Hub Genes Spleen

tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))

tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))

log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)

log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])

log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5] 

log.tdata.FPKM.sample.info.subset <- cbind(log.tdata.FPKM.subset,tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info.subset <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.sample.info.subset.spleen <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(Tissue == "Spleen") %>% column_to_rownames()

module.labels <- readRDS(here("Data","Spleen","log.tdata.FPKM.sample.info.subset.spleen.WGCNA.module.labels.RData"))

modules <- readRDS(here("Data","Spleen","log.tdata.FPKM.sample.info.subset.spleen.WGCNA.module.membership.RData"))

net.deg <- readRDS(here("Data","Spleen","Chang_2DG_BL6_connectivity_spleen.RData"))

ensembl.location <- readRDS(here("Data","Ensembl_gene_id_and_location.RData"))

Hub Genes

Hub genes are genes in the module network that have the highest connectivity. For instance, if the gene significance of a particular module is associated with treatment the hub genes in this module are likely associated with this trait.

hub.genes.list <- hub.genes(net.deg,module.labels,modules,ensembl.location)

Palevioletred3 Module

DT.table.hub(hub.genes.list[[1]])

Moccasin Module

DT.table.hub(hub.genes.list[[2]])

Grey Module

DT.table.hub(hub.genes.list[[3]])

Mediumpurple1 Module

DT.table.hub(hub.genes.list[[4]])

Indianred4 Module

DT.table.hub(hub.genes.list[[5]])

Slateblue1 Module

DT.table.hub(hub.genes.list[[6]])

Coral2 Module

DT.table.hub(hub.genes.list[[7]])

Blue3 Module

DT.table.hub(hub.genes.list[[8]])

Blue2 Module

DT.table.hub(hub.genes.list[[9]])

Black Module

DT.table.hub(hub.genes.list[[10]])

Orangered4 Module

DT.table.hub(hub.genes.list[[11]])

Tan4 Module

DT.table.hub(hub.genes.list[[12]])

Orange Module

DT.table.hub(hub.genes.list[[13]])

Thistle1 Module

DT.table.hub(hub.genes.list[[14]])

Brown4 Module

DT.table.hub(hub.genes.list[[15]])

Darkgreen Module

DT.table.hub(hub.genes.list[[16]])

Darkseagreen4 Module

DT.table.hub(hub.genes.list[[17]])

Mediumorchid Module

DT.table.hub(hub.genes.list[[18]])

Plum Module

DT.table.hub(hub.genes.list[[19]])

Thistle3 Module

DT.table.hub(hub.genes.list[[20]])

Darkseagreen3 Module

DT.table.hub(hub.genes.list[[21]])

Navajowhite Module

DT.table.hub(hub.genes.list[[22]])

Sienna2 Module

DT.table.hub(hub.genes.list[[23]])

Lightskyblue4 Module

DT.table.hub(hub.genes.list[[24]])

Mediumpurple Module

DT.table.hub(hub.genes.list[[25]])

Indianred2 Module

DT.table.hub(hub.genes.list[[26]])

Royalblue3 Module

DT.table.hub(hub.genes.list[[27]])

Cornflowerblue Module

DT.table.hub(hub.genes.list[[28]])

Pink2 Module

DT.table.hub(hub.genes.list[[29]])

Indianred1 Module

DT.table.hub(hub.genes.list[[30]])

Lightblue2 Module

DT.table.hub(hub.genes.list[[31]])

ANOVA

To perform analysis of variance Aligned Rank Transformation was performed, which is designed to handle non-parametric multi-factorial experiments. P-value was adjusted using Benjamini-hochberg procedure. Only the top 10 hub genes are listed.

log.tdata.FPKM.sample.info.subset.spleen$Time <- as.factor(log.tdata.FPKM.sample.info.subset.spleen$Time)
log.tdata.FPKM.sample.info.subset.spleen$Treatment <- as.factor(log.tdata.FPKM.sample.info.subset.spleen$Treatment)

for(m in module.labels) {
    name <- str_split(m,"_")[[1]][2]
    hub.met <- net.deg[modules$Gene,] %>%
      dplyr::mutate(Gene=modules$Gene) %>%
      dplyr::filter(modules$Module == m) %>%
      dplyr::arrange(desc(kWithin)) %>%
      dplyr::select(Gene, kWithin)
    gene <- ensembl.location$external_gene_name[match(hub.met$Gene,ensembl.location$ensembl_gene_id)]
    hub.met <- cbind(gene,hub.met)
    cat("\n###",name, "{.tabset .tabset-fade .tabset-pills}","\n")
          for(i in 1:10){
             cat("\n####",hub.met$gene[i],"\n")
             m <- art(data = log.tdata.FPKM.sample.info.subset.spleen, log.tdata.FPKM.sample.info.subset.spleen[,hub.met$Gene[i]] ~ Time*Treatment)
             model <- anova(m)
             adjust <- p.adjust(model$`Pr(>F)`, method = "BH")
             print(knitr::kable(cbind(model,adjust)) %>% 
                      column_spec(8, color = "white", background = spec_color(adjust, end = 0.05, scale_from = c(0,0.05))) %>% kable_styling(bootstrap_options = c("striped", "hover", "responsive")))
             cat("\n \n")
             }
          cat("\n \n")
          }

palevioletred3

Nfat5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	227.5	5.8153846	0.0328221	0.0984664
Treatment	Treatment	1	12	25.00	294.5	1.0186757	0.3327521	0.4991282
Time:Treatment	Time:Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500

Rufy2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	206.5	7.6852300	0.0168921	0.0506763
Treatment	Treatment	1	12	20.25	306.5	0.7928222	0.3907507	0.5861260
Time:Treatment	Time:Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945

Mysm1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	214.5	6.7692308	0.0231501	0.0694502
Treatment	Treatment	1	12	30.25	299.5	1.2120200	0.2925258	0.4387887
Time:Treatment	Time:Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013

Tet2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	216.5	6.7066975	0.0236697	0.0710091
Treatment	Treatment	1	12	30.25	303.5	1.1960461	0.2955811	0.4433717
Time:Treatment	Time:Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7112404

Sf3b1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	212	6.8490566	0.0225062	0.0675187
Treatment	Treatment	1	12	30.25	298	1.2181208	0.2913705	0.4370558
Time:Treatment	Time:Treatment	1	12	9.00	330	0.3272727	0.5778293	0.5778293

Gm17131

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	237.5	5.0526316	0.0441715	0.1325146
Treatment	Treatment	1	12	20.25	303.5	0.8006590	0.3884918	0.5827377
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Kdm5d

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	193.5	8.9302326	0.0113089	0.0339267
Treatment	Treatment	1	12	12.25	306.5	0.4796085	0.5017821	0.7526731
Time:Treatment	Time:Treatment	1	12	2.25	330.5	0.0816944	0.7798882	0.7798882

Tnrc6a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	228.5	5.7899344	0.0331400	0.0994201
Treatment	Treatment	1	12	42.25	291.5	1.7392796	0.2118446	0.3177669
Time:Treatment	Time:Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.5769737

Slc30a7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	261.5	3.3154876	0.0936419	0.2809258
Treatment	Treatment	1	12	30.25	300.5	1.2079867	0.2932931	0.4399396
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

BC016423

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	254.0	3.8267717	0.0741204	0.2223613
Treatment	Treatment	1	12	30.25	305.5	1.1882160	0.2970951	0.4456426
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

moccasin

H2-Ab1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	322.0	0.3354037	0.5732055	0.5755362
Treatment	Treatment	1	12	9.00	326.0	0.3312883	0.5755362	0.5755362
Time:Treatment	Time:Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757

Ttc7b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.1430700	0.7118542	0.7818029
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Time:Treatment	Time:Treatment	1	12	81.00	259.0	3.7528958	0.0766112	0.2298335

Aamp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	302.0	1.430464	0.2547871	0.2970951
Treatment	Treatment	1	12	30.25	305.5	1.188216	0.2970951	0.2970951
Time:Treatment	Time:Treatment	1	12	90.25	249.5	4.340681	0.0592616	0.1777848

Marcksl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	306.5	1.1843393	0.2978486	0.4002654
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Time:Treatment	Time:Treatment	1	12	100.00	239.5	5.0104384	0.0449263	0.1347788

Csnk1g2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	327.5	0.1465649	0.7085349	0.7085349
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.6003981
Time:Treatment	Time:Treatment	1	12	100.00	237.5	5.0526316	0.0441715	0.1325146

Arhgdia

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	323.5	0.5935085	0.4559656	0.4563052
Treatment	Treatment	1	12	16.00	324.0	0.5925926	0.4563052	0.4563052
Time:Treatment	Time:Treatment	1	12	90.25	249.5	4.3406814	0.0592616	0.1777848

Actb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313.5	0.7751196	0.3959282	0.3959282
Treatment	Treatment	1	12	20.25	313.5	0.7751196	0.3959282	0.3959282
Time:Treatment	Time:Treatment	1	12	64.00	273.5	2.8080439	0.1196311	0.3588933

Vat1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	335.0	0.1432836	0.7116500	0.853373
Treatment	Treatment	1	12	1	336.5	0.0356612	0.8533730	0.853373
Time:Treatment	Time:Treatment	1	12	100	239.0	5.0209205	0.0447373	0.134212

Vps18

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	330.5	0.0816944	0.7798882	0.7798882
Treatment	Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.4490236
Time:Treatment	Time:Treatment	1	12	90.25	248.5	4.3581489	0.0588233	0.1764698

Cotl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	327.5	0.2290076	0.6408615	0.6408615
Treatment	Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.6408615
Time:Treatment	Time:Treatment	1	12	64.00	273.5	2.8080439	0.1196311	0.3588933

grey

Lect1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

D130043K22Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	192.0	3.515625	0.0853301	0.237984
Treatment	Treatment	1	12	25.00	193.0	1.554404	0.2362737	0.237984
Time:Treatment	Time:Treatment	1	12	25.00	194.5	1.542417	0.2379840	0.237984

Dcdc2a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	159.5	4.815047	0.0486296	0.1458889
Treatment	Treatment	1	12	30.25	177.0	2.050848	0.1776511	0.1776511
Time:Treatment	Time:Treatment	1	12	30.25	177.0	2.050848	0.1776511	0.1776511

Metazoa_SRP

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	337.5	0.080000	0.7821172	0.7821172
Treatment	Treatment	1	12	72.25	267.5	3.241122	0.0969812	0.1454718
Time:Treatment	Time:Treatment	1	12	72.25	261.5	3.315488	0.0936419	0.1454718

Metazoa_SRP

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	337.5	0.080000	0.7821172	0.7821172
Treatment	Treatment	1	12	72.25	267.5	3.241122	0.0969812	0.1454718
Time:Treatment	Time:Treatment	1	12	72.25	261.5	3.315488	0.0936419	0.1454718

Gm3883

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	306.5	1.1843393	0.2978486	0.5136651
Treatment	Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.5136651
Time:Treatment	Time:Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.5136651

Gm21093

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	306.5	1.1843393	0.2978486	0.5136651
Treatment	Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.5136651
Time:Treatment	Time:Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.5136651

Tspan11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	223.5	1.9328859	0.1896914	0.5690742
Treatment	Treatment	1	12	12.25	216.0	0.6805556	0.4254910	0.6382366
Time:Treatment	Time:Treatment	1	12	2.25	283.0	0.0954064	0.7627103	0.7627103

Gm21860

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Treatment	Treatment	1	12	12.25	315.5	0.4659271	0.5078301	0.7617451
Time:Treatment	Time:Treatment	1	12	20.25	306.5	0.7928222	0.3907507	0.7617451

Gm21748

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Treatment	Treatment	1	12	12.25	315.5	0.4659271	0.5078301	0.7617451
Time:Treatment	Time:Treatment	1	12	20.25	306.5	0.7928222	0.3907507	0.7617451

mediumpurple1

Diap3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	180.5	10.3878116	0.0073135	0.0219405
Treatment	Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.5772595
Time:Treatment	Time:Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.5772595

Chac2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	154.5	14.1553398	0.0027092	0.0081277
Treatment	Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Time:Treatment	Time:Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232

Kif14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	156.5	13.9744409	0.0028310	0.0084931
Treatment	Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.7118542
Time:Treatment	Time:Treatment	1	12	9.00	330.0	0.3272727	0.5778293	0.7118542

Kif22

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	157.5	13.8857143	0.0028931	0.0086793
Treatment	Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500
Time:Treatment	Time:Treatment	1	12	16.00	322.0	0.5962733	0.4549430	0.6824144

Sox6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	170.5	11.8944282	0.0048154	0.0144461
Treatment	Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.5155648
Time:Treatment	Time:Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.5155648

St3gal5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	157.5	13.8857143	0.0028931	0.0086793
Treatment	Treatment	1	12	4.00	332.0	0.1445783	0.7104160	0.7104160
Time:Treatment	Time:Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232

Abcg2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	168.5	12.0356083	0.0046375	0.0139124
Treatment	Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.5136651
Time:Treatment	Time:Treatment	1	12	25.00	312.5	0.9600000	0.3465280	0.5136651

Mcm4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	169.0	12.0000000	0.0046816	0.0140448
Treatment	Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Prc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	183.5	10.2179837	0.0076814	0.0230443
Treatment	Treatment	1	12	2.25	330.5	0.0816944	0.7798882	0.7798882
Time:Treatment	Time:Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.7704976

Abcb4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	180.5	10.3878116	0.0073135	0.0219405
Treatment	Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6438533
Time:Treatment	Time:Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533

indianred4

Tcf25

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	246.5	4.3935091	0.0579478	0.1738435
Treatment	Treatment	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238
Time:Treatment	Time:Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.6819012

Zbtb4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.0	2.7927273	0.1205459	0.2683517
Treatment	Treatment	1	12	12.25	325.5	0.4516129	0.5143008	0.5143008
Time:Treatment	Time:Treatment	1	12	49.00	288.5	2.0381282	0.1789011	0.2683517

Slc38a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	288.5	2.0381282	0.1789011	0.2683517
Treatment	Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500
Time:Treatment	Time:Treatment	1	12	56.25	283.5	2.3809524	0.1487723	0.2683517

Rnf144a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.5	3.760155	0.076362	0.222174
Treatment	Treatment	1	12	25.00	312.5	0.960000	0.346528	0.346528
Time:Treatment	Time:Treatment	1	12	56.25	282.5	2.389381	0.148116	0.222174

Zdhhc8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	245.5	4.4114053	0.0575108	0.1130482
Treatment	Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.4546008
Time:Treatment	Time:Treatment	1	12	81.00	256.5	3.7894737	0.0753654	0.1130482

Cerk

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	274.0	2.8029197	0.1199362	0.3210556
Treatment	Treatment	1	12	9.00	322.5	0.3348837	0.5734989	0.5734989
Time:Treatment	Time:Treatment	1	12	42.25	294.5	1.7215620	0.2140371	0.3210556

Sh2b3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.3995488

Mtss1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	261.5	3.3154876	0.0936419	0.1404629
Treatment	Treatment	1	12	12.25	318.5	0.4615385	0.5097981	0.5097981
Time:Treatment	Time:Treatment	1	12	110.25	222.5	5.9460674	0.0312459	0.0937377

Il16

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.5	2.7876588	0.1208505	0.3243215
Treatment	Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7808518
Time:Treatment	Time:Treatment	1	12	42.25	297.5	1.7042017	0.2162143	0.3243215

Fam102a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	248.5	4.358149	0.0588233	0.0882349
Treatment	Treatment	1	12	2.25	337.5	0.080000	0.7821172	0.7821172
Time:Treatment	Time:Treatment	1	12	90.25	234.5	4.618337	0.0527344	0.0882349

slateblue1

U2surp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	293.5	1.7274276	0.2133079	0.3199619
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.3199619
Time:Treatment	Time:Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.5769737

Ccar1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	289.0	2.0346021	0.1792497	0.2688745
Treatment	Treatment	1	12	64.00	274.0	2.8029197	0.1199362	0.2688745
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.5117430

Noc3l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	281.0	2.0925267	0.1736324	0.3210556
Treatment	Treatment	1	12	42.25	294.5	1.7215620	0.2140371	0.3210556
Time:Treatment	Time:Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.6423668

Stag2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	312.5	0.7776000	0.3951964	0.5927946
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.4443480
Time:Treatment	Time:Treatment	1	12	6.25	327.5	0.2290076	0.6408615	0.6408615

Zkscan1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313.5	0.7751196	0.3959282	0.5938923
Treatment	Treatment	1	12	42.25	296.5	1.7099494	0.2154903	0.5938923
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Abce1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	302.5	1.2000000	0.2948207	0.4422311
Treatment	Treatment	1	12	49.00	290.5	2.0240964	0.1802933	0.4422311
Time:Treatment	Time:Treatment	1	12	4.00	323.5	0.1483771	0.7068318	0.7068318

Ranbp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	322.5	0.3348837	0.5734989	0.8602484
Treatment	Treatment	1	12	36.00	303.5	1.4233937	0.2559012	0.7677036
Time:Treatment	Time:Treatment	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238

Skiv2l2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25	306.5	0.9787928	0.3420268	0.5130402
Treatment	Treatment	1	12	49	290.5	2.0240964	0.1802933	0.5130402
Time:Treatment	Time:Treatment	1	12	0	314.0	0.0000000	1.0000000	1.0000000

Sp3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	303.5	1.1960461	0.2955811	0.4433717
Treatment	Treatment	1	12	49.00	289.0	2.0346021	0.1792497	0.4433717
Time:Treatment	Time:Treatment	1	12	2.25	326.5	0.0826953	0.7785834	0.7785834

Naa25

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	319.0	0.6018809	0.4528805	0.6793207
Treatment	Treatment	1	12	64	275.5	2.7876588	0.1208505	0.3625516
Time:Treatment	Time:Treatment	1	12	4	332.0	0.1445783	0.7104160	0.7104160

coral2

Acap1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	267.0	2.8764045	0.1156516	0.3469549
Treatment	Treatment	1	12	2.25	326.5	0.0826953	0.7785834	0.7785834
Time:Treatment	Time:Treatment	1	12	16.00	315.5	0.6085578	0.4504449	0.6756674

Pde1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	237.5	4.5600000	0.0540309	0.1620927
Treatment	Treatment	1	12	20.25	312.5	0.7776000	0.3951964	0.3951964
Time:Treatment	Time:Treatment	1	12	20.25	309.5	0.7851373	0.3929854	0.3951964

Map4k2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	269.5	2.8497217	0.1171851	0.3515552
Treatment	Treatment	1	12	2.25	328.5	0.0821918	0.7792387	0.7792387
Time:Treatment	Time:Treatment	1	12	20.25	309.5	0.7851373	0.3929854	0.5894781

Il27ra

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	271.0	2.8339483	0.1181034	0.3543103
Treatment	Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Time:Treatment	Time:Treatment	1	12	16.00	316.0	0.6075949	0.4507948	0.6438533

Hmha1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	273.5	2.4680073	0.1421660	0.4264979
Treatment	Treatment	1	12	9.00	326.0	0.3312883	0.5755362	0.8633043
Time:Treatment	Time:Treatment	1	12	0.00	337.5	0.0000000	1.0000000	1.0000000

Ppp1r12c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	297.5	1.704202	0.2162143	0.648643
Treatment	Treatment	1	12	0.00	337.5	0.000000	1.0000000	1.000000
Time:Treatment	Time:Treatment	1	12	2.25	337.5	0.080000	0.7821172	1.000000

Gmip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	267.5	3.2411215	0.0969812	0.2909436
Treatment	Treatment	1	12	0.25	333.5	0.0089955	0.9260036	0.9260036
Time:Treatment	Time:Treatment	1	12	2.25	335.5	0.0804769	0.7814873	0.9260036

Dennd6b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	245	4.4204082	0.0572924	0.1718772
Treatment	Treatment	1	12	6.25	311	0.2411576	0.6322295	0.6322295
Time:Treatment	Time:Treatment	1	12	20.25	306	0.7941176	0.3903759	0.5855638

Gimap3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	277.5	2.4324324	0.1448201	0.4344602
Treatment	Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.7676145
Time:Treatment	Time:Treatment	1	12	1.00	334.5	0.0358744	0.8529409	0.8529409

Pstpip1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	240.0	5.0000000	0.0451154	0.1353461
Treatment	Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.9265504
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

blue3

Spred2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	326.5	0.4502297	0.5149340	0.5149340
Treatment	Treatment	1	12	12.25	318.5	0.4615385	0.5097981	0.5149340
Time:Treatment	Time:Treatment	1	12	90.25	246.5	4.3935091	0.0579478	0.1738435

Ubap2l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	313.0	0.9584665	0.3468991	0.5091447
Treatment	Treatment	1	12	12.25	317.5	0.4629921	0.5091447	0.5091447
Time:Treatment	Time:Treatment	1	12	169.00	170.0	11.9294118	0.0047706	0.0143117

Scaf8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.9266583
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	121.00	218.5	6.6453089	0.0241934	0.0725801

Taok3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.4388892
Treatment	Treatment	1	12	16.00	299.5	0.6410684	0.4388892	0.4388892
Time:Treatment	Time:Treatment	1	12	100.00	239.5	5.0104384	0.0449263	0.1347788

Eif4ebp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.9265504
Time:Treatment	Time:Treatment	1	12	169.00	170.0	11.9294118	0.0047706	0.0143117

Tmem131

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Treatment	Treatment	1	12	20.25	317.5	0.7653543	0.3988298	0.5982446
Time:Treatment	Time:Treatment	1	12	110.25	228.5	5.7899344	0.0331400	0.0994201

Patz1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	339.5	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232
Time:Treatment	Time:Treatment	1	12	90.25	249.5	4.3406814	0.0592616	0.1777848

Phf2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	334.5	0.0807175	0.7811702	0.7811702
Treatment	Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.7811702
Time:Treatment	Time:Treatment	1	12	156.25	177.5	10.5633803	0.0069547	0.0208641

Scaf4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	250.5	3.880240	0.0723790	0.1085684
Treatment	Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.2993491
Time:Treatment	Time:Treatment	1	12	100.00	238.0	5.042017	0.0443600	0.1085684

Chd4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	331.0	0.3262840	0.5783968	0.7808518
Treatment	Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7808518
Time:Treatment	Time:Treatment	1	12	156.25	176.5	10.6232295	0.0068371	0.0205114

blue2

Ndufa2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	239.0	5.0209205	0.0447373	0.1342120
Treatment	Treatment	1	12	25	314.5	0.9538951	0.3480088	0.3480088
Time:Treatment	Time:Treatment	1	12	36	302.0	1.4304636	0.2547871	0.3480088

Rpl37a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	314.5	0.9538951	0.3480088	0.4556254
Treatment	Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.4556254
Time:Treatment	Time:Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.4556254

Uqcc2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.0	3.7674419	0.0761128	0.2283384
Treatment	Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.4002654
Time:Treatment	Time:Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654

Ndufa1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.0	3.767442	0.0761128	0.2221740
Treatment	Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.2993491
Time:Treatment	Time:Treatment	1	12	56.25	282.5	2.389381	0.1481160	0.2221740

Rps14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	319.5	0.7605634	0.4002654	0.514934
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.514934
Time:Treatment	Time:Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.514934

Rpp25l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	239.0	5.0209205	0.0447373	0.1342120
Treatment	Treatment	1	12	25.00	313.0	0.9584665	0.3468991	0.5203486
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Rps29

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	308.5	1.1766613	0.2993491	0.4490236
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.4559656
Time:Treatment	Time:Treatment	1	12	42.25	296.5	1.7099494	0.2154903	0.4490236

Rps19

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.4559656
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.4559656
Time:Treatment	Time:Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.4559656

Rps20

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	308.5	1.1766613	0.2993491	0.5143008
Treatment	Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.5143008
Time:Treatment	Time:Treatment	1	12	12.25	325.5	0.4516129	0.5143008	0.5143008

Rpl22l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	263.5	3.2903226	0.0947559	0.2842677
Treatment	Treatment	1	12	25.00	314.0	0.9554140	0.3476395	0.5117430
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.5117430

black

Slc39a5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	178.5	1.075630	0.3201249	0.3201249
Treatment	Treatment	1	12	16	178.5	1.075630	0.3201249	0.3201249
Time:Treatment	Time:Treatment	1	12	16	172.5	1.113044	0.3122001	0.3201249

Cuzd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	177	1.084746	0.3181679	0.3181679
Treatment	Treatment	1	12	16	171	1.122807	0.3101778	0.3181679
Time:Treatment	Time:Treatment	1	12	16	177	1.084746	0.3181679	0.3181679

Ovol2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Hspb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Cldn23

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Mab21l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Crb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Cldn9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Neu2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

C130080G10Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

orangered4

Irx2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Tnni3k

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Mettl11b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Syt9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

0610040F04Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Klhdc7b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Kcnj11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

A330033J07Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

4732463B04Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Mep1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	187.0	6.4171123	0.0262644	0.0787932
Treatment	Treatment	1	12	6.25	237.0	0.3164557	0.5841019	0.6655907
Time:Treatment	Time:Treatment	1	12	4.00	244.5	0.1963190	0.6655907	0.6655907

tan4

Prdx6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	170.5	11.8944282	0.0048154	0.0144461
Treatment	Treatment	1	12	42.25	297.5	1.7042017	0.2162143	0.3243215
Time:Treatment	Time:Treatment	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238

Ndufa8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	191.0	9.0471204	0.0109066	0.0327197
Treatment	Treatment	1	12	42.25	295.5	1.7157360	0.2147645	0.3221468
Time:Treatment	Time:Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323

Timm13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	167.0	12.1437126	0.0045065	0.0135194
Treatment	Treatment	1	12	42.25	295.5	1.7157360	0.2147645	0.3221468
Time:Treatment	Time:Treatment	1	12	25.00	311.0	0.9646302	0.3454109	0.3454109

Tmem147

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	194.0	8.907217	0.0113902	0.0341706
Treatment	Treatment	1	12	42.25	297.5	1.704202	0.2162143	0.3243215
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.081448	0.7802108	0.7802108

Ap2s1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	174.5	10.744986	0.0066051	0.0198153
Treatment	Treatment	1	12	30.25	302.5	1.200000	0.2948207	0.4422311
Time:Treatment	Time:Treatment	1	12	6.25	326.5	0.229709	0.6403555	0.6403555

Atp5g3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	182.5	10.273973	0.0075578	0.0226734
Treatment	Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.4490236
Time:Treatment	Time:Treatment	1	12	0.00	336.0	0.000000	1.0000000	1.0000000

Oaz1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144	195.5	8.8388747	0.0116356	0.0349068
Treatment	Treatment	1	12	36	302.0	1.4304636	0.2547871	0.3821807
Time:Treatment	Time:Treatment	1	12	4	335.0	0.1432836	0.7116500	0.7116500

Psmg3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196.00	141.5	16.6219081	0.0015343	0.0046028
Treatment	Treatment	1	12	6.25	327.5	0.2290076	0.6408615	0.6418671
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.6418671

Hspbp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	180.5	10.3878116	0.0073135	0.0219405
Treatment	Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.5130269
Time:Treatment	Time:Treatment	1	12	12.25	323.5	0.4544049	0.5130269	0.5130269

Psmc4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	206.5	7.685230	0.0168921	0.0506763
Treatment	Treatment	1	12	81.00	254.0	3.826772	0.0741204	0.1111807
Time:Treatment	Time:Treatment	1	12	9.00	312.5	0.345600	0.5675132	0.5675132

orange

Cd209f

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	279.5	1.298748	0.2766796	0.2766796
Treatment	Treatment	1	12	64.00	218.0	3.522936	0.0850439	0.2551317
Time:Treatment	Time:Treatment	1	12	30.25	279.5	1.298748	0.2766796	0.2766796

Plin4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	311.5	0.4719101	0.5051691	0.5051691
Treatment	Treatment	1	12	56.25	244.5	2.7607362	0.1224848	0.3674545
Time:Treatment	Time:Treatment	1	12	30.25	287.5	1.2626087	0.2831347	0.4247020

Timp4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	301.0	0.6378738	0.4400031	0.4400031
Treatment	Treatment	1	12	42.25	260.5	1.9462572	0.1882748	0.4174624
Time:Treatment	Time:Treatment	1	12	30.25	281.5	1.2895204	0.2783083	0.4174624

Adrb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	310.0	0.3483871	0.5659772	0.5659772
Treatment	Treatment	1	12	42.25	263.5	1.9240987	0.1906299	0.5659772
Time:Treatment	Time:Treatment	1	12	16.00	297.5	0.6453782	0.4373939	0.5659772

Cd209g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	275	1.320000	0.2729778	0.2729778
Treatment	Treatment	1	12	64.00	191	4.020942	0.0680279	0.2040837
Time:Treatment	Time:Treatment	1	12	30.25	275	1.320000	0.2729778	0.2729778

Glb1l2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	307.0	0.6254072	0.4443943	0.4443943
Treatment	Treatment	1	12	36.00	272.0	1.5882353	0.2315344	0.4443943
Time:Treatment	Time:Treatment	1	12	20.25	301.5	0.8059701	0.3869723	0.4443943

Lyve1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	303.5	0.800659	0.3884918	0.3884918
Treatment	Treatment	1	12	132.25	197.5	8.035443	0.0150444	0.0451331
Time:Treatment	Time:Treatment	1	12	30.25	291.5	1.245283	0.2863032	0.3884918

Cidec

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	303.0	0.8019802	0.3881130	0.388113
Treatment	Treatment	1	12	49.00	265.5	2.2146893	0.1625039	0.388113
Time:Treatment	Time:Treatment	1	12	25.00	294.0	1.0204082	0.3323575	0.388113

Nnat

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	286.5	1.267016	0.2823364	0.2823364
Treatment	Treatment	1	12	42.25	268.5	1.888268	0.1945193	0.2823364
Time:Treatment	Time:Treatment	1	12	36.00	283.0	1.526502	0.2402802	0.2823364

Adipoq

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	303	0.8019802	0.3881130	0.3881130
Treatment	Treatment	1	12	100.00	233	5.1502146	0.0424833	0.1274500
Time:Treatment	Time:Treatment	1	12	42.25	273	1.8571429	0.1979818	0.2969727

thistle1

Serpina1e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	269.5	2.8497217	0.1171851	0.3515552
Treatment	Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.5136651
Time:Treatment	Time:Treatment	1	12	16.00	322.0	0.5962733	0.4549430	0.5136651

Gc

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	295.5	1.4619289	0.2499075	0.6819012
Treatment	Treatment	1	12	4	335.5	0.1430700	0.7118542	0.7118542
Time:Treatment	Time:Treatment	1	12	16	321.5	0.5972006	0.4546008	0.6819012

Ces1c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	272.5	2.157798	0.1675697	0.4422311
Treatment	Treatment	1	12	30.25	302.5	1.200000	0.2948207	0.4422311
Time:Treatment	Time:Treatment	1	12	16.00	320.0	0.600000	0.4535705	0.4535705

Fga

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	302.5	1.2000000	0.2948207	0.7112404
Treatment	Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7112404
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.7112404

Serpina3k

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	297.5	1.7042017	0.2162143	0.4002654
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Time:Treatment	Time:Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.4002654

Rdh7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	299.5	1.2120200	0.2925258	0.4387887
Treatment	Treatment	1	12	36.00	291.0	1.4845361	0.2464790	0.4387887
Time:Treatment	Time:Treatment	1	12	12.25	323.5	0.4544049	0.5130269	0.5130269

Pzp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	282.5	1.7946903	0.2051747	0.5110972
Treatment	Treatment	1	12	16.00	316.0	0.6075949	0.4507948	0.5110972
Time:Treatment	Time:Treatment	1	12	12.25	320.5	0.4586583	0.5110972	0.5110972

Fabp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	286.0	2.0559441	0.1771533	0.4556254
Treatment	Treatment	1	12	16	323.0	0.5944272	0.4556254	0.4556254
Time:Treatment	Time:Treatment	1	12	25	314.5	0.9538951	0.3480088	0.4556254

Ttr

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	275	2.7927273	0.1205459	0.3616377
Treatment	Treatment	1	12	25	313	0.9584665	0.3468991	0.5203486
Time:Treatment	Time:Treatment	1	12	9	330	0.3272727	0.5778293	0.5778293

Ahsg

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	298.5	1.2160804	0.2917562	0.7704976
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.7704976

brown4

H2-Eb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	322.5	0.0837209	0.7772551	0.7772551
Treatment	Treatment	1	12	56.25	281.5	2.3978686	0.1474588	0.4423763
Time:Treatment	Time:Treatment	1	12	9.00	322.5	0.3348837	0.5734989	0.7772551

Chmp1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	315.5	0.6085578	0.4504449	0.5665936
Treatment	Treatment	1	12	36	294.0	1.4693878	0.2487692	0.5665936
Time:Treatment	Time:Treatment	1	12	9	311.0	0.3472669	0.5665936	0.5665936

0610031J06Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	326.0	0.0368098	0.8510610	0.851061
Treatment	Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.851061
Time:Treatment	Time:Treatment	1	12	2.25	319.5	0.0845070	0.7762430	0.851061

Sys1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	329.0	0.3282675	0.5772595	0.7085349
Treatment	Treatment	1	12	25	302.0	0.9933775	0.3385921	0.7085349
Time:Treatment	Time:Treatment	1	12	4	327.5	0.1465649	0.7085349	0.7085349

Rnh1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	319.5	0.600939	0.4532258	0.5675132
Treatment	Treatment	1	12	56.25	272.5	2.477064	0.1415000	0.4245001
Time:Treatment	Time:Treatment	1	12	9.00	312.5	0.345600	0.5675132	0.5675132

Cdipt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	331.5	0.0814480	0.7802108	0.851061
Treatment	Treatment	1	12	25.00	310.0	0.9677419	0.3446632	0.851061
Time:Treatment	Time:Treatment	1	12	1.00	326.0	0.0368098	0.8510610	0.851061

Adck1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Treatment	Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.7818029

Pex16

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	327.5	0.2290076	0.6408615	0.6408615
Treatment	Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.6408615
Time:Treatment	Time:Treatment	1	12	16.00	320.0	0.6000000	0.4535705	0.6408615

Nudt16l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	314.0	0.611465	0.4493913	0.6330400
Treatment	Treatment	1	12	49.00	284.5	2.066784	0.1761006	0.5283017
Time:Treatment	Time:Treatment	1	12	6.25	312.5	0.240000	0.6330400	0.6330400

Rps9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	312.5	0.777600	0.3951964	0.3951964
Treatment	Treatment	1	12	42.25	294.5	1.721562	0.2140371	0.3210556
Time:Treatment	Time:Treatment	1	12	42.25	294.5	1.721562	0.2140371	0.3210556

darkgreen

Crhr2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Chodl

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Kcnip4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

A930017M01Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Mroh3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Rbp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25	235.5	1.2738854	0.2810984	0.6732822
Treatment	Treatment	1	12	4	257.0	0.1867704	0.6732822	0.6732822
Time:Treatment	Time:Treatment	1	12	4	257.0	0.1867704	0.6732822	0.6732822

Mtmr7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	252	0.0476190	0.8309262	0.8309262
Treatment	Treatment	1	12	9.00	290	0.3724138	0.5530733	0.8309262
Time:Treatment	Time:Treatment	1	12	6.25	225	0.3333333	0.5743756	0.8309262

Sis

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	220	0.8727273	0.3686193	0.5529290
Treatment	Treatment	1	12	2.25	245	0.1102041	0.7456384	0.7456384
Time:Treatment	Time:Treatment	1	12	30.25	241	1.5062241	0.2432490	0.5529290

Atp10b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	241	1.506224	0.2432490	0.2432490
Treatment	Treatment	1	12	64.00	191	4.020942	0.0680279	0.2040837
Time:Treatment	Time:Treatment	1	12	30.25	241	1.506224	0.2432490	0.2432490

C230012O17Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	278.0	0.1726619	0.6850907	0.6850907
Treatment	Treatment	1	12	56.25	222.5	3.0337079	0.1070993	0.1606489
Time:Treatment	Time:Treatment	1	12	56.25	222.5	3.0337079	0.1070993	0.1606489

darkseagreen4

Nmrk2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

1700007K13Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Clec18a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Golt1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Morc2b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

A230009B12Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Elavl4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	151.5	1.267327	0.2822802	0.3161949
Treatment	Treatment	1	12	16	175.5	1.094017	0.3161949	0.3161949
Time:Treatment	Time:Treatment	1	12	16	175.5	1.094017	0.3161949	0.3161949

Lgr6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	205.5	0.7153285	0.4142276	0.4944689
Treatment	Treatment	1	12	9.00	217.5	0.4965517	0.4944689	0.4944689
Time:Treatment	Time:Treatment	1	12	16.00	193.0	0.9948187	0.3382554	0.4944689

Zan

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	201.0	3.358209	0.0917873	0.0932196
Treatment	Treatment	1	12	56.25	203.0	3.325123	0.0932196	0.0932196
Time:Treatment	Time:Treatment	1	12	64.00	200.5	3.830424	0.0739999	0.0932196

Pla2g2c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	274.0	1.5766423	0.2331440	0.6994321
Treatment	Treatment	1	12	1	222.5	0.0539326	0.8202697	0.8202697
Time:Treatment	Time:Treatment	1	12	9	210.5	0.5130641	0.4875216	0.7312824

mediumorchid

Shh

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Grp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Sall4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Lmod3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Tmem232

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

B430212C06Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Rmst

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

2610017I09Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	174	1.103448	0.3142057	0.3142057
Treatment	Treatment	1	12	16	150	1.280000	0.2800026	0.3142057
Time:Treatment	Time:Treatment	1	12	16	174	1.103448	0.3142057	0.3142057

D430041D05Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	192.5	0.9974026	0.3376530	0.337653
Treatment	Treatment	1	12	16	191.0	1.0052356	0.3358364	0.337653
Time:Treatment	Time:Treatment	1	12	16	192.5	0.9974026	0.3376530	0.337653

Tmc5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	249.5	0.0480962	0.8300958	0.9175642
Treatment	Treatment	1	12	0.25	268.5	0.0111732	0.9175642	0.9175642
Time:Treatment	Time:Treatment	1	12	4.00	232.5	0.2064516	0.6576723	0.9175642

plum

Kcnmb2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Ankrd34b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Mas1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm17546

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

2410004I01Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Cdsn

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	202	2.509901	0.1391183	0.1391183
Treatment	Treatment	1	12	56.25	199	3.391960	0.0903538	0.1355308
Time:Treatment	Time:Treatment	1	12	56.25	199	3.391960	0.0903538	0.1355308

Slc13a4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	258.0	1.965116	0.1862999	0.215372
Treatment	Treatment	1	12	36.00	252.5	1.710891	0.2153720	0.215372
Time:Treatment	Time:Treatment	1	12	42.25	258.0	1.965116	0.1862999	0.215372

Aoc3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	301.5	0.8059701	0.3869723	0.3869723
Treatment	Treatment	1	12	56.25	247.5	2.7272727	0.1245547	0.2975465
Time:Treatment	Time:Treatment	1	12	42.25	273.5	1.8537477	0.1983644	0.2975465

Aqp7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	280.0	1.296429	0.2770877	0.3226840
Treatment	Treatment	1	12	64.00	234.5	3.275053	0.0954397	0.2863192
Time:Treatment	Time:Treatment	1	12	25.00	282.0	1.063830	0.3226840	0.3226840

Sprn

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	227.5	1.5956044	0.2305189	0.6915567
Treatment	Treatment	1	12	2.25	256.5	0.1052632	0.7511885	0.7511885
Time:Treatment	Time:Treatment	1	12	2.25	256.5	0.1052632	0.7511885	0.7511885

thistle3

Ascl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

4930451C15Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Scd3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Irx5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Plk5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Lrfn5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Dct

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	186	1.032258	0.3296766	0.33216
Treatment	Treatment	1	12	16	188	1.021277	0.3321600	0.33216
Time:Treatment	Time:Treatment	1	12	16	188	1.021277	0.3321600	0.33216

Efcab6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	190.5	1.007874	0.3352276	0.3352276
Treatment	Treatment	1	12	16	189.0	1.015873	0.3333919	0.3352276
Time:Treatment	Time:Treatment	1	12	16	183.0	1.049180	0.3259019	0.3352276

Gabrb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	225.0	0.3333333	0.5743756	0.5743756
Treatment	Treatment	1	12	25.00	214.5	1.3986014	0.2598605	0.5743756
Time:Treatment	Time:Treatment	1	12	16.00	244.0	0.7868852	0.3924754	0.5743756

Lrrc9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	192	3.515625	0.0853301	0.1344551
Treatment	Treatment	1	12	42.25	198	2.560606	0.1355384	0.1355384
Time:Treatment	Time:Treatment	1	12	56.25	198	3.409091	0.0896367	0.1344551

darkseagreen3

1700093K21Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Tekt1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Tacr3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gpr110

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm694

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

4732418A04Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

A830073O21Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm17634

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Zbtb8b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	267.0	0.0112360	0.9173339	0.9173339
Treatment	Treatment	1	12	0.25	267.0	0.0112360	0.9173339	0.9173339
Time:Treatment	Time:Treatment	1	12	4.00	217.5	0.2206897	0.6469367	0.9173339

Zmat4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	260.5	0.0115163	0.9163131	0.9163131
Treatment	Treatment	1	12	49.00	229.5	2.5620915	0.1354353	0.4063058
Time:Treatment	Time:Treatment	1	12	16.00	238.5	0.8050314	0.3872402	0.5808603

navajowhite

Pitx2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Dsg1c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Abca12

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Slitrk1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Kcnh8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Ddit4l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	228	0.3289474	0.5768707	0.8653061
Treatment	Treatment	1	12	0.25	258	0.0116279	0.9159103	0.9159103
Time:Treatment	Time:Treatment	1	12	6.25	228	0.3289474	0.5768707	0.8653061

Gpr22

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	225	0.2133333	0.6524285	0.6524285
Treatment	Treatment	1	12	16	177	1.0847458	0.3181679	0.6524285
Time:Treatment	Time:Treatment	1	12	4	225	0.2133333	0.6524285	0.6524285

Negr1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	213.5	3.597190	0.0822027	0.1233040
Treatment	Treatment	1	12	81.00	207.0	4.695652	0.0510732	0.1233040
Time:Treatment	Time:Treatment	1	12	42.25	260.0	1.950000	0.1878807	0.1878807

Cpne9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	290.0	0.6620690	0.4316801	0.7716924
Treatment	Treatment	1	12	2.25	306.5	0.0880914	0.7716924	0.7716924
Time:Treatment	Time:Treatment	1	12	2.25	306.5	0.0880914	0.7716924	0.7716924

Has2os

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	256	33.5	91.70149	0.0000006	0.0000017
Treatment	Treatment	1	12	81	187.5	5.18400	0.0419169	0.0419169
Time:Treatment	Time:Treatment	1	12	81	187.5	5.18400	0.0419169	0.0419169

sienna2

Cwh43

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Fut2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm10639

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

9330158H04Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	177	1.084746	0.3181679	0.3181679
Treatment	Treatment	1	12	16	171	1.122807	0.3101778	0.3181679
Time:Treatment	Time:Treatment	1	12	16	177	1.084746	0.3181679	0.3181679

1110002E22Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	194	0.9896907	0.3394556	0.3394556
Treatment	Treatment	1	12	36	204	2.1176471	0.1712665	0.3394556
Time:Treatment	Time:Treatment	1	12	16	194	0.9896907	0.3394556	0.3394556

Chrna4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	151	1.271523	0.2815232	0.8445697
Treatment	Treatment	1	12	0	247	0.000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	0	247	0.000000	1.0000000	1.0000000

Ankrd45

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257
Treatment	Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257
Time:Treatment	Time:Treatment	1	12	0.00	249.0	0.0000000	1.0000000	1.0000000

Csrnp3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Tmem54

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	302.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	12.25	287.5	0.5113043	0.4882538	0.7323807
Time:Treatment	Time:Treatment	1	12	12.25	287.5	0.5113043	0.4882538	0.7323807

Mapk10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	258.5	2.2746615	0.1573727	0.2360591
Treatment	Treatment	1	12	6.25	278.5	0.2692998	0.6132381	0.6132381
Time:Treatment	Time:Treatment	1	12	64.00	235.0	3.2680851	0.0957538	0.2360591

lightskyblue4

Slc26a4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Ccdc108

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Cntnap5a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

March10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Speer7-ps1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Hpcal4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	221.5	0.6636569	0.4311428	0.4311428
Treatment	Treatment	1	12	30.25	203.5	1.7837838	0.2064656	0.4311428
Time:Treatment	Time:Treatment	1	12	12.25	221.5	0.6636569	0.4311428	0.4311428

2700046A07Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257
Treatment	Treatment	1	12	0.00	249.0	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257

Ndst3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	254	0.2952756	0.5968096	0.8388983
Treatment	Treatment	1	12	1.00	278	0.0431655	0.8388983	0.8388983
Time:Treatment	Time:Treatment	1	12	4.00	263	0.1825095	0.6767906	0.8388983

Rnf112

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	249.5	2.032064	0.1795011	0.2418618
Treatment	Treatment	1	12	30.25	239.5	1.515658	0.2418618	0.2418618
Time:Treatment	Time:Treatment	1	12	64.00	212.0	3.622641	0.0812555	0.2418618

C130071C03Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	216	0	1.0000000	1.0000000
Treatment	Treatment	1	12	0	216	0	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	16	96	2	0.1827168	0.5481503

mediumpurple

Zic1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm14492

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Lingo3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

2310016G11Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Dio3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm4524

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm16754

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Col9a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Col2a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	249.0	0.0481928	0.8299282	0.8299282
Treatment	Treatment	1	12	4	228.5	0.2100656	0.6549053	0.8299282
Time:Treatment	Time:Treatment	1	12	9	211.5	0.5106383	0.4885314	0.8299282

Col24a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	266.5	0.0112570	0.9172567	0.9172567
Treatment	Treatment	1	12	4.00	217.0	0.2211982	0.6465613	0.9172567
Time:Treatment	Time:Treatment	1	12	0.25	266.5	0.0112570	0.9172567	0.9172567

indianred2

Cntn5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Mrap2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Zfp352

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Diras1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	227	0.845815	0.3758563	0.3758563
Treatment	Treatment	1	12	20.25	214	1.135514	0.3075736	0.3758563
Time:Treatment	Time:Treatment	1	12	42.25	201	2.522388	0.1382258	0.3758563

Slc10a4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Grm7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Abcc12

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	247.5	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	16	151.5	1.267327	0.2822802	0.8468407
Time:Treatment	Time:Treatment	1	12	0	247.5	0.000000	1.0000000	1.0000000

Nepn

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627

Dcx

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	241	1.506224	0.2432490	0.2432490
Treatment	Treatment	1	12	64.00	191	4.020942	0.0680279	0.2040837
Time:Treatment	Time:Treatment	1	12	30.25	241	1.506224	0.2432490	0.2432490

Arntl2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	281.5	0.5222025	0.48375	0.957465
Treatment	Treatment	1	12	6.25	322.5	0.2325581	0.63831	0.957465
Time:Treatment	Time:Treatment	1	12	0.00	276.0	0.0000000	1.00000	1.000000

royalblue3

Wif1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Acot3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Arhgap36

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Nxph4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Ppp1r3g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm14097

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Kcna4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	188	1.021277	0.3321600	0.33216
Treatment	Treatment	1	12	16	186	1.032258	0.3296766	0.33216
Time:Treatment	Time:Treatment	1	12	16	180	1.066667	0.3220661	0.33216

Wdr17

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	266.5	0.0112570	0.9172567	0.9172567
Treatment	Treatment	1	12	0.25	266.5	0.0112570	0.9172567	0.9172567
Time:Treatment	Time:Treatment	1	12	4.00	217.0	0.2211982	0.6465613	0.9172567

Scaf1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	291.5	0.8336192	0.3792066	0.5688099
Treatment	Treatment	1	12	0.00	307.5	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	20.25	274.5	0.8852459	0.3653241	0.5688099

Rab40b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	306.5	0.0391517	0.8464607	0.9233212
Treatment	Treatment	1	12	6.25	296.5	0.2529511	0.6241081	0.9233212
Time:Treatment	Time:Treatment	1	12	0.25	310.5	0.0096618	0.9233212	0.9233212

cornflowerblue

Rpl32

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	1.0000000
Treatment	Treatment	1	12	0.00	335.0	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	36.00	303.5	1.4233937	0.2559012	0.7677036

Rpl23a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	333.5	0.0089955	0.9260036	0.9263331
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Time:Treatment	Time:Treatment	1	12	30.25	305.5	1.1882160	0.2970951	0.8912852

Rps23-ps

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	338.5	0.0354505	0.8538013	0.8538013
Treatment	Treatment	1	12	1	338.0	0.0355030	0.8536945	0.8538013
Time:Treatment	Time:Treatment	1	12	49	291.0	2.0206186	0.1806405	0.5419216

Rps7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	323.0	0.5944272	0.4556254	0.7818029
Treatment	Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Rpl38

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	327.5	0.0824427	0.7789118	0.7789118
Treatment	Treatment	1	12	9.00	318.5	0.3390895	0.5711345	0.7789118
Time:Treatment	Time:Treatment	1	12	30.25	303.5	1.1960461	0.2955811	0.7789118

Rpl18a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	324.5	0.4530046	0.5136651	0.7818029
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Time:Treatment	Time:Treatment	1	12	9.00	326.5	0.3307810	0.5758249	0.7818029

Rps17

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	337.5	0.000000	1.0000000	1.000000
Treatment	Treatment	1	12	4.00	335.5	0.143070	0.7118542	1.000000
Time:Treatment	Time:Treatment	1	12	56.25	282.5	2.389381	0.1481160	0.444348

Rpl21

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	332.5	0.2255639	0.6433598	0.8536945
Treatment	Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945
Time:Treatment	Time:Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945

Rpl23

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	297.0	1.0101010	0.3347151	0.443306
Treatment	Treatment	1	12	16.00	305.5	0.6284779	0.4433060	0.443306
Time:Treatment	Time:Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.443306

Rpl22

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	340.0	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	42.25	295.5	1.715736	0.2147645	0.3221468
Time:Treatment	Time:Treatment	1	12	81.00	250.0	3.888000	0.0721303	0.2163910

pink2

Tssk1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Lrp1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	185	1.037838	0.3284251	0.3284251
Treatment	Treatment	1	12	16	185	1.037838	0.3284251	0.3284251
Time:Treatment	Time:Treatment	1	12	16	153	1.254902	0.2845381	0.3284251

Tmem145

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627

Syndig1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	196.5	3.908397	0.0714818	0.0714818
Treatment	Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818
Time:Treatment	Time:Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818

Ttc18

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	243.0	3.160494	0.1007684	0.1010811
Treatment	Treatment	1	12	64	243.5	3.154004	0.1010811	0.1010811
Time:Treatment	Time:Treatment	1	12	64	243.5	3.154004	0.1010811	0.1010811

Sox2ot

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	234.5	1.2793177	0.2801246	0.4201869
Treatment	Treatment	1	12	2.25	260.0	0.1038462	0.7528069	0.7528069
Time:Treatment	Time:Treatment	1	12	49.00	258.5	2.2746615	0.1573727	0.4201869

Tgm7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	293.5	0.0408859	0.8431459	0.8431459
Treatment	Treatment	1	12	16	283.5	0.6772487	0.4265876	0.8431459
Time:Treatment	Time:Treatment	1	12	1	293.5	0.0408859	0.8431459	0.8431459

Cplx1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	270.5	1.5970425	0.2303214	0.4907502
Treatment	Treatment	1	12	25	287.5	1.0434783	0.3271668	0.4907502
Time:Treatment	Time:Treatment	1	12	4	310.0	0.1548387	0.7008554	0.7008554

Gm13075

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	327	0.0825688	0.7787478	0.7787478
Treatment	Treatment	1	12	110.25	204	6.4852941	0.0256243	0.0768729
Time:Treatment	Time:Treatment	1	12	36.00	282	1.5319149	0.2394958	0.3592437

Clvs1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	290.0	1.748276	0.2107426	0.2874815
Treatment	Treatment	1	12	30.25	293.0	1.238908	0.2874815	0.2874815
Time:Treatment	Time:Treatment	1	12	81.00	249.5	3.895792	0.0718818	0.2156453

indianred1

Upk3b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	337.5	0.0800000	0.7821172	0.9266583
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Upk1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.143070	0.7118542	0.7821172
Treatment	Treatment	1	12	42.25	297.5	1.704202	0.2162143	0.6486430
Time:Treatment	Time:Treatment	1	12	2.25	337.5	0.080000	0.7821172	0.7821172

Igfbp6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.143070	0.7118542	0.7821172
Treatment	Treatment	1	12	2.25	337.5	0.080000	0.7821172	0.7821172
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.143928	0.7110350	0.7821172

Krt19

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	324.5	0.4530046	0.5136651	0.7704976
Treatment	Treatment	1	12	49.00	290.5	2.0240964	0.1802933	0.5408800
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Lrrn4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.0	0.1432836	0.7116500	0.71165
Treatment	Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.71165
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.71165

Cldn15

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	317.5	0.7653543	0.3988298	0.7093755
Treatment	Treatment	1	12	4.00	329.5	0.1456753	0.7093755	0.7093755
Time:Treatment	Time:Treatment	1	12	4.00	327.5	0.1465649	0.7085349	0.7093755

Msln

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	320.0	0.6000000	0.4535705	0.6803558
Treatment	Treatment	1	12	56.25	283.5	2.3809524	0.1487723	0.4463168
Time:Treatment	Time:Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7112404

Gpm6a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	339	0.0353982	0.8539077	1
Treatment	Treatment	1	12	0	331	0.0000000	1.0000000	1
Time:Treatment	Time:Treatment	1	12	9	322	0.3354037	0.5732055	1

Fmo2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	333.5	0.2248876	0.6438533	0.9265504
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.9265504

Wnt2b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	320.0	0.6000000	0.4535705	0.6803558
Treatment	Treatment	1	12	4.00	332.0	0.1445783	0.7104160	0.7104160
Time:Treatment	Time:Treatment	1	12	20.25	313.5	0.7751196	0.3959282	0.6803558

lightblue2

Sall3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	216	0	1.0000000	1.0000000
Treatment	Treatment	1	12	0	216	0	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	16	96	2	0.1827168	0.5481503

Stk32b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627

Grm1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	270	0.1777778	0.6807446	1
Treatment	Treatment	1	12	0	266	0.0000000	1.0000000	1
Time:Treatment	Time:Treatment	1	12	0	305	0.0000000	1.0000000	1

Olfm3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	275	1.320000	0.2729778	0.2729778
Treatment	Treatment	1	12	30.25	275	1.320000	0.2729778	0.2729778
Time:Treatment	Time:Treatment	1	12	64.00	191	4.020942	0.0680279	0.2040837

Gm973

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	309.0	0.6213592	0.4458356	0.4458356
Treatment	Treatment	1	12	49.00	271.5	2.1657459	0.1668500	0.2502751
Time:Treatment	Time:Treatment	1	12	110.25	226.0	5.8539823	0.0323469	0.0970408

Gm13378

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	275.5	0.8820327	0.3661657	0.9251028
Treatment	Treatment	1	12	0.25	325.5	0.0092166	0.9251028	0.9251028
Time:Treatment	Time:Treatment	1	12	0.25	320.5	0.0093604	0.9245228	0.9251028

Nr3c2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	306.5	1.1843393	0.2978486	0.4467730
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	49.00	276.5	2.1265823	0.1704349	0.4467730

Gm16283

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	314.0	0.955414	0.3476395	0.5214593
Treatment	Treatment	1	12	4.00	335.5	0.143070	0.7118542	0.7118542
Time:Treatment	Time:Treatment	1	12	132.25	194.5	8.159383	0.0144484	0.0433451

Megf10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	327.5	0.0824427	0.7789118	0.7818029
Treatment	Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Slc1a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	264	3.2840909	0.0950343	0.1425514
Treatment	Treatment	1	12	20.25	318	0.7641509	0.3991896	0.3991896
Time:Treatment	Time:Treatment	1	12	81.00	256	3.7968750	0.0751164	0.1425514

---

Analysis performed by Ann Wells

The Carter Lab The Jackson Laboratory 2023

ann.wells@jax.org