5.225 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01459 0.8632 0.1726 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1972 0.01867 2.38 143 1 pearson

NULL

darkorange2

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.2859 0.0005612 -3.531 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2859 0.0005625 -3.53 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.2862 0.0005551 -3.534 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.2657 0.001393 -3.261 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2859 0.0005627 -3.53 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02256 0.7898 0.267 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.2656 0.0014 -3.26 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02176 0.7971 0.2576 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.02241 0.7912 0.2652 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.02224 0.7928 0.2632 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.2657 0.001393 3.261 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.02755 0.7449 0.3261 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02172 0.7975 0.2571 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.2661 0.001368 3.267 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.02833 0.7378 -0.3354 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.02544 0.7638 -0.3011 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.02559 0.7624 -0.3029 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.02674 0.7521 -0.3165 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.02755 0.7449 -0.3261 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.02256 0.7898 -0.267 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.02574 0.7611 -0.3047 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02176 0.7971 0.2576 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2859 0.0005625 -3.53 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.112 0.1847 -1.333 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1117 0.1857 -1.33 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2753 0.0009145 -3.388 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02195 0.7955 0.2597 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.02574 0.7611 0.3047 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01885 0.8238 0.2231 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.02544 0.7638 -0.3011 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.02224 0.7928 0.2632 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.2539 0.002296 3.106 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.01977 0.8154 0.2339 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01938 0.8189 0.2294 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.2554 0.002155 3.126 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.02833 0.7378 -0.3354 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2864 0.0005503 -3.537 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.2862 0.0005551 -3.534 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.2662 0.001361 -3.268 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2864 0.0005496 -3.537 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.2864 0.000549 -3.537 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.2661 0.001368 -3.267 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02148 0.7997 0.2542 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2864 0.0005503 -3.537 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.112 0.1847 -1.333 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.02674 0.7521 -0.3165 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2768 0.0008554 -3.408 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02172 0.7975 0.2571 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1119 0.1848 -1.333 143 1 pearson

NULL

lightcyan1

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.2101 0.01207 -2.543 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2101 0.0121 -2.542 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.2102 0.01206 -2.543 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1982 0.01807 -2.392 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2101 0.0121 -2.542 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.00122 0.9885 -0.01443 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1982 0.01807 -2.392 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02367 0.7797 0.2802 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.02429 0.7742 0.2875 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.02428 0.7743 0.2873 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1982 0.01807 2.392 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.003967 0.9626 0.04694 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02364 0.78 0.2798 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1982 0.01806 2.392 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.002937 0.9723 -0.03475 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.001556 0.9853 -0.01841 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.001726 0.9837 -0.02043 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.002393 0.9775 -0.02831 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.003967 0.9626 -0.04694 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.00122 0.9885 0.01443 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.001722 0.9838 -0.02037 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02367 0.7797 0.2802 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2101 0.0121 -2.542 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.07514 0.3741 -0.8916 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.07512 0.3743 -0.8914 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2053 0.01423 -2.483 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02363 0.7801 0.2797 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.001722 0.9838 0.02037 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02328 0.7833 0.2755 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.001556 0.9853 -0.01841 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.02428 0.7743 0.2873 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1931 0.02132 2.329 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.02401 0.7767 0.2842 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02366 0.7798 0.2801 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1939 0.02075 2.339 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.002937 0.9723 -0.03475 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2101 0.01209 -2.543 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.2102 0.01206 -2.543 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1982 0.01806 -2.393 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2101 0.01208 -2.543 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.2102 0.01206 -2.543 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1982 0.01806 -2.392 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.02364 0.78 0.2798 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.2101 0.01209 -2.543 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.07514 0.3741 -0.8916 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.002393 0.9775 -0.02831 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.2061 0.01385 -2.493 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.02364 0.78 0.2798 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.07514 0.3741 -0.8916 143 1 pearson

NULL

lightyellow

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.2007 0.01664 2.424 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2008 0.01659 2.425 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.2006 0.01667 2.423 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1734 0.03906 2.083 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.2008 0.01659 2.425 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01676 0.8431 0.1983 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1734 0.03899 2.084 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01388 0.8698 0.1642 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.0125 0.8826 0.1479 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01241 0.8835 0.1468 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1734 0.03906 -2.083 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.01473 0.8619 0.1743 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.0139 0.8696 0.1645 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1731 0.03936 -2.08 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.0128 0.8798 -0.1515 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.01355 0.8729 -0.1603 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.01364 0.8721 -0.1613 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.0128 0.8799 -0.1514 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.01473 0.8619 -0.1743 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.01676 0.8431 -0.1983 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.01372 0.8712 -0.1624 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01388 0.8698 0.1642 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2008 0.01659 2.425 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.1034 0.2207 1.23 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1035 0.2202 1.231 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.1997 0.01716 2.412 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01407 0.868 0.1665 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.01372 0.8712 0.1624 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01254 0.8822 0.1484 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.01355 0.8729 -0.1603 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01241 0.8835 0.1468 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1721 0.04057 -2.067 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.01109 0.8958 0.1312 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01217 0.8857 0.1441 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1727 0.03991 -2.074 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.0128 0.8798 -0.1515 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2005 0.01674 2.421 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.2006 0.01667 2.423 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1731 0.03942 2.079 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.2005 0.01676 2.421 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.2004 0.01679 2.42 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1731 0.03936 2.08 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01375 0.871 0.1627 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2005 0.01674 2.421 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.1034 0.2207 1.23 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.0128 0.8799 -0.1514 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.2002 0.01693 2.417 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.0139 0.8696 0.1645 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1034 0.2208 1.23 143 1 pearson

NULL

midnightblue

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.4964 3.343e-10 6.765 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.4964 3.329e-10 6.766 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.4964 3.344e-10 6.765 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.4506 1.83e-08 5.973 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.4964 3.328e-10 6.766 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01038 0.9025 0.1228 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.4506 1.829e-08 5.973 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.009306 0.9125 0.1101 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.005375 0.9494 0.0636 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.00536 0.9495 0.06342 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.4506 1.83e-08 -5.973 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.002601 0.9755 0.03077 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.009383 0.9118 0.111 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.4505 1.843e-08 -5.971 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.0006799 0.9936 0.008044 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.002076 0.9804 -0.02456 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.002114 0.9801 -0.02501 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-6.787e-05 0.9994 -0.000803 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.002601 0.9755 -0.03077 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.01038 0.9025 -0.1228 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.002204 0.9792 -0.02607 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.009306 0.9125 0.1101 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.4964 3.329e-10 6.766 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.2333 0.005206 2.839 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.2333 0.005204 2.839 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.4875 7.607e-10 6.606 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.009485 0.9108 0.1122 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.002204 0.9792 0.02607 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.009334 0.9122 0.1104 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.002076 0.9804 -0.02456 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.00536 0.9495 0.06342 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.4402 4.202e-08 -5.801 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.005141 0.9516 0.06083 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.00831 0.9218 0.09832 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.4422 3.605e-08 -5.833 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.0006799 0.9936 0.008044 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.4963 3.354e-10 6.765 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.4964 3.344e-10 6.765 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.4505 1.844e-08 5.971 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.4963 3.358e-10 6.764 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.4963 3.369e-10 6.764 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.4505 1.843e-08 5.971 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.009313 0.9124 0.1102 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.4963 3.354e-10 6.765 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.2333 0.005206 2.839 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-6.787e-05 0.9994 -0.000803 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.4892 6.534e-10 6.636 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.009383 0.9118 0.111 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.2333 0.005206 2.839 143 1 pearson

NULL

orangered4

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.1902 0.0234 -2.292 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.1901 0.02346 -2.291 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.1932 0.02123 -2.33 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.185 0.0275 -2.228 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.1901 0.02346 -2.291 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.1515 0.0719 1.813 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1843 0.02808 -2.219 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.03451 0.6835 0.4085 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.03491 0.68 0.4133 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.03424 0.6858 0.4054 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.185 0.0275 2.228 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.1538 0.06758 1.842 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.03448 0.6837 0.4082 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1876 0.02536 2.26 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.1552 0.06517 -1.859 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.1512 0.07253 -1.809 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.1513 0.07225 -1.811 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1521 0.07084 -1.82 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.1538 0.06758 -1.842 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.1515 0.0719 -1.813 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1516 0.07178 -1.814 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.03451 0.6835 0.4085 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.1901 0.02346 -2.291 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.05847 0.4894 -0.693 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.05647 0.5045 -0.6692 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.1574 0.06133 -1.886 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.03599 0.6707 0.4262 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1516 0.07178 1.814 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01891 0.8233 0.2237 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.1512 0.07253 -1.809 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.03424 0.6858 0.4054 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1485 0.07783 1.776 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.0197 0.816 0.2331 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01925 0.8201 0.2278 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1517 0.07159 1.815 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.1552 0.06517 -1.859 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.193 0.02138 -2.327 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.1932 0.02123 -2.33 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1883 0.02484 -2.268 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.193 0.02136 -2.328 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.1931 0.02133 -2.328 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1876 0.02536 -2.26 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.03295 0.697 0.3901 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.193 0.02138 -2.327 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.05847 0.4894 -0.693 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1521 0.07084 -1.82 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.1609 0.05576 -1.929 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.03448 0.6837 0.4082 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.05782 0.4943 -0.6852 143 1 pearson

NULL

royalblue

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.4268 1.183e-07 -5.584 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.4271 1.153e-07 -5.589 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.4296 9.569e-08 -5.629 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.4082 4.591e-07 -5.291 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.4269 1.169e-07 -5.586 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.1064 0.2075 1.266 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.4078 4.729e-07 -5.284 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.05774 0.4949 0.6843 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.05454 0.5191 0.6463 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.05411 0.5225 0.6411 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.4082 4.591e-07 5.291 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.1067 0.2061 1.27 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.05772 0.495 0.6841 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.41 4.045e-07 5.318 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.1155 0.1713 -1.375 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.1019 0.2278 -1.211 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.1021 0.2267 -1.214 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1045 0.2157 -1.244 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.1067 0.2061 -1.27 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.1064 0.2075 -1.266 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1032 0.2216 -1.228 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.05774 0.4949 0.6843 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.4271 1.153e-07 -5.589 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.1496 0.07558 -1.79 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1479 0.07897 -1.77 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.3987 8.916e-07 -5.144 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.05878 0.4871 0.6967 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1032 0.2216 1.228 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.046 0.5867 0.5448 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.1019 0.2278 -1.211 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.05411 0.5225 0.6411 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.3766 3.856e-06 4.81 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.04414 0.6019 0.5228 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.04688 0.5796 0.5553 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.38 3.104e-06 4.86 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.1155 0.1713 -1.375 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.429 9.959e-08 -5.62 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.4296 9.569e-08 -5.629 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.4104 3.93e-07 -5.325 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.4289 1.004e-07 -5.618 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.4287 1.022e-07 -5.615 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.41 4.045e-07 -5.318 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.05659 0.5036 0.6706 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.429 9.959e-08 -5.62 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.1496 0.07558 -1.79 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1045 0.2157 -1.244 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.4021 7.041e-07 -5.196 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.05772 0.495 0.6841 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1488 0.07712 -1.781 143 1 pearson

NULL

skyblue

Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.2011 0.01641 2.429 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2012 0.01633 2.431 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.2011 0.01642 2.429 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1713 0.04146 2.058 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.2012 0.01633 2.431 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.008318 0.9217 0.09843 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1714 0.04143 2.058 143 1 pearson

NULL

Treatment

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01946 0.8182 0.2303 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.01797 0.8319 0.2127 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01793 0.8322 0.2122 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1713 0.04146 -2.058 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.006994 0.9342 0.08276 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01949 0.8179 0.2307 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.1712 0.04159 -2.056 143 1 pearson

NULL

Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.00435 0.959 -0.05147 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.005231 0.9507 -0.06189 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
-0.005356 0.9496 -0.06338 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.00443 0.9583 -0.05241 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
-0.006994 0.9342 -0.08276 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
-0.008318 0.9217 -0.09843 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.005402 0.9491 -0.06392 143 1 pearson

NULL

Treat.Tissue

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01946 0.8182 0.2303 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2012 0.01633 2.431 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.1085 0.1985 1.292 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1086 0.1984 1.292 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.1987 0.01774 2.399 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01957 0.8172 0.2316 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.005402 0.9491 0.06392 143 1 pearson

NULL

Treat.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01895 0.8229 0.2242 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
-0.005231 0.9507 -0.06189 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.01793 0.8322 0.2122 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.1683 0.04524 -2.021 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.01736 0.8375 0.2054 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01858 0.8263 0.2199 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
-0.169 0.04434 -2.029 143 1 pearson

NULL

Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
-0.00435 0.959 -0.05147 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2011 0.0164 2.429 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.2011 0.01642 2.429 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
0.1712 0.04162 2.056 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.2011 0.01642 2.429 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.201 0.01647 2.428 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1712 0.04159 2.056 143 1 pearson

NULL

Treat.Tissue.Time

Partial Correlation Tissue

estimate p.value statistic n gp Method
0.01942 0.8186 0.2298 143 1 pearson

NULL

Partial Correlation Treatment

estimate p.value statistic n gp Method
0.2011 0.0164 2.429 143 1 pearson

NULL

Partial Correlation Time

estimate p.value statistic n gp Method
0.1085 0.1985 1.292 143 1 pearson

NULL

Partial Correlation Treat.Tissue

estimate p.value statistic n gp Method
-0.00443 0.9583 -0.05241 143 1 pearson

NULL

Partial Correlation Treat.Time

estimate p.value statistic n gp Method
0.1993 0.01741 2.407 143 1 pearson

NULL

Partial Correlation Tissue.Time

estimate p.value statistic n gp Method
0.01949 0.8179 0.2307 143 1 pearson

NULL

Partial Correlation Treat.Tissue.Time

estimate p.value statistic n gp Method
0.1085 0.1986 1.292 143 1 pearson

NULL

Scatterplots Module membership vs. Gene significance

Treatment <- unclass(as.factor(log.tdata.FPKM.sample.info[,27238]))
Tissue <- unclass(as.factor(log.tdata.FPKM.sample.info[,27239]))
Time <- unclass(as.factor(log.tdata.FPKM.sample.info[,27237]))
Treat.Tissue <- paste0(Treatment,Tissue)
Treat.Time <- paste0(Treatment, Time)
Tissue.Time <- paste0(Tissue, Time)
Treat.Tissue.Time <- paste0(Treatment,Tissue, Time)
phenotype <- data.frame(cbind(Tissue, Treatment, Time, Treat.Tissue, Treat.Time, Tissue.Time, Treat.Tissue.Time))

Tissue

tissue.contribution(phenotype, log.tdata.FPKM.subset, MEs)

royalblue

black

violet

orangered4

skyblue3

floralwhite

grey

lightsteelblue1

ivory

lightyellow

turquoise

skyblue

lightcyan

pink

lightcyan1

darkorange2

mediumpurple3

darkolivegreen

darkgreen

midnightblue

Treatment

treat.contribution(phenotype, log.tdata.FPKM.subset, MEs)

royalblue

black

violet

orangered4

skyblue3

floralwhite

grey

lightsteelblue1

ivory

lightyellow

turquoise

skyblue

lightcyan

pink

lightcyan1

darkorange2

mediumpurple3

darkolivegreen

darkgreen

midnightblue

Time

time.contribution(phenotype, log.tdata.FPKM.subset, MEs)

royalblue

black

violet

orangered4

skyblue3

floralwhite

grey

lightsteelblue1

ivory

lightyellow

turquoise

skyblue

lightcyan

pink

lightcyan1

darkorange2

mediumpurple3

darkolivegreen

darkgreen

midnightblue

Treatment by Time

treat.time.contribution(phenotype, log.tdata.FPKM.subset, MEs)

royalblue

black

violet

orangered4

skyblue3

floralwhite

grey

lightsteelblue1

ivory

lightyellow

turquoise

skyblue

lightcyan

pink

lightcyan1

darkorange2

mediumpurple3

darkolivegreen

darkgreen

midnightblue

Treatment by Tissue

treat.tissue.contribution(phenotype, log.tdata.FPKM.subset, MEs)

royalblue

black

violet

orangered4

skyblue3

floralwhite

grey

lightsteelblue1

ivory

lightyellow

turquoise

skyblue

lightcyan

pink

lightcyan1

darkorange2

mediumpurple3

darkolivegreen

darkgreen

midnightblue

Time by Tissue

tissue.time.contribution(phenotype, log.tdata.FPKM.subset, MEs)

royalblue

black

violet

orangered4

skyblue3

floralwhite

grey

lightsteelblue1

ivory

lightyellow

turquoise

skyblue

lightcyan

pink

lightcyan1

darkorange2

mediumpurple3

darkolivegreen

darkgreen

midnightblue

Treatment by Time by Tissue

time.treat.tissue.contribution(phenotype, log.tdata.FPKM.subset, MEs)

royalblue

black

violet

orangered4

skyblue3

floralwhite

grey

lightsteelblue1

ivory

lightyellow

turquoise

skyblue

lightcyan

pink

lightcyan1

darkorange2

mediumpurple3

darkolivegreen

darkgreen

midnightblue

Analysis performed by Ann Wells

The Carter Lab The Jackson Laboratory 2023

ann.wells@jax.org