Hub Genes Small Intestine

tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))

tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))

log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)

log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])

log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5] 

log.tdata.FPKM.sample.info.subset <- cbind(log.tdata.FPKM.subset,tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info.subset <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.sample.info.subset.small.intestine <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(Tissue == "Small Intestine") %>% column_to_rownames()

module.labels <- readRDS(here("Data","Small Intestine","log.tdata.FPKM.sample.info.subset.small.intestine.WGCNA.module.labels.RData"))

modules <- readRDS(here("Data","Small Intestine","log.tdata.FPKM.sample.info.subset.small.intestine.WGCNA.module.membership.RData"))

net.deg <- readRDS(here("Data","Small Intestine","Chang_2DG_BL6_connectivity_small_intestine.RData"))

ensembl.location <- readRDS(here("Data","Ensembl_gene_id_and_location.RData"))

Hub Genes

Hub genes are genes in the module network that have the highest connectivity. For instance, if the gene significance of a particular module is associated with treatment the hub genes in this module are likely associated with this trait.

hub.genes.list <- hub.genes(net.deg,module.labels,modules,ensembl.location)

Cornsilk Module

DT.table.hub(hub.genes.list[[1]])

Blue1 Module

DT.table.hub(hub.genes.list[[2]])

Rosybrown3 Module

DT.table.hub(hub.genes.list[[3]])

Antiquewhite2 Module

DT.table.hub(hub.genes.list[[4]])

Aliceblue Module

DT.table.hub(hub.genes.list[[5]])

Blue3 Module

DT.table.hub(hub.genes.list[[6]])

Coral1 Module

DT.table.hub(hub.genes.list[[7]])

Magenta3 Module

DT.table.hub(hub.genes.list[[8]])

Burlywood Module

DT.table.hub(hub.genes.list[[9]])

Lightblue2 Module

DT.table.hub(hub.genes.list[[10]])

Green4 Module

DT.table.hub(hub.genes.list[[11]])

Antiquewhite1 Module

DT.table.hub(hub.genes.list[[12]])

Sienna3 Module

DT.table.hub(hub.genes.list[[13]])

Coral4 Module

DT.table.hub(hub.genes.list[[14]])

Blue2 Module

DT.table.hub(hub.genes.list[[15]])

Antiquewhite4 Module

DT.table.hub(hub.genes.list[[16]])

Firebrick Module

DT.table.hub(hub.genes.list[[17]])

Deepskyblue Module

DT.table.hub(hub.genes.list[[18]])

Hotpink4 Module

DT.table.hub(hub.genes.list[[19]])

Grey Module

DT.table.hub(hub.genes.list[[20]])

Lightgreen Module

DT.table.hub(hub.genes.list[[21]])

Rosybrown4 Module

DT.table.hub(hub.genes.list[[22]])

Royalblue Module

DT.table.hub(hub.genes.list[[23]])

Orange Module

DT.table.hub(hub.genes.list[[24]])

White Module

DT.table.hub(hub.genes.list[[25]])

Slateblue2 Module

DT.table.hub(hub.genes.list[[26]])

Magenta2 Module

DT.table.hub(hub.genes.list[[27]])

Mediumpurple3 Module

DT.table.hub(hub.genes.list[[28]])

Thistle2 Module

DT.table.hub(hub.genes.list[[29]])

Yellow4 Module

DT.table.hub(hub.genes.list[[30]])

Indianred Module

DT.table.hub(hub.genes.list[[31]])

Antiquewhite Module

DT.table.hub(hub.genes.list[[32]])

Mediumpurple1 Module

DT.table.hub(hub.genes.list[[33]])

Lightblue4 Module

DT.table.hub(hub.genes.list[[34]])

Firebrick3 Module

DT.table.hub(hub.genes.list[[35]])

Mistyrose Module

DT.table.hub(hub.genes.list[[36]])

Moccasin Module

DT.table.hub(hub.genes.list[[37]])

Chocolate3 Module

DT.table.hub(hub.genes.list[[38]])

Pink2 Module

DT.table.hub(hub.genes.list[[39]])

Sienna1 Module

DT.table.hub(hub.genes.list[[40]])

Darkgoldenrod4 Module

DT.table.hub(hub.genes.list[[41]])

Lightskyblue2 Module

DT.table.hub(hub.genes.list[[42]])

Linen Module

DT.table.hub(hub.genes.list[[43]])

Oldlace Module

DT.table.hub(hub.genes.list[[44]])

Lightblue Module

DT.table.hub(hub.genes.list[[45]])

Red4 Module

DT.table.hub(hub.genes.list[[46]])

ANOVA

To perform analysis of variance Aligned Rank Transformation was performed, which is designed to handle non-parametric multi-factorial experiments. P-value was adjusted using Benjamini-hochberg procedure. Only the top 10 hub genes are listed.

log.tdata.FPKM.sample.info.subset.small.intestine$Time <- as.factor(log.tdata.FPKM.sample.info.subset.small.intestine$Time)
log.tdata.FPKM.sample.info.subset.small.intestine$Treatment <- as.factor(log.tdata.FPKM.sample.info.subset.small.intestine$Treatment)

for(m in module.labels) {
    name <- str_split(m,"_")[[1]][2]
    hub.met <- net.deg[modules$Gene,] %>%
      dplyr::mutate(Gene=modules$Gene) %>%
      dplyr::filter(modules$Module == m) %>%
      dplyr::arrange(desc(kWithin)) %>%
      dplyr::select(Gene, kWithin)
    gene <- ensembl.location$external_gene_name[match(hub.met$Gene,ensembl.location$ensembl_gene_id)]
    hub.met <- cbind(gene,hub.met)
    cat("\n###",name, "{.tabset .tabset-fade .tabset-pills}","\n")
          for(i in 1:10){
             cat("\n####",hub.met$gene[i],"\n")
             m <- art(data = log.tdata.FPKM.sample.info.subset.small.intestine, log.tdata.FPKM.sample.info.subset.small.intestine[,hub.met$Gene[i]] ~ Time*Treatment)
             model <- anova(m)
             adjust <- p.adjust(model$`Pr(>F)`, method = "BH")
             print(knitr::kable(cbind(model,adjust)) %>% 
                      column_spec(8, color = "white", background = spec_color(adjust, end = 0.05, scale_from = c(0,0.05))) %>% kable_styling(bootstrap_options = c("striped", "hover", "responsive")))
             cat("\n \n")
             }
          cat("\n \n")
          }

cornsilk

Zfp800

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	156.5	13.9744409	0.0028310	0.0084931
Treatment	Treatment	1	12	81.00	251.0	3.8725100	0.0726276	0.1089414
Time:Treatment	Time:Treatment	1	12	25.00	308.5	0.9724473	0.3435370	0.3435370

Mdm4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144	193.5	8.9302326	0.0113089	0.0339267
Treatment	Treatment	1	12	100	236.0	5.0847458	0.0436072	0.0654108
Time:Treatment	Time:Treatment	1	12	25	313.0	0.9584665	0.3468991	0.3468991

Gm17131

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	214.0	6.7850467	0.0230208	0.0690623
Treatment	Treatment	1	12	90.25	246.5	4.3935091	0.0579478	0.0869218
Time:Treatment	Time:Treatment	1	12	2.25	327.5	0.0824427	0.7789118	0.7789118

AI987944

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	169.0	12.0000000	0.0046816	0.0140448
Treatment	Treatment	1	12	81.00	256.5	3.7894737	0.0753654	0.1130482
Time:Treatment	Time:Treatment	1	12	12.25	317.5	0.4629921	0.5091447	0.5091447

Papolg

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196	136.0	17.2941176	0.0013261	0.0039782
Treatment	Treatment	1	12	121	214.0	6.7850467	0.0230208	0.0345312
Time:Treatment	Time:Treatment	1	12	9	318.5	0.3390895	0.5711345	0.5711345

Sp3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	210.25	123.5	20.429150	0.0007020	0.0021059
Treatment	Treatment	1	12	100.00	235.0	5.106383	0.0432319	0.0648478
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.081448	0.7802108	0.7802108

Zfp148

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121	214	6.785047	0.0230208	0.0690623
Treatment	Treatment	1	12	64	271	2.833948	0.1181034	0.1771551
Time:Treatment	Time:Treatment	1	12	36	299	1.444816	0.2525455	0.2525455

Prpf4b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	200	7.9350000	0.0155487	0.0466462
Treatment	Treatment	1	12	100.00	221	5.4298643	0.0380561	0.0570842
Time:Treatment	Time:Treatment	1	12	12.25	312	0.4711538	0.5055041	0.5055041

Gm21897

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	164.5	12.3282675	0.0042927	0.0128781
Treatment	Treatment	1	12	121.00	218.5	6.6453089	0.0241934	0.0362901
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Atrx

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	235.0	5.1063830	0.0432319	0.1296957
Treatment	Treatment	1	12	64	263.5	2.9146110	0.1134990	0.1702484
Time:Treatment	Time:Treatment	1	12	9	328.5	0.3287671	0.5769737	0.5769737

blue1

Rps6ka4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.0	2.0275862	0.1799458	0.2699187
Treatment	Treatment	1	12	90.25	247.5	4.3757576	0.0583853	0.1751560
Time:Treatment	Time:Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.5772595

Mlf2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.0	2.027586	0.1799458	0.4490236
Treatment	Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.4490236
Time:Treatment	Time:Treatment	1	12	12.25	316.5	0.464455	0.5084887	0.5084887

Prkcsh

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	206.5	7.6852300	0.0168921	0.0506763
Treatment	Treatment	1	12	100.00	235.5	5.0955414	0.0434195	0.0651292
Time:Treatment	Time:Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654

Fto

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	282	2.393617	0.1477875	0.4433625
Treatment	Treatment	1	12	30.25	306	1.186274	0.2974721	0.4462082
Time:Treatment	Time:Treatment	1	12	2.25	331	0.081571	0.7800497	0.7800497

2510039O18Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	313.0	0.9584665	0.3468991	0.5203486
Treatment	Treatment	1	12	36.00	304.0	1.4210526	0.2562716	0.5203486
Time:Treatment	Time:Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.6423668

Plvap

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	266.5	3.253283	0.0964252	0.2892757
Treatment	Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.4490236
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.143928	0.7110350	0.7110350

Cenpb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	267.5	3.2411215	0.0969812	0.1454718
Treatment	Treatment	1	12	121.00	218.5	6.6453089	0.0241934	0.0725801
Time:Treatment	Time:Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.5781134

Edem2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	229.5	5.764706	0.0334588	0.1003764
Treatment	Treatment	1	12	42.25	296.5	1.709949	0.2154903	0.3232354
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.081448	0.7802108	0.7802108

D17Wsu92e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	276.0	2.7826087	0.1211550	0.3634650
Treatment	Treatment	1	12	36.00	302.0	1.4304636	0.2547871	0.3821807
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.5117430

Psmd3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	297.5	1.7042017	0.2162143	0.3243215
Treatment	Treatment	1	12	64.00	274.0	2.8029197	0.1199362	0.3243215
Time:Treatment	Time:Treatment	1	12	1.00	332.5	0.0360902	0.8525050	0.8525050

rosybrown3

Ly9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	269.5	0.0111317	0.9177167	0.9177167
Treatment	Treatment	1	12	36.00	236.0	1.8305085	0.2010086	0.6030258
Time:Treatment	Time:Treatment	1	12	6.25	278.5	0.2692998	0.6132381	0.9177167

5031414D18Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	270.5	0.0443623	0.8367151	0.8367151
Treatment	Treatment	1	12	20.25	254.5	0.9548134	0.3477855	0.5216782
Time:Treatment	Time:Treatment	1	12	36.00	263.0	1.6425856	0.2241816	0.5216782

Fmnl3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	272.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	42.25	237.5	2.1347368	0.1696804	0.5090412
Time:Treatment	Time:Treatment	1	12	20.25	288.5	0.8422877	0.3768207	0.5652310

Cnr2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	263	0.0114068	0.9167102	0.9167102
Treatment	Treatment	1	12	12.25	257	0.5719844	0.4640607	0.8192656
Time:Treatment	Time:Treatment	1	12	9.00	280	0.3857143	0.5461771	0.8192656

Rhoh

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	282.5	0.0424779	0.8401668	0.8401668
Treatment	Treatment	1	12	30.25	249.5	1.4549098	0.2509850	0.7529550
Time:Treatment	Time:Treatment	1	12	6.25	323.5	0.2318393	0.6388247	0.8401668

Atp6v0d2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	264.5	0.1020794	0.7548421	0.7548421
Treatment	Treatment	1	12	2.25	260.5	0.1036468	0.7530356	0.7548421
Time:Treatment	Time:Treatment	1	12	49.00	227.5	2.5846154	0.1338836	0.4016507

Stap1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	268.0	0.2798507	0.6064462	0.6064462
Treatment	Treatment	1	12	9.00	262.5	0.4114286	0.5333055	0.6064462
Time:Treatment	Time:Treatment	1	12	12.25	318.0	0.4622642	0.5094718	0.6064462

Cd180

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	260.0	0.0000000	1.0000000	1
Treatment	Treatment	1	12	9.00	258.0	0.4186047	0.5298161	1
Time:Treatment	Time:Treatment	1	12	2.25	292.5	0.0923077	0.7664673	1

Slamf1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	247.0	0.194332	0.6671724	0.6671724
Treatment	Treatment	1	12	42.25	231.5	2.190065	0.1646723	0.2590761
Time:Treatment	Time:Treatment	1	12	36.00	205.5	2.102190	0.1727174	0.2590761

Lyl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	273.5	0.0109689	0.9183182	0.9183182
Treatment	Treatment	1	12	12.25	261.5	0.5621415	0.4678438	0.8512698
Time:Treatment	Time:Treatment	1	12	9.00	312.5	0.3456000	0.5675132	0.8512698

antiquewhite2

Tmem208

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	303.5	1.4233937	0.2559012	0.3838518
Treatment	Treatment	1	12	72.25	263.5	3.2903226	0.0947559	0.2842677
Time:Treatment	Time:Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.8534804

Rps14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313.5	0.7751196	0.3959282	0.5938923
Treatment	Treatment	1	12	64.00	274.0	2.8029197	0.1199362	0.3598085
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Ndufa2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	254.0	3.8267717	0.0741204	0.1111807
Treatment	Treatment	1	12	81.00	251.0	3.8725100	0.0726276	0.1111807
Time:Treatment	Time:Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.6423668

Tmem205

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.5	2.0240964	0.1802933	0.2704400
Treatment	Treatment	1	12	72.25	261.5	3.3154876	0.0936419	0.2704400
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Snrpe

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	266.5	3.253283	0.0964252	0.2231584
Treatment	Treatment	1	12	56.25	283.5	2.380952	0.1487723	0.2231584
Time:Treatment	Time:Treatment	1	12	0.00	339.0	0.000000	1.0000000	1.0000000

Tomm7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	239.0	5.0209205	0.0447373	0.1342120
Treatment	Treatment	1	12	72.25	265.5	3.2655367	0.0958690	0.1438035
Time:Treatment	Time:Treatment	1	12	1.00	332.5	0.0360902	0.8525050	0.8525050

Rps27l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	290.5	1.7452668	0.2111103	0.3166655
Treatment	Treatment	1	12	56.25	276.5	2.4412297	0.1441580	0.3166655
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.5117430

Rpl37a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	323.5	0.4544049	0.5130269	0.7695403
Treatment	Treatment	1	12	72.25	263.5	3.2903226	0.0947559	0.2842677
Time:Treatment	Time:Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.8534804

Atp6v1f

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	287.5	1.7634783	0.2088974	0.3133461
Treatment	Treatment	1	12	90.25	233.5	4.6381156	0.0523033	0.1569099
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.6418671

Lamtor4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	240.0	5.0000000	0.0451154	0.1353461
Treatment	Treatment	1	12	72.25	263.5	3.2903226	0.0947559	0.1421338
Time:Treatment	Time:Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500

aliceblue

Slc13a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	272.5	2.1577982	0.1675697	0.4294549
Treatment	Treatment	1	12	30.25	291.5	1.2452830	0.2863032	0.4294549
Time:Treatment	Time:Treatment	1	12	0.25	311.5	0.0096308	0.9234439	0.9234439

Tmem135

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	267.5	2.523365	0.1381563	0.3679903
Treatment	Treatment	1	12	36.00	289.5	1.492228	0.2453269	0.3679903
Time:Treatment	Time:Treatment	1	12	0.00	306.0	0.000000	1.0000000	1.0000000

Slc23a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	310.0	0.9677419	0.3446632	0.9253311
Treatment	Treatment	1	12	4.00	309.5	0.1550889	0.7006270	0.9253311
Time:Treatment	Time:Treatment	1	12	0.25	327.5	0.0091603	0.9253311	0.9253311

Gnpnat1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	281.5	1.5346359	0.2391029	0.6372741
Treatment	Treatment	1	12	12.25	312.5	0.4704000	0.5058384	0.6372741
Time:Treatment	Time:Treatment	1	12	6.25	320.5	0.2340094	0.6372741	0.6372741

Aldh18a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	257.0	3.7821012	0.0756145	0.2268436
Treatment	Treatment	1	12	25.00	300.5	0.9983361	0.3374358	0.5061537
Time:Treatment	Time:Treatment	1	12	2.25	310.5	0.0869565	0.7731220	0.7731220

Efr3b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	321.5	0.4572317	0.511743	0.7676145
Treatment	Treatment	1	12	20.25	297.5	0.8168067	0.383900	0.7676145
Time:Treatment	Time:Treatment	1	12	2.25	319.5	0.0845070	0.776243	0.7762430

Tmigd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	273.5	1.3272395	0.2717323	0.6286544
Treatment	Treatment	1	12	6.25	304.5	0.2463054	0.6286544	0.6286544
Time:Treatment	Time:Treatment	1	12	9.00	279.0	0.3870968	0.5454699	0.6286544

Rbp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	293.5	1.727428	0.2133079	0.6399238
Treatment	Treatment	1	12	1.00	324.5	0.036980	0.8507217	0.9249878
Time:Treatment	Time:Treatment	1	12	0.25	324.5	0.009245	0.9249878	0.9249878

Sec14l2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	319.0	0.6018809	0.4528805	0.7102088
Treatment	Treatment	1	12	4	327.5	0.1465649	0.7085349	0.7102088
Time:Treatment	Time:Treatment	1	12	4	331.5	0.1447964	0.7102088	0.7102088

Cyb5r3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	276.5	2.1265823	0.1704349	0.3838518
Treatment	Treatment	1	12	36.00	303.5	1.4233937	0.2559012	0.3838518
Time:Treatment	Time:Treatment	1	12	0.25	332.5	0.0090226	0.9258928	0.9258928

blue3

Slc39a5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	176.5	10.6232295	0.0068371	0.0169634
Treatment	Treatment	1	12	144.00	193.5	8.9302326	0.0113089	0.0169634
Time:Treatment	Time:Treatment	1	12	0.25	332.5	0.0090226	0.9258928	0.9258928

Krcc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	248.5	4.358149	0.0588233	0.0882349
Treatment	Treatment	1	12	132.25	204.5	7.760391	0.0164739	0.0494217
Time:Treatment	Time:Treatment	1	12	20.25	315.5	0.770206	0.3973841	0.3973841

Fam134c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	170.5	11.894428	0.0048154	0.0144461
Treatment	Treatment	1	12	110.25	229.5	5.764706	0.0334588	0.0501882
Time:Treatment	Time:Treatment	1	12	4.00	335.5	0.143070	0.7118542	0.7118542

Prdx6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	249.5	4.340681	0.0592616	0.0888924
Treatment	Treatment	1	12	110.25	226.5	5.841060	0.0325051	0.0888924
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.2993491

Hiatl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	156.5	13.974441	0.0028310	0.0084931
Treatment	Treatment	1	12	144.00	195.5	8.838875	0.0116356	0.0174534
Time:Treatment	Time:Treatment	1	12	0.00	335.0	0.000000	1.0000000	1.0000000

Nudcd3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	166.5	12.1801802	0.0044633	0.0066949
Treatment	Treatment	1	12	196.00	143.0	16.4475524	0.0015944	0.0047831
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.3981082

Maea

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121	206.0	7.048544	0.0209879	0.0314818
Treatment	Treatment	1	12	144	195.5	8.838875	0.0116356	0.0314818
Time:Treatment	Time:Treatment	1	12	49	290.5	2.024096	0.1802933	0.1802933

Bckdha

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	193.5	8.9302326	0.0113089	0.0243996
Treatment	Treatment	1	12	132.25	203.5	7.7985258	0.0162664	0.0243996
Time:Treatment	Time:Treatment	1	12	9.00	330.0	0.3272727	0.5778293	0.5778293

Naprt1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	177.5	10.5633803	0.0069547	0.0208641
Treatment	Treatment	1	12	110.25	229.5	5.7647059	0.0334588	0.0501882
Time:Treatment	Time:Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323

Rsrc2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121	218.0	6.660551	0.0240621	0.0662573
Treatment	Treatment	1	12	100	237.5	5.052632	0.0441715	0.0662573
Time:Treatment	Time:Treatment	1	12	1	338.0	0.035503	0.8536945	0.8536945

coral1

Mapk8ip3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	333.5	0.0089955	0.9260036	0.9260036
Treatment	Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.9260036
Time:Treatment	Time:Treatment	1	12	90.25	229.5	4.7189542	0.0505849	0.1517547

Arl14ep

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	326.5	0.0826953	0.7785834	0.7785834
Treatment	Treatment	1	12	6.25	320.5	0.2340094	0.6372741	0.7785834
Time:Treatment	Time:Treatment	1	12	49.00	246.0	2.3902439	0.1480490	0.4441469

Pias3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	331.0	0.326284	0.5783968	0.7053168
Treatment	Treatment	1	12	4.00	320.0	0.150000	0.7053168	0.7053168
Time:Treatment	Time:Treatment	1	12	72.25	256.5	3.380117	0.0908537	0.2725610

Zscan26

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	312.5	0.470400	0.5058384	0.5058384
Treatment	Treatment	1	12	25.00	282.5	1.061947	0.3230950	0.4846425
Time:Treatment	Time:Treatment	1	12	30.25	281.5	1.289520	0.2783083	0.4846425

Ogt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	297.5	1.704202	0.2162143	0.3243215
Treatment	Treatment	1	12	49.00	278.0	2.115108	0.1715037	0.3243215
Time:Treatment	Time:Treatment	1	12	20.25	312.5	0.777600	0.3951964	0.3951964

Zfp780b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	309.5	1.172859	0.3000959	0.3000959
Treatment	Treatment	1	12	49.00	284.5	2.066784	0.1761006	0.2641509
Time:Treatment	Time:Treatment	1	12	72.25	265.5	3.265537	0.0958690	0.2641509

Pisd-ps2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.1430700	0.7118542	0.7782535
Treatment	Treatment	1	12	2.25	325.5	0.0829493	0.7782535	0.7782535
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.7782535

Ndor1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	330.5	0.0090772	0.9256696	0.9256696
Treatment	Treatment	1	12	2.25	315.5	0.0855784	0.7748719	0.9256696
Time:Treatment	Time:Treatment	1	12	30.25	287.5	1.2626087	0.2831347	0.8494040

Pisd-ps1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	337.5	0.0088889	0.9264420	0.926442
Treatment	Treatment	1	12	0.25	329.5	0.0091047	0.9255573	0.926442
Time:Treatment	Time:Treatment	1	12	12.25	320.5	0.4586583	0.5110972	0.926442

Fbxo3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25	312.5	0.960000	0.3465280	0.5197919
Treatment	Treatment	1	12	9	308.5	0.350081	0.5650477	0.5650477
Time:Treatment	Time:Treatment	1	12	100	227.0	5.286344	0.0402555	0.1207664

magenta3

Prpf8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	331.0	0.1450151	0.7100011	0.7100011
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232
Time:Treatment	Time:Treatment	1	12	36.00	303.5	1.4233937	0.2559012	0.5993232

Btbd7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	299.5	1.4424040	0.2529204	0.5220133
Treatment	Treatment	1	12	1	338.5	0.0354505	0.8538013	0.8538013
Time:Treatment	Time:Treatment	1	12	25	314.5	0.9538951	0.3480088	0.5220133

Nup98

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25	314.0	0.9554140	0.3476395	0.6824144
Treatment	Treatment	1	12	4	335.5	0.1430700	0.7118542	0.7118542
Time:Treatment	Time:Treatment	1	12	16	322.0	0.5962733	0.4549430	0.6824144

Kidins220

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	330.5	0.3267776	0.5781134	0.8539077
Treatment	Treatment	1	12	1	339.0	0.0353982	0.8539077	0.8539077
Time:Treatment	Time:Treatment	1	12	25	310.0	0.9677419	0.3446632	0.8539077

Ankrd17

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	311.0	0.6173633	0.4472660	0.670899
Treatment	Treatment	1	12	0.00	335.0	0.0000000	1.0000000	1.000000
Time:Treatment	Time:Treatment	1	12	20.25	317.5	0.7653543	0.3988298	0.670899

Dopey2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	331.5	0.2262443	0.6428643	0.9263331
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Time:Treatment	Time:Treatment	1	12	36.00	304.0	1.4210526	0.2562716	0.7688147

Ppp6r3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.0	0.3272727	0.5778293	0.8534804
Treatment	Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.8534804
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.8534804

Numb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	330.5	0.2269289	0.6423668	0.9635501
Treatment	Treatment	1	12	0.00	338.0	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.9635501

Atp6v0a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	331.0	0.1450151	0.7100011	0.7100011
Treatment	Treatment	1	12	9.00	323.0	0.3343653	0.5737917	0.7100011
Time:Treatment	Time:Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.7100011

Disp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	327.5	0.4488550	0.5155648	0.5155648
Treatment	Treatment	1	12	16.00	317.5	0.6047244	0.4518406	0.5155648
Time:Treatment	Time:Treatment	1	12	36.00	300.0	1.4400000	0.2532947	0.5155648

burlywood

Myh11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	296.5	1.7099494	0.2154903	0.5993232
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Kif1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	321.5	0.5972006	0.4546008	0.8528323
Treatment	Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.8528323
Time:Treatment	Time:Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323

Atp2b4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	275.5	2.7876588	0.1208505	0.3480088
Treatment	Treatment	1	12	25	314.5	0.9538951	0.3480088	0.3480088
Time:Treatment	Time:Treatment	1	12	25	310.0	0.9677419	0.3446632	0.3480088

Abcc9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	301.5	1.4328358	0.2544148	0.5181164
Treatment	Treatment	1	12	25.00	311.0	0.9646302	0.3454109	0.5181164
Time:Treatment	Time:Treatment	1	12	2.25	330.5	0.0816944	0.7798882	0.7798882

Lamb2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	254.0	3.8267717	0.0741204	0.2223613
Treatment	Treatment	1	12	1.00	339.0	0.0353982	0.8539077	0.9265504
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Rbms3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	317.5	0.7653543	0.3988298	0.9628006
Treatment	Treatment	1	12	0.00	339.5	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.9628006

Jam2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.5	2.0240964	0.1802933	0.5408800
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.6433598
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Chrm2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	306.5	1.1843393	0.2978486	0.6839484
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.6839484
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331

Pdzrn3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	294.5	1.7215620	0.2140371	0.5993232
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.7110350

Snap25

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	309.5	1.1728595	0.3000959	0.7100011
Treatment	Treatment	1	12	4.00	331.0	0.1450151	0.7100011	0.7100011
Time:Treatment	Time:Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.7100011

lightblue2

Pdcd6ip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.1430700	0.7118542	0.9262238
Treatment	Treatment	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238
Time:Treatment	Time:Treatment	1	12	6.25	326.5	0.2297090	0.6403555	0.9262238

Ccnk

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	331.5	0.2262443	0.6428643	0.711035
Treatment	Treatment	1	12	4.00	331.0	0.1450151	0.7100011	0.711035
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.711035

Ubap2l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	330.5	0.0816944	0.7798882	0.9265504
Treatment	Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.9265504
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Cmip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	335.0	0.0000000	1.0000000	1
Treatment	Treatment	1	12	2.25	334.5	0.0807175	0.7811702	1
Time:Treatment	Time:Treatment	1	12	4.00	335.0	0.1432836	0.7116500	1

Ski

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	333.5	0.0089955	0.9260036	0.9260036
Treatment	Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.9260036
Time:Treatment	Time:Treatment	1	12	12.25	325.5	0.4516129	0.5143008	0.9260036

Pabpc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238
Treatment	Treatment	1	12	0.25	333.5	0.0089955	0.9260036	0.9262238
Time:Treatment	Time:Treatment	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238

Pigt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	331.0	0.1450151	0.7100011	0.7100011
Treatment	Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.7100011
Time:Treatment	Time:Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.7100011

Samd4b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	312.5	0.9600000	0.3465280	0.7818029
Treatment	Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Wbp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Treatment	Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.9265504
Time:Treatment	Time:Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.9265504

Med15

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	316.5	0.7677725	0.3981082	0.7808518
Treatment	Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7808518
Time:Treatment	Time:Treatment	1	12	6.25	327.5	0.2290076	0.6408615	0.7808518

green4

Csf2rb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	339.0	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	90.25	248.5	4.358149	0.0588233	0.1764698
Time:Treatment	Time:Treatment	1	12	64.00	272.0	2.823529	0.1187149	0.1780724

Slc15a3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	307.5	1.180488	0.2986000	0.2986000
Treatment	Treatment	1	12	121.00	212.5	6.832941	0.0226345	0.0679034
Time:Treatment	Time:Treatment	1	12	72.25	264.5	3.277883	0.0953126	0.1429688

Irf8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.143070	0.7118542	0.7118542
Treatment	Treatment	1	12	210.25	128.5	19.634241	0.0008196	0.0024587
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.143928	0.7110350	0.7118542

Itgb2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	332.5	0.0360902	0.8525050	0.8525050
Treatment	Treatment	1	12	56.25	276.5	2.4412297	0.1441580	0.3243215
Time:Treatment	Time:Treatment	1	12	42.25	297.5	1.7042017	0.2162143	0.3243215

Cd274

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	302.0	1.430464	0.2547871	0.3000959
Treatment	Treatment	1	12	169.00	171.0	11.859649	0.0048604	0.0145812
Time:Treatment	Time:Treatment	1	12	30.25	309.5	1.172859	0.3000959	0.3000959

Mpeg1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	321	0.5981308	0.4542580	0.4542580
Treatment	Treatment	1	12	110.25	226	5.8539823	0.0323469	0.0970408
Time:Treatment	Time:Treatment	1	12	42.25	293	1.7303754	0.2129427	0.3194141

Fgr

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	308.5	0.7876823	0.3922431	0.3922431
Treatment	Treatment	1	12	100.00	239.5	5.0104384	0.0449263	0.0673894
Time:Treatment	Time:Treatment	1	12	100.00	238.0	5.0420168	0.0443600	0.0673894

Gm2a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313.5	0.7751196	0.3959282	0.3959282
Treatment	Treatment	1	12	144.00	191.0	9.0471204	0.0109066	0.0327197
Time:Treatment	Time:Treatment	1	12	64.00	275.0	2.7927273	0.1205459	0.1808188

Pirb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	337.5	0.0355556	0.8535876	0.8535876
Treatment	Treatment	1	12	72.25	267.0	3.2471910	0.0967033	0.2662553
Time:Treatment	Time:Treatment	1	12	49.00	286.5	2.0523560	0.1775035	0.2662553

Il2rb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	337.5	0.080000	0.7821172	0.7821172
Treatment	Treatment	1	12	100.00	236.0	5.084746	0.0436072	0.1308217
Time:Treatment	Time:Treatment	1	12	64.00	275.0	2.792727	0.1205459	0.1808188

antiquewhite1

Gtf3c6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	274.0	2.8029197	0.1199362	0.1812758
Treatment	Treatment	1	12	64	275.5	2.7876588	0.1208505	0.1812758
Time:Treatment	Time:Treatment	1	12	16	324.0	0.5925926	0.4563052	0.4563052

Rsl1d1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	291.5	1.7392796	0.2118446	0.5197919
Treatment	Treatment	1	12	25.00	312.5	0.9600000	0.3465280	0.5197919
Time:Treatment	Time:Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.8533730

Mphosph6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Treatment	Treatment	1	12	20.25	310.5	0.7826087	0.3937250	0.4563052
Time:Treatment	Time:Treatment	1	12	16.00	324.0	0.5925926	0.4563052	0.4563052

Ssb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	273.5	2.8080439	0.1196311	0.1794466
Treatment	Treatment	1	12	81.00	257.0	3.7821012	0.0756145	0.1794466
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Cfdp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	308.5	1.1766613	0.2993491	0.3995488
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.3995488

Hsd17b12

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	252.5	3.8495050	0.0733739	0.2201216
Treatment	Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.4490236
Time:Treatment	Time:Treatment	1	12	4.00	331.5	0.1447964	0.7102088	0.7102088

Rars

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	196.0	8.8163265	0.0117179	0.0351538
Treatment	Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.4501439
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331

Manf

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	289.0	2.0346021	0.1792497	0.2688745
Treatment	Treatment	1	12	56.25	281.5	2.3978686	0.1474588	0.2688745
Time:Treatment	Time:Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533

Mphosph10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	254.0	3.8267717	0.0741204	0.2223613
Treatment	Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.4501439
Time:Treatment	Time:Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013

Eif2s1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	254.0	3.8267717	0.0741204	0.2223613
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.7724010
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

sienna3

Eef1g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	147.5	14.82712	0.0023076	0.0034615
Treatment	Treatment	1	12	240.25	93.5	30.83422	0.0001252	0.0003756
Time:Treatment	Time:Treatment	1	12	0.00	317.5	0.00000	1.0000000	1.0000000

Atp6v0d1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	193.5	8.9302326	0.0113089	0.0339267
Treatment	Treatment	1	12	110.25	218.5	6.0549199	0.0300014	0.0450021
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Cuta

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196	137.5	17.1054545	0.0013810	0.0021845
Treatment	Treatment	1	12	196	139.5	16.8602151	0.0014563	0.0021845
Time:Treatment	Time:Treatment	1	12	9	304.5	0.3546798	0.5625398	0.5625398

Gstp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	256	84	36.571429	0.0000578	0.0001734
Treatment	Treatment	1	12	144	188	9.191489	0.0104327	0.0156490
Time:Treatment	Time:Treatment	1	12	0	330	0.000000	1.0000000	1.0000000

Gnb2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	201.5	7.8759305	0.0158547	0.0237820
Treatment	Treatment	1	12	156.25	180.5	10.3878116	0.0073135	0.0219405
Time:Treatment	Time:Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533

Snf8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	256	84.0	36.5714286	0.0000578	0.0001734
Treatment	Treatment	1	12	169	166.0	12.2168675	0.0044203	0.0066304
Time:Treatment	Time:Treatment	1	12	1	330.5	0.0363086	0.8520652	0.8520652

Dpp4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196.00	127.0	18.5196850	0.0010256	0.0030769
Treatment	Treatment	1	12	72.25	260.5	3.3282150	0.0930846	0.1396270
Time:Treatment	Time:Treatment	1	12	0.25	326.5	0.0091884	0.9252172	0.9252172

Eif3f

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	177.5	9.735211	0.0088527	0.0174406
Treatment	Treatment	1	12	132.25	179.5	8.841226	0.0116271	0.0174406
Time:Treatment	Time:Treatment	1	12	30.25	263.5	1.377609	0.2632782	0.2632782

Tmem134

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	158.5	12.7949527	0.0038031	0.0057047
Treatment	Treatment	1	12	210.25	120.5	20.9377593	0.0006371	0.0019112
Time:Treatment	Time:Treatment	1	12	0.25	323.5	0.0092736	0.9248724	0.9248724

Rab3ip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196	142.0	16.5633803	0.0015541	0.0046624
Treatment	Treatment	1	12	49	283.0	2.0777385	0.1750448	0.2625672
Time:Treatment	Time:Treatment	1	12	25	306.5	0.9787928	0.3420268	0.3420268

coral4

Fpgt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.0	2.7927273	0.1205459	0.1808188
Treatment	Treatment	1	12	90.25	247.5	4.3757576	0.0583853	0.1751560
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.3981082

Mospd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	295.5	1.4619289	0.2499075	0.3748612
Treatment	Treatment	1	12	100.00	235.0	5.1063830	0.0432319	0.1296957
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.5149340

Zfyve16

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	293.5	1.7274276	0.2133079	0.3199619
Treatment	Treatment	1	12	100.00	230.0	5.2173913	0.0413660	0.1240980
Time:Treatment	Time:Treatment	1	12	20.25	310.5	0.7826087	0.3937250	0.3937250

Zfp760

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013
Treatment	Treatment	1	12	36.00	295.0	1.4644068	0.2495286	0.7485857
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.8538013

Sacm1l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313.5	0.7751196	0.3959282	0.5938923
Treatment	Treatment	1	12	110.25	226.5	5.8410596	0.0325051	0.0975154
Time:Treatment	Time:Treatment	1	12	2.25	337.5	0.0800000	0.7821172	0.7821172

Gm14403

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	330.5	0.2269289	0.6423668	0.7779222
Treatment	Treatment	1	12	132.25	201.5	7.8759305	0.0158547	0.0475640
Time:Treatment	Time:Treatment	1	12	2.25	324.5	0.0832049	0.7779222	0.7779222

Zmpste24

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	286.0	2.0559441	0.1771533	0.3929854
Treatment	Treatment	1	12	20.25	309.5	0.7851373	0.3929854	0.3929854
Time:Treatment	Time:Treatment	1	12	25.00	310.0	0.9677419	0.3446632	0.3929854

Jrkl

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	267.5	2.523365	0.1381563	0.2625672
Treatment	Treatment	1	12	49.00	283.0	2.077739	0.1750448	0.2625672
Time:Treatment	Time:Treatment	1	12	20.25	315.5	0.770206	0.3973841	0.3973841

Fmr1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	262.5	2.5714286	0.1347893	0.2021840
Treatment	Treatment	1	12	72.25	260.5	3.3282150	0.0930846	0.2021840
Time:Treatment	Time:Treatment	1	12	2.25	321.5	0.0839813	0.7769193	0.7769193

Smc5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	288.5	2.0381282	0.1789011	0.4329816
Treatment	Treatment	1	12	30.25	294.5	1.2325976	0.2886544	0.4329816
Time:Treatment	Time:Treatment	1	12	16.00	311.0	0.6173633	0.4472660	0.4472660

blue2

Tmem109

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	158.5	12.7949527	0.0038031	0.0114094
Treatment	Treatment	1	12	72.25	265.5	3.2655367	0.0958690	0.1438035
Time:Treatment	Time:Treatment	1	12	6.25	291.5	0.2572899	0.6211807	0.6211807

Mgll

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	182.0	10.302198	0.0074963	0.0224890
Treatment	Treatment	1	12	81.00	258.0	3.767442	0.0761128	0.1141692
Time:Treatment	Time:Treatment	1	12	36.00	298.5	1.447236	0.2521702	0.2521702

Apbb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	170.5	11.894428	0.0048154	0.0144461
Treatment	Treatment	1	12	56.25	282.5	2.389381	0.1481160	0.2147645
Time:Treatment	Time:Treatment	1	12	42.25	295.5	1.715736	0.2147645	0.2147645

Flna

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	181.5	10.3305785	0.0074351	0.0223054
Treatment	Treatment	1	12	25.00	313.0	0.9584665	0.3468991	0.3468991
Time:Treatment	Time:Treatment	1	12	42.25	291.5	1.7392796	0.2118446	0.3177669

Acta2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196.00	139.0	16.9208633	0.0014373	0.0043118
Treatment	Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.7785834
Time:Treatment	Time:Treatment	1	12	2.25	326.5	0.0826953	0.7785834	0.7785834

Col6a3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	210.25	122.5	20.5959184	0.0006799	0.0020396
Treatment	Treatment	1	12	72.25	267.5	3.2411215	0.0969812	0.1454718
Time:Treatment	Time:Treatment	1	12	6.25	315.5	0.2377179	0.6346451	0.6346451

Gpr37l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	204.5	7.760391	0.0164739	0.0494217
Treatment	Treatment	1	12	36.00	300.0	1.440000	0.2532947	0.2532947
Time:Treatment	Time:Treatment	1	12	49.00	286.0	2.055944	0.1771533	0.2532947

Lims2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	229.5	5.7647059	0.0334588	0.1003764
Treatment	Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.8533730
Time:Treatment	Time:Treatment	1	12	42.25	294.5	1.7215620	0.2140371	0.3210556

Cryab

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	154.5	14.155340	0.0027092	0.0081277
Treatment	Treatment	1	12	30.25	309.5	1.172859	0.3000959	0.3000959
Time:Treatment	Time:Treatment	1	12	81.00	250.5	3.880240	0.0723790	0.1085684

Nsg1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	226.5	5.8410596	0.0325051	0.0975154
Treatment	Treatment	1	12	16.00	322.0	0.5962733	0.4549430	0.6824144
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

antiquewhite4

Rpl11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	300.0	1.4400000	0.2532947	0.5971623
Treatment	Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7808518
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.5971623

Rps6-ps4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	315.5	0.7702060	0.3973841	0.4002654
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Time:Treatment	Time:Treatment	1	12	25.00	314.0	0.9554140	0.3476395	0.4002654

Rpl23

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	328.5	0.3287671	0.5769737	0.5778293
Treatment	Treatment	1	12	9	330.0	0.3272727	0.5778293	0.5778293
Time:Treatment	Time:Treatment	1	12	49	288.5	2.0381282	0.1789011	0.5367034

Rpl6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	288.5	1.7573657	0.2096367	0.511743
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.511743
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.511743

Rps3a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	332.5	0.2255639	0.6433598	0.7118542
Treatment	Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.7118542
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.7118542

Rpl19

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	301.5	1.4328358	0.2544148	0.7632443
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7818029

Gm10123

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Treatment	Treatment	1	12	2.25	337.5	0.0800000	0.7821172	0.9265504
Time:Treatment	Time:Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.9265504

Rps7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	331.5	0.2262443	0.6428643	0.7112404
Treatment	Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7112404
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.7112404

Rps24

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.0	0.3272727	0.5778293	0.8538013
Treatment	Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013
Time:Treatment	Time:Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.8538013

Rpl35a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	327.0	0.3302752	0.5761130	0.9263331
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Time:Treatment	Time:Treatment	1	12	6.25	327.5	0.2290076	0.6408615	0.9263331

firebrick

Sebox

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

4732463B04Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Sele

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	177	1.084746	0.3181679	0.3181679
Treatment	Treatment	1	12	16	177	1.084746	0.3181679	0.3181679
Time:Treatment	Time:Treatment	1	12	16	177	1.084746	0.3181679	0.3181679

Celsr3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	236	0.6228814	0.4452927	0.6679391
Treatment	Treatment	1	12	2.25	245	0.1102041	0.7456384	0.7456384
Time:Treatment	Time:Treatment	1	12	20.25	240	1.0125000	0.3341642	0.6679391

Gm4750

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257
Treatment	Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257
Time:Treatment	Time:Treatment	1	12	0.00	243.0	0.0000000	1.0000000	1.0000000

Arhgap36

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	177.0	1.0847458	0.3181679	0.6524285
Treatment	Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.6524285
Time:Treatment	Time:Treatment	1	12	4.00	225.0	0.2133333	0.6524285	0.6524285

C130080G10Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	156.5	4.907348	0.0468363	0.0468363
Treatment	Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363
Time:Treatment	Time:Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363

Rasd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	248.5	0.5915493	0.4566926	0.6834817
Treatment	Treatment	1	12	121.00	194.0	7.4845361	0.0180718	0.0542153
Time:Treatment	Time:Treatment	1	12	4.00	275.0	0.1745455	0.6834817	0.6834817

Socs3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	178.0	8.1573034	0.0144582	0.0433745
Treatment	Treatment	1	12	42.25	219.5	2.3097950	0.1544620	0.2316929
Time:Treatment	Time:Treatment	1	12	6.25	255.5	0.2935421	0.5978759	0.5978759

Cpn2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	264.5	0.2835539	0.6041017	0.6041017
Treatment	Treatment	1	12	49.00	246.5	2.3853955	0.1484258	0.4452775
Time:Treatment	Time:Treatment	1	12	12.25	270.5	0.5434381	0.4751789	0.6041017

deepskyblue

Spta1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	192.5	0.9974026	0.3376530	0.337653
Treatment	Treatment	1	12	16	192.5	0.9974026	0.3376530	0.337653
Time:Treatment	Time:Treatment	1	12	16	190.0	1.0105263	0.3346173	0.337653

Prss35

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	225.0	3.413333	0.0894602	0.0894602
Treatment	Treatment	1	12	64	214.5	3.580420	0.0828341	0.0894602
Time:Treatment	Time:Treatment	1	12	64	225.0	3.413333	0.0894602	0.0894602

Cuzd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Ppp1r3g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Sim2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm16548

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Bmx

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	234.5	4.144989	0.0644522	0.0966783
Treatment	Treatment	1	12	132.25	192.5	8.244156	0.0140568	0.0421703
Time:Treatment	Time:Treatment	1	12	64.00	251.5	3.053678	0.1060702	0.1060702

Hck

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	162.5	11.538462	0.0053007	0.0119066
Treatment	Treatment	1	12	100.00	199.0	6.030151	0.0302793	0.0302793
Time:Treatment	Time:Treatment	1	12	144.00	171.0	10.105263	0.0079377	0.0119066

Kcnj16

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	202.0	3.801980	0.0749452	0.1753743
Treatment	Treatment	1	12	49	206.0	2.854369	0.1169162	0.1753743
Time:Treatment	Time:Treatment	1	12	25	216.5	1.385681	0.2619568	0.2619568

Sh2d6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144	183.0	9.442623	0.0096648	0.0144973
Treatment	Treatment	1	12	196	131.5	17.885932	0.0011697	0.0035091
Time:Treatment	Time:Treatment	1	12	81	234.0	4.153846	0.0642057	0.0642057

hotpink4

Lmtk2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	337.5	0.0088889	0.9264420	0.926442
Treatment	Treatment	1	12	25.00	312.5	0.9600000	0.3465280	0.926442
Time:Treatment	Time:Treatment	1	12	2.25	330.5	0.0816944	0.7798882	0.926442

Dsp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945
Treatment	Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.8536945
Time:Treatment	Time:Treatment	1	12	2.25	335.5	0.0804769	0.7814873	0.8536945

Rxra

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	324.5	0.3328197	0.5746666	0.8510610
Treatment	Treatment	1	12	42.25	293.5	1.7274276	0.2133079	0.6399238
Time:Treatment	Time:Treatment	1	12	1.00	326.0	0.0368098	0.8510610	0.8510610

Dab2ip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	329.0	0.3282675	0.5772595	0.5772595
Treatment	Treatment	1	12	42.25	293.5	1.7274276	0.2133079	0.5772595
Time:Treatment	Time:Treatment	1	12	16.00	311.5	0.6163724	0.4476219	0.5772595

Plagl2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	321.5	0.5972006	0.4546008	0.5755362
Treatment	Treatment	1	12	36	301.5	1.4328358	0.2544148	0.5755362
Time:Treatment	Time:Treatment	1	12	9	326.0	0.3312883	0.5755362	0.5755362

Magi1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238
Treatment	Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.9262238
Time:Treatment	Time:Treatment	1	12	9.00	326.0	0.3312883	0.5755362	0.9262238

Add1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	312.5	0.9600000	0.3465280	0.5197919
Treatment	Treatment	1	12	30.25	303.5	1.1960461	0.2955811	0.5197919
Time:Treatment	Time:Treatment	1	12	6.25	309.5	0.2423263	0.6314136	0.6314136

Arhgef11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	337.5	0.0000000	1.0000000	1
Treatment	Treatment	1	12	16.00	323.0	0.5944272	0.4556254	1
Time:Treatment	Time:Treatment	1	12	0.25	332.5	0.0090226	0.9258928	1

Plcb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	337.5	0.080000	0.7821172	0.7821172
Treatment	Treatment	1	12	49.00	290.0	2.027586	0.1799458	0.5398374
Time:Treatment	Time:Treatment	1	12	4.00	335.5	0.143070	0.7118542	0.7821172

Sipa1l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	327.5	0.0824427	0.7789118	0.7802108
Treatment	Treatment	1	12	25.00	310.0	0.9677419	0.3446632	0.7802108
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.0814480	0.7802108	0.7802108

grey

Amt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Treatment	Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.8538013
Time:Treatment	Time:Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013

Rhot1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	282.5	2.3893805	0.1481160	0.444348
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	1.000000
Time:Treatment	Time:Treatment	1	12	0.00	339.0	0.0000000	1.0000000	1.000000

Gm21967

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	282.5	2.3893805	0.1481160	0.3821807
Treatment	Treatment	1	12	36.00	302.0	1.4304636	0.2547871	0.3821807
Time:Treatment	Time:Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.4559656

Pex5l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	327.5	0.4488550	0.5155648	0.6433598
Treatment	Treatment	1	12	25.00	308.5	0.9724473	0.3435370	0.6433598
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Pop1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.0	2.0275862	0.1799458	0.5398374
Treatment	Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.7676145
Time:Treatment	Time:Treatment	1	12	2.25	328.5	0.0821918	0.7792387	0.7792387

Gm21989

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	335.0	0.0089552	0.9261689	0.9261689
Treatment	Treatment	1	12	16.00	318.5	0.6028257	0.4525345	0.9261689
Time:Treatment	Time:Treatment	1	12	6.25	328.0	0.2286585	0.6411137	0.9261689

Rspo1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	282.0	2.3936170	0.1477875	0.4433625
Treatment	Treatment	1	12	4.00	334.5	0.1434978	0.7114454	0.8532653
Time:Treatment	Time:Treatment	1	12	1.00	336.0	0.0357143	0.8532653	0.8532653

Cdhr3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	244.0	1.7704918	0.2080532	0.6241597
Treatment	Treatment	1	12	0.25	318.5	0.0094192	0.9242870	0.9242870
Time:Treatment	Time:Treatment	1	12	0.25	318.5	0.0094192	0.9242870	0.9242870

Adarb2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	316	0.7689873	0.3977464	0.8530493
Treatment	Treatment	1	12	1.00	335	0.0358209	0.8530493	0.8530493
Time:Treatment	Time:Treatment	1	12	4.00	330	0.1454545	0.7095845	0.8530493

Nkpd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	332.5	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	12.25	320.5	0.4586583	0.5110972	0.7666459
Time:Treatment	Time:Treatment	1	12	25.00	309.5	0.9693053	0.3442884	0.7666459

lightgreen

Lpl

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	249.0	3.903615	0.0716332	0.0716332
Treatment	Treatment	1	12	182.25	154.5	14.155340	0.0027092	0.0081277
Time:Treatment	Time:Treatment	1	12	110.25	225.5	5.866962	0.0321890	0.0482835

Hp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	295.5	1.461929	0.2499075	0.2499075
Treatment	Treatment	1	12	72.25	254.5	3.406680	0.0897372	0.1346059
Time:Treatment	Time:Treatment	1	12	132.25	203.5	7.798526	0.0162664	0.0487993

Adrb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	299.0	1.444816	0.2525455	0.2525455
Treatment	Treatment	1	12	81.00	258.0	3.767442	0.0761128	0.1446378
Time:Treatment	Time:Treatment	1	12	72.25	266.5	3.253283	0.0964252	0.1446378

Mrap

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	237.0	5.063291	0.0439832	0.0439832
Treatment	Treatment	1	12	110.25	225.0	5.880000	0.0320312	0.0439832
Time:Treatment	Time:Treatment	1	12	144.00	195.5	8.838875	0.0116356	0.0349068

Cyp2e1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	266.5	3.253283	0.0964252	0.0969812
Treatment	Treatment	1	12	72.25	267.5	3.241122	0.0969812	0.0969812
Time:Treatment	Time:Treatment	1	12	110.25	227.5	5.815385	0.0328221	0.0969812

Thrsp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	280.5	2.406417	0.1468005	0.1468005
Treatment	Treatment	1	12	121.00	217.0	6.691244	0.0238003	0.0357004
Time:Treatment	Time:Treatment	1	12	156.25	180.5	10.387812	0.0073135	0.0219405

Retn

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	306	1.186274	0.2974721	0.2974721
Treatment	Treatment	1	12	90.25	243	4.456790	0.0564200	0.0846300
Time:Treatment	Time:Treatment	1	12	121.00	216	6.722222	0.0235394	0.0706183

Serpina3c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	293	1.730375	0.2129427	0.2129427
Treatment	Treatment	1	12	56.25	282	2.393617	0.1477875	0.2129427
Time:Treatment	Time:Treatment	1	12	64.00	275	2.792727	0.1205459	0.2129427

Car5b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	273.5	2.808044	0.1196311	0.1196311
Treatment	Treatment	1	12	156.25	182.5	10.273973	0.0075578	0.0226734
Time:Treatment	Time:Treatment	1	12	100.00	236.0	5.084746	0.0436072	0.0654108

Tusc5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	271.0	2.833948	0.1181034	0.1181034
Treatment	Treatment	1	12	110.25	225.5	5.866962	0.0321890	0.0482835
Time:Treatment	Time:Treatment	1	12	132.25	207.5	7.648193	0.0171028	0.0482835

rosybrown4

Ell

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196	143.0	16.4475524	0.0015944	0.0047831
Treatment	Treatment	1	12	9	330.5	0.3267776	0.5781134	0.8671701
Time:Treatment	Time:Treatment	1	12	0	339.5	0.0000000	1.0000000	1.0000000

Tbl1x

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313.5	0.7751196	0.3959282	0.8658893
Treatment	Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.8658893
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Tjp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	238.5	4.5408805	0.0544642	0.1633925
Treatment	Treatment	1	12	20.25	309.5	0.7851373	0.3929854	0.5894781
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Igf1r

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	321.5	0.5972006	0.4546008	0.6433598
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.6433598
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Atf6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	285.5	1.5131349	0.2422317	0.7266951
Treatment	Treatment	1	12	4	316.0	0.1518987	0.7035563	0.8520652
Time:Treatment	Time:Treatment	1	12	1	330.5	0.0363086	0.8520652	0.8520652

Daam1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	155.5	14.0643087	0.0027698	0.0083093
Treatment	Treatment	1	12	1.00	334.5	0.0358744	0.8529409	0.8529409
Time:Treatment	Time:Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.8529409

Caskin2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	272.0	2.823529	0.1187149	0.3561448
Treatment	Treatment	1	12	4.00	335.5	0.143070	0.7118542	0.7802108
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.081448	0.7802108	0.7802108

Atxn7l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	194.5	8.1593830	0.0144484	0.0433451
Treatment	Treatment	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Time:Treatment	Time:Treatment	1	12	30.25	307.5	1.1804878	0.2986000	0.4479000

Adam10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	231.5	5.1835853	0.0419238	0.1257715
Treatment	Treatment	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Time:Treatment	Time:Treatment	1	12	20.25	317.5	0.7653543	0.3988298	0.5982446

Qser1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	293.5	1.7274276	0.2133079	0.6399238
Treatment	Treatment	1	12	4.00	336.0	0.1428571	0.7120579	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

royalblue

Tceal7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm13844

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Xist

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	195.5	1.2429668	0.2867306	0.4086316
Treatment	Treatment	1	12	20.25	194.5	1.2493573	0.2855537	0.4086316
Time:Treatment	Time:Treatment	1	12	12.25	200.5	0.7331671	0.4086316	0.4086316

Mtg1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	204.0	3.7647059	0.0762062	0.2146709
Treatment	Treatment	1	12	42.25	206.5	2.4552058	0.1431139	0.2146709
Time:Treatment	Time:Treatment	1	12	12.25	235.5	0.6242038	0.4448220	0.4448220

Mstn

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81	221.5	4.388262	0.0580767	0.0580767
Treatment	Treatment	1	12	144	119.5	14.460251	0.0025176	0.0075528
Time:Treatment	Time:Treatment	1	12	81	221.5	4.388262	0.0580767	0.0580767

Itih2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	253	0.9604743	0.3464133	0.6144069
Treatment	Treatment	1	12	4.00	273	0.1758242	0.6823953	0.6823953
Time:Treatment	Time:Treatment	1	12	16.00	263	0.7300380	0.4096046	0.6144069

Myh4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	272	2.161765	0.1672100	0.1672100
Treatment	Treatment	1	12	72.25	246	3.524390	0.0849871	0.1274807
Time:Treatment	Time:Treatment	1	12	100.00	227	5.286344	0.0402555	0.1207664

mt-Atp8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	288.5	0.2599653	0.6193911	0.9178683
Treatment	Treatment	1	12	0.25	270.5	0.0110906	0.9178683	0.9178683
Time:Treatment	Time:Treatment	1	12	6.25	228.5	0.3282276	0.5772824	0.9178683

Dmrta1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	254.0	0.5787402	0.4614941	0.9196955
Treatment	Treatment	1	12	0.25	283.0	0.0106007	0.9196955	0.9196955
Time:Treatment	Time:Treatment	1	12	1.00	276.5	0.0433996	0.8384686	0.9196955

1700109H08Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	244.0	2.4098361	0.1465383	0.2198075
Treatment	Treatment	1	12	49	244.0	2.4098361	0.1465383	0.2198075
Time:Treatment	Time:Treatment	1	12	4	311.5	0.1540931	0.7015375	0.7015375

orange

Wdr95

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Nodal

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Col2a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	189.5	1.013193	0.3340054	0.3340054
Treatment	Treatment	1	12	16	189.5	1.013193	0.3340054	0.3340054
Time:Treatment	Time:Treatment	1	12	16	176.0	1.090909	0.3168544	0.3340054

F12

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	222.5	3.451685	0.0878837	0.0941827
Treatment	Treatment	1	12	64	232.5	3.303226	0.0941827	0.0941827
Time:Treatment	Time:Treatment	1	12	64	210.5	3.648456	0.0803084	0.0941827

Gm9754

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	191	4.020942	0.0680279	0.2040837
Treatment	Treatment	1	12	30.25	241	1.506224	0.2432490	0.2432490
Time:Treatment	Time:Treatment	1	12	30.25	241	1.506224	0.2432490	0.2432490

Nepn

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257
Treatment	Treatment	1	12	0.00	249.0	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257

Gm16758

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	257	1.9727626	0.1855068	0.2782602
Treatment	Treatment	1	12	9.00	295	0.3661017	0.5564063	0.5564063
Time:Treatment	Time:Treatment	1	12	42.25	257	1.9727626	0.1855068	0.2782602

Sec14l5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	196.5	3.908397	0.0714818	0.0714818
Treatment	Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818
Time:Treatment	Time:Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818

Scml2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	272.0	0.0110294	0.9180942	0.9180942
Treatment	Treatment	1	12	9.00	256.5	0.4210526	0.5286356	0.9180942
Time:Treatment	Time:Treatment	1	12	1.00	278.0	0.0431655	0.8388983	0.9180942

Slc22a30

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	267.0	0.4044944	0.5367189	0.5367189
Treatment	Treatment	1	12	36	260.5	1.6583493	0.2221069	0.3331603
Time:Treatment	Time:Treatment	1	12	36	260.5	1.6583493	0.2221069	0.3331603

white

Slc16a14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Cyp4a12b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm15627

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Amy2a5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	156.5	4.907348	0.0468363	0.0468363
Treatment	Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363
Time:Treatment	Time:Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363

Amy2a3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	156.5	4.907348	0.0468363	0.0468363
Treatment	Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363
Time:Treatment	Time:Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363

Amy2a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	156.5	4.907348	0.0468363	0.0468363
Treatment	Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363
Time:Treatment	Time:Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363

Amy2a4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	156.5	4.907348	0.0468363	0.0468363
Treatment	Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363
Time:Treatment	Time:Treatment	1	12	64	156.5	4.907348	0.0468363	0.0468363

Prg4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	250	0.0480000	0.8302629	0.8302629
Treatment	Treatment	1	12	4.00	235	0.2042553	0.6593682	0.8302629
Time:Treatment	Time:Treatment	1	12	2.25	244	0.1106557	0.7451380	0.8302629

A330094K24Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	196.5	3.908397	0.0714818	0.0714818
Treatment	Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818
Time:Treatment	Time:Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818

Tubb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627

slateblue2

Khk

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	287.0	2.0487805	0.1778534	0.5335603
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.6003981
Time:Treatment	Time:Treatment	1	12	0.25	337.5	0.0088889	0.9264420	0.9264420

Tmem120a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	168.5	12.0356083	0.0046375	0.0139124
Treatment	Treatment	1	12	64.00	272.0	2.8235294	0.1187149	0.1780724
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Dgat1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	228.5	5.7899344	0.0331400	0.0994201
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.1446378
Time:Treatment	Time:Treatment	1	12	0.25	332.5	0.0090226	0.9258928	0.9258928

Tmem86b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	225.5	5.8669623	0.0321890	0.0965669
Treatment	Treatment	1	12	36.00	303.0	1.4257426	0.2555303	0.3832955
Time:Treatment	Time:Treatment	1	12	1.00	334.5	0.0358744	0.8529409	0.8529409

Cpd

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	238.0	5.042017	0.0443600	0.1330799
Treatment	Treatment	1	12	49	290.5	2.024096	0.1802933	0.2704400
Time:Treatment	Time:Treatment	1	12	16	319.5	0.600939	0.4532258	0.4532258

Tmem19

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	226.5	5.8410596	0.0325051	0.0875780
Treatment	Treatment	1	12	90.25	247.5	4.3757576	0.0583853	0.0875780
Time:Treatment	Time:Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323

Cideb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	249.5	4.3406814	0.0592616	0.1777848
Treatment	Treatment	1	12	56.25	283.5	2.3809524	0.1487723	0.2231584
Time:Treatment	Time:Treatment	1	12	16.00	315.0	0.6095238	0.4500944	0.4500944

Gstk1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	246.5	4.3935091	0.0579478	0.1738435
Treatment	Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6438533

Eci1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196.00	137.5	17.105455	0.0013810	0.0041429
Treatment	Treatment	1	12	100.00	237.5	5.052632	0.0441715	0.0662573
Time:Treatment	Time:Treatment	1	12	30.25	298.5	1.216080	0.2917562	0.2917562

Cda

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196	143.0	16.4475524	0.0015944	0.0047831
Treatment	Treatment	1	12	16	321.5	0.5972006	0.4546008	0.6819012
Time:Treatment	Time:Treatment	1	12	4	333.5	0.1439280	0.7110350	0.7110350

magenta2

Rnasel

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	210.25	128.5	19.6342412	0.0008196	0.0024587
Treatment	Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.4490236

Hgf

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	166.0	12.2168675	0.0044203	0.0132608
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Time:Treatment	Time:Treatment	1	12	30.25	307.5	1.1804878	0.2986000	0.4479000

1110057K04Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196	143.0	16.4475524	0.0015944	0.0047831
Treatment	Treatment	1	12	1	337.0	0.0356083	0.8534804	0.8534804
Time:Treatment	Time:Treatment	1	12	49	290.5	2.0240964	0.1802933	0.2704400

Alpk1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196.00	141.5	16.6219081	0.0015343	0.0046028
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232
Time:Treatment	Time:Treatment	1	12	2.25	337.5	0.0800000	0.7821172	0.7821172

Sgpp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.0	2.0275862	0.1799458	0.5398374
Treatment	Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598
Time:Treatment	Time:Treatment	1	12	16.00	324.0	0.5925926	0.4563052	0.6433598

Dcp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	243.5	4.4476386	0.0566379	0.1699138
Treatment	Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7112404
Time:Treatment	Time:Treatment	1	12	56.25	279.5	2.4150268	0.1461414	0.2192120

Gm16238

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	226.5	5.8410596	0.0325051	0.0975154
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	9.00	331.0	0.3262840	0.5783968	0.8675953

Casp8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	256.00	81.5	37.6932515	0.0000503	0.0001508
Treatment	Treatment	1	12	2.25	326.5	0.0826953	0.7785834	0.7785834
Time:Treatment	Time:Treatment	1	12	20.25	310.5	0.7826087	0.3937250	0.5905875

Pdp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169	161.5	12.5572755	0.0040438	0.0121313
Treatment	Treatment	1	12	9	317.5	0.3401575	0.5705372	0.5705372
Time:Treatment	Time:Treatment	1	12	16	318.5	0.6028257	0.4525345	0.5705372

Lamc2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81	258.0	3.7674419	0.0761128	0.2283384
Treatment	Treatment	1	12	0	339.5	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	1	334.0	0.0359281	0.8528323	1.0000000

mediumpurple3

Col19a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gpr12

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Car1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	153	1.254902	0.2845381	0.3284251
Treatment	Treatment	1	12	16	185	1.037838	0.3284251	0.3284251
Time:Treatment	Time:Treatment	1	12	16	185	1.037838	0.3284251	0.3284251

Abca12

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	241.5	0.4472050	0.5163238	0.7744857
Treatment	Treatment	1	12	9	241.5	0.4472050	0.5163238	0.7744857
Time:Treatment	Time:Treatment	1	12	1	251.0	0.0478088	0.8305955	0.8305955

Gm6086

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	281.5	0.0106572	0.9194827	0.9194827
Treatment	Treatment	1	12	49.00	228.5	2.5733042	0.1346600	0.4039801
Time:Treatment	Time:Treatment	1	12	12.25	261.5	0.5621415	0.4678438	0.7017657

Synpr

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	267	0.4044944	0.5367189	0.8050784
Treatment	Treatment	1	12	0.25	283	0.0106007	0.9196955	0.9196955
Time:Treatment	Time:Treatment	1	12	20.25	263	0.9239544	0.3554081	0.8050784

Aqp8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	230.5	0.208243	0.6562971	0.6562971
Treatment	Treatment	1	12	16	188.5	1.018568	0.3327767	0.6562971
Time:Treatment	Time:Treatment	1	12	4	230.5	0.208243	0.6562971	0.6562971

Gm16119

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	276.5	0.1735986	0.6842893	0.8270016
Treatment	Treatment	1	12	6.25	216.0	0.3472222	0.5666182	0.8270016
Time:Treatment	Time:Treatment	1	12	1.00	240.5	0.0498960	0.8270016	0.8270016

Vsig4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	267	0.4044944	0.5367189	0.5367189
Treatment	Treatment	1	12	9	267	0.4044944	0.5367189	0.5367189
Time:Treatment	Time:Treatment	1	12	64	183	4.1967213	0.0630284	0.1890852

Nsun4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	233.0	2.5236052	0.1381392	0.2072088
Treatment	Treatment	1	12	64.00	228.5	3.3610503	0.0916656	0.2072088
Time:Treatment	Time:Treatment	1	12	6.25	281.0	0.2669039	0.6148042	0.6148042

thistle2

Hbq1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

4732444A12Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm10010

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

D430041D05Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	189.0	1.0158730	0.3333919	0.6556033
Treatment	Treatment	1	12	6.25	219.0	0.3424658	0.5692507	0.6556033
Time:Treatment	Time:Treatment	1	12	4.00	229.5	0.2091503	0.6556033	0.6556033

Rxfp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Wdr72

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Lmx1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	286.0	0.3776224	0.5503525	0.9172567
Treatment	Treatment	1	12	1.00	274.0	0.0437956	0.8377449	0.9172567
Time:Treatment	Time:Treatment	1	12	0.25	266.5	0.0112570	0.9172567	0.9172567

Igsf1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	287.5	0.5113043	0.4882538	0.7323807
Treatment	Treatment	1	12	0.00	304.0	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	12.25	268.5	0.5474860	0.4735747	0.7323807

Olig1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	247	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	16	151	1.271523	0.2815232	0.8445697
Time:Treatment	Time:Treatment	1	12	0	247	0.000000	1.0000000	1.0000000

Unc79

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	273.0	0.0109890	0.9182437	1
Treatment	Treatment	1	12	0.00	274.5	0.0000000	1.0000000	1
Time:Treatment	Time:Treatment	1	12	0.25	284.0	0.0105634	0.9198365	1

yellow4

Ipo5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.5	3.7601547	0.0763620	0.2290859
Treatment	Treatment	1	12	2.25	325.5	0.0829493	0.7782535	0.7782535
Time:Treatment	Time:Treatment	1	12	30.25	305.5	1.1882160	0.2970951	0.4456426

Kif20a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	277.5	2.4324324	0.1448201	0.3476395
Treatment	Treatment	1	12	25.00	314.0	0.9554140	0.3476395	0.3476395
Time:Treatment	Time:Treatment	1	12	25.00	310.0	0.9677419	0.3446632	0.3476395

Hfe2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	261.0	0.4137931	0.5321509	0.696424
Treatment	Treatment	1	12	4	276.5	0.1735986	0.6842893	0.696424
Time:Treatment	Time:Treatment	1	12	4	300.5	0.1597338	0.6964240	0.696424

Myef2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	245.5	4.4114053	0.0575108	0.1725323
Treatment	Treatment	1	12	1.00	314.0	0.0382166	0.8482800	0.8482800
Time:Treatment	Time:Treatment	1	12	25.00	299.0	1.0033445	0.3362737	0.5044105

Tfdp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	294.5	1.2325976	0.2886544	0.6418671
Treatment	Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.6418671
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.6418671

Imp4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	302.5	1.2000000	0.2948207	0.3454109
Treatment	Treatment	1	12	25.00	311.0	0.9646302	0.3454109	0.3454109
Time:Treatment	Time:Treatment	1	12	30.25	303.5	1.1960461	0.2955811	0.3454109

Melk

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	280.5	2.4064171	0.1468005	0.4404016
Treatment	Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.9263331
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331

Exoc3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	291.5	1.739280	0.2118446	0.2925258
Treatment	Treatment	1	12	30.25	299.5	1.212020	0.2925258	0.2925258
Time:Treatment	Time:Treatment	1	12	144.00	183.5	9.416894	0.0097404	0.0292211

Kif23

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	206.5	7.6852300	0.0168921	0.0506763
Treatment	Treatment	1	12	2.25	324.5	0.0832049	0.7779222	0.7802108
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.0814480	0.7802108	0.7802108

Kif4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	288.5	2.0381282	0.1789011	0.5367034
Treatment	Treatment	1	12	9.00	331.0	0.3262840	0.5783968	0.5783968
Time:Treatment	Time:Treatment	1	12	20.25	306.5	0.7928222	0.3907507	0.5783968

indianred

Parp14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	257.5	3.3669903	0.0914117	0.2742350
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.4559656
Time:Treatment	Time:Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4559656

Sbno2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	233.5	4.638116	0.0523033	0.1569099
Treatment	Treatment	1	12	56.25	282.5	2.389381	0.1481160	0.2014087
Time:Treatment	Time:Treatment	1	12	42.25	277.5	1.827027	0.2014087	0.2014087

Etv3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	255.5	3.3933464	0.0902955	0.1354433
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Time:Treatment	Time:Treatment	1	12	156.25	177.5	10.5633803	0.0069547	0.0208641

Dtx3l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	220.5	6.0000000	0.0306218	0.0918653
Treatment	Treatment	1	12	12.25	323.5	0.4544049	0.5130269	0.5130269
Time:Treatment	Time:Treatment	1	12	49.00	290.0	2.0275862	0.1799458	0.2699187

Thoc7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	214.0	6.7850467	0.0230208	0.0690623
Treatment	Treatment	1	12	16.00	319.5	0.6009390	0.4532258	0.6418671
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.6418671

Stat2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	238.0	5.0420168	0.0443600	0.1330799
Treatment	Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Time:Treatment	Time:Treatment	1	12	64.00	275.0	2.7927273	0.1205459	0.1808188

Tirap

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81	258.0	3.7674419	0.0761128	0.2283384
Treatment	Treatment	1	12	4	331.5	0.1447964	0.7102088	0.7102088
Time:Treatment	Time:Treatment	1	12	49	282.5	2.0814159	0.1746922	0.2620383

Irf9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	229.5	5.764706	0.0334588	0.1003764
Treatment	Treatment	1	12	49.00	291.0	2.020619	0.1806405	0.2544148
Time:Treatment	Time:Treatment	1	12	36.00	301.5	1.432836	0.2544148	0.2544148

Irak2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	264.5	3.2778828	0.0953126	0.2859377
Treatment	Treatment	1	12	4.00	336.0	0.1428571	0.7120579	0.7811702
Time:Treatment	Time:Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.7811702

Ifit2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	254.0	3.826772	0.0741204	0.0741204
Treatment	Treatment	1	12	90.25	249.5	4.340681	0.0592616	0.0741204
Time:Treatment	Time:Treatment	1	12	100.00	239.5	5.010438	0.0449263	0.0741204

antiquewhite

Fam3c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	333.5	0.1439280	0.7110350	0.9265504
Treatment	Treatment	1	12	16.00	315.5	0.6085578	0.4504449	0.9265504
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Slc40a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.5	3.7601547	0.0763620	0.2290859
Treatment	Treatment	1	12	20.25	315.5	0.7702060	0.3973841	0.5732055
Time:Treatment	Time:Treatment	1	12	9.00	322.0	0.3354037	0.5732055	0.5732055

Reg3b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	263.5	2.5616698	0.1354645	0.2031968
Treatment	Treatment	1	12	64.00	274.0	2.8029197	0.1199362	0.2031968
Time:Treatment	Time:Treatment	1	12	20.25	292.5	0.8307692	0.3799961	0.3799961

Dhfr

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	308.5	1.1766613	0.2993491	0.6428643
Treatment	Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.6428643
Time:Treatment	Time:Treatment	1	12	6.25	331.5	0.2262443	0.6428643	0.6428643

Aspg

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	327.0	0.3302752	0.5761130	0.7811702
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.7811702
Time:Treatment	Time:Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.7811702

Prmt2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Treatment	Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.9266583
Time:Treatment	Time:Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.9266583

Elovl7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	326.5	0.3307810	0.5758249	0.6423668
Treatment	Treatment	1	12	25.00	302.0	0.9933775	0.3385921	0.6423668
Time:Treatment	Time:Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.6423668

Nkain1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25	314.0	0.9554140	0.3476395	0.5214593
Treatment	Treatment	1	12	49	290.5	2.0240964	0.1802933	0.5214593
Time:Treatment	Time:Treatment	1	12	9	328.5	0.3287671	0.5769737	0.5769737

Entpd7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	337.5	0.0800000	0.7821172	0.7821172
Treatment	Treatment	1	12	30.25	306.5	1.1843393	0.2978486	0.7821172
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.7821172

Reg3g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	216.5	6.7066975	0.0236697	0.0673894
Treatment	Treatment	1	12	100.00	239.5	5.0104384	0.0449263	0.0673894
Time:Treatment	Time:Treatment	1	12	20.25	306.5	0.7928222	0.3907507	0.3907507

mediumpurple1

Rfx4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Zcchc16

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Grm7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	261.5	0.1835564	0.6759241	1.0000000
Treatment	Treatment	1	12	20.25	238.0	1.0210084	0.3322210	0.9966629
Time:Treatment	Time:Treatment	1	12	0.00	267.0	0.0000000	1.0000000	1.0000000

Arntl2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	253.5	1.7041420	0.2162219	0.6486656
Treatment	Treatment	1	12	9.00	290.5	0.3717728	0.5534100	0.7625075
Time:Treatment	Time:Treatment	1	12	2.25	282.5	0.0955752	0.7625075	0.7625075

Aloxe3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	250.5	2.023952	0.1803077	0.1803077
Treatment	Treatment	1	12	64.00	225.0	3.413333	0.0894602	0.1803077
Time:Treatment	Time:Treatment	1	12	49.00	229.0	2.567686	0.1350478	0.1803077

Fign

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	297.0	0.0000000	1.0000000	1
Treatment	Treatment	1	12	12.25	291.0	0.5051546	0.4908278	1
Time:Treatment	Time:Treatment	1	12	1.00	313.5	0.0382775	0.8481607	1

Atp6v0a4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	200.5	5.985037	0.0307934	0.0866218
Treatment	Treatment	1	12	64	220.5	3.482993	0.0866218	0.0866218
Time:Treatment	Time:Treatment	1	12	64	198.5	3.869018	0.0727403	0.0866218

Pla2g4e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	269.0	1.605948	0.2291035	0.3436552
Treatment	Treatment	1	12	42.25	268.5	1.888268	0.1945193	0.3436552
Time:Treatment	Time:Treatment	1	12	12.25	316.5	0.464455	0.5084887	0.5084887

March10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	242.5	2.0907216	0.1738040	0.5214121
Treatment	Treatment	1	12	6.25	253.5	0.2958580	0.5964522	0.5964522
Time:Treatment	Time:Treatment	1	12	9.00	238.0	0.4537815	0.5133108	0.5964522

Clic3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	196.5	3.908397	0.0714818	0.0714818
Treatment	Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818
Time:Treatment	Time:Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818

lightblue4

Scd3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm867

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Tas1r1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	247	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	16	151	1.271523	0.2815232	0.8445697
Time:Treatment	Time:Treatment	1	12	0	247	0.000000	1.0000000	1.0000000

Ftcd

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	249.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.9786428
Time:Treatment	Time:Treatment	1	12	4.00	225.0	0.2133333	0.6524285	0.9786428

Sall4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	276.0	0.3913043	0.5433284	0.5433284
Treatment	Treatment	1	12	42.25	244.5	2.0736196	0.1754408	0.5119653
Time:Treatment	Time:Treatment	1	12	20.25	247.5	0.9818182	0.3413102	0.5119653

Pcyt1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	311.0	0.1543408	0.7013107	0.7013107
Treatment	Treatment	1	12	20.25	264.5	0.9187146	0.3567268	0.5350902
Time:Treatment	Time:Treatment	1	12	36.00	279.0	1.5483871	0.2371301	0.5350902

Tmem132c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	299	0.0903010	0.7689374	0.7689374
Treatment	Treatment	1	12	12.25	295	0.4983051	0.4937229	0.7689374
Time:Treatment	Time:Treatment	1	12	6.25	303	0.2475248	0.6278145	0.7689374

Pcdhb6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	332.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	20.25	310.5	0.7826087	0.3937250	0.7617451
Time:Treatment	Time:Treatment	1	12	12.25	315.5	0.4659271	0.5078301	0.7617451

Gm807

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Clvs1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	317.5	0.1511811	0.7042202	0.9258928
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.9258928
Time:Treatment	Time:Treatment	1	12	0.25	332.5	0.0090226	0.9258928	0.9258928

firebrick3

Hoxb6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	323.5	0.5935085	0.4559656	0.5155648
Treatment	Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.5155648
Time:Treatment	Time:Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.5155648

Hoxb5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Time:Treatment	Time:Treatment	1	12	25.00	314.5	0.9538951	0.3480088	0.3995488

Hoxb7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	329.5	0.2276176	0.6418671	0.6418671
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.6418671
Time:Treatment	Time:Treatment	1	12	25.00	315.0	0.9523810	0.3483776	0.6418671

Slc17a8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	296.5	1.7099494	0.2154903	0.5197919
Treatment	Treatment	1	12	25.00	312.5	0.9600000	0.3465280	0.5197919
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Hsd3b3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	321.5	0.5972006	0.4546008	0.5778293
Treatment	Treatment	1	12	25	314.5	0.9538951	0.3480088	0.5778293
Time:Treatment	Time:Treatment	1	12	9	330.0	0.3272727	0.5778293	0.5778293

Prkaa2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232
Treatment	Treatment	1	12	72.25	267.5	3.2411215	0.0969812	0.2909436
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Bcmo1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Treatment	Treatment	1	12	42.25	297.5	1.7042017	0.2162143	0.6486430
Time:Treatment	Time:Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7818029

Npl

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	337.5	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	9.00	331.0	0.3262840	0.5783968	0.9657799
Time:Treatment	Time:Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.9657799

Lamb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	301.5	1.4328358	0.2544148	0.5993232
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5993232
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.7110350

Fam151a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	322.0	0.5962733	0.4549430	0.6824144
Treatment	Treatment	1	12	42.25	296.5	1.7099494	0.2154903	0.6464708
Time:Treatment	Time:Treatment	1	12	1.00	339.0	0.0353982	0.8539077	0.8539077

mistyrose

Qpct

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.5	2.0240964	0.1802933	0.4528805
Treatment	Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.4528805
Time:Treatment	Time:Treatment	1	12	16.00	319.0	0.6018809	0.4528805	0.4528805

Col5a3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	290	2.0275862	0.1799458	0.5398374
Treatment	Treatment	1	12	9	331	0.3262840	0.5783968	0.7120579
Time:Treatment	Time:Treatment	1	12	4	336	0.1428571	0.7120579	0.7120579

Gm10687

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	273.0	2.8131868	0.1193258	0.3579775
Treatment	Treatment	1	12	36	298.5	1.4472362	0.2521702	0.3782553
Time:Treatment	Time:Treatment	1	12	1	334.5	0.0358744	0.8529409	0.8529409

Aox1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.5	2.024096	0.1802933	0.2133079
Treatment	Treatment	1	12	72.25	264.5	3.277883	0.0953126	0.2133079
Time:Treatment	Time:Treatment	1	12	42.25	293.5	1.727428	0.2133079	0.2133079

Cav2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	312.5	0.777600	0.3951964	0.3951964
Treatment	Treatment	1	12	42.25	296.5	1.709949	0.2154903	0.3788183
Time:Treatment	Time:Treatment	1	12	36.00	299.0	1.444816	0.2525455	0.3788183

Hoxb3os

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	309	1.1747573	0.2997228	0.6426158
Treatment	Treatment	1	12	6.25	331	0.2265861	0.6426158	0.6426158
Time:Treatment	Time:Treatment	1	12	12.25	327	0.4495413	0.5152497	0.6426158

Dpt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.0	2.7927273	0.1205459	0.3616377
Treatment	Treatment	1	12	30.25	306.5	1.1843393	0.2978486	0.4467730
Time:Treatment	Time:Treatment	1	12	2.25	327.5	0.0824427	0.7789118	0.7789118

Ecm2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	313.0	0.9584665	0.3468991	0.9265504
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.9265504

Adam33

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.5	2.7876588	0.1208505	0.3625516
Treatment	Treatment	1	12	6.25	317.5	0.2362205	0.6357035	0.6372741
Time:Treatment	Time:Treatment	1	12	6.25	320.5	0.2340094	0.6372741	0.6372741

Pnck

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	239.5	5.0104384	0.0449263	0.1347788
Treatment	Treatment	1	12	25	315.0	0.9523810	0.3483776	0.5225663
Time:Treatment	Time:Treatment	1	12	1	339.0	0.0353982	0.8539077	0.8539077

moccasin

Plekha6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	324.5	0.4530046	0.5136651	0.8539077
Treatment	Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.8539077
Time:Treatment	Time:Treatment	1	12	1.00	339.0	0.0353982	0.8539077	0.8539077

L1cam

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	324.5	0.3328197	0.5746666	0.6438533
Treatment	Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6438533
Time:Treatment	Time:Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533

Grhl2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	331.0	0.0815710	0.7800497	1
Treatment	Treatment	1	12	1.00	337.5	0.0355556	0.8535876	1
Time:Treatment	Time:Treatment	1	12	0.00	335.5	0.0000000	1.0000000	1

Unc13b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	318.5	0.4615385	0.5097981	0.5778293
Treatment	Treatment	1	12	9.00	330.0	0.3272727	0.5778293	0.5778293
Time:Treatment	Time:Treatment	1	12	20.25	315.5	0.7702060	0.3973841	0.5778293

Znrf3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.5778293
Treatment	Treatment	1	12	25.00	312.5	0.9600000	0.3465280	0.5778293
Time:Treatment	Time:Treatment	1	12	9.00	330.0	0.3272727	0.5778293	0.5778293

Plxnb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Treatment	Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.7733472
Time:Treatment	Time:Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.7733472

Csnk1e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	335.5	0.0804769	0.7814873	0.8536945
Treatment	Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945
Time:Treatment	Time:Treatment	1	12	9.00	327.0	0.3302752	0.5761130	0.8536945

Gm17296

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.0	0.035503	0.8536945	1.0000000
Treatment	Treatment	1	12	0.00	339.0	0.000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.8980472

Socs6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	302.5	0.9917355	0.3389763	0.5084644
Treatment	Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Time:Treatment	Time:Treatment	1	12	30.25	302.5	1.2000000	0.2948207	0.5084644

Abcc8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	336.0	0.1428571	0.7120579	0.9265504
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.9265504

chocolate3

Mprip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	1
Treatment	Treatment	1	12	4.00	336.0	0.1428571	0.7120579	1
Time:Treatment	Time:Treatment	1	12	0.00	339.0	0.0000000	1.0000000	1

Rbak

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	322.5	0.2325581	0.6383100	0.7818029
Treatment	Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Als2cl

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	334.0	0.1437126	0.7112404	0.8536945
Treatment	Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.8536945

Slc6a20b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	334.5	0.0358744	0.8529409	0.8529409
Treatment	Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.8529409
Time:Treatment	Time:Treatment	1	12	4.00	331.5	0.1447964	0.7102088	0.8529409

Sema4g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	334.5	0.0807175	0.7811702	0.852505
Treatment	Treatment	1	12	1.00	331.0	0.0362538	0.8521755	0.852505
Time:Treatment	Time:Treatment	1	12	1.00	332.5	0.0360902	0.8525050	0.852505

Adcy6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	337.0	0.0356083	0.8534804	0.9263331
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.9263331

Vwa5b2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	330.5	0.0816944	0.7798882	0.7811702
Treatment	Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.7811702
Time:Treatment	Time:Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.7811702

Stx17

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.0	0.0355030	0.8536945	0.9266583
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Acvr1c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.5	0.3267776	0.5781134	0.71165
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.71165
Time:Treatment	Time:Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.71165

1300002K09Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Treatment	Treatment	1	12	25.00	313.0	0.9584665	0.3468991	0.9266583
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.9266583

pink2

Tnfrsf1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Treatment	Treatment	1	12	49.00	289.0	2.0346021	0.1792497	0.5377491
Time:Treatment	Time:Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.9266583

Ankrd13a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Treatment	Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.9265504
Time:Treatment	Time:Treatment	1	12	6.25	331.5	0.2262443	0.6428643	0.9265504

Msantd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	329.5	0.2276176	0.6418671	0.6418671
Treatment	Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.6418671
Time:Treatment	Time:Treatment	1	12	25.00	314.5	0.9538951	0.3480088	0.6418671

Prr13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.5	0.3267776	0.5781134	0.6433598
Treatment	Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.6433598
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Efhd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500
Treatment	Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.6839484
Time:Treatment	Time:Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.6839484

St14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	337.5	0.0088889	0.9264420	0.926442
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.926442
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.926442

Slc9a3r1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.853373
Treatment	Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.853373
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.853373

Pak4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	1
Treatment	Treatment	1	12	25.00	315.0	0.9523810	0.3483776	1
Time:Treatment	Time:Treatment	1	12	0.00	340.0	0.0000000	1.0000000	1

0610009B22Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	327.5	0.4488550	0.5155648	0.6433598
Treatment	Treatment	1	12	25.00	314.5	0.9538951	0.3480088	0.6433598
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Rac1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	337.5	0.0088889	0.9264420	0.926442
Treatment	Treatment	1	12	25.00	315.0	0.9523810	0.3483776	0.926442
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.926442

sienna1

Tfap2b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Acmsd

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm10032

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Il11ra2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Lipo2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Ranbp3l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	254	0.0472441	0.8315819	0.8315819
Treatment	Treatment	1	12	12.25	207	0.7101449	0.4158763	0.6459536
Time:Treatment	Time:Treatment	1	12	12.25	221	0.6651584	0.4306357	0.6459536

C230012O17Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Prtg

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	283.5	0.0952381	0.7629126	0.7629126
Treatment	Treatment	1	12	36.00	240.0	1.8000000	0.2045501	0.5311223
Time:Treatment	Time:Treatment	1	12	20.25	261.5	0.9292543	0.3540815	0.5311223

Slc4a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	231.0	0.6363636	0.4405312	0.4405312
Treatment	Treatment	1	12	64.00	159.5	4.8150470	0.0486296	0.1458889
Time:Treatment	Time:Treatment	1	12	12.25	231.0	0.6363636	0.4405312	0.4405312

Adamts17

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	297.0	0.3636364	0.5577189	0.7716924
Treatment	Treatment	1	12	6.25	309.5	0.2423263	0.6314136	0.7716924
Time:Treatment	Time:Treatment	1	12	2.25	306.5	0.0880914	0.7716924	0.7716924

darkgoldenrod4

Lrrn4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	217.0	6.691244	0.0238003	0.0714008
Treatment	Treatment	1	12	90.25	245.5	4.411405	0.0575108	0.0862661
Time:Treatment	Time:Treatment	1	12	36.00	299.0	1.444816	0.2525455	0.2525455

Gpm6a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	226.5	5.841060	0.0325051	0.0975154
Treatment	Treatment	1	12	64.00	275.5	2.787659	0.1208505	0.1208505
Time:Treatment	Time:Treatment	1	12	64.00	273.5	2.808044	0.1196311	0.1208505

Upk3b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	169.00	170.5	11.8944282	0.0048154	0.0144461
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.5778293
Time:Treatment	Time:Treatment	1	12	9.00	330.0	0.3272727	0.5778293	0.5778293

Pkhd1l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	231.0	5.194805	0.0417377	0.1014963
Treatment	Treatment	1	12	81	241.0	4.033195	0.0676642	0.1014963
Time:Treatment	Time:Treatment	1	12	49	271.5	2.165746	0.1668500	0.1668500

Wt1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	215.5	6.737819	0.0234094	0.0702281
Treatment	Treatment	1	12	72.25	265.5	3.265537	0.0958690	0.0958690
Time:Treatment	Time:Treatment	1	12	72.25	259.5	3.341041	0.0925272	0.0958690

Igfbp6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	195.5	8.8388747	0.0116356	0.0349068
Treatment	Treatment	1	12	9.00	330.0	0.3272727	0.5778293	0.7821172
Time:Treatment	Time:Treatment	1	12	2.25	337.5	0.0800000	0.7821172	0.7821172

Msln

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	281.5	2.3978686	0.1474588	0.4423763
Treatment	Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.7110350
Time:Treatment	Time:Treatment	1	12	25.00	314.5	0.9538951	0.3480088	0.5220133

Slpi

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	155.5	14.0643087	0.0027698	0.0083093
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Time:Treatment	Time:Treatment	1	12	49.00	286.0	2.0559441	0.1771533	0.2657300

Sema3e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	156.25	181	10.359116	0.0073742	0.0221225
Treatment	Treatment	1	12	132.25	205	7.741463	0.0165781	0.0248671
Time:Treatment	Time:Treatment	1	12	49.00	283	2.077739	0.1750448	0.1750448

Kdm1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	290.0	2.0275862	0.1799458	0.2699187
Treatment	Treatment	1	12	100	239.0	5.0209205	0.0447373	0.1342120
Time:Treatment	Time:Treatment	1	12	9	318.5	0.3390895	0.5711345	0.5711345

lightskyblue2

Cacnb4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	193.5	0.9922481	0.3388563	0.3394556
Treatment	Treatment	1	12	16	192.0	1.0000000	0.3370491	0.3394556
Time:Treatment	Time:Treatment	1	12	16	194.0	0.9896907	0.3394556	0.3394556

Slc26a7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	186	3.16129	0.1007301	0.1007301
Treatment	Treatment	1	12	49	186	3.16129	0.1007301	0.1007301
Time:Treatment	Time:Treatment	1	12	49	186	3.16129	0.1007301	0.1007301

Clvs2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	219.5	0.3416856	0.5696848	0.5696848
Treatment	Treatment	1	12	16.00	193.0	0.9948187	0.3382554	0.5696848
Time:Treatment	Time:Treatment	1	12	9.00	211.0	0.5118483	0.4880272	0.5696848

Gm10369

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	249.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257
Time:Treatment	Time:Treatment	1	12	6.25	214.5	0.3496503	0.5652838	0.8479257

Gm11732

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	216	0	1.0000000	1.0000000
Treatment	Treatment	1	12	16	96	2	0.1827168	0.5481503
Time:Treatment	Time:Treatment	1	12	0	216	0	1.0000000	1.0000000

Gm26555

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	258.0	0.1046512	0.7518860	0.7518860
Treatment	Treatment	1	12	36.00	260.5	1.6583493	0.2221069	0.6651037
Time:Treatment	Time:Treatment	1	12	12.25	234.0	0.6282051	0.4434025	0.6651037

Car5a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	296	0.4966216	0.4944391	0.7416587
Treatment	Treatment	1	12	16.00	288	0.6666667	0.4301273	0.7416587
Time:Treatment	Time:Treatment	1	12	0.25	325	0.0092308	0.9250454	0.9250454

Gm4804

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	247.5	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	16	151.5	1.267327	0.2822802	0.8468407
Time:Treatment	Time:Treatment	1	12	0	247.5	0.000000	1.0000000	1.0000000

Pou3f1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	326	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	9	302	0.3576159	0.5609503	0.8414255
Time:Treatment	Time:Treatment	1	12	25	286	1.0489510	0.3259526	0.8414255

Olfr1033

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	314.5	0.0381558	0.8483990	0.8483990
Treatment	Treatment	1	12	12.25	298.5	0.4924623	0.4962166	0.7443248
Time:Treatment	Time:Treatment	1	12	16.00	315.5	0.6085578	0.4504449	0.7443248

linen

Pak2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	274.0	2.8029197	0.1199362	0.3598085
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.9265504

Sox13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	276.0	2.7826087	0.1211550	0.3634650
Treatment	Treatment	1	12	9.00	331.0	0.3262840	0.5783968	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Syt7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	299.0	1.4448161	0.2525455	0.7576366
Treatment	Treatment	1	12	0	337.5	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	9	328.5	0.3287671	0.5769737	0.8654606

Aim1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	243.5	4.4476386	0.0566379	0.1699138
Treatment	Treatment	1	12	12.25	323.5	0.4544049	0.5130269	0.7118542
Time:Treatment	Time:Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.7118542

Trim2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	319.5	0.7605634	0.4002654	0.7818029
Treatment	Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Epb4.1l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	269.5	2.8497217	0.1171851	0.3515552
Treatment	Treatment	1	12	0.00	336.0	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	1.0000000

Mid2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	294.5	1.7215620	0.2140371	0.6421112
Treatment	Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Sept8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.143070	0.7118542	0.7821172
Treatment	Treatment	1	12	12.25	327.5	0.448855	0.5155648	0.7821172
Time:Treatment	Time:Treatment	1	12	2.25	337.5	0.080000	0.7821172	0.7821172

Itpr2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	326.5	0.4502297	0.5149340	1
Treatment	Treatment	1	12	0.00	339.5	0.0000000	1.0000000	1
Time:Treatment	Time:Treatment	1	12	1.00	338.5	0.0354505	0.8538013	1

Tns4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	299.5	1.4424040	0.2529204	0.4002654
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Time:Treatment	Time:Treatment	1	12	30.25	302.5	1.2000000	0.2948207	0.4002654

oldlace

1700095B22Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Alx4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	216	0	1.0000000	1.0000000
Treatment	Treatment	1	12	16	96	2	0.1827168	0.5481503
Time:Treatment	Time:Treatment	1	12	0	216	0	1.0000000	1.0000000

Hspa1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	317.5	0.2362205	0.6357035	0.6978446
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.6978446
Time:Treatment	Time:Treatment	1	12	4.00	303.5	0.1581549	0.6978446	0.6978446

Hspa8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	328.5	0.0091324	0.9254444	0.9254444
Treatment	Treatment	1	12	121.00	214.0	6.7850467	0.0230208	0.0690623
Time:Treatment	Time:Treatment	1	12	1.00	324.5	0.0369800	0.8507217	0.9254444

Hsph1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	337.5	0.00000	1.0000000	1.0000000
Treatment	Treatment	1	12	110.25	226.5	5.84106	0.0325051	0.0975154
Time:Treatment	Time:Treatment	1	12	0.00	332.0	0.00000	1.0000000	1.0000000

Hspa1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	322.5	0.3348837	0.5734989	0.5755362
Treatment	Treatment	1	12	42.25	287.5	1.7634783	0.2088974	0.5755362
Time:Treatment	Time:Treatment	1	12	9.00	326.0	0.3312883	0.5755362	0.5755362

Gm5620

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	285.5	1.0507881	0.3255465	0.3632059
Treatment	Treatment	1	12	49.00	270.5	2.1737523	0.1661290	0.3632059
Time:Treatment	Time:Treatment	1	12	20.25	272.0	0.8933824	0.3632059	0.3632059

Twf1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	316.5	0.0379147	0.8488722	0.8488722
Treatment	Treatment	1	12	81.00	259.0	3.7528958	0.0766112	0.2298335
Time:Treatment	Time:Treatment	1	12	2.25	330.5	0.0816944	0.7798882	0.8488722

Dnajb9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	323.5	0.1483771	0.7068318	0.7068318
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Time:Treatment	Time:Treatment	1	12	16.00	317.5	0.6047244	0.4518406	0.6777609

A130066N16Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	324.0	0.0092593	0.9249302	0.9249302
Treatment	Treatment	1	12	49.00	270.5	2.1737523	0.1661290	0.4983871
Time:Treatment	Time:Treatment	1	12	0.25	318.0	0.0094340	0.9242277	0.9249302

lightblue

Thrap3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	284.5	2.0667838	0.1761006	0.5197919
Treatment	Treatment	1	12	25.00	312.5	0.9600000	0.3465280	0.5197919
Time:Treatment	Time:Treatment	1	12	2.25	322.5	0.0837209	0.7772551	0.7772551

Hnrnpf

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.0	2.7927273	0.1205459	0.3616377
Treatment	Treatment	1	12	20.25	315.5	0.7702060	0.3973841	0.5960761
Time:Treatment	Time:Treatment	1	12	2.25	324.5	0.0832049	0.7779222	0.7779222

Kpnb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.0	3.7674419	0.0761128	0.2283384
Treatment	Treatment	1	12	30.25	305.5	1.1882160	0.2970951	0.4456426
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.5117430

Lnx2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	279.5	2.4150268	0.1461414	0.4384241
Treatment	Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.5772595
Time:Treatment	Time:Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.5772595

Kif2a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.5	3.760155	0.0763620	0.2290859
Treatment	Treatment	1	12	42.25	296.5	1.709949	0.2154903	0.3232354
Time:Treatment	Time:Treatment	1	12	0.00	337.5	0.000000	1.0000000	1.0000000

Mapre1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	248.5	4.3581489	0.0588233	0.1764698
Treatment	Treatment	1	12	12.25	299.5	0.4908180	0.4969224	0.7453835
Time:Treatment	Time:Treatment	1	12	2.25	301.5	0.0895522	0.7698668	0.7698668

Hpx

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	273.5	2.8080439	0.1196311	0.3588933
Treatment	Treatment	1	12	16	322.5	0.5953488	0.4552845	0.4552845
Time:Treatment	Time:Treatment	1	12	25	312.0	0.9615385	0.3461562	0.4552845

Mettl14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	299.5	1.4424040	0.2529204	0.7587611
Treatment	Treatment	1	12	1	334.0	0.0359281	0.8528323	0.8528323
Time:Treatment	Time:Treatment	1	12	1	334.0	0.0359281	0.8528323	0.8528323

Elovl6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	265.5	3.2655367	0.0958690	0.287607
Treatment	Treatment	1	12	4.00	319.0	0.1504702	0.7048796	0.853373
Time:Treatment	Time:Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.853373

Nars

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	267.5	3.241122	0.0969812	0.2909436
Treatment	Treatment	1	12	4.00	333.5	0.143928	0.7110350	0.7110350
Time:Treatment	Time:Treatment	1	12	16.00	319.5	0.600939	0.4532258	0.6798388

red4

Erbb4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Ttc18

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	178.5	1.07563	0.3201249	0.3201249
Treatment	Treatment	1	12	16	178.5	1.07563	0.3201249	0.3201249
Time:Treatment	Time:Treatment	1	12	16	178.5	1.07563	0.3201249	0.3201249

Rnf182

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	181.0	2.005525	0.1821574	0.3290517
Treatment	Treatment	1	12	25.00	193.5	1.550388	0.2368449	0.3290517
Time:Treatment	Time:Treatment	1	12	16.00	185.5	1.035040	0.3290517	0.3290517

Gm8093

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	206	0.5242718	0.4829030	0.8275291
Treatment	Treatment	1	12	1	242	0.0495868	0.8275291	0.8275291
Time:Treatment	Time:Treatment	1	12	4	278	0.1726619	0.6850907	0.8275291

Lect1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Adh5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	231.0	3.3246753	0.0932392	0.2797177
Treatment	Treatment	1	12	25	278.5	1.0771993	0.3197868	0.4201321
Time:Treatment	Time:Treatment	1	12	16	275.5	0.6969147	0.4201321	0.4201321

Gm12394

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	330	0.1454545	0.7095845	0.7095845
Treatment	Treatment	1	12	36	292	1.4794521	0.2472444	0.3708667
Time:Treatment	Time:Treatment	1	12	36	292	1.4794521	0.2472444	0.3708667

Hist2h2aa1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	239.5	4.5219207	0.0548979	0.1646938
Treatment	Treatment	1	12	16.00	311.0	0.6173633	0.4472660	0.6708990
Time:Treatment	Time:Treatment	1	12	1.00	331.0	0.0362538	0.8521755	0.8521755

Ndufa9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	287.5	0.2608696	0.618789	0.848399
Treatment	Treatment	1	12	6.25	312.5	0.2400000	0.633040	0.848399
Time:Treatment	Time:Treatment	1	12	1.00	314.5	0.0381558	0.848399	0.848399

Eif4g2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	323.0	0.3343653	0.5737917	0.5737917
Treatment	Treatment	1	12	42.25	260.5	1.9462572	0.1882748	0.5648243
Time:Treatment	Time:Treatment	1	12	16.00	291.5	0.6586621	0.4328365	0.5737917

---

Analysis performed by Ann Wells

The Carter Lab The Jackson Laboratory 2023

ann.wells@jax.org