tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))

tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))

log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)

log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])

log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5] 

log.tdata.FPKM.sample.info.subset <- cbind(log.tdata.FPKM.subset,tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info.subset <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.sample.info.subset.kidney <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(Tissue == "Kidney") %>% column_to_rownames()

module.labels <- readRDS(here("Data","Kidney","log.tdata.FPKM.sample.info.subset.kidney.WGCNA.module.labels.RData"))

modules <- readRDS(here("Data","Kidney","log.tdata.FPKM.sample.info.subset.kidney.WGCNA.module.membership.RData"))

net.deg <- readRDS(here("Data","Kidney","Chang_2DG_BL6_connectivity_kidney.RData"))

ensembl.location <- readRDS(here("Data","Ensembl_gene_id_and_location.RData"))

Hub Genes

Hub genes are genes in the module network that have the highest connectivity. For instance, if the gene significance of a particular module is associated with treatment the hub genes in this module are likely associated with this trait.

hub.genes.list <- hub.genes(net.deg,module.labels,modules,ensembl.location)

Cyan Module

DT.table.hub(hub.genes.list[[1]])

Blue Module

DT.table.hub(hub.genes.list[[2]])

Red Module

DT.table.hub(hub.genes.list[[3]])

Pink Module

DT.table.hub(hub.genes.list[[4]])

Magenta Module

DT.table.hub(hub.genes.list[[5]])

Darkred Module

DT.table.hub(hub.genes.list[[6]])

Midnightblue Module

DT.table.hub(hub.genes.list[[7]])

Purple Module

DT.table.hub(hub.genes.list[[8]])

Greenyellow Module

DT.table.hub(hub.genes.list[[9]])

Salmon Module

DT.table.hub(hub.genes.list[[10]])

Lightcyan Module

DT.table.hub(hub.genes.list[[11]])

Grey60 Module

DT.table.hub(hub.genes.list[[12]])

Lightgreen Module

DT.table.hub(hub.genes.list[[13]])

Lightyellow Module

DT.table.hub(hub.genes.list[[14]])

Darkgreen Module

DT.table.hub(hub.genes.list[[15]])

Darkturquoise Module

DT.table.hub(hub.genes.list[[16]])

Darkgrey Module

DT.table.hub(hub.genes.list[[17]])

ANOVA

To perform analysis of variance Aligned Rank Transformation was performed, which is designed to handle non-parametric multi-factorial experiments. P-value was adjusted using Benjamini-hochberg procedure. Only the top 10 hub genes are listed.

log.tdata.FPKM.sample.info.subset.kidney$Time <- as.factor(log.tdata.FPKM.sample.info.subset.kidney$Time)
log.tdata.FPKM.sample.info.subset.kidney$Treatment <- as.factor(log.tdata.FPKM.sample.info.subset.kidney$Treatment)

for(m in module.labels) {
    name <- str_split(m,"_")[[1]][2]
    hub.met <- net.deg[modules$Gene,] %>%
      dplyr::mutate(Gene=modules$Gene) %>%
      dplyr::filter(modules$Module == m) %>%
      dplyr::arrange(desc(kWithin)) %>%
      dplyr::select(Gene, kWithin)
    gene <- ensembl.location$external_gene_name[match(hub.met$Gene,ensembl.location$ensembl_gene_id)]
    hub.met <- cbind(gene,hub.met)
    cat("\n###",name, "{.tabset .tabset-fade .tabset-pills}","\n")
          for(i in 1:10){
             cat("\n####",hub.met$gene[i],"\n")
             m <- art(data = log.tdata.FPKM.sample.info.subset.kidney, log.tdata.FPKM.sample.info.subset.kidney[,hub.met$Gene[i]] ~ Time*Treatment)
             model <- anova(m)
             adjust <- p.adjust(model$`Pr(>F)`, method = "BH")
             print(knitr::kable(cbind(model,adjust)) %>% 
                      column_spec(8, color = "white", background = spec_color(adjust, end = 0.05, scale_from = c(0,0.05))) %>% kable_styling(bootstrap_options = c("striped", "hover", "responsive")))
             cat("\n \n")
             }
          cat("\n \n")
          }

cyan

Sf3b2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49.00 291.0 2.0206186 0.1806405 0.5419216
Treatment Treatment 1 12 12.25 325.5 0.4516129 0.5143008 0.6433598
Time:Treatment Time:Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.6433598

Zdhhc5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 323.5 0.5935085 0.4559656 0.7120579
Treatment Treatment 1 12 9 331.0 0.3262840 0.5783968 0.7120579
Time:Treatment Time:Treatment 1 12 4 336.0 0.1428571 0.7120579 0.7120579

Gnai2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 326.5 0.4502297 0.5149340 0.71165
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.71165
Time:Treatment Time:Treatment 1 12 4.00 335.0 0.1432836 0.7116500 0.71165

Rab5b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 324.0 0.5925926 0.4563052 0.7818029
Treatment Treatment 1 12 6.25 333.5 0.2248876 0.6438533 0.7818029
Time:Treatment Time:Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029

Pcnx

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36.00 304.0 1.4210526 0.2562716 0.6438533
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.6438533
Time:Treatment Time:Treatment 1 12 6.25 333.5 0.2248876 0.6438533 0.6438533

Ube2v1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 318.5 0.7629513 0.3995488 1
Treatment Treatment 1 12 2.25 336.5 0.0802377 0.7818029 1
Time:Treatment Time:Treatment 1 12 0.00 339.5 0.0000000 1.0000000 1

Ctdsp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 308.5 1.1766613 0.2993491 0.6433598
Treatment Treatment 1 12 12.25 326.5 0.4502297 0.5149340 0.6433598
Time:Treatment Time:Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.6433598

Zdhhc9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.5 0.9538951 0.3480088 0.9266583
Treatment Treatment 1 12 6.25 333.5 0.2248876 0.6438533 0.9266583
Time:Treatment Time:Treatment 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583

Slc38a10

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 314.5 0.9538951 0.3480088 0.4002654
Treatment Treatment 1 12 20.25 319.5 0.7605634 0.4002654 0.4002654
Time:Treatment Time:Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.4002654

Sgta

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 271.0 2.8339483 0.1181034 0.3543103
Treatment Treatment 1 12 9 328.5 0.3287671 0.5769737 0.5783968
Time:Treatment Time:Treatment 1 12 9 331.0 0.3262840 0.5783968 0.5783968

blue

Puf60

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 283.5 2.3809524 0.1487723 0.4463168
Treatment Treatment 1 12 9.00 330.5 0.3267776 0.5781134 0.8538013
Time:Treatment Time:Treatment 1 12 1.00 338.5 0.0354505 0.8538013 0.8538013

Ergic3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 275.5 2.7876588 0.1208505 0.3625516
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Time:Treatment Time:Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.7811702

Atg4d

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 275.0 2.7927273 0.1205459 0.3616377
Treatment Treatment 1 12 25.00 312.5 0.9600000 0.3465280 0.5197919
Time:Treatment Time:Treatment 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583

Actr1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 276.0 2.7826087 0.1211550 0.3634650
Treatment Treatment 1 12 30.25 308.5 1.1766613 0.2993491 0.4490236
Time:Treatment Time:Treatment 1 12 9.00 330.0 0.3272727 0.5778293 0.5778293

Maea

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 100.00 237.5 5.0526316 0.0441715 0.1325146
Treatment Treatment 1 12 25.00 310.0 0.9677419 0.3446632 0.5169948
Time:Treatment Time:Treatment 1 12 2.25 328.5 0.0821918 0.7792387 0.7792387

Tspan33

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49 288.5 2.0381282 0.1789011 0.5367034
Treatment Treatment 1 12 16 324.0 0.5925926 0.4563052 0.6844579
Time:Treatment Time:Treatment 1 12 4 335.0 0.1432836 0.7116500 0.7116500

Ddb1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 276.0 2.7826087 0.1211550 0.3634650
Treatment Treatment 1 12 16.00 323.0 0.5944272 0.4556254 0.6834380
Time:Treatment Time:Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029

Aldh1l1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 276.0 2.7826087 0.1211550 0.3634650
Treatment Treatment 1 12 12.25 327.5 0.4488550 0.5155648 0.7733472
Time:Treatment Time:Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029

Smim12

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 282.5 2.3893805 0.1481160 0.4443480
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Time:Treatment Time:Treatment 1 12 1.00 339.0 0.0353982 0.8539077 0.8539077

Copg1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49.00 290.0 2.0275862 0.1799458 0.4563052
Treatment Treatment 1 12 20.25 317.5 0.7653543 0.3988298 0.4563052
Time:Treatment Time:Treatment 1 12 16.00 324.0 0.5925926 0.4563052 0.4563052

red

Gm12481

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 316.5 0.4644550 0.5084887 0.6930299
Treatment Treatment 1 12 4.00 293.5 0.1635434 0.6930299 0.6930299
Time:Treatment Time:Treatment 1 12 12.25 303.5 0.4843493 0.4997165 0.6930299

Rpl36

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1 316.5 0.0379147 0.8488722 0.8488722
Treatment Treatment 1 12 1 298.0 0.0402685 0.8443175 0.8488722
Time:Treatment Time:Treatment 1 12 1 310.0 0.0387097 0.8473178 0.8488722

Hint2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 337.5 0.0000000 1.000000 1
Treatment Treatment 1 12 0.25 318.5 0.0094192 0.924287 1
Time:Treatment Time:Treatment 1 12 6.25 322.5 0.2325581 0.638310 1

Atox1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 334.5 0.0807175 0.7811702 1
Treatment Treatment 1 12 0.00 333.5 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 4.00 327.0 0.1467890 0.7083237 1

Atp6v1f

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1 318.5 0.0376766 0.8493410 0.849341
Treatment Treatment 1 12 4 321.5 0.1493002 0.7059689 0.849341
Time:Treatment Time:Treatment 1 12 16 321.5 0.5972006 0.4546008 0.849341

Aprt

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 333.5 0.1439280 0.7110350 1
Treatment Treatment 1 12 6.25 327.5 0.2290076 0.6408615 1
Time:Treatment Time:Treatment 1 12 0.00 332.0 0.0000000 1.0000000 1

Smim22

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 318.5 0.0376766 0.8493410 0.849341
Treatment Treatment 1 12 1.00 318.5 0.0376766 0.8493410 0.849341
Time:Treatment Time:Treatment 1 12 2.25 335.5 0.0804769 0.7814873 0.849341

Psmb4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 317.5 0.6047244 0.4518406 0.9246399
Treatment Treatment 1 12 2.25 309.5 0.0872375 0.7727672 0.9246399
Time:Treatment Time:Treatment 1 12 0.25 321.5 0.0093313 0.9246399 0.9246399

Tmem205

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 330.5 0.0363086 0.8520652 1
Treatment Treatment 1 12 0.00 330.0 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 2.25 336.5 0.0802377 0.7818029 1

Khk

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 329.5 0.2276176 0.6418671 1
Treatment Treatment 1 12 0.00 336.0 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 1.00 335.0 0.0358209 0.8530493 1

pink

Cyp2c50

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 252.5 3.4336634 0.0886202 0.1329304
Treatment Treatment 1 12 20.25 291.5 0.8336192 0.3792066 0.3792066
Time:Treatment Time:Treatment 1 12 72.25 252.5 3.4336634 0.0886202 0.1329304

Mat1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 100.00 221.5 5.417607 0.0382383 0.0698179
Treatment Treatment 1 12 42.25 276.0 1.836957 0.2002703 0.2002703
Time:Treatment Time:Treatment 1 12 90.25 220.0 4.922727 0.0465453 0.0698179

Serpind1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 121.00 194.0 7.484536 0.0180718 0.0542153
Treatment Treatment 1 12 42.25 269.5 1.881262 0.1952918 0.1952918
Time:Treatment Time:Treatment 1 12 90.25 234.5 4.618337 0.0527344 0.0791015

Otc

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 225 3.413333 0.0894602 0.1341903
Treatment Treatment 1 12 36.00 231 1.870130 0.1965274 0.1965274
Time:Treatment Time:Treatment 1 12 72.25 212 4.089623 0.0660193 0.1341903

Mug2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 100.00 211 5.687204 0.0344611 0.0516917
Treatment Treatment 1 12 30.25 279 1.301075 0.2762708 0.2762708
Time:Treatment Time:Treatment 1 12 100.00 195 6.153846 0.0289212 0.0516917

Apof

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 110.25 221.5 5.9729120 0.0309334 0.0626066
Treatment Treatment 1 12 20.25 297.5 0.8168067 0.3839000 0.3839000
Time:Treatment Time:Treatment 1 12 100.00 231.0 5.1948052 0.0417377 0.0626066

Cps1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 251.5 3.447316 0.0880616 0.1320923
Treatment Treatment 1 12 6.25 312.5 0.240000 0.6330400 0.6330400
Time:Treatment Time:Treatment 1 12 121.00 214.0 6.785047 0.0230208 0.0690623

Tdo2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49.00 264.5 2.2230624 0.1617749 0.2426624
Treatment Treatment 1 12 12.25 304.5 0.4827586 0.5004078 0.5004078
Time:Treatment Time:Treatment 1 12 64.00 241.5 3.1801242 0.0998299 0.2426624

Tat

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 121.00 173.5 8.368876 0.0135032 0.019983
Treatment Treatment 1 12 110.25 184.0 7.190217 0.0199830 0.019983
Time:Treatment Time:Treatment 1 12 132.25 165.0 9.618182 0.0091675 0.019983

Serpina3n

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 100 190 6.315790 0.0272511 0.0817534
Treatment Treatment 1 12 64 215 3.572093 0.0831498 0.0831498
Time:Treatment Time:Treatment 1 12 64 215 3.572093 0.0831498 0.0831498

magenta

Hecw1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Asphd2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gipr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slc38a5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Grpr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Myo16

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Chad

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

2700046A07Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Klhl40

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Myoz1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 247.0 0.7773279 0.3952765 0.5929148
Treatment Treatment 1 12 16.00 243.5 0.7885010 0.3920048 0.5929148
Time:Treatment Time:Treatment 1 12 6.25 297.0 0.2525253 0.6243971 0.6243971

darkred

Bcat1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 330.5 0.0090772 0.9256696 0.9256696
Treatment Treatment 1 12 0.25 330.5 0.0090772 0.9256696 0.9256696
Time:Treatment Time:Treatment 1 12 30.25 309.5 1.1728595 0.3000959 0.9002878

Mpped1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 337.5 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 42.25 291.5 1.7392796 0.2118446 0.5971623
Time:Treatment Time:Treatment 1 12 20.25 316.5 0.7677725 0.3981082 0.5971623

Tspan13

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 332.0 0.1445783 0.7104160 0.9263331
Treatment Treatment 1 12 0.25 336.5 0.0089153 0.9263331 0.9263331
Time:Treatment Time:Treatment 1 12 42.25 297.5 1.7042017 0.2162143 0.6486430

Wasf3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.5 0.0802377 0.7818029 0.9265504
Treatment Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504
Time:Treatment Time:Treatment 1 12 16.00 314.0 0.6114650 0.4493913 0.9265504

Wnt7b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 326.5 0.0091884 0.9252172 0.9252172
Treatment Treatment 1 12 64.00 271.0 2.8339483 0.1181034 0.3543103
Time:Treatment Time:Treatment 1 12 12.25 311.5 0.4719101 0.5051691 0.7577537

Esrp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 338.0 0.0355030 0.8536945 1
Treatment Treatment 1 12 0.00 339.5 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 12.25 323.5 0.4544049 0.5130269 1

Col23a1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 339.0 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 1.00 339.0 0.0353982 0.8539077 1.0000000
Time:Treatment Time:Treatment 1 12 30.25 300.5 1.2079867 0.2932931 0.8798793

Ceacam2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 320.5 0.4586583 0.5110972 0.7666459
Treatment Treatment 1 12 0.00 337.5 0.0000000 1.0000000 1.0000000
Time:Treatment Time:Treatment 1 12 36.00 303.5 1.4233937 0.2559012 0.7666459

Ppp1r1b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 326.5 0.4502297 0.5149340 0.5149340
Treatment Treatment 1 12 12.25 325.5 0.4516129 0.5143008 0.5149340
Time:Treatment Time:Treatment 1 12 56.25 280.5 2.4064171 0.1468005 0.4404016

Ghr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 338.5 0.0354505 0.8538013 0.8538013
Treatment Treatment 1 12 6.25 327.5 0.2290076 0.6408615 0.8538013
Time:Treatment Time:Treatment 1 12 30.25 309.5 1.1728595 0.3000959 0.8538013

midnightblue

Zmat2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 269.5 2.8497217 0.1171851 0.2556523
Treatment Treatment 1 12 49.00 276.5 2.1265823 0.1704349 0.2556523
Time:Treatment Time:Treatment 1 12 12.25 320.5 0.4586583 0.5110972 0.5110972

Atp6v1d

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 249.5 4.340681 0.0592616 0.1777848
Treatment Treatment 1 12 64.00 273.5 2.808044 0.1196311 0.1794466
Time:Treatment Time:Treatment 1 12 30.25 306.5 1.184339 0.2978486 0.2978486

Pls1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 275.5 2.7876588 0.1208505 0.3625516
Treatment Treatment 1 12 20.25 315.5 0.7702060 0.3973841 0.5960761
Time:Treatment Time:Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.6433598

Tceal8

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 247.5 4.375758 0.0583853 0.087578
Treatment Treatment 1 12 110.25 228.5 5.789934 0.0331400 0.087578
Time:Treatment Time:Treatment 1 12 0.00 338.0 0.000000 1.0000000 1.000000

Zfp125

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49 286.0 2.055944 0.1771533 0.26573
Treatment Treatment 1 12 64 275.0 2.792727 0.1205459 0.26573
Time:Treatment Time:Treatment 1 12 0 339.5 0.000000 1.0000000 1.00000

Cdc42

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 294.5 1.721562 0.2140371 0.2162143
Treatment Treatment 1 12 42.25 297.5 1.704202 0.2162143 0.2162143
Time:Treatment Time:Treatment 1 12 42.25 297.5 1.704202 0.2162143 0.2162143

Gm21917

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 303.0 1.198020 0.2952012 0.4428018
Treatment Treatment 1 12 36.00 301.5 1.432836 0.2544148 0.4428018
Time:Treatment Time:Treatment 1 12 4.00 333.5 0.143928 0.7110350 0.7110350

Swi5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Treatment Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Time:Treatment Time:Treatment 1 12 4.00 335.5 0.1430700 0.7118542 0.7118542

Angptl3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 329.5 0.1456753 0.7093755 0.7093755
Treatment Treatment 1 12 81.00 250.5 3.8802395 0.0723790 0.2171369
Time:Treatment Time:Treatment 1 12 20.25 313.5 0.7751196 0.3959282 0.5938923

Arhgap5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 282.5 2.389381 0.1481160 0.2154903
Treatment Treatment 1 12 110.25 229.5 5.764706 0.0334588 0.1003764
Time:Treatment Time:Treatment 1 12 42.25 296.5 1.709949 0.2154903 0.2154903

purple

F13a1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 303 0.6336634 0.4414782 0.6622172
Treatment Treatment 1 12 64.00 225 3.4133333 0.0894602 0.2683806
Time:Treatment Time:Treatment 1 12 2.25 325 0.0830769 0.7780881 0.7780881

Serpina3c

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 279.5 1.298748 0.2766796 0.2766796
Treatment Treatment 1 12 64.00 219.5 3.498861 0.0859907 0.2579721
Time:Treatment Time:Treatment 1 12 30.25 279.5 1.298748 0.2766796 0.2766796

Plin4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 307.0 0.1563518 0.6994770 0.7691241
Treatment Treatment 1 12 64.00 261.5 2.9369025 0.1122659 0.3367976
Time:Treatment Time:Treatment 1 12 2.25 299.5 0.0901503 0.7691241 0.7691241

Slpi

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 294.5 0.6519525 0.4351287 0.6327704
Treatment Treatment 1 12 56.25 255.0 2.6470588 0.1296965 0.3890894
Time:Treatment Time:Treatment 1 12 6.25 312.0 0.2403846 0.6327704 0.6327704

Lyve1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 320.5 0.4586583 0.5110972 0.5110972
Treatment Treatment 1 12 182.25 152.5 14.3409836 0.0025906 0.0077718
Time:Treatment Time:Treatment 1 12 25.00 301.5 0.9950249 0.3382073 0.5073110

Vit

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1 324.0 0.037037 0.8506081 0.8506081
Treatment Treatment 1 12 81 252.0 3.857143 0.0731251 0.2193752
Time:Treatment Time:Treatment 1 12 9 312.5 0.345600 0.5675132 0.8506081

Msln

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36.00 253.5 1.7041420 0.2162219 0.3243328
Treatment Treatment 1 12 42.25 268.5 1.8882682 0.1945193 0.3243328
Time:Treatment Time:Treatment 1 12 2.25 292.5 0.0923077 0.7664673 0.7664673

Adipoq

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 311.5 0.4719101 0.5051691 0.5051691
Treatment Treatment 1 12 64.00 241.0 3.1867220 0.0995168 0.2985505
Time:Treatment Time:Treatment 1 12 36.00 284.5 1.5184534 0.2414527 0.3621790

Slc7a10

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 297 0.6464646 0.4370182 0.4370182
Treatment Treatment 1 12 64 201 3.8208955 0.0743149 0.2229448
Time:Treatment Time:Treatment 1 12 16 297 0.6464646 0.4370182 0.4370182

Clec3b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 325.5 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 210.25 129.5 19.4826255 0.0008445 0.0025336
Time:Treatment Time:Treatment 1 12 0.25 321.5 0.0093313 0.9246399 1.0000000

greenyellow

Elavl2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 174 1.103448 0.3142057 0.3142057
Treatment Treatment 1 12 16 150 1.280000 0.2800026 0.3142057
Time:Treatment Time:Treatment 1 12 16 174 1.103448 0.3142057 0.3142057

Fsd1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Jph3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Dach2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Arhgap36

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

D830039M14Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm17382

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Sntg1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 177.0 1.0847458 0.3181679 0.6524285
Treatment Treatment 1 12 4.00 225.0 0.2133333 0.6524285 0.6524285
Time:Treatment Time:Treatment 1 12 6.25 214.5 0.3496503 0.5652838 0.6524285

Gpr123

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 282 0.0106383 0.9195538 0.9195538
Treatment Treatment 1 12 20.25 250 0.9720000 0.3436439 0.6948138
Time:Treatment Time:Treatment 1 12 12.25 256 0.5742188 0.4632092 0.6948138

Gabra1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 211.5 0.5106383 0.4885314 0.6569868
Treatment Treatment 1 12 4 231.5 0.2073434 0.6569868 0.6569868
Time:Treatment Time:Treatment 1 12 16 189.5 1.0131926 0.3340054 0.6569868

salmon

Grp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cntnap4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cdhr3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

March4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

B430212C06Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Vps13d

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Scn9a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Trim30c

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm16067

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 217.5 0.4965517 0.4944689 0.5739555
Treatment Treatment 1 12 6.25 224.5 0.3340757 0.5739555 0.5739555
Time:Treatment Time:Treatment 1 12 16.00 187.0 1.0267380 0.3309216 0.5739555

Gal3st4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 222 0.2162162 0.6502627 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 16 150 1.2800000 0.2800026 0.6502627

lightcyan

Sacm1l

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49 290.5 2.0240964 0.1802933 0.2704400
Treatment Treatment 1 12 100 239.5 5.0104384 0.0449263 0.1347788
Time:Treatment Time:Treatment 1 12 4 329.5 0.1456753 0.7093755 0.7093755

Tra2a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36.00 301.5 1.4328358 0.2544148 0.3816222
Treatment Treatment 1 12 132.25 207.5 7.6481928 0.0171028 0.0513084
Time:Treatment Time:Treatment 1 12 1.00 330.5 0.0363086 0.8520652 0.8520652

Phf20l1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Treatment Treatment 1 12 132.25 207.5 7.6481928 0.0171028 0.0513084
Time:Treatment Time:Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504

Xiap

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 274.0 2.8029197 0.1199362 0.1799043
Treatment Treatment 1 12 110.25 223.5 5.9194631 0.0315594 0.0946781
Time:Treatment Time:Treatment 1 12 25.00 311.0 0.9646302 0.3454109 0.3454109

Ugt8a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 339.5 0.0088365 0.9266583 1.0000000
Treatment Treatment 1 12 90.25 238.5 4.5408805 0.0544642 0.1633925
Time:Treatment Time:Treatment 1 12 0.00 333.5 0.0000000 1.0000000 1.0000000

Zcchc9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64.00 273.5 2.808044 0.1196311 0.1794466
Treatment Treatment 1 12 72.25 263.5 3.290323 0.0947559 0.1794466
Time:Treatment Time:Treatment 1 12 12.25 327.5 0.448855 0.5155648 0.5155648

Selt

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 330.5 0.2269289 0.6423668 0.6423668
Treatment Treatment 1 12 121.00 218.0 6.6605505 0.0240621 0.0721863
Time:Treatment Time:Treatment 1 12 30.25 305.5 1.1882160 0.2970951 0.4456426

Ireb2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 323.5 0.4544049 0.5130269 0.5130269
Treatment Treatment 1 12 49.00 290.5 2.0240964 0.1802933 0.5130269
Time:Treatment Time:Treatment 1 12 25.00 314.5 0.9538951 0.3480088 0.5130269

Amd1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 310.0 0.9677419 0.3446632 0.4556254
Treatment Treatment 1 12 20.25 310.5 0.7826087 0.3937250 0.4556254
Time:Treatment Time:Treatment 1 12 16.00 323.0 0.5944272 0.4556254 0.4556254

Mpp5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 132.25 207.5 7.648193 0.0171028 0.0360931
Treatment Treatment 1 12 121.00 218.0 6.660551 0.0240621 0.0360931
Time:Treatment Time:Treatment 1 12 30.25 308.5 1.176661 0.2993491 0.2993491

grey60

Grin2b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 178 1.078652 0.3194744 0.3296766
Treatment Treatment 1 12 16 184 1.043478 0.3271668 0.3296766
Time:Treatment Time:Treatment 1 12 16 186 1.032258 0.3296766 0.3296766

Grm1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Wbscr25

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cntn4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 148.5 1.292929 0.2777051 0.2777051
Treatment Treatment 1 12 16 148.5 1.292929 0.2777051 0.2777051
Time:Treatment Time:Treatment 1 12 16 148.5 1.292929 0.2777051 0.2777051

Kcna6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 276.5 0.2712477 0.6119715 0.8378904
Treatment Treatment 1 12 42.25 259.5 1.9537572 0.1874862 0.5624585
Time:Treatment Time:Treatment 1 12 1.00 274.5 0.0437158 0.8378904 0.8378904

Rit2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 183 4.196721 0.0630284 0.1890852
Treatment Treatment 1 12 25 239 1.255230 0.2844781 0.2844781
Time:Treatment Time:Treatment 1 12 25 239 1.255230 0.2844781 0.2844781

Dgki

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 308 0.2435065 0.6305923 0.9231359
Treatment Treatment 1 12 0.25 309 0.0097087 0.9231359 0.9231359
Time:Treatment Time:Treatment 1 12 16.00 296 0.6486486 0.4362646 0.9231359

Cdh15

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 150 1.2800000 0.2800026 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627

Sertm1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 150 1.2800000 0.2800026 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627

Bmp5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 278.0 0.3884892 0.5447594 1
Treatment Treatment 1 12 0.00 312.5 0.0000000 1.0000000 1
Time:Treatment Time:Treatment 1 12 0.25 309.5 0.0096931 0.9231978 1

lightgreen

Th

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Tenm1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cdh9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Hcrtr2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Rgs13

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

5930412G12Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm14005

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Kcnq3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 199.5 1.5037594 0.2436132 0.7308395
Treatment Treatment 1 12 2.25 244.0 0.1106557 0.7451380 0.8309262
Time:Treatment Time:Treatment 1 12 1.00 252.0 0.0476190 0.8309262 0.8309262

Slc24a5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 232.5 1.5612903 0.2352986 0.5039258
Treatment Treatment 1 12 9.00 227.5 0.4747253 0.5039258 0.5039258
Time:Treatment Time:Treatment 1 12 9.00 227.5 0.4747253 0.5039258 0.5039258

4930570G19Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 232.5 0.2064516 0.6576723 0.659031
Treatment Treatment 1 12 4 234.5 0.2046908 0.6590310 0.659031
Time:Treatment Time:Treatment 1 12 16 192.0 1.0000000 0.3370491 0.659031

lightyellow

Tgm3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

St18

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ly6g6f

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Nptx2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm15663

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 280.5 0.0962567 0.7616911 0.7616911
Treatment Treatment 1 12 16.00 223.0 0.8609865 0.3717505 0.7616911
Time:Treatment Time:Treatment 1 12 2.25 245.5 0.1099796 0.7458874 0.7616911

Ccdc177

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 222 0.2162162 0.6502627 0.6502627
Treatment Treatment 1 12 16 150 1.2800000 0.2800026 0.6502627
Time:Treatment Time:Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627

Kcnip4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 241.0 1.506224 0.2432490 0.2432490
Treatment Treatment 1 12 30.25 241.0 1.506224 0.2432490 0.2432490
Time:Treatment Time:Treatment 1 12 64.00 159.5 4.815047 0.0486296 0.1458889

Wnt7a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 237.0 1.265823 0.2825522 0.3297691
Treatment Treatment 1 12 56.25 207.5 3.253012 0.0964376 0.2893128
Time:Treatment Time:Treatment 1 12 20.25 235.5 1.031847 0.3297691 0.3297691

Sfmbt2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 244.5 0.4417178 0.5188627 1
Treatment Treatment 1 12 1 252.5 0.0475248 0.8310909 1
Time:Treatment Time:Treatment 1 12 0 266.5 0.0000000 1.0000000 1

Rnf182

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49 201.5 2.918114 0.1133041 0.2849574
Treatment Treatment 1 12 36 229.0 1.886463 0.1947180 0.2849574
Time:Treatment Time:Treatment 1 12 25 239.5 1.252610 0.2849574 0.2849574

darkgreen

Cuzd1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Tmem196

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Tmem121

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Fam183b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Lsmem1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm5532

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm26589

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

A830018L16Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 197.5 3.417721 0.0892781 0.232984
Treatment Treatment 1 12 42.25 220.5 2.299320 0.1553226 0.232984
Time:Treatment Time:Treatment 1 12 25.00 238.5 1.257862 0.2839980 0.283998

Dock3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 268.5 0.4022346 0.5378403 0.9196955
Treatment Treatment 1 12 0.25 283.0 0.0106007 0.9196955 0.9196955
Time:Treatment Time:Treatment 1 12 1.00 296.5 0.0404722 0.8439299 0.9196955

Pold3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 266.5 0.5515947 0.4719560 0.6890081
Treatment Treatment 1 12 25.00 274.0 1.0948905 0.3160099 0.6890081
Time:Treatment Time:Treatment 1 12 4.00 285.5 0.1681261 0.6890081 0.6890081

darkturquoise

2310007L24Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Tceal7

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm19345

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm2694

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

6330403A02Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 195 0.9846154 0.3406495 0.3406495
Treatment Treatment 1 12 16 195 0.9846154 0.3406495 0.3406495
Time:Treatment Time:Treatment 1 12 16 195 0.9846154 0.3406495 0.3406495

Col2a1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 175.5 1.094017 0.3161949 0.3161949
Treatment Treatment 1 12 16 151.5 1.267327 0.2822802 0.3161949
Time:Treatment Time:Treatment 1 12 16 175.5 1.094017 0.3161949 0.3161949

Col22a1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 224.5 1.616926 0.2276137 0.2276137
Treatment Treatment 1 12 30.25 224.5 1.616926 0.2276137 0.2276137
Time:Treatment Time:Treatment 1 12 36.00 194.0 2.226804 0.1614505 0.2276137

Kcng2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36.00 205.5 2.1021898 0.1727174 0.5181522
Treatment Treatment 1 12 9.00 218.5 0.4942792 0.4954388 0.5772824
Time:Treatment Time:Treatment 1 12 6.25 228.5 0.3282276 0.5772824 0.5772824

Lrrc36

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 251.0 0.0478088 0.8305955 0.8305955
Treatment Treatment 1 12 1.00 248.5 0.0482897 0.8297602 0.8305955
Time:Treatment Time:Treatment 1 12 20.25 213.0 1.1408451 0.3064902 0.8305955

Gm16119

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 243.0 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 6.25 214.5 0.3496503 0.5652838 0.8479257
Time:Treatment Time:Treatment 1 12 6.25 214.5 0.3496503 0.5652838 0.8479257

darkgrey

Zp2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Kcnh4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Tnni3k

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slitrk3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Abca12

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Sh2d6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Caln1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ntn5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Clvs2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 236.5 0.2029598 0.6603738 0.6603738
Treatment Treatment 1 12 6.25 226.5 0.3311258 0.5756286 0.6603738
Time:Treatment Time:Treatment 1 12 6.25 224.5 0.3340757 0.5739555 0.6603738

Cpb1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 196.5 1.526718 0.2402488 0.3346173
Treatment Treatment 1 12 16 190.0 1.010526 0.3346173 0.3346173
Time:Treatment Time:Treatment 1 12 25 194.0 1.546392 0.2374150 0.3346173

Analysis performed by Ann Wells

The Carter Lab The Jackson Laboratory 2023

ann.wells@jax.org