tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))

tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))

log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)

log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])

log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5] 

log.tdata.FPKM.sample.info.subset <- cbind(log.tdata.FPKM.subset,tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info.subset <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.sample.info.subset.hypothalamus <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(Tissue == "Hypothanamus") %>% column_to_rownames()

module.labels <- readRDS(here("Data","Hypothalamus","log.tdata.FPKM.sample.info.subset.hypothalamus.WGCNA.module.labels.RData"))

modules <- readRDS(here("Data","Hypothalamus","log.tdata.FPKM.sample.info.subset.hypothalamus.WGCNA.module.membership.RData"))

net.deg <- readRDS(here("Data","Hypothalamus","Chang_2DG_BL6_connectivity_hypothalamus.RData"))

ensembl.location <- readRDS(here("Data","Ensembl_gene_id_and_location.RData"))

Hub Genes

Hub genes are genes in the module network that have the highest connectivity. For instance, if the gene significance of a particular module is associated with treatment the hub genes in this module are likely associated with this trait.

hub.genes.list <- hub.genes(net.deg,module.labels,modules,ensembl.location)

Black Module

DT.table.hub(hub.genes.list[[1]])

Indianred4 Module

DT.table.hub(hub.genes.list[[2]])

Lightgreen Module

DT.table.hub(hub.genes.list[[3]])

Antiquewhite2 Module

DT.table.hub(hub.genes.list[[4]])

Blue Module

DT.table.hub(hub.genes.list[[5]])

Antiquewhite4 Module

DT.table.hub(hub.genes.list[[6]])

Lightblue4 Module

DT.table.hub(hub.genes.list[[7]])

Darkgreen Module

DT.table.hub(hub.genes.list[[8]])

Brown2 Module

DT.table.hub(hub.genes.list[[9]])

Bisque4 Module

DT.table.hub(hub.genes.list[[10]])

Darkturquoise Module

DT.table.hub(hub.genes.list[[11]])

Lightpink4 Module

DT.table.hub(hub.genes.list[[12]])

Midnightblue Module

DT.table.hub(hub.genes.list[[13]])

Thistle3 Module

DT.table.hub(hub.genes.list[[14]])

Skyblue Module

DT.table.hub(hub.genes.list[[15]])

Lightsteelblue1 Module

DT.table.hub(hub.genes.list[[16]])

Darkslateblue Module

DT.table.hub(hub.genes.list[[17]])

Grey Module

DT.table.hub(hub.genes.list[[18]])

Salmon4 Module

DT.table.hub(hub.genes.list[[19]])

Plum Module

DT.table.hub(hub.genes.list[[21]])

Lavenderblush2 Module

DT.table.hub(hub.genes.list[[22]])

Orangered1 Module

DT.table.hub(hub.genes.list[[23]])

Mediumpurple1 Module

DT.table.hub(hub.genes.list[[24]])

Lightslateblue Module

DT.table.hub(hub.genes.list[[25]])

ANOVA

To perform analysis of variance Aligned Rank Transformation was performed, which is designed to handle non-parametric multi-factorial experiments. P-value was adjusted using Benjamini-hochberg procedure. Only the top 10 hub genes are listed.

log.tdata.FPKM.sample.info.subset.hypothalamus$Time <- as.factor(log.tdata.FPKM.sample.info.subset.hypothalamus$Time)
log.tdata.FPKM.sample.info.subset.hypothalamus$Treatment <- as.factor(log.tdata.FPKM.sample.info.subset.hypothalamus$Treatment)

for(m in module.labels) {
    name <- str_split(m,"_")[[1]][2]
    hub.met <- net.deg[modules$Gene,] %>%
      dplyr::mutate(Gene=modules$Gene) %>%
      dplyr::filter(modules$Module == m) %>%
      dplyr::arrange(desc(kWithin)) %>%
      dplyr::select(Gene, kWithin)
    gene <- ensembl.location$external_gene_name[match(hub.met$Gene,ensembl.location$ensembl_gene_id)]
    hub.met <- cbind(gene,hub.met)
    cat("\n###",name, "{.tabset .tabset-fade .tabset-pills}","\n")
          for(i in 1:10){
             cat("\n####",hub.met$gene[i],"\n")
             m <- art(data = log.tdata.FPKM.sample.info.subset.hypothalamus, log.tdata.FPKM.sample.info.subset.hypothalamus[,hub.met$Gene[i]] ~ Time*Treatment)
             model <- anova(m)
             adjust <- p.adjust(model$`Pr(>F)`, method = "BH")
             print(knitr::kable(cbind(model,adjust)) %>% 
                      column_spec(8, color = "white", background = spec_color(adjust, end = 0.05, scale_from = c(0,0.05))) %>% kable_styling(bootstrap_options = c("striped", "hover", "responsive")))
             cat("\n \n")
             }
          cat("\n \n")
          }

black

Smarcc1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 334.0 0.1437126 0.7112404 1
Treatment Treatment 1 12 2.25 334.5 0.0807175 0.7811702 1
Time:Treatment Time:Treatment 1 12 0.00 335.0 0.0000000 1.0000000 1

Cnnm2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 333.5 0.0809595 0.7808518 0.9263331
Treatment Treatment 1 12 4.00 333.5 0.1439280 0.7110350 0.9263331
Time:Treatment Time:Treatment 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331

Dag1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 333.5 0.1439280 0.7110350 0.8528323
Treatment Treatment 1 12 9 330.5 0.3267776 0.5781134 0.8528323
Time:Treatment Time:Treatment 1 12 1 334.0 0.0359281 0.8528323 0.8528323

Kcnb1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.5 0.0802377 0.7818029 0.8534804
Treatment Treatment 1 12 9.00 330.5 0.3267776 0.5781134 0.8534804
Time:Treatment Time:Treatment 1 12 1.00 337.0 0.0356083 0.8534804 0.8534804

Pom121

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 331.5 0.0814480 0.7802108 0.7802108
Treatment Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.7802108
Time:Treatment Time:Treatment 1 12 6.25 331.5 0.2262443 0.6428643 0.7802108

Cmip

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 334.5 0.0807175 0.7811702 0.9260036
Treatment Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.9260036
Time:Treatment Time:Treatment 1 12 0.25 333.5 0.0089955 0.9260036 0.9260036

Nyap1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 334.5 0.0358744 0.8529409 0.9263331
Treatment Treatment 1 12 4.00 334.0 0.1437126 0.7112404 0.9263331
Time:Treatment Time:Treatment 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331

Mta3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 335.5 0.1430700 0.7118542 0.7118542
Treatment Treatment 1 12 9 330.5 0.3267776 0.5781134 0.7118542
Time:Treatment Time:Treatment 1 12 4 331.0 0.1450151 0.7100011 0.7118542

Arhgef17

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 335.5 0.0804769 0.7814873 0.9263331
Treatment Treatment 1 12 2.25 335.5 0.0804769 0.7814873 0.9263331
Time:Treatment Time:Treatment 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331

Dos

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 333.5 0.0089955 0.9260036 0.9260036
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.9260036
Time:Treatment Time:Treatment 1 12 4.00 333.5 0.1439280 0.7110350 0.9260036

indianred4

Vamp2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 337.5 0.0800000 0.7821172 1
Treatment Treatment 1 12 9.00 330.0 0.3272727 0.5778293 1
Time:Treatment Time:Treatment 1 12 0.00 340.0 0.0000000 1.0000000 1

Pitpna

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 335.5 0.143070 0.7118542 0.8536945
Treatment Treatment 1 12 30.25 308.5 1.176661 0.2993491 0.8536945
Time:Treatment Time:Treatment 1 12 1.00 338.0 0.035503 0.8536945 0.8536945

Apba2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 327.5 0.4488550 0.5155648 0.8538013
Treatment Treatment 1 12 6.25 330.5 0.2269289 0.6423668 0.8538013
Time:Treatment Time:Treatment 1 12 1.00 338.5 0.0354505 0.8538013 0.8538013

Rph3a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 337.5 0.0800000 0.7821172 1
Treatment Treatment 1 12 6.25 330.5 0.2269289 0.6423668 1
Time:Treatment Time:Treatment 1 12 0.00 339.5 0.0000000 1.0000000 1

Ctso

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583
Treatment Treatment 1 12 25.00 314.5 0.9538951 0.3480088 0.9266583
Time:Treatment Time:Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9266583

Sdcbp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.5 0.0802377 0.7818029 0.853373
Treatment Treatment 1 12 30.25 306.5 1.1843393 0.2978486 0.853373
Time:Treatment Time:Treatment 1 12 1.00 336.5 0.0356612 0.8533730 0.853373

Cdk5r2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.5 0.0802377 0.7818029 0.853373
Treatment Treatment 1 12 30.25 308.5 1.1766613 0.2993491 0.853373
Time:Treatment Time:Treatment 1 12 1.00 336.5 0.0356612 0.8533730 0.853373

Rps3a1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 338.0 0.0355030 0.8536945 0.9266583
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.9266583
Time:Treatment Time:Treatment 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583

Chmp5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 338.5 0.0088626 0.9265504 1
Treatment Treatment 1 12 12.25 326.5 0.4502297 0.5149340 1
Time:Treatment Time:Treatment 1 12 0.00 339.5 0.0000000 1.0000000 1

Git1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 333.5 0.2248876 0.6438533 0.9262238
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.9262238
Time:Treatment Time:Treatment 1 12 0.25 335.5 0.0089419 0.9262238 0.9262238

lightgreen

Spryd3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 323.5 0.5935085 0.4559656 0.7733472
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.7733472
Time:Treatment Time:Treatment 1 12 2.25 335.5 0.0804769 0.7814873 0.7814873

Vps18

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.0 0.9554140 0.3476395 0.6408615
Treatment Treatment 1 12 16.00 323.0 0.5944272 0.4556254 0.6408615
Time:Treatment Time:Treatment 1 12 6.25 327.5 0.2290076 0.6408615 0.6408615

Rab11b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 323.5 0.5935085 0.4559656 0.7733472
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.7733472
Time:Treatment Time:Treatment 1 12 2.25 326.5 0.0826953 0.7785834 0.7785834

Clptm1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 318.5 0.7629513 0.3995488 0.7818029
Treatment Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029
Time:Treatment Time:Treatment 1 12 4.00 331.0 0.1450151 0.7100011 0.7818029

Mfn2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 308.5 1.1766613 0.2993491 0.5155648
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.5155648
Time:Treatment Time:Treatment 1 12 12.25 323.5 0.4544049 0.5130269 0.5155648

App

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 327.5 0.4488550 0.5155648 1
Treatment Treatment 1 12 0.00 338.0 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 4.00 331.5 0.1447964 0.7102088 1

Prkar1b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 319.5 0.7605634 0.4002654 0.7811702
Treatment Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.7811702
Time:Treatment Time:Treatment 1 12 9.00 326.0 0.3312883 0.5755362 0.7811702

Tkt

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 315 0.9523810 0.3483776 0.4563052
Treatment Treatment 1 12 16 324 0.5925926 0.4563052 0.4563052
Time:Treatment Time:Treatment 1 12 16 319 0.6018809 0.4528805 0.4563052

Astn2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36.00 300.0 1.4400000 0.2532947 0.6438533
Treatment Treatment 1 12 6.25 333.5 0.2248876 0.6438533 0.6438533
Time:Treatment Time:Treatment 1 12 6.25 320.5 0.2340094 0.6372741 0.6438533

Dhdds

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 312.5 0.9600000 0.3465280 0.6834380
Treatment Treatment 1 12 16.00 323.0 0.5944272 0.4556254 0.6834380
Time:Treatment Time:Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029

antiquewhite2

Tet2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 288.5 1.7573657 0.2096367 0.6289102
Treatment Treatment 1 12 16.00 323.5 0.5935085 0.4559656 0.6418671
Time:Treatment Time:Treatment 1 12 6.25 329.5 0.2276176 0.6418671 0.6418671

Lin7c

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 306.5 0.9787928 0.3420268 0.5130402
Treatment Treatment 1 12 30.25 307.5 1.1804878 0.2986000 0.5130402
Time:Treatment Time:Treatment 1 12 9.00 331.0 0.3262840 0.5783968 0.5783968

Fgd4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 310.0 0.9677419 0.3446632 0.6408615
Treatment Treatment 1 12 9.00 330.5 0.3267776 0.5781134 0.6408615
Time:Treatment Time:Treatment 1 12 6.25 327.5 0.2290076 0.6408615 0.6408615

Upf3b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 316.0 0.6075949 0.4507948 0.8675953
Treatment Treatment 1 12 9.00 331.0 0.3262840 0.5783968 0.8675953
Time:Treatment Time:Treatment 1 12 0.25 332.5 0.0090226 0.9258928 0.9258928

Fubp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 311.0 0.9646302 0.3454109 0.5220133
Treatment Treatment 1 12 25 314.5 0.9538951 0.3480088 0.5220133
Time:Treatment Time:Treatment 1 12 0 339.0 0.0000000 1.0000000 1.0000000

Clcn3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 306.0 0.9803922 0.3416477 0.5130269
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5130269
Time:Treatment Time:Treatment 1 12 12.25 323.5 0.4544049 0.5130269 0.5130269

Prex2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 310.5 0.6183575 0.4469094 0.6703641
Treatment Treatment 1 12 30.25 308.0 1.1785714 0.2989748 0.6703641
Time:Treatment Time:Treatment 1 12 2.25 325.0 0.0830769 0.7780881 0.7780881

Slc38a6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 319.0 0.6018809 0.4528805 0.4528805
Treatment Treatment 1 12 20.25 319.5 0.7605634 0.4002654 0.4528805
Time:Treatment Time:Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.4528805

Zfp292

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 321.5 0.5972006 0.4546008 0.6423668
Treatment Treatment 1 12 6.25 330.5 0.2269289 0.6423668 0.6423668
Time:Treatment Time:Treatment 1 12 25.00 313.0 0.9584665 0.3468991 0.6423668

Taf9b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 332.5 0.2255639 0.6433598 0.8530493
Treatment Treatment 1 12 9.00 329.0 0.3282675 0.5772595 0.8530493
Time:Treatment Time:Treatment 1 12 1.00 335.0 0.0358209 0.8530493 0.8530493

blue

Rpl36

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 312.5 0.960000 0.3465280 0.5197919
Treatment Treatment 1 12 49 288.5 2.038128 0.1789011 0.5197919
Time:Treatment Time:Treatment 1 12 0 337.5 0.000000 1.0000000 1.0000000

Psmb4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 319.0 0.6018809 0.4528805 0.6793207
Treatment Treatment 1 12 42.25 294.5 1.7215620 0.2140371 0.6421112
Time:Treatment Time:Treatment 1 12 1.00 338.5 0.0354505 0.8538013 0.8538013

Rps20

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 325.5 0.4516129 0.5143008 0.7714512
Treatment Treatment 1 12 42.25 293.5 1.7274276 0.2133079 0.6399238
Time:Treatment Time:Treatment 1 12 1.00 334.0 0.0359281 0.8528323 0.8528323

Atp6v1f

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 325.5 0.4516129 0.5143008 0.5155648
Treatment Treatment 1 12 49.00 288.5 2.0381282 0.1789011 0.5155648
Time:Treatment Time:Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.5155648

Cox6b1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 320 0.600000 0.4535705 0.6803558
Treatment Treatment 1 12 36 304 1.421053 0.2562716 0.6803558
Time:Treatment Time:Treatment 1 12 0 338 0.000000 1.0000000 1.0000000

Rpl37a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 321.5 0.5972006 0.4546008 0.6819012
Treatment Treatment 1 12 56.25 283.5 2.3809524 0.1487723 0.4463168
Time:Treatment Time:Treatment 1 12 0.25 333.5 0.0089955 0.9260036 0.9260036

Rplp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 332.5 0.2255639 0.6433598 0.8536945
Treatment Treatment 1 12 72.25 266.5 3.2532833 0.0964252 0.2892757
Time:Treatment Time:Treatment 1 12 1.00 338.0 0.0355030 0.8536945 0.8536945

Fam173a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 326.5 0.4502297 0.5149340 0.7110350
Treatment Treatment 1 12 64.00 275.5 2.7876588 0.1208505 0.3625516
Time:Treatment Time:Treatment 1 12 4.00 333.5 0.1439280 0.7110350 0.7110350

Rpl9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 325.5 0.4516129 0.5143008 0.7714512
Treatment Treatment 1 12 64.00 275.5 2.7876588 0.1208505 0.3625516
Time:Treatment Time:Treatment 1 12 0.25 332.5 0.0090226 0.9258928 0.9258928

Atp5l

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 326.5 0.4502297 0.5149340 0.7724010
Treatment Treatment 1 12 42.25 294.5 1.7215620 0.2140371 0.6421112
Time:Treatment Time:Treatment 1 12 0.25 335.5 0.0089419 0.9262238 0.9262238

antiquewhite4

Mt3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 288.5 1.2582322 0.2839304 0.4258957
Treatment Treatment 1 12 64.00 274.0 2.8029197 0.1199362 0.3598085
Time:Treatment Time:Treatment 1 12 16.00 317.5 0.6047244 0.4518406 0.4518406

2310011J03Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 121 186.5 7.785523 0.0163368 0.0490105
Treatment Treatment 1 12 36 295.0 1.464407 0.2495286 0.3354957
Time:Treatment Time:Treatment 1 12 25 298.0 1.006711 0.3354957 0.3354957

Tspan3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 268.5 2.5139665 0.1388269 0.2231584
Treatment Treatment 1 12 56.25 283.5 2.3809524 0.1487723 0.2231584
Time:Treatment Time:Treatment 1 12 25.00 306.0 0.9803922 0.3416477 0.3416477

Map2k1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 290.0 1.034483 0.3291768 0.3291768
Treatment Treatment 1 12 100 225.5 5.321508 0.0397029 0.1191086
Time:Treatment Time:Treatment 1 12 64 268.0 2.865672 0.1162654 0.1743981

mt-Nd1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49.00 282.0 2.0851064 0.1743393 0.3793806
Treatment Treatment 1 12 36.00 299.5 1.4424040 0.2529204 0.3793806
Time:Treatment Time:Treatment 1 12 12.25 321.5 0.4572317 0.5117430 0.5117430

Impdh2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 255.5 2.641879 0.1300375 0.2029203
Treatment Treatment 1 12 49.00 283.0 2.077739 0.1750448 0.2029203
Time:Treatment Time:Treatment 1 12 42.25 279.5 1.813953 0.2029203 0.2029203

Ptov1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 218.5 4.956522 0.0459133 0.0688700
Treatment Treatment 1 12 110.25 227.5 5.815385 0.0328221 0.0688700
Time:Treatment Time:Treatment 1 12 12.25 316.5 0.464455 0.5084887 0.5084887

mt-Nd4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 291.5 1.7392796 0.2118446 0.3821807
Treatment Treatment 1 12 36.00 302.0 1.4304636 0.2547871 0.3821807
Time:Treatment Time:Treatment 1 12 4.00 327.5 0.1465649 0.7085349 0.7085349

Cyc1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 306.5 0.9787928 0.3420268 0.393725
Treatment Treatment 1 12 49.00 288.5 2.0381282 0.1789011 0.393725
Time:Treatment Time:Treatment 1 12 20.25 310.5 0.7826087 0.3937250 0.393725

Usp5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 267.5 2.5233645 0.1381563 0.3907507
Treatment Treatment 1 12 25.00 313.0 0.9584665 0.3468991 0.3907507
Time:Treatment Time:Treatment 1 12 20.25 306.5 0.7928222 0.3907507 0.3907507

lightblue4

Plekhg1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 338.0 0.000000 1.0000000 1.0000000
Treatment Treatment 1 12 30.25 300.5 1.207987 0.2932931 0.8798793
Time:Treatment Time:Treatment 1 12 2.25 331.5 0.081448 0.7802108 1.0000000

Ntng1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 335.5 0.0804769 0.7814873 0.7814873
Treatment Treatment 1 12 30.25 305.5 1.1882160 0.2970951 0.7814873
Time:Treatment Time:Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.7814873

Rasgrp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 333.5 0.2248876 0.6438533 0.6438533
Treatment Treatment 1 12 30.25 300.5 1.2079867 0.2932931 0.6438533
Time:Treatment Time:Treatment 1 12 6.25 327.5 0.2290076 0.6408615 0.6438533

Adcy1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 333.5 0.1439280 0.7110350 0.7112404
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.7112404
Time:Treatment Time:Treatment 1 12 4.00 334.0 0.1437126 0.7112404 0.7112404

Nexn

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 323.5 0.5935085 0.4559656 0.6839484
Treatment Treatment 1 12 16 315.5 0.6085578 0.4504449 0.6839484
Time:Treatment Time:Treatment 1 12 4 331.0 0.1450151 0.7100011 0.7100011

Adra2b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 333.0 0.0090090 0.9259482 0.9259482
Treatment Treatment 1 12 9.00 322.5 0.3348837 0.5734989 0.9259482
Time:Treatment Time:Treatment 1 12 6.25 322.0 0.2329193 0.6380519 0.9259482

Rgs7bp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 338.5 0.0354505 0.8538013 1.0000000
Treatment Treatment 1 12 30.25 299.5 1.2120200 0.2925258 0.8775774
Time:Treatment Time:Treatment 1 12 0.00 338.0 0.0000000 1.0000000 1.0000000

Synpo2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 337.5 0.0800000 0.7821172 0.8534804
Treatment Treatment 1 12 12.25 326.5 0.4502297 0.5149340 0.8534804
Time:Treatment Time:Treatment 1 12 1.00 337.0 0.0356083 0.8534804 0.8534804

Necab1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 323.5 0.5935085 0.4559656 0.5772595
Treatment Treatment 1 12 12.25 326.5 0.4502297 0.5149340 0.5772595
Time:Treatment Time:Treatment 1 12 9.00 329.0 0.3282675 0.5772595 0.5772595

Gpr4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 332.5 0.2255639 0.6433598 0.8536945
Treatment Treatment 1 12 16.00 323.5 0.5935085 0.4559656 0.8536945
Time:Treatment Time:Treatment 1 12 1.00 338.0 0.0355030 0.8536945 0.8536945

darkgreen

Sytl4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 323.5 0.0092736 0.9248724 0.9248724
Treatment Treatment 1 12 4.00 335.5 0.1430700 0.7118542 0.9248724
Time:Treatment Time:Treatment 1 12 1.00 322.0 0.0372671 0.8501511 0.9248724

Rsph4a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36 303.5 1.4233937 0.2559012 0.7677036
Treatment Treatment 1 12 9 318.0 0.3396226 0.5708361 0.8528323
Time:Treatment Time:Treatment 1 12 1 334.0 0.0359281 0.8528323 0.8528323

Arhgap6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 318.5 0.0376766 0.8493410 0.8493410
Treatment Treatment 1 12 16.00 323.5 0.5935085 0.4559656 0.7485334
Time:Treatment Time:Treatment 1 12 12.25 302.5 0.4859504 0.4990223 0.7485334

Maats1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 325.5 0.4516129 0.5143008 0.7818029
Treatment Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029
Time:Treatment Time:Treatment 1 12 4.00 335.0 0.1432836 0.7116500 0.7818029

Rsph1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 323.5 0.1483771 0.7068318 1
Treatment Treatment 1 12 9 330.5 0.3267776 0.5781134 1
Time:Treatment Time:Treatment 1 12 0 324.0 0.0000000 1.0000000 1

Tmem255a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 315.5 0.7702060 0.3973841 0.9262238
Treatment Treatment 1 12 0.25 335.5 0.0089419 0.9262238 0.9262238
Time:Treatment Time:Treatment 1 12 0.25 332.5 0.0090226 0.9258928 0.9262238

Cd24a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 319.5 0.7605634 0.4002654 0.9265504
Treatment Treatment 1 12 2.25 333.5 0.0809595 0.7808518 0.9265504
Time:Treatment Time:Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504

Cdc14a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 309.5 0.1550889 0.7006270 0.7767508
Treatment Treatment 1 12 4.00 333.5 0.1439280 0.7110350 0.7767508
Time:Treatment Time:Treatment 1 12 2.25 321.0 0.0841121 0.7767508 0.7767508

Fndc3a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 303.5 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 30.25 303.5 1.1960461 0.2955811 0.7432617
Time:Treatment Time:Treatment 1 12 12.25 297.5 0.4941176 0.4955078 0.7432617

Eno4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 330.5 0.3267776 0.5781134 0.8538013
Treatment Treatment 1 12 9 330.5 0.3267776 0.5781134 0.8538013
Time:Treatment Time:Treatment 1 12 1 338.5 0.0354505 0.8538013 0.8538013

brown2

Efemp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 319.5 0.6009390 0.4532258 0.9265504
Treatment Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.9265504
Time:Treatment Time:Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504

Islr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36 303.0 1.425743 0.2555303 0.766591
Treatment Treatment 1 12 1 338.0 0.035503 0.8536945 1.000000
Time:Treatment Time:Treatment 1 12 0 337.5 0.000000 1.0000000 1.000000

Crabp2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 288.5 1.7573657 0.2096367 0.6289102
Treatment Treatment 1 12 6.25 333.5 0.2248876 0.6438533 0.9263331
Time:Treatment Time:Treatment 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331

Aldh1a2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 316.5 0.7677725 0.3981082 1
Treatment Treatment 1 12 0.00 339.5 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 0.00 337.5 0.0000000 1.0000000 1

Cdh1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 325.5 0.4516129 0.5143008 0.8538013
Treatment Treatment 1 12 1.00 338.5 0.0354505 0.8538013 0.8538013
Time:Treatment Time:Treatment 1 12 9.00 327.0 0.3302752 0.5761130 0.8538013

Cfh

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 332.5 0.2255639 0.6433598 1
Treatment Treatment 1 12 0.25 339.5 0.0088365 0.9266583 1
Time:Treatment Time:Treatment 1 12 0.00 339.5 0.0000000 1.0000000 1

Gstm2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 309.5 1.1728595 0.3000959 0.9002878
Treatment Treatment 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583
Time:Treatment Time:Treatment 1 12 4.00 333.5 0.1439280 0.7110350 0.9266583

Mpzl2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 335.5 0.0089419 0.9262238 1
Treatment Treatment 1 12 0.00 338.0 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 9.00 328.5 0.3287671 0.5769737 1

Fgfbp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 328.5 0.3287671 0.5769737 0.9265504
Treatment Treatment 1 12 1.00 338.0 0.0355030 0.8536945 0.9265504
Time:Treatment Time:Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504

Sned1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331
Treatment Treatment 1 12 9.00 330.5 0.3267776 0.5781134 0.9263331
Time:Treatment Time:Treatment 1 12 1.00 338.0 0.0355030 0.8536945 0.9263331

bisque4

Tmem159

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 296 1.712838 0.2151276 0.2967174
Treatment Treatment 1 12 56.25 279 2.419355 0.1458114 0.2967174
Time:Treatment Time:Treatment 1 12 30.25 305 1.190164 0.2967174 0.2967174

Trim28

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 100.00 231.5 5.183585 0.0419238 0.0628858
Treatment Treatment 1 12 182.25 154.5 14.155340 0.0027092 0.0081277
Time:Treatment Time:Treatment 1 12 36.00 295.5 1.461929 0.2499075 0.2499075

Gnptg

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 295.5 0.822335 0.3823470 0.3823470
Treatment Treatment 1 12 182.25 144.5 15.134948 0.0021472 0.0064416
Time:Treatment Time:Treatment 1 12 42.25 293.5 1.727428 0.2133079 0.3199619

Npc2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 320.0 0.600000 0.4535705 0.4535705
Treatment Treatment 1 12 42.25 275.5 1.840290 0.1998900 0.4535705
Time:Treatment Time:Treatment 1 12 16.00 319.5 0.600939 0.4532258 0.4535705

Baiap3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 242.5 4.4659794 0.0562022 0.0843033
Treatment Treatment 1 12 196.00 136.0 17.2941176 0.0013261 0.0039782
Time:Treatment Time:Treatment 1 12 2.25 326.5 0.0826953 0.7785834 0.7785834

Mcam

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 121.00 203.0 7.1527094 0.0202434 0.0607301
Treatment Treatment 1 12 90.25 245.5 4.4114053 0.0575108 0.0862661
Time:Treatment Time:Treatment 1 12 12.25 318.5 0.4615385 0.5097981 0.5097981

Clvs1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 81 252.5 3.8495050 0.0733739 0.1100608
Treatment Treatment 1 12 169 170.0 11.9294118 0.0047706 0.0143117
Time:Treatment Time:Treatment 1 12 25 313.0 0.9584665 0.3468991 0.3468991

Wdr34

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.5 0.9538951 0.3480088 0.5220133
Treatment Treatment 1 12 132.25 204.5 7.7603912 0.0164739 0.0494217
Time:Treatment Time:Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.6433598

Tmco6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 296.5 1.709949 0.2154903 0.2154903
Treatment Treatment 1 12 182.25 157.5 13.885714 0.0028931 0.0086793
Time:Treatment Time:Treatment 1 12 64.00 275.0 2.792727 0.1205459 0.1808188

Pnck

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 333.5 0.0809595 0.7808518 0.9263331
Treatment Treatment 1 12 144.00 193.5 8.9302326 0.0113089 0.0339267
Time:Treatment Time:Treatment 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331

darkturquoise

Tmem30b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 306.5 0.0391517 0.8464607 0.9263331
Treatment Treatment 1 12 4.00 303.5 0.1581549 0.6978446 0.9263331
Time:Treatment Time:Treatment 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331

Tnk1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 294.5 0.4991511 0.4933637 0.9194827
Treatment Treatment 1 12 0.25 281.5 0.0106572 0.9194827 0.9194827
Time:Treatment Time:Treatment 1 12 6.25 292.5 0.2564103 0.6217716 0.9194827

Gnb3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 308.0 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 30.25 288.5 1.2582322 0.2839304 0.8517913
Time:Treatment Time:Treatment 1 12 6.25 317.5 0.2362205 0.6357035 0.9535553

Epcam

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 318.5 0.2354788 0.6362293 0.7048796
Treatment Treatment 1 12 4.00 319.0 0.1504702 0.7048796 0.7048796
Time:Treatment Time:Treatment 1 12 16.00 311.5 0.6163724 0.4476219 0.7048796

Tmem184a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 257.5 3.3669903 0.0914117 0.2742350
Treatment Treatment 1 12 12.25 305.5 0.4811784 0.5010963 0.5010963
Time:Treatment Time:Treatment 1 12 20.25 297.5 0.8168067 0.3839000 0.5010963

Alox15

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 285.5 0.2626970 0.6175761 0.6175761
Treatment Treatment 1 12 9.00 271.5 0.3977901 0.5400590 0.6175761
Time:Treatment Time:Treatment 1 12 16.00 264.5 0.7258979 0.4108975 0.6175761

Esrp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 300.5 0.0099834 0.9220603 0.9220603
Treatment Treatment 1 12 1.00 306.5 0.0391517 0.8464607 0.9220603
Time:Treatment Time:Treatment 1 12 9.00 323.0 0.3343653 0.5737917 0.9220603

1810019J16Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 287 0.3763066 0.5510374 0.5510374
Treatment Treatment 1 12 16 281 0.6832740 0.4245930 0.5510374
Time:Treatment Time:Treatment 1 12 9 275 0.3927273 0.5426079 0.5510374

Mat1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 304.5 0.2463054 0.6286544 0.6357035
Treatment Treatment 1 12 30.25 272.5 1.3321101 0.2708988 0.6357035
Time:Treatment Time:Treatment 1 12 6.25 317.5 0.2362205 0.6357035 0.6357035

Irf6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 304.0 0.1578947 0.6980794 0.7727672
Treatment Treatment 1 12 12.25 306.5 0.4796085 0.5017821 0.7727672
Time:Treatment Time:Treatment 1 12 2.25 309.5 0.0872375 0.7727672 0.7727672

lightpink4

Gm13563

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 335.5 0.1430700 0.7118542 0.8538013
Treatment Treatment 1 12 64 273.5 2.8080439 0.1196311 0.3588933
Time:Treatment Time:Treatment 1 12 1 338.5 0.0354505 0.8538013 0.8538013

Znf512b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 312.5 0.9600000 0.3465280 0.5197919
Treatment Treatment 1 12 100.00 240.0 5.0000000 0.0451154 0.1353461
Time:Treatment Time:Treatment 1 12 0.25 333.5 0.0089955 0.9260036 0.9260036

Crocc

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 331.5 0.0814480 0.7802108 0.9258928
Treatment Treatment 1 12 64.00 275.0 2.7927273 0.1205459 0.3616377
Time:Treatment Time:Treatment 1 12 0.25 332.5 0.0090226 0.9258928 0.9258928

Fam227a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 334.5 0.0807175 0.7811702 0.926442
Treatment Treatment 1 12 56.25 282.5 2.3893805 0.1481160 0.444348
Time:Treatment Time:Treatment 1 12 0.25 337.5 0.0088889 0.9264420 0.926442

4930402H24Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 333.5 0.143928 0.7110350 1.0000000
Treatment Treatment 1 12 42.25 294.5 1.721562 0.2140371 0.6421112
Time:Treatment Time:Treatment 1 12 0.00 335.5 0.000000 1.0000000 1.0000000

Atxn7l2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 335.5 0.1430700 0.7118542 0.7818029
Treatment Treatment 1 12 36.00 303.5 1.4233937 0.2559012 0.7677036
Time:Treatment Time:Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029

Gm10134

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 323.0 0.4551084 0.5127068 0.7690603
Treatment Treatment 1 12 64.00 273.5 2.8080439 0.1196311 0.3588933
Time:Treatment Time:Treatment 1 12 1.00 336.0 0.0357143 0.8532653 0.8532653

Shc2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 308.5 0.9724473 0.3435370 0.5153056
Treatment Treatment 1 12 81 258.0 3.7674419 0.0761128 0.2283384
Time:Treatment Time:Treatment 1 12 4 334.0 0.1437126 0.7112404 0.7112404

Traip

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 329.5 0.2276176 0.6418671 0.8528323
Treatment Treatment 1 12 81.00 257.0 3.7821012 0.0756145 0.2268436
Time:Treatment Time:Treatment 1 12 1.00 334.0 0.0359281 0.8528323 0.8528323

Slc25a42

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583
Treatment Treatment 1 12 16.00 321.5 0.5972006 0.4546008 0.6844579
Time:Treatment Time:Treatment 1 12 16.00 324.0 0.5925926 0.4563052 0.6844579

midnightblue

C3ar1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 256 83.5 36.79042 5.62e-05 5.62e-05
Treatment Treatment 1 12 256 83.5 36.79042 5.62e-05 5.62e-05
Time:Treatment Time:Treatment 1 12 256 83.0 37.01205 5.47e-05 5.62e-05

Aoah

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 240.25 99.5 28.97487 0.0001646 0.0002469
Treatment Treatment 1 12 256.00 84.0 36.57143 0.0000578 0.0001734
Time:Treatment Time:Treatment 1 12 210.25 129.5 19.48263 0.0008445 0.0008445

Lilrb4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 256 80 38.40000 4.61e-05 5.78e-05
Treatment Treatment 1 12 256 84 36.57143 5.78e-05 5.78e-05
Time:Treatment Time:Treatment 1 12 256 82 37.46341 5.17e-05 5.78e-05

Cd84

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 132.25 200.5 7.915212 0.0156504 0.0156504
Treatment Treatment 1 12 256.00 82.0 37.463415 0.0000517 0.0001551
Time:Treatment Time:Treatment 1 12 169.00 170.0 11.929412 0.0047706 0.0071558

Gp49a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 256 83.5 36.79042 5.62e-05 5.78e-05
Treatment Treatment 1 12 256 84.0 36.57143 5.78e-05 5.78e-05
Time:Treatment Time:Treatment 1 12 256 83.5 36.79042 5.62e-05 5.78e-05

AI607873

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 240.25 95.5 30.18848 0.0001375 0.0001375
Treatment Treatment 1 12 256.00 82.5 37.23636 0.0000532 0.0000798
Time:Treatment Time:Treatment 1 12 256.00 75.0 40.96000 0.0000340 0.0000798

Slfn2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 210.25 129.0 19.558139 0.0008320 0.0012480
Treatment Treatment 1 12 256.00 81.5 37.693252 0.0000503 0.0001508
Time:Treatment Time:Treatment 1 12 132.25 201.0 7.895522 0.0157524 0.0157524

Ly9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 256.5 3.380117 0.0908537 0.0908537
Treatment Treatment 1 12 256.00 83.5 36.790419 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 100.00 237.5 5.052632 0.0441715 0.0662573

Tlr7

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 182.25 156.5 13.974441 0.0028310 0.0042466
Treatment Treatment 1 12 256.00 83.5 36.790419 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 100.00 236.0 5.084746 0.0436072 0.0436072

Cd68

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 110.25 227.5 5.815385 0.0328221 0.0492332
Treatment Treatment 1 12 256.00 83.5 36.790419 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 90.25 248.5 4.358149 0.0588233 0.0588233

thistle3

2700081O15Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 331.5 0.1447964 0.7102088 0.9262238
Treatment Treatment 1 12 64.00 263.5 2.9146110 0.1134990 0.3404969
Time:Treatment Time:Treatment 1 12 0.25 335.5 0.0089419 0.9262238 0.9262238

Elavl2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 319.5 0.7605634 0.4002654 0.8536945
Treatment Treatment 1 12 4.00 335.5 0.1430700 0.7118542 0.8536945
Time:Treatment Time:Treatment 1 12 1.00 338.0 0.0355030 0.8536945 0.8536945

A930011O12Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 314.5 0.9538951 0.3480088 0.711035
Treatment Treatment 1 12 9 328.5 0.3287671 0.5769737 0.711035
Time:Treatment Time:Treatment 1 12 4 333.5 0.1439280 0.7110350 0.711035

Pcsk1n

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 337.5 0.0800000 0.7821172 1
Treatment Treatment 1 12 0.00 338.0 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 1.00 338.5 0.0354505 0.8538013 1

Acsl4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.0 0.9554140 0.3476395 0.5214593
Treatment Treatment 1 12 36.00 303.5 1.4233937 0.2559012 0.5214593
Time:Treatment Time:Treatment 1 12 6.25 329.5 0.2276176 0.6418671 0.6418671

Dhx34

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Time:Treatment Time:Treatment 1 12 2.25 337.5 0.0800000 0.7821172 0.7821172

C130071C03Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1 332.5 0.0360902 0.8525050 0.8530493
Treatment Treatment 1 12 1 335.0 0.0358209 0.8530493 0.8530493
Time:Treatment Time:Treatment 1 12 4 334.0 0.1437126 0.7112404 0.8530493

Gm20695

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 284.5 1.7820738 0.2066690 0.5214593
Treatment Treatment 1 12 25.00 314.0 0.9554140 0.3476395 0.5214593
Time:Treatment Time:Treatment 1 12 0.25 333.5 0.0089955 0.9260036 0.9260036

Pgrmc1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36 303 1.4257426 0.2555303 0.3832955
Treatment Treatment 1 12 49 290 2.0275862 0.1799458 0.3832955
Time:Treatment Time:Treatment 1 12 16 322 0.5962733 0.4549430 0.4549430

Mettl9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 312.5 0.9600000 0.3465280 0.5197919
Treatment Treatment 1 12 25.00 312.5 0.9600000 0.3465280 0.5197919
Time:Treatment Time:Treatment 1 12 6.25 331.5 0.2262443 0.6428643 0.6428643

skyblue

Gm6377

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 239.0 0.3138075 0.5856593 0.5856593
Treatment Treatment 1 12 9.00 228.5 0.4726477 0.5048428 0.5856593
Time:Treatment Time:Treatment 1 12 36.00 215.0 2.0093023 0.1817763 0.5453288

Crp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 144 120 14.400000 0.0025542 0.0076625
Treatment Treatment 1 12 81 174 5.586207 0.0358215 0.0358215
Time:Treatment Time:Treatment 1 12 81 174 5.586207 0.0358215 0.0358215

Ahsg

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 290 0.5068966 0.4900963 0.7351444
Treatment Treatment 1 12 56.25 259 2.6061776 0.1324189 0.3972566
Time:Treatment Time:Treatment 1 12 2.25 301 0.0897010 0.7696818 0.7696818

Saa4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 191.0 4.020942 0.0680279 0.2040837
Treatment Treatment 1 12 36 271.5 1.591160 0.2311306 0.2311306
Time:Treatment Time:Treatment 1 12 36 271.5 1.591160 0.2311306 0.2311306

Mug1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36 274 1.576642 0.2331440 0.233144
Treatment Treatment 1 12 49 258 2.279070 0.1570037 0.233144
Time:Treatment Time:Treatment 1 12 64 250 3.072000 0.1051368 0.233144

Gm7592

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 258 0.0116279 0.9159103 0.9159103
Treatment Treatment 1 12 90.25 192 5.6406250 0.0350807 0.1052422
Time:Treatment Time:Treatment 1 12 6.25 223 0.3363229 0.5726876 0.8590314

Hp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 311.0 0.1543408 0.7013107 0.7013107
Treatment Treatment 1 12 9.00 306.5 0.3523654 0.5637992 0.7013107
Time:Treatment Time:Treatment 1 12 90.25 213.5 5.0725995 0.0438196 0.1314589

Serpina3m

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 249.0 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 6.25 214.5 0.3496503 0.5652838 0.8479257
Time:Treatment Time:Treatment 1 12 6.25 214.5 0.3496503 0.5652838 0.8479257

Otc

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 285 1.0526316 0.3251396 0.4877095
Treatment Treatment 1 12 2.25 325 0.0830769 0.7780881 0.7780881
Time:Treatment Time:Treatment 1 12 42.25 258 1.9651163 0.1862999 0.4877095

C9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 290.5 0.0413081 0.8423500 0.8423500
Treatment Treatment 1 12 42.25 241.5 2.0993789 0.1729829 0.5189488
Time:Treatment Time:Treatment 1 12 2.25 260.5 0.1036468 0.7530356 0.8423500

lightsteelblue1

Lyz1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.5 0.0802377 0.7818029 0.7821172
Treatment Treatment 1 12 2.25 337.5 0.0800000 0.7821172 0.7821172
Time:Treatment Time:Treatment 1 12 4.00 334.0 0.1437126 0.7112404 0.7821172

AY761184

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 337.5 0.0000000 1.0000000 1
Treatment Treatment 1 12 1.00 337.5 0.0355556 0.8535876 1
Time:Treatment Time:Treatment 1 12 0.25 336.0 0.0089286 0.9262785 1

Gm15284

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 332 0.0090361 0.9258372 0.9262785
Treatment Treatment 1 12 0.25 336 0.0089286 0.9262785 0.9262785
Time:Treatment Time:Treatment 1 12 2.25 327 0.0825688 0.7787478 0.9262785

Itln1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 337.5 0.0088889 0.9264420 0.926442
Treatment Treatment 1 12 4.00 335.5 0.1430700 0.7118542 0.926442
Time:Treatment Time:Treatment 1 12 2.25 333.5 0.0809595 0.7808518 0.926442

Clec2h

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 321 0.4579439 0.5114204 0.9262785
Treatment Treatment 1 12 0.25 336 0.0089286 0.9262785 0.9262785
Time:Treatment Time:Treatment 1 12 0.25 330 0.0090909 0.9256135 0.9262785

Zg16

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 327.0 0.3302752 0.5761130 0.7102088
Treatment Treatment 1 12 16 323.5 0.5935085 0.4559656 0.7102088
Time:Treatment Time:Treatment 1 12 4 331.5 0.1447964 0.7102088 0.7102088

Gm14851

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1 335.5 0.0357675 0.8531574 0.8532653
Treatment Treatment 1 12 1 336.0 0.0357143 0.8532653 0.8532653
Time:Treatment Time:Treatment 1 12 25 312.0 0.9615385 0.3461562 0.8532653

Mep1b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 331.5 0.0090498 0.9257814 0.9262238
Treatment Treatment 1 12 0.25 335.5 0.0089419 0.9262238 0.9262238
Time:Treatment Time:Treatment 1 12 0.25 331.5 0.0090498 0.9257814 0.9262238

Cdh17

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 327 0.3302752 0.5761130 0.8534804
Treatment Treatment 1 12 4 334 0.1437126 0.7112404 0.8534804
Time:Treatment Time:Treatment 1 12 1 337 0.0356083 0.8534804 0.8534804

Ang4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1 321 0.0373832 0.8499210 0.8534804
Treatment Treatment 1 12 1 337 0.0356083 0.8534804 0.8534804
Time:Treatment Time:Treatment 1 12 4 315 0.1523810 0.7031112 0.8534804

darkslateblue

Strip2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.5 0.9538951 0.3480088 0.7811702
Treatment Treatment 1 12 4.00 335.5 0.1430700 0.7118542 0.7811702
Time:Treatment Time:Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.7811702

Rxfp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 315.5 0.7702060 0.3973841 0.9265504
Treatment Treatment 1 12 4.00 334.0 0.1437126 0.7112404 0.9265504
Time:Treatment Time:Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504

Slc17a6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.5 0.9538951 0.3480088 0.853373
Treatment Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.853373
Time:Treatment Time:Treatment 1 12 1.00 336.5 0.0356612 0.8533730 0.853373

Cpne9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 324.5 0.3328197 0.5746666 0.7808518
Treatment Treatment 1 12 2.25 333.5 0.0809595 0.7808518 0.7808518
Time:Treatment Time:Treatment 1 12 4.00 327.0 0.1467890 0.7083237 0.7808518

Ctxn3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 316.5 0.7677725 0.3981082 0.6844579
Treatment Treatment 1 12 1.00 336.5 0.0356612 0.8533730 0.8533730
Time:Treatment Time:Treatment 1 12 16.00 324.0 0.5925926 0.4563052 0.6844579

Slitrk6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 296.5 1.7099494 0.2154903 0.4546008
Treatment Treatment 1 12 16.00 317.5 0.6047244 0.4518406 0.4546008
Time:Treatment Time:Treatment 1 12 16.00 321.5 0.5972006 0.4546008 0.4546008

Fras1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 314.0 0.9554140 0.3476395 0.5752469
Treatment Treatment 1 12 9 325.5 0.3317972 0.5752469 0.5752469
Time:Treatment Time:Treatment 1 12 16 322.5 0.5953488 0.4552845 0.5752469

Epha8

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 319.5 0.7605634 0.4002654 0.4002654
Treatment Treatment 1 12 20.25 319.5 0.7605634 0.4002654 0.4002654
Time:Treatment Time:Treatment 1 12 56.25 280.5 2.4064171 0.1468005 0.4002654

E530001K10Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49.00 288.5 2.0381282 0.1789011 0.3210556
Treatment Treatment 1 12 42.25 294.5 1.7215620 0.2140371 0.3210556
Time:Treatment Time:Treatment 1 12 9.00 330.5 0.3267776 0.5781134 0.5781134

Fbln7

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 275.0 2.7927273 0.1205459 0.3616377
Treatment Treatment 1 12 25 308.5 0.9724473 0.3435370 0.5153056
Time:Treatment Time:Treatment 1 12 1 336.5 0.0356612 0.8533730 0.8533730

grey

1110020A21Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 156.25 181.5 10.3305785 0.0074351 0.0223054
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.3995488
Time:Treatment Time:Treatment 1 12 121.00 218.0 6.6605505 0.0240621 0.0360931

Dcbld2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.0 0.955414 0.3476395 0.3476395
Treatment Treatment 1 12 30.25 309.5 1.172859 0.3000959 0.3476395
Time:Treatment Time:Treatment 1 12 42.25 297.5 1.704202 0.2162143 0.3476395

Ephx3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 316.0 0.4651899 0.5081597 0.7622396
Treatment Treatment 1 12 16.00 322.5 0.5953488 0.4552845 0.7622396
Time:Treatment Time:Treatment 1 12 2.25 326.0 0.0828221 0.7784186 0.7784186

Klhl6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0 340 0.0000000 1.0000000 1
Treatment Treatment 1 12 0 340 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 4 336 0.1428571 0.7120579 1

Gm13710

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 330.5 0.0363086 0.8520652 0.8520652
Treatment Treatment 1 12 6.25 320.0 0.2343750 0.6370138 0.8520652
Time:Treatment Time:Treatment 1 12 9.00 317.5 0.3401575 0.5705372 0.8520652

Prnd

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 309.5 1.1728595 0.3000959 0.4501439
Treatment Treatment 1 12 16.00 323.0 0.5944272 0.4556254 0.4556254
Time:Treatment Time:Treatment 1 12 90.25 248.5 4.3581489 0.0588233 0.1764698

Tceal7

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49 283.5 2.0740741 0.1753971 0.5261912
Treatment Treatment 1 12 4 328.5 0.1461187 0.7089561 0.7089561
Time:Treatment Time:Treatment 1 12 9 325.5 0.3317972 0.5752469 0.7089561

8430429K09Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 269.5 2.849722 0.1171851 0.2231584
Treatment Treatment 1 12 56.25 283.5 2.380952 0.1487723 0.2231584
Time:Treatment Time:Treatment 1 12 30.25 305.5 1.188216 0.2970951 0.2970951

Cd6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 240.5 2.108108 0.1721600 0.1721600
Treatment Treatment 1 12 42.25 240.5 2.108108 0.1721600 0.1721600
Time:Treatment Time:Treatment 1 12 121.00 181.0 8.022099 0.0151102 0.0453307

9430038I01Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 326.5 0.4502297 0.5149340 0.9657799
Treatment Treatment 1 12 6.25 333.5 0.2248876 0.6438533 0.9657799
Time:Treatment Time:Treatment 1 12 0.00 339.5 0.0000000 1.0000000 1.0000000

salmon4

Heatr5b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 328.5 0.3287671 0.5769737 0.5769737
Treatment Treatment 1 12 12.25 326.5 0.4502297 0.5149340 0.5769737
Time:Treatment Time:Treatment 1 12 20.25 317.5 0.7653543 0.3988298 0.5769737

Uba1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 327.5 0.2290076 0.6408615 0.6408615
Treatment Treatment 1 12 30.25 309.5 1.1728595 0.3000959 0.5214593
Time:Treatment Time:Treatment 1 12 25.00 314.0 0.9554140 0.3476395 0.5214593

Prnp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 328.5 0.0821918 0.7792387 0.7792387
Treatment Treatment 1 12 9.00 327.0 0.3302752 0.5761130 0.7792387
Time:Treatment Time:Treatment 1 12 42.25 296.5 1.7099494 0.2154903 0.6464708

Cops7a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504
Treatment Treatment 1 12 42.25 294.5 1.7215620 0.2140371 0.3210556
Time:Treatment Time:Treatment 1 12 56.25 276.5 2.4412297 0.1441580 0.3210556

Nolc1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029
Treatment Treatment 1 12 30.25 308.5 1.1766613 0.2993491 0.5181164
Time:Treatment Time:Treatment 1 12 25.00 311.0 0.9646302 0.3454109 0.5181164

Zfp358

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 326.5 0.4502297 0.5149340 0.7724010
Treatment Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504
Time:Treatment Time:Treatment 1 12 36.00 301.5 1.4328358 0.2544148 0.7632443

Kat5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 337.5 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 9.00 330.0 0.3272727 0.5778293 0.9657799
Time:Treatment Time:Treatment 1 12 6.25 333.5 0.2248876 0.6438533 0.9657799

Snrpa

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 330.5 0.0816944 0.7798882 0.8520652
Treatment Treatment 1 12 1.00 330.5 0.0363086 0.8520652 0.8520652
Time:Treatment Time:Treatment 1 12 12.25 320.5 0.4586583 0.5110972 0.8520652

Hexim1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 315.5 0.770206 0.3973841 0.3973841
Treatment Treatment 1 12 49.00 288.5 2.038128 0.1789011 0.3973841
Time:Treatment Time:Treatment 1 12 25.00 312.5 0.960000 0.3465280 0.3973841

Ints9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 330.5 0.3267776 0.5781134 0.5781134
Treatment Treatment 1 12 20.25 316.5 0.7677725 0.3981082 0.5781134
Time:Treatment Time:Treatment 1 12 42.25 296.5 1.7099494 0.2154903 0.5781134

plum

Meiob

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Sectm1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 222 0.2162162 0.6502627 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 16 150 1.2800000 0.2800026 0.6502627

Il9r

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 178.5 1.0756303 0.3201249 0.6534965
Treatment Treatment 1 12 4 226.5 0.2119205 0.6534965 0.6534965
Time:Treatment Time:Treatment 1 12 4 226.5 0.2119205 0.6534965 0.6534965

Igfn1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 238.5 0.1132075 0.7423323 1
Treatment Treatment 1 12 0.00 265.5 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 1.00 250.5 0.0479042 0.8304294 1

Mmp27

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 150 1.2800000 0.2800026 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627

Slc15a5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 295.5 0.1624365 0.6940112 0.8422162
Treatment Treatment 1 12 1 290.0 0.0413793 0.8422162 0.8422162
Time:Treatment Time:Treatment 1 12 1 290.0 0.0413793 0.8422162 0.8422162

Ftcd

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 307.0 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 30.25 273.0 1.3296703 0.2713159 0.8139477
Time:Treatment Time:Treatment 1 12 4.00 294.5 0.1629881 0.6935218 1.0000000

Desi2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 314.0 0.3439490 0.5684271 0.8526406
Treatment Treatment 1 12 16 311.5 0.6163724 0.4476219 0.8526406
Time:Treatment Time:Treatment 1 12 0 321.5 0.0000000 1.0000000 1.0000000

Cml2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 262.5 2.9257143 0.1128827 0.3386480
Treatment Treatment 1 12 9 324.0 0.3333333 0.5743756 0.5743756
Time:Treatment Time:Treatment 1 12 36 295.0 1.4644068 0.2495286 0.3742928

Pklr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 228.0 3.8026316 0.0749234 0.2247701
Treatment Treatment 1 12 16.00 294.5 0.6519525 0.4351287 0.4351287
Time:Treatment Time:Treatment 1 12 30.25 281.0 1.2918149 0.2779021 0.4168531

lavenderblush2

Eml1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 308.5 0.7876823 0.3922431 0.7085349
Treatment Treatment 1 12 9.00 324.5 0.3328197 0.5746666 0.7085349
Time:Treatment Time:Treatment 1 12 4.00 327.5 0.1465649 0.7085349 0.7085349

Avpi1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 317.5 0.1511811 0.7042202 0.7789118
Treatment Treatment 1 12 12.25 323.5 0.4544049 0.5130269 0.7789118
Time:Treatment Time:Treatment 1 12 2.25 327.5 0.0824427 0.7789118 0.7789118

Nell1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0 339.0 0.0000000 1.0000000 1
Treatment Treatment 1 12 1 336.5 0.0356612 0.8533730 1
Time:Treatment Time:Treatment 1 12 1 337.0 0.0356083 0.8534804 1

Bok

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 328.5 0.3287671 0.5769737 0.5778293
Treatment Treatment 1 12 12.25 326.5 0.4502297 0.5149340 0.5778293
Time:Treatment Time:Treatment 1 12 9.00 330.0 0.3272727 0.5778293 0.5778293

Ebf4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 329.0 0.0364742 0.8517327 0.8517327
Treatment Treatment 1 12 2.25 335.5 0.0804769 0.7814873 0.8517327
Time:Treatment Time:Treatment 1 12 2.25 331.5 0.0814480 0.7802108 0.8517327

St3gal4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 299.0 0.0401338 0.8445743 0.8445743
Treatment Treatment 1 12 6.25 302.5 0.2479339 0.6275332 0.8445743
Time:Treatment Time:Treatment 1 12 20.25 308.5 0.7876823 0.3922431 0.8445743

Stmn4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 321.5 0.0839813 0.7769193 1
Treatment Treatment 1 12 9.00 318.0 0.3396226 0.5708361 1
Time:Treatment Time:Treatment 1 12 0.00 322.0 0.0000000 1.0000000 1

Nucb2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 291.5 1.2452830 0.2863032 0.8517327
Treatment Treatment 1 12 4.00 327.5 0.1465649 0.7085349 0.8517327
Time:Treatment Time:Treatment 1 12 1.00 329.0 0.0364742 0.8517327 0.8517327

Pcgf2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 310.5 0.7826087 0.3937250 0.6433598
Treatment Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.6433598
Time:Treatment Time:Treatment 1 12 9.00 323.0 0.3343653 0.5737917 0.6433598

Vdac1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 327.0 0.1467890 0.7083237 0.9254444
Treatment Treatment 1 12 9.00 329.0 0.3282675 0.5772595 0.9254444
Time:Treatment Time:Treatment 1 12 0.25 328.5 0.0091324 0.9254444 0.9254444

orangered1

Hoxb3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ifi205

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

9130230L23Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Olfr1034

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

4930552P12Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Itih1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 203.5 3.316953 0.0935775 0.1116927
Treatment Treatment 1 12 49.00 199.5 2.947368 0.1116927 0.1116927
Time:Treatment Time:Treatment 1 12 56.25 203.5 3.316953 0.0935775 0.1116927

Ubash3a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 180.0 2.0166667 0.1810361 0.5431084
Treatment Treatment 1 12 4.00 226.5 0.2119205 0.6534965 0.6534965
Time:Treatment Time:Treatment 1 12 16.00 222.0 0.8648649 0.3707118 0.5560677

Lgr5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 308.5 0.0097245 0.9230739 0.9230739
Treatment Treatment 1 12 49.00 278.0 2.1151079 0.1715037 0.4484004
Time:Treatment Time:Treatment 1 12 25.00 254.5 1.1787819 0.2989336 0.4484004

Hrg

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 285 0.6736842 0.4277747 0.4277747
Treatment Treatment 1 12 16 285 0.6736842 0.4277747 0.4277747
Time:Treatment Time:Treatment 1 12 16 285 0.6736842 0.4277747 0.4277747

Aqp7

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 285.5 0.262697 0.6175761 0.6175761
Treatment Treatment 1 12 42.25 243.5 2.082136 0.1746233 0.2619350
Time:Treatment Time:Treatment 1 12 81.00 210.5 4.617577 0.0527510 0.1582530

mediumpurple1

Timd2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Pon1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0 262.5 0 1 1
Treatment Treatment 1 12 0 262.5 0 1 1
Time:Treatment Time:Treatment 1 12 0 264.0 0 1 1

Slc4a1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 199 4.356784 0.0588574 0.0882861
Treatment Treatment 1 12 132.25 169 9.390533 0.0098185 0.0294554
Time:Treatment Time:Treatment 1 12 49.00 202 2.910891 0.1137064 0.1137064

Sgol1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49.00 206.5 2.8474576 0.1173163 0.1759745
Treatment Treatment 1 12 72.25 200.5 4.3241895 0.0596791 0.1759745
Time:Treatment Time:Treatment 1 12 16.00 239.0 0.8033473 0.3877216 0.3877216

Gata3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 292 0.0924658 0.7662740 0.766274
Treatment Treatment 1 12 16.00 269 0.7137546 0.4147271 0.766274
Time:Treatment Time:Treatment 1 12 6.25 288 0.2604167 0.6190904 0.766274

Fgfr4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 266.5 0.2814259 0.6054465 1
Treatment Treatment 1 12 0.00 299.5 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 2.25 291.5 0.0926244 0.7660802 1

Clec4e

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 271.5 0.0441989 0.8370114 0.9173339
Treatment Treatment 1 12 1.00 243.5 0.0492813 0.8280517 0.9173339
Time:Treatment Time:Treatment 1 12 0.25 267.0 0.0112360 0.9173339 0.9173339

Zp2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 282 0.6808511 0.4253933 1
Treatment Treatment 1 12 0 306 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 1 294 0.0408163 0.8432774 1

Slc23a1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 308.5 0.2431118 0.6308667 0.7720523
Treatment Treatment 1 12 16.00 280.5 0.6844920 0.4241916 0.7720523
Time:Treatment Time:Treatment 1 12 2.25 307.5 0.0878049 0.7720523 0.7720523

Atf3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 297.5 0.0403361 0.8441886 0.8441886
Treatment Treatment 1 12 2.25 321.0 0.0841121 0.7767508 0.8441886
Time:Treatment Time:Treatment 1 12 2.25 301.0 0.0897010 0.7696818 0.8441886

lightslateblue

Clec4g

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Capn9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 241 0.3112033 0.5871994 0.5871994
Treatment Treatment 1 12 12.25 207 0.7101449 0.4158763 0.5871994
Time:Treatment Time:Treatment 1 12 6.25 228 0.3289474 0.5768707 0.5871994

Aadac

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 259.5 0.7398844 0.4065552 0.4065552
Treatment Treatment 1 12 16 259.5 0.7398844 0.4065552 0.4065552
Time:Treatment Time:Treatment 1 12 16 259.5 0.7398844 0.4065552 0.4065552

1300015D01Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 296.5 0.6475548 0.4366418 0.4403729
Treatment Treatment 1 12 16 296.5 0.6475548 0.4366418 0.4403729
Time:Treatment Time:Treatment 1 12 16 301.5 0.6368159 0.4403729 0.4403729

Tnni3k

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 288.0 0.5104167 0.4886239 0.8470744
Treatment Treatment 1 12 1.00 309.0 0.0388350 0.8470744 0.8470744
Time:Treatment Time:Treatment 1 12 4.00 291.5 0.1646655 0.6920391 0.8470744

Ppara

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 294.5 1.2325976 0.2886544 0.7769193
Treatment Treatment 1 12 2.25 319.5 0.0845070 0.7762430 0.7769193
Time:Treatment Time:Treatment 1 12 2.25 321.5 0.0839813 0.7769193 0.7769193

Gm16199

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 302.5 0.9917355 0.3389763 0.5084644
Treatment Treatment 1 12 56.25 276.5 2.4412297 0.1441580 0.4324739
Time:Treatment Time:Treatment 1 12 2.25 335.5 0.0804769 0.7814873 0.7814873

4930423O20Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 309.5 0.7851373 0.3929854 0.5894781
Treatment Treatment 1 12 42.25 294.5 1.7215620 0.2140371 0.5894781
Time:Treatment Time:Treatment 1 12 4.00 329.5 0.1456753 0.7093755 0.7093755

C1qtnf9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 326.0 0.3312883 0.5755362 0.8633043
Treatment Treatment 1 12 81.00 254.5 3.8192534 0.0743694 0.2231081
Time:Treatment Time:Treatment 1 12 0.25 333.5 0.0089955 0.9260036 0.9260036

Klrb1c

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 316.0 0.3417722 0.5696366 1
Treatment Treatment 1 12 0.00 331.5 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 2.25 325.5 0.0829493 0.7782535 1

Analysis performed by Ann Wells

The Carter Lab The Jackson Laboratory 2023

ann.wells@jax.org