tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))
tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))
log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)
log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()
log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5]
log.tdata.FPKM.sample.info.subset <- cbind(log.tdata.FPKM.subset,tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info.subset <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()
log.tdata.FPKM.sample.info.subset.kidney <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(Tissue == "Kidney") %>% column_to_rownames()
module.labels <- readRDS(here("Data","Kidney","log.tdata.FPKM.sample.info.subset.kidney.WGCNA.module.labels.RData"))
modules <- readRDS(here("Data","Kidney","log.tdata.FPKM.sample.info.subset.kidney.WGCNA.module.membership.RData"))
net.deg <- readRDS(here("Data","Kidney","Chang_2DG_BL6_connectivity_kidney.RData"))
ensembl.location <- readRDS(here("Data","Ensembl_gene_id_and_location.RData"))
Hub Genes
Hub genes are genes in the module network that have the highest connectivity. For instance, if the gene significance of a particular module is associated with treatment the hub genes in this module are likely associated with this trait.
hub.genes.list <- hub.genes(net.deg,module.labels,modules,ensembl.location)
Cyan Module
DT.table.hub(hub.genes.list[[1]])
Blue Module
DT.table.hub(hub.genes.list[[2]])
Red Module
DT.table.hub(hub.genes.list[[3]])
Pink Module
DT.table.hub(hub.genes.list[[4]])
Magenta Module
DT.table.hub(hub.genes.list[[5]])
Darkred Module
DT.table.hub(hub.genes.list[[6]])
Midnightblue Module
DT.table.hub(hub.genes.list[[7]])
Purple Module
DT.table.hub(hub.genes.list[[8]])
Greenyellow Module
DT.table.hub(hub.genes.list[[9]])
Salmon Module
DT.table.hub(hub.genes.list[[10]])
Lightcyan Module
DT.table.hub(hub.genes.list[[11]])
Grey60 Module
DT.table.hub(hub.genes.list[[12]])
Lightgreen Module
DT.table.hub(hub.genes.list[[13]])
Lightyellow Module
DT.table.hub(hub.genes.list[[14]])
Darkgreen Module
DT.table.hub(hub.genes.list[[15]])
Darkturquoise Module
DT.table.hub(hub.genes.list[[16]])
Darkgrey Module
DT.table.hub(hub.genes.list[[17]])
ANOVA
To perform analysis of variance Aligned Rank Transformation was performed, which is designed to handle non-parametric multi-factorial experiments. P-value was adjusted using Benjamini-hochberg procedure. Only the top 10 hub genes are listed.
log.tdata.FPKM.sample.info.subset.kidney$Time <- as.factor(log.tdata.FPKM.sample.info.subset.kidney$Time)
log.tdata.FPKM.sample.info.subset.kidney$Treatment <- as.factor(log.tdata.FPKM.sample.info.subset.kidney$Treatment)
for(m in module.labels) {
name <- str_split(m,"_")[[1]][2]
hub.met <- net.deg[modules$Gene,] %>%
dplyr::mutate(Gene=modules$Gene) %>%
dplyr::filter(modules$Module == m) %>%
dplyr::arrange(desc(kWithin)) %>%
dplyr::select(Gene, kWithin)
gene <- ensembl.location$external_gene_name[match(hub.met$Gene,ensembl.location$ensembl_gene_id)]
hub.met <- cbind(gene,hub.met)
cat("\n###",name, "{.tabset .tabset-fade .tabset-pills}","\n")
for(i in 1:10){
cat("\n####",hub.met$gene[i],"\n")
m <- art(data = log.tdata.FPKM.sample.info.subset.kidney, log.tdata.FPKM.sample.info.subset.kidney[,hub.met$Gene[i]] ~ Time*Treatment)
model <- anova(m)
adjust <- p.adjust(model$`Pr(>F)`, method = "BH")
print(knitr::kable(cbind(model,adjust)) %>%
column_spec(8, color = "white", background = spec_color(adjust, end = 0.05, scale_from = c(0,0.05))) %>% kable_styling(bootstrap_options = c("striped", "hover", "responsive")))
cat("\n \n")
}
cat("\n \n")
}
cyan
Sf3b2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
49.00
291.0
2.0206186
0.1806405
0.5419216
Treatment
Treatment
1
12
12.25
325.5
0.4516129
0.5143008
0.6433598
Time:Treatment
Time:Treatment
1
12
6.25
332.5
0.2255639
0.6433598
0.6433598
Zdhhc5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
323.5
0.5935085
0.4559656
0.7120579
Treatment
Treatment
1
12
9
331.0
0.3262840
0.5783968
0.7120579
Time:Treatment
Time:Treatment
1
12
4
336.0
0.1428571
0.7120579
0.7120579
Gnai2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
326.5
0.4502297
0.5149340
0.71165
Treatment
Treatment
1
12
12.25
327.5
0.4488550
0.5155648
0.71165
Time:Treatment
Time:Treatment
1
12
4.00
335.0
0.1432836
0.7116500
0.71165
Rab5b
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16.00
324.0
0.5925926
0.4563052
0.7818029
Treatment
Treatment
1
12
6.25
333.5
0.2248876
0.6438533
0.7818029
Time:Treatment
Time:Treatment
1
12
2.25
336.5
0.0802377
0.7818029
0.7818029
Pcnx
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
36.00
304.0
1.4210526
0.2562716
0.6438533
Treatment
Treatment
1
12
12.25
327.5
0.4488550
0.5155648
0.6438533
Time:Treatment
Time:Treatment
1
12
6.25
333.5
0.2248876
0.6438533
0.6438533
Ube2v1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
20.25
318.5
0.7629513
0.3995488
1
Treatment
Treatment
1
12
2.25
336.5
0.0802377
0.7818029
1
Time:Treatment
Time:Treatment
1
12
0.00
339.5
0.0000000
1.0000000
1
Ctdsp1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
30.25
308.5
1.1766613
0.2993491
0.6433598
Treatment
Treatment
1
12
12.25
326.5
0.4502297
0.5149340
0.6433598
Time:Treatment
Time:Treatment
1
12
6.25
332.5
0.2255639
0.6433598
0.6433598
Zdhhc9
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
25.00
314.5
0.9538951
0.3480088
0.9266583
Treatment
Treatment
1
12
6.25
333.5
0.2248876
0.6438533
0.9266583
Time:Treatment
Time:Treatment
1
12
0.25
339.5
0.0088365
0.9266583
0.9266583
Slc38a10
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
25.00
314.5
0.9538951
0.3480088
0.4002654
Treatment
Treatment
1
12
20.25
319.5
0.7605634
0.4002654
0.4002654
Time:Treatment
Time:Treatment
1
12
20.25
318.5
0.7629513
0.3995488
0.4002654
Sgta
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64
271.0
2.8339483
0.1181034
0.3543103
Treatment
Treatment
1
12
9
328.5
0.3287671
0.5769737
0.5783968
Time:Treatment
Time:Treatment
1
12
9
331.0
0.3262840
0.5783968
0.5783968
blue
Puf60
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
56.25
283.5
2.3809524
0.1487723
0.4463168
Treatment
Treatment
1
12
9.00
330.5
0.3267776
0.5781134
0.8538013
Time:Treatment
Time:Treatment
1
12
1.00
338.5
0.0354505
0.8538013
0.8538013
Ergic3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
275.5
2.7876588
0.1208505
0.3625516
Treatment
Treatment
1
12
20.25
318.5
0.7629513
0.3995488
0.5993232
Time:Treatment
Time:Treatment
1
12
2.25
334.5
0.0807175
0.7811702
0.7811702
Atg4d
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
275.0
2.7927273
0.1205459
0.3616377
Treatment
Treatment
1
12
25.00
312.5
0.9600000
0.3465280
0.5197919
Time:Treatment
Time:Treatment
1
12
0.25
339.5
0.0088365
0.9266583
0.9266583
Actr1a
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
276.0
2.7826087
0.1211550
0.3634650
Treatment
Treatment
1
12
30.25
308.5
1.1766613
0.2993491
0.4490236
Time:Treatment
Time:Treatment
1
12
9.00
330.0
0.3272727
0.5778293
0.5778293
Maea
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
100.00
237.5
5.0526316
0.0441715
0.1325146
Treatment
Treatment
1
12
25.00
310.0
0.9677419
0.3446632
0.5169948
Time:Treatment
Time:Treatment
1
12
2.25
328.5
0.0821918
0.7792387
0.7792387
Tspan33
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
49
288.5
2.0381282
0.1789011
0.5367034
Treatment
Treatment
1
12
16
324.0
0.5925926
0.4563052
0.6844579
Time:Treatment
Time:Treatment
1
12
4
335.0
0.1432836
0.7116500
0.7116500
Ddb1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
276.0
2.7826087
0.1211550
0.3634650
Treatment
Treatment
1
12
16.00
323.0
0.5944272
0.4556254
0.6834380
Time:Treatment
Time:Treatment
1
12
2.25
336.5
0.0802377
0.7818029
0.7818029
Aldh1l1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
276.0
2.7826087
0.1211550
0.3634650
Treatment
Treatment
1
12
12.25
327.5
0.4488550
0.5155648
0.7733472
Time:Treatment
Time:Treatment
1
12
2.25
336.5
0.0802377
0.7818029
0.7818029
Smim12
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
56.25
282.5
2.3893805
0.1481160
0.4443480
Treatment
Treatment
1
12
20.25
318.5
0.7629513
0.3995488
0.5993232
Time:Treatment
Time:Treatment
1
12
1.00
339.0
0.0353982
0.8539077
0.8539077
Copg1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
49.00
290.0
2.0275862
0.1799458
0.4563052
Treatment
Treatment
1
12
20.25
317.5
0.7653543
0.3988298
0.4563052
Time:Treatment
Time:Treatment
1
12
16.00
324.0
0.5925926
0.4563052
0.4563052
red
Gm12481
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
316.5
0.4644550
0.5084887
0.6930299
Treatment
Treatment
1
12
4.00
293.5
0.1635434
0.6930299
0.6930299
Time:Treatment
Time:Treatment
1
12
12.25
303.5
0.4843493
0.4997165
0.6930299
Rpl36
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1
316.5
0.0379147
0.8488722
0.8488722
Treatment
Treatment
1
12
1
298.0
0.0402685
0.8443175
0.8488722
Time:Treatment
Time:Treatment
1
12
1
310.0
0.0387097
0.8473178
0.8488722
Hint2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.00
337.5
0.0000000
1.000000
1
Treatment
Treatment
1
12
0.25
318.5
0.0094192
0.924287
1
Time:Treatment
Time:Treatment
1
12
6.25
322.5
0.2325581
0.638310
1
Atox1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
2.25
334.5
0.0807175
0.7811702
1
Treatment
Treatment
1
12
0.00
333.5
0.0000000
1.0000000
1
Time:Treatment
Time:Treatment
1
12
4.00
327.0
0.1467890
0.7083237
1
Atp6v1f
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1
318.5
0.0376766
0.8493410
0.849341
Treatment
Treatment
1
12
4
321.5
0.1493002
0.7059689
0.849341
Time:Treatment
Time:Treatment
1
12
16
321.5
0.5972006
0.4546008
0.849341
Aprt
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4.00
333.5
0.1439280
0.7110350
1
Treatment
Treatment
1
12
6.25
327.5
0.2290076
0.6408615
1
Time:Treatment
Time:Treatment
1
12
0.00
332.0
0.0000000
1.0000000
1
Smim22
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1.00
318.5
0.0376766
0.8493410
0.849341
Treatment
Treatment
1
12
1.00
318.5
0.0376766
0.8493410
0.849341
Time:Treatment
Time:Treatment
1
12
2.25
335.5
0.0804769
0.7814873
0.849341
Psmb4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16.00
317.5
0.6047244
0.4518406
0.9246399
Treatment
Treatment
1
12
2.25
309.5
0.0872375
0.7727672
0.9246399
Time:Treatment
Time:Treatment
1
12
0.25
321.5
0.0093313
0.9246399
0.9246399
Tmem205
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1.00
330.5
0.0363086
0.8520652
1
Treatment
Treatment
1
12
0.00
330.0
0.0000000
1.0000000
1
Time:Treatment
Time:Treatment
1
12
2.25
336.5
0.0802377
0.7818029
1
Khk
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
6.25
329.5
0.2276176
0.6418671
1
Treatment
Treatment
1
12
0.00
336.0
0.0000000
1.0000000
1
Time:Treatment
Time:Treatment
1
12
1.00
335.0
0.0358209
0.8530493
1
pink
Cyp2c50
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
72.25
252.5
3.4336634
0.0886202
0.1329304
Treatment
Treatment
1
12
20.25
291.5
0.8336192
0.3792066
0.3792066
Time:Treatment
Time:Treatment
1
12
72.25
252.5
3.4336634
0.0886202
0.1329304
Mat1a
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
100.00
221.5
5.417607
0.0382383
0.0698179
Treatment
Treatment
1
12
42.25
276.0
1.836957
0.2002703
0.2002703
Time:Treatment
Time:Treatment
1
12
90.25
220.0
4.922727
0.0465453
0.0698179
Serpind1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
121.00
194.0
7.484536
0.0180718
0.0542153
Treatment
Treatment
1
12
42.25
269.5
1.881262
0.1952918
0.1952918
Time:Treatment
Time:Treatment
1
12
90.25
234.5
4.618337
0.0527344
0.0791015
Otc
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
225
3.413333
0.0894602
0.1341903
Treatment
Treatment
1
12
36.00
231
1.870130
0.1965274
0.1965274
Time:Treatment
Time:Treatment
1
12
72.25
212
4.089623
0.0660193
0.1341903
Mug2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
100.00
211
5.687204
0.0344611
0.0516917
Treatment
Treatment
1
12
30.25
279
1.301075
0.2762708
0.2762708
Time:Treatment
Time:Treatment
1
12
100.00
195
6.153846
0.0289212
0.0516917
Apof
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
110.25
221.5
5.9729120
0.0309334
0.0626066
Treatment
Treatment
1
12
20.25
297.5
0.8168067
0.3839000
0.3839000
Time:Treatment
Time:Treatment
1
12
100.00
231.0
5.1948052
0.0417377
0.0626066
Cps1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
72.25
251.5
3.447316
0.0880616
0.1320923
Treatment
Treatment
1
12
6.25
312.5
0.240000
0.6330400
0.6330400
Time:Treatment
Time:Treatment
1
12
121.00
214.0
6.785047
0.0230208
0.0690623
Tdo2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
49.00
264.5
2.2230624
0.1617749
0.2426624
Treatment
Treatment
1
12
12.25
304.5
0.4827586
0.5004078
0.5004078
Time:Treatment
Time:Treatment
1
12
64.00
241.5
3.1801242
0.0998299
0.2426624
Tat
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
121.00
173.5
8.368876
0.0135032
0.019983
Treatment
Treatment
1
12
110.25
184.0
7.190217
0.0199830
0.019983
Time:Treatment
Time:Treatment
1
12
132.25
165.0
9.618182
0.0091675
0.019983
Serpina3n
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
100
190
6.315790
0.0272511
0.0817534
Treatment
Treatment
1
12
64
215
3.572093
0.0831498
0.0831498
Time:Treatment
Time:Treatment
1
12
64
215
3.572093
0.0831498
0.0831498
magenta
Hecw1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Asphd2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gipr
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Slc38a5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Grpr
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Myo16
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Chad
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
2700046A07Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Klhl40
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Myoz1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16.00
247.0
0.7773279
0.3952765
0.5929148
Treatment
Treatment
1
12
16.00
243.5
0.7885010
0.3920048
0.5929148
Time:Treatment
Time:Treatment
1
12
6.25
297.0
0.2525253
0.6243971
0.6243971
darkred
Bcat1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.25
330.5
0.0090772
0.9256696
0.9256696
Treatment
Treatment
1
12
0.25
330.5
0.0090772
0.9256696
0.9256696
Time:Treatment
Time:Treatment
1
12
30.25
309.5
1.1728595
0.3000959
0.9002878
Mpped1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.00
337.5
0.0000000
1.0000000
1.0000000
Treatment
Treatment
1
12
42.25
291.5
1.7392796
0.2118446
0.5971623
Time:Treatment
Time:Treatment
1
12
20.25
316.5
0.7677725
0.3981082
0.5971623
Tspan13
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4.00
332.0
0.1445783
0.7104160
0.9263331
Treatment
Treatment
1
12
0.25
336.5
0.0089153
0.9263331
0.9263331
Time:Treatment
Time:Treatment
1
12
42.25
297.5
1.7042017
0.2162143
0.6486430
Wasf3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
2.25
336.5
0.0802377
0.7818029
0.9265504
Treatment
Treatment
1
12
0.25
338.5
0.0088626
0.9265504
0.9265504
Time:Treatment
Time:Treatment
1
12
16.00
314.0
0.6114650
0.4493913
0.9265504
Wnt7b
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.25
326.5
0.0091884
0.9252172
0.9252172
Treatment
Treatment
1
12
64.00
271.0
2.8339483
0.1181034
0.3543103
Time:Treatment
Time:Treatment
1
12
12.25
311.5
0.4719101
0.5051691
0.7577537
Esrp1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1.00
338.0
0.0355030
0.8536945
1
Treatment
Treatment
1
12
0.00
339.5
0.0000000
1.0000000
1
Time:Treatment
Time:Treatment
1
12
12.25
323.5
0.4544049
0.5130269
1
Col23a1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.00
339.0
0.0000000
1.0000000
1.0000000
Treatment
Treatment
1
12
1.00
339.0
0.0353982
0.8539077
1.0000000
Time:Treatment
Time:Treatment
1
12
30.25
300.5
1.2079867
0.2932931
0.8798793
Ceacam2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
320.5
0.4586583
0.5110972
0.7666459
Treatment
Treatment
1
12
0.00
337.5
0.0000000
1.0000000
1.0000000
Time:Treatment
Time:Treatment
1
12
36.00
303.5
1.4233937
0.2559012
0.7666459
Ppp1r1b
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
326.5
0.4502297
0.5149340
0.5149340
Treatment
Treatment
1
12
12.25
325.5
0.4516129
0.5143008
0.5149340
Time:Treatment
Time:Treatment
1
12
56.25
280.5
2.4064171
0.1468005
0.4404016
Ghr
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1.00
338.5
0.0354505
0.8538013
0.8538013
Treatment
Treatment
1
12
6.25
327.5
0.2290076
0.6408615
0.8538013
Time:Treatment
Time:Treatment
1
12
30.25
309.5
1.1728595
0.3000959
0.8538013
midnightblue
Zmat2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
269.5
2.8497217
0.1171851
0.2556523
Treatment
Treatment
1
12
49.00
276.5
2.1265823
0.1704349
0.2556523
Time:Treatment
Time:Treatment
1
12
12.25
320.5
0.4586583
0.5110972
0.5110972
Atp6v1d
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
90.25
249.5
4.340681
0.0592616
0.1777848
Treatment
Treatment
1
12
64.00
273.5
2.808044
0.1196311
0.1794466
Time:Treatment
Time:Treatment
1
12
30.25
306.5
1.184339
0.2978486
0.2978486
Pls1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
275.5
2.7876588
0.1208505
0.3625516
Treatment
Treatment
1
12
20.25
315.5
0.7702060
0.3973841
0.5960761
Time:Treatment
Time:Treatment
1
12
6.25
332.5
0.2255639
0.6433598
0.6433598
Tceal8
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
90.25
247.5
4.375758
0.0583853
0.087578
Treatment
Treatment
1
12
110.25
228.5
5.789934
0.0331400
0.087578
Time:Treatment
Time:Treatment
1
12
0.00
338.0
0.000000
1.0000000
1.000000
Zfp125
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
49
286.0
2.055944
0.1771533
0.26573
Treatment
Treatment
1
12
64
275.0
2.792727
0.1205459
0.26573
Time:Treatment
Time:Treatment
1
12
0
339.5
0.000000
1.0000000
1.00000
Cdc42
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
42.25
294.5
1.721562
0.2140371
0.2162143
Treatment
Treatment
1
12
42.25
297.5
1.704202
0.2162143
0.2162143
Time:Treatment
Time:Treatment
1
12
42.25
297.5
1.704202
0.2162143
0.2162143
Gm21917
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
30.25
303.0
1.198020
0.2952012
0.4428018
Treatment
Treatment
1
12
36.00
301.5
1.432836
0.2544148
0.4428018
Time:Treatment
Time:Treatment
1
12
4.00
333.5
0.143928
0.7110350
0.7110350
Swi5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
20.25
318.5
0.7629513
0.3995488
0.5993232
Treatment
Treatment
1
12
20.25
318.5
0.7629513
0.3995488
0.5993232
Time:Treatment
Time:Treatment
1
12
4.00
335.5
0.1430700
0.7118542
0.7118542
Angptl3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4.00
329.5
0.1456753
0.7093755
0.7093755
Treatment
Treatment
1
12
81.00
250.5
3.8802395
0.0723790
0.2171369
Time:Treatment
Time:Treatment
1
12
20.25
313.5
0.7751196
0.3959282
0.5938923
Arhgap5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
56.25
282.5
2.389381
0.1481160
0.2154903
Treatment
Treatment
1
12
110.25
229.5
5.764706
0.0334588
0.1003764
Time:Treatment
Time:Treatment
1
12
42.25
296.5
1.709949
0.2154903
0.2154903
purple
F13a1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16.00
303
0.6336634
0.4414782
0.6622172
Treatment
Treatment
1
12
64.00
225
3.4133333
0.0894602
0.2683806
Time:Treatment
Time:Treatment
1
12
2.25
325
0.0830769
0.7780881
0.7780881
Serpina3c
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
30.25
279.5
1.298748
0.2766796
0.2766796
Treatment
Treatment
1
12
64.00
219.5
3.498861
0.0859907
0.2579721
Time:Treatment
Time:Treatment
1
12
30.25
279.5
1.298748
0.2766796
0.2766796
Plin4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4.00
307.0
0.1563518
0.6994770
0.7691241
Treatment
Treatment
1
12
64.00
261.5
2.9369025
0.1122659
0.3367976
Time:Treatment
Time:Treatment
1
12
2.25
299.5
0.0901503
0.7691241
0.7691241
Slpi
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16.00
294.5
0.6519525
0.4351287
0.6327704
Treatment
Treatment
1
12
56.25
255.0
2.6470588
0.1296965
0.3890894
Time:Treatment
Time:Treatment
1
12
6.25
312.0
0.2403846
0.6327704
0.6327704
Lyve1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
320.5
0.4586583
0.5110972
0.5110972
Treatment
Treatment
1
12
182.25
152.5
14.3409836
0.0025906
0.0077718
Time:Treatment
Time:Treatment
1
12
25.00
301.5
0.9950249
0.3382073
0.5073110
Vit
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1
324.0
0.037037
0.8506081
0.8506081
Treatment
Treatment
1
12
81
252.0
3.857143
0.0731251
0.2193752
Time:Treatment
Time:Treatment
1
12
9
312.5
0.345600
0.5675132
0.8506081
Msln
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
36.00
253.5
1.7041420
0.2162219
0.3243328
Treatment
Treatment
1
12
42.25
268.5
1.8882682
0.1945193
0.3243328
Time:Treatment
Time:Treatment
1
12
2.25
292.5
0.0923077
0.7664673
0.7664673
Adipoq
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
311.5
0.4719101
0.5051691
0.5051691
Treatment
Treatment
1
12
64.00
241.0
3.1867220
0.0995168
0.2985505
Time:Treatment
Time:Treatment
1
12
36.00
284.5
1.5184534
0.2414527
0.3621790
Slc7a10
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
297
0.6464646
0.4370182
0.4370182
Treatment
Treatment
1
12
64
201
3.8208955
0.0743149
0.2229448
Time:Treatment
Time:Treatment
1
12
16
297
0.6464646
0.4370182
0.4370182
Clec3b
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.00
325.5
0.0000000
1.0000000
1.0000000
Treatment
Treatment
1
12
210.25
129.5
19.4826255
0.0008445
0.0025336
Time:Treatment
Time:Treatment
1
12
0.25
321.5
0.0093313
0.9246399
1.0000000
greenyellow
Elavl2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
174
1.103448
0.3142057
0.3142057
Treatment
Treatment
1
12
16
150
1.280000
0.2800026
0.3142057
Time:Treatment
Time:Treatment
1
12
16
174
1.103448
0.3142057
0.3142057
Fsd1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Jph3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Dach2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Arhgap36
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
D830039M14Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm17382
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Sntg1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16.00
177.0
1.0847458
0.3181679
0.6524285
Treatment
Treatment
1
12
4.00
225.0
0.2133333
0.6524285
0.6524285
Time:Treatment
Time:Treatment
1
12
6.25
214.5
0.3496503
0.5652838
0.6524285
Gpr123
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.25
282
0.0106383
0.9195538
0.9195538
Treatment
Treatment
1
12
20.25
250
0.9720000
0.3436439
0.6948138
Time:Treatment
Time:Treatment
1
12
12.25
256
0.5742188
0.4632092
0.6948138
Gabra1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
9
211.5
0.5106383
0.4885314
0.6569868
Treatment
Treatment
1
12
4
231.5
0.2073434
0.6569868
0.6569868
Time:Treatment
Time:Treatment
1
12
16
189.5
1.0131926
0.3340054
0.6569868
salmon
Grp
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Cntnap4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Cdhr3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
March4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
B430212C06Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Vps13d
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Scn9a
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Trim30c
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm16067
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
9.00
217.5
0.4965517
0.4944689
0.5739555
Treatment
Treatment
1
12
6.25
224.5
0.3340757
0.5739555
0.5739555
Time:Treatment
Time:Treatment
1
12
16.00
187.0
1.0267380
0.3309216
0.5739555
Gal3st4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4
222
0.2162162
0.6502627
0.6502627
Treatment
Treatment
1
12
4
222
0.2162162
0.6502627
0.6502627
Time:Treatment
Time:Treatment
1
12
16
150
1.2800000
0.2800026
0.6502627
lightcyan
Sacm1l
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
49
290.5
2.0240964
0.1802933
0.2704400
Treatment
Treatment
1
12
100
239.5
5.0104384
0.0449263
0.1347788
Time:Treatment
Time:Treatment
1
12
4
329.5
0.1456753
0.7093755
0.7093755
Tra2a
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
36.00
301.5
1.4328358
0.2544148
0.3816222
Treatment
Treatment
1
12
132.25
207.5
7.6481928
0.0171028
0.0513084
Time:Treatment
Time:Treatment
1
12
1.00
330.5
0.0363086
0.8520652
0.8520652
Phf20l1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
20.25
318.5
0.7629513
0.3995488
0.5993232
Treatment
Treatment
1
12
132.25
207.5
7.6481928
0.0171028
0.0513084
Time:Treatment
Time:Treatment
1
12
0.25
338.5
0.0088626
0.9265504
0.9265504
Xiap
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
274.0
2.8029197
0.1199362
0.1799043
Treatment
Treatment
1
12
110.25
223.5
5.9194631
0.0315594
0.0946781
Time:Treatment
Time:Treatment
1
12
25.00
311.0
0.9646302
0.3454109
0.3454109
Ugt8a
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.25
339.5
0.0088365
0.9266583
1.0000000
Treatment
Treatment
1
12
90.25
238.5
4.5408805
0.0544642
0.1633925
Time:Treatment
Time:Treatment
1
12
0.00
333.5
0.0000000
1.0000000
1.0000000
Zcchc9
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64.00
273.5
2.808044
0.1196311
0.1794466
Treatment
Treatment
1
12
72.25
263.5
3.290323
0.0947559
0.1794466
Time:Treatment
Time:Treatment
1
12
12.25
327.5
0.448855
0.5155648
0.5155648
Selt
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
6.25
330.5
0.2269289
0.6423668
0.6423668
Treatment
Treatment
1
12
121.00
218.0
6.6605505
0.0240621
0.0721863
Time:Treatment
Time:Treatment
1
12
30.25
305.5
1.1882160
0.2970951
0.4456426
Ireb2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
323.5
0.4544049
0.5130269
0.5130269
Treatment
Treatment
1
12
49.00
290.5
2.0240964
0.1802933
0.5130269
Time:Treatment
Time:Treatment
1
12
25.00
314.5
0.9538951
0.3480088
0.5130269
Amd1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
25.00
310.0
0.9677419
0.3446632
0.4556254
Treatment
Treatment
1
12
20.25
310.5
0.7826087
0.3937250
0.4556254
Time:Treatment
Time:Treatment
1
12
16.00
323.0
0.5944272
0.4556254
0.4556254
Mpp5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
132.25
207.5
7.648193
0.0171028
0.0360931
Treatment
Treatment
1
12
121.00
218.0
6.660551
0.0240621
0.0360931
Time:Treatment
Time:Treatment
1
12
30.25
308.5
1.176661
0.2993491
0.2993491
grey60
Grin2b
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
178
1.078652
0.3194744
0.3296766
Treatment
Treatment
1
12
16
184
1.043478
0.3271668
0.3296766
Time:Treatment
Time:Treatment
1
12
16
186
1.032258
0.3296766
0.3296766
Grm1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Wbscr25
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Cntn4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
148.5
1.292929
0.2777051
0.2777051
Treatment
Treatment
1
12
16
148.5
1.292929
0.2777051
0.2777051
Time:Treatment
Time:Treatment
1
12
16
148.5
1.292929
0.2777051
0.2777051
Kcna6
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
6.25
276.5
0.2712477
0.6119715
0.8378904
Treatment
Treatment
1
12
42.25
259.5
1.9537572
0.1874862
0.5624585
Time:Treatment
Time:Treatment
1
12
1.00
274.5
0.0437158
0.8378904
0.8378904
Rit2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
64
183
4.196721
0.0630284
0.1890852
Treatment
Treatment
1
12
25
239
1.255230
0.2844781
0.2844781
Time:Treatment
Time:Treatment
1
12
25
239
1.255230
0.2844781
0.2844781
Dgki
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
6.25
308
0.2435065
0.6305923
0.9231359
Treatment
Treatment
1
12
0.25
309
0.0097087
0.9231359
0.9231359
Time:Treatment
Time:Treatment
1
12
16.00
296
0.6486486
0.4362646
0.9231359
Cdh15
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
150
1.2800000
0.2800026
0.6502627
Treatment
Treatment
1
12
4
222
0.2162162
0.6502627
0.6502627
Time:Treatment
Time:Treatment
1
12
4
222
0.2162162
0.6502627
0.6502627
Sertm1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
150
1.2800000
0.2800026
0.6502627
Treatment
Treatment
1
12
4
222
0.2162162
0.6502627
0.6502627
Time:Treatment
Time:Treatment
1
12
4
222
0.2162162
0.6502627
0.6502627
Bmp5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
9.00
278.0
0.3884892
0.5447594
1
Treatment
Treatment
1
12
0.00
312.5
0.0000000
1.0000000
1
Time:Treatment
Time:Treatment
1
12
0.25
309.5
0.0096931
0.9231978
1
lightgreen
Th
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Tenm1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Cdh9
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Hcrtr2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Rgs13
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
5930412G12Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm14005
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Kcnq3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
25.00
199.5
1.5037594
0.2436132
0.7308395
Treatment
Treatment
1
12
2.25
244.0
0.1106557
0.7451380
0.8309262
Time:Treatment
Time:Treatment
1
12
1.00
252.0
0.0476190
0.8309262
0.8309262
Slc24a5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
30.25
232.5
1.5612903
0.2352986
0.5039258
Treatment
Treatment
1
12
9.00
227.5
0.4747253
0.5039258
0.5039258
Time:Treatment
Time:Treatment
1
12
9.00
227.5
0.4747253
0.5039258
0.5039258
4930570G19Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4
232.5
0.2064516
0.6576723
0.659031
Treatment
Treatment
1
12
4
234.5
0.2046908
0.6590310
0.659031
Time:Treatment
Time:Treatment
1
12
16
192.0
1.0000000
0.3370491
0.659031
lightyellow
Tgm3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
St18
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Ly6g6f
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Nptx2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm15663
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
2.25
280.5
0.0962567
0.7616911
0.7616911
Treatment
Treatment
1
12
16.00
223.0
0.8609865
0.3717505
0.7616911
Time:Treatment
Time:Treatment
1
12
2.25
245.5
0.1099796
0.7458874
0.7616911
Ccdc177
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4
222
0.2162162
0.6502627
0.6502627
Treatment
Treatment
1
12
16
150
1.2800000
0.2800026
0.6502627
Time:Treatment
Time:Treatment
1
12
4
222
0.2162162
0.6502627
0.6502627
Kcnip4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
30.25
241.0
1.506224
0.2432490
0.2432490
Treatment
Treatment
1
12
30.25
241.0
1.506224
0.2432490
0.2432490
Time:Treatment
Time:Treatment
1
12
64.00
159.5
4.815047
0.0486296
0.1458889
Wnt7a
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
25.00
237.0
1.265823
0.2825522
0.3297691
Treatment
Treatment
1
12
56.25
207.5
3.253012
0.0964376
0.2893128
Time:Treatment
Time:Treatment
1
12
20.25
235.5
1.031847
0.3297691
0.3297691
Sfmbt2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
9
244.5
0.4417178
0.5188627
1
Treatment
Treatment
1
12
1
252.5
0.0475248
0.8310909
1
Time:Treatment
Time:Treatment
1
12
0
266.5
0.0000000
1.0000000
1
Rnf182
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
49
201.5
2.918114
0.1133041
0.2849574
Treatment
Treatment
1
12
36
229.0
1.886463
0.1947180
0.2849574
Time:Treatment
Time:Treatment
1
12
25
239.5
1.252610
0.2849574
0.2849574
darkgreen
Cuzd1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Tmem196
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Tmem121
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Fam183b
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Lsmem1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm5532
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm26589
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
A830018L16Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
56.25
197.5
3.417721
0.0892781
0.232984
Treatment
Treatment
1
12
42.25
220.5
2.299320
0.1553226
0.232984
Time:Treatment
Time:Treatment
1
12
25.00
238.5
1.257862
0.2839980
0.283998
Dock3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
9.00
268.5
0.4022346
0.5378403
0.9196955
Treatment
Treatment
1
12
0.25
283.0
0.0106007
0.9196955
0.9196955
Time:Treatment
Time:Treatment
1
12
1.00
296.5
0.0404722
0.8439299
0.9196955
Pold3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
12.25
266.5
0.5515947
0.4719560
0.6890081
Treatment
Treatment
1
12
25.00
274.0
1.0948905
0.3160099
0.6890081
Time:Treatment
Time:Treatment
1
12
4.00
285.5
0.1681261
0.6890081
0.6890081
darkturquoise
2310007L24Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Tceal7
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm19345
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Gm2694
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
6330403A02Rik
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
195
0.9846154
0.3406495
0.3406495
Treatment
Treatment
1
12
16
195
0.9846154
0.3406495
0.3406495
Time:Treatment
Time:Treatment
1
12
16
195
0.9846154
0.3406495
0.3406495
Col2a1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
175.5
1.094017
0.3161949
0.3161949
Treatment
Treatment
1
12
16
151.5
1.267327
0.2822802
0.3161949
Time:Treatment
Time:Treatment
1
12
16
175.5
1.094017
0.3161949
0.3161949
Col22a1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
30.25
224.5
1.616926
0.2276137
0.2276137
Treatment
Treatment
1
12
30.25
224.5
1.616926
0.2276137
0.2276137
Time:Treatment
Time:Treatment
1
12
36.00
194.0
2.226804
0.1614505
0.2276137
Kcng2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
36.00
205.5
2.1021898
0.1727174
0.5181522
Treatment
Treatment
1
12
9.00
218.5
0.4942792
0.4954388
0.5772824
Time:Treatment
Time:Treatment
1
12
6.25
228.5
0.3282276
0.5772824
0.5772824
Lrrc36
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
1.00
251.0
0.0478088
0.8305955
0.8305955
Treatment
Treatment
1
12
1.00
248.5
0.0482897
0.8297602
0.8305955
Time:Treatment
Time:Treatment
1
12
20.25
213.0
1.1408451
0.3064902
0.8305955
Gm16119
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
0.00
243.0
0.0000000
1.0000000
1.0000000
Treatment
Treatment
1
12
6.25
214.5
0.3496503
0.5652838
0.8479257
Time:Treatment
Time:Treatment
1
12
6.25
214.5
0.3496503
0.5652838
0.8479257
darkgrey
Zp2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Kcnh4
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Tnni3k
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Slitrk3
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Abca12
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Sh2d6
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Caln1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Ntn5
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
16
147
1.306122
0.2753873
0.2753873
Treatment
Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Time:Treatment
Time:Treatment
1
12
16
147
1.306122
0.2753873
0.2753873
Clvs2
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
4.00
236.5
0.2029598
0.6603738
0.6603738
Treatment
Treatment
1
12
6.25
226.5
0.3311258
0.5756286
0.6603738
Time:Treatment
Time:Treatment
1
12
6.25
224.5
0.3340757
0.5739555
0.6603738
Cpb1
Term
Df
Df.res
Sum Sq
Sum Sq.res
F value
Pr(>F)
adjust
Time
Time
1
12
25
196.5
1.526718
0.2402488
0.3346173
Treatment
Treatment
1
12
16
190.0
1.010526
0.3346173
0.3346173
Time:Treatment
Time:Treatment
1
12
25
194.0
1.546392
0.2374150
0.3346173
Analysis performed by Ann Wells
The Carter Lab The Jackson Laboratory 2023
ann.wells@jax.org