Hub Genes Hippocampus

tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))

tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))

log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)

log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])

log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5] 

log.tdata.FPKM.sample.info.subset <- cbind(log.tdata.FPKM.subset,tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info.subset <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.sample.info.subset.hippocampus <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(Tissue == "Hippocampus") %>% column_to_rownames()

module.labels <- readRDS(here("Data","Hippocampus","log.tdata.FPKM.sample.info.subset.hippocampus.WGCNA.module.labels.RData"))

modules <- readRDS(here("Data","Hippocampus","log.tdata.FPKM.sample.info.subset.hippocampus.WGCNA.module.membership.RData"))

net.deg <- readRDS(here("Data","Hippocampus","Chang_2DG_BL6_connectivity_hippocampus.RData"))

ensembl.location <- readRDS(here("Data","Ensembl_gene_id_and_location.RData"))

Hub Genes

Hub genes are genes in the module network that have the highest connectivity. For instance, if the gene significance of a particular module is associated with treatment the hub genes in this module are likely associated with this trait.

hub.genes.list <- hub.genes(net.deg,module.labels,modules,ensembl.location)

Goldenrod4 Module

DT.table.hub(hub.genes.list[[1]])

Brown2 Module

DT.table.hub(hub.genes.list[[2]])

Deepskyblue4 Module

DT.table.hub(hub.genes.list[[3]])

Coral1 Module

DT.table.hub(hub.genes.list[[4]])

Turquoise Module

DT.table.hub(hub.genes.list[[5]])

Darkseagreen2 Module

DT.table.hub(hub.genes.list[[6]])

Chocolate3 Module

DT.table.hub(hub.genes.list[[7]])

Darkgrey Module

DT.table.hub(hub.genes.list[[8]])

Brown1 Module

DT.table.hub(hub.genes.list[[9]])

Pink1 Module

DT.table.hub(hub.genes.list[[10]])

Indianred1 Module

DT.table.hub(hub.genes.list[[11]])

Tan4 Module

DT.table.hub(hub.genes.list[[12]])

Dodgerblue1 Module

DT.table.hub(hub.genes.list[[13]])

Green Module

DT.table.hub(hub.genes.list[[14]])

Darkslateblue Module

DT.table.hub(hub.genes.list[[15]])

Grey Module

DT.table.hub(hub.genes.list[[16]])

Lavenderblush2 Module

DT.table.hub(hub.genes.list[[17]])

Indianred4 Module

DT.table.hub(hub.genes.list[[18]])

Tomato Module

DT.table.hub(hub.genes.list[[19]])

Pink4 Module

DT.table.hub(hub.genes.list[[20]])

Slateblue1 Module

DT.table.hub(hub.genes.list[[21]])

Blue3 Module

DT.table.hub(hub.genes.list[[22]])

Blanchedalmond Module

DT.table.hub(hub.genes.list[[23]])

Darkolivegreen Module

DT.table.hub(hub.genes.list[[24]])

Green3 Module

DT.table.hub(hub.genes.list[[25]])

Dodgerblue3 Module

DT.table.hub(hub.genes.list[[26]])

Chocolate2 Module

DT.table.hub(hub.genes.list[[27]])

Lavenderblush3 Module

DT.table.hub(hub.genes.list[[28]])

Chocolate Module

DT.table.hub(hub.genes.list[[29]])

Orangered1 Module

DT.table.hub(hub.genes.list[[30]])

Firebrick3 Module

DT.table.hub(hub.genes.list[[31]])

Deeppink Module

DT.table.hub(hub.genes.list[[32]])

Salmon1 Module

DT.table.hub(hub.genes.list[[33]])

Lavenderblush1 Module

DT.table.hub(hub.genes.list[[34]])

Firebrick2 Module

DT.table.hub(hub.genes.list[[35]])

Indianred2 Module

DT.table.hub(hub.genes.list[[36]])

Blue1 Module

DT.table.hub(hub.genes.list[[37]])

Darkgoldenrod4 Module

DT.table.hub(hub.genes.list[[38]])

Antiquewhite Module

DT.table.hub(hub.genes.list[[39]])

Orange3 Module

DT.table.hub(hub.genes.list[[40]])

Tan1 Module

DT.table.hub(hub.genes.list[[41]])

Darkgoldenrod1 Module

DT.table.hub(hub.genes.list[[42]])

Rosybrown3 Module

DT.table.hub(hub.genes.list[[43]])

Khaki3 Module

DT.table.hub(hub.genes.list[[44]])

Bisque2 Module

DT.table.hub(hub.genes.list[[45]])

ANOVA

To perform analysis of variance Aligned Rank Transformation was performed, which is designed to handle non-parametric multi-factorial experiments. P-value was adjusted using Benjamini-hochberg procedure. Only the top 10 hub genes are listed.

log.tdata.FPKM.sample.info.subset.hippocampus$Time <- as.factor(log.tdata.FPKM.sample.info.subset.hippocampus$Time)
log.tdata.FPKM.sample.info.subset.hippocampus$Treatment <- as.factor(log.tdata.FPKM.sample.info.subset.hippocampus$Treatment)

for(m in module.labels) {
    name <- str_split(m,"_")[[1]][2]
    hub.met <- net.deg[modules$Gene,] %>%
      dplyr::mutate(Gene=modules$Gene) %>%
      dplyr::filter(modules$Module == m) %>%
      dplyr::arrange(desc(kWithin)) %>%
      dplyr::select(Gene, kWithin)
    gene <- ensembl.location$external_gene_name[match(hub.met$Gene,ensembl.location$ensembl_gene_id)]
    hub.met <- cbind(gene,hub.met)
    cat("\n###",name, "{.tabset .tabset-fade .tabset-pills}","\n")
          for(i in 1:10){
             cat("\n####",hub.met$gene[i],"\n")
             m <- art(data = log.tdata.FPKM.sample.info.subset.hippocampus, log.tdata.FPKM.sample.info.subset.hippocampus[,hub.met$Gene[i]] ~ Time*Treatment)
             model <- anova(m)
             adjust <- p.adjust(model$`Pr(>F)`, method = "BH")
             print(knitr::kable(cbind(model,adjust)) %>% 
                      column_spec(8, color = "white", background = spec_color(adjust, end = 0.05, scale_from = c(0,0.05))) %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")))
             
             cat("\n \n")
             }
          cat("\n \n")
          }

goldenrod4

Pip4k2b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	331.0	0.3262840	0.5783968	0.5783968
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.5783968
Time:Treatment	Time:Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.5783968

Erc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	334.5	0.0807175	0.7811702	0.7811702
Treatment	Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.5971623
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.5971623

Gsk3a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	314.0	0.9554140	0.3476395	0.5214593
Treatment	Treatment	1	12	42.25	288.5	1.7573657	0.2096367	0.5214593
Time:Treatment	Time:Treatment	1	12	4.00	321.5	0.1493002	0.7059689	0.7059689

Rab6b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	330.5	0.2269289	0.6423668	0.9635501
Treatment	Treatment	1	12	16.00	323.5	0.5935085	0.4559656	0.9635501
Time:Treatment	Time:Treatment	1	12	0.00	336.0	0.0000000	1.0000000	1.0000000

Cyfip2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	323.5	0.4544049	0.5130269	0.5130269
Treatment	Treatment	1	12	56.25	277.5	2.4324324	0.1448201	0.3788183
Time:Treatment	Time:Treatment	1	12	36.00	299.0	1.4448161	0.2525455	0.3788183

Pcdha2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	330.5	0.2269289	0.6423668	0.6423668
Treatment	Treatment	1	12	12.25	327.5	0.4488550	0.5155648	0.6423668
Time:Treatment	Time:Treatment	1	12	9.00	326.5	0.3307810	0.5758249	0.6423668

Mapre2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	333.5	0.1439280	0.711035	0.711035
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.514934	0.711035
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.514934	0.711035

Prep

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	331.5	0.2262443	0.6428643	0.7118542
Treatment	Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.7118542
Time:Treatment	Time:Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.7118542

Dlg4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	327.5	0.4488550	0.5155648	0.71165
Treatment	Treatment	1	12	25.00	314.5	0.9538951	0.3480088	0.71165
Time:Treatment	Time:Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.71165

Fry

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	319.0	0.6018809	0.4528805	0.4528805
Treatment	Treatment	1	12	49.00	288.5	2.0381282	0.1789011	0.4479000
Time:Treatment	Time:Treatment	1	12	30.25	307.5	1.1804878	0.2986000	0.4479000

brown2

Atp5j2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	306.5	0.9787928	0.3420268	0.5130402
Treatment	Treatment	1	12	30.25	297.5	1.2201681	0.2909843	0.5130402
Time:Treatment	Time:Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.8533730

Rpl36a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	316.5	0.7677725	0.3981082	0.5971623
Treatment	Treatment	1	12	30.25	303.5	1.1960461	0.2955811	0.5971623
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331

Rps14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	295.5	1.4619289	0.2499075	0.3446632
Treatment	Treatment	1	12	49	278.5	2.1113106	0.1718594	0.3446632
Time:Treatment	Time:Treatment	1	12	25	310.0	0.9677419	0.3446632	0.3446632

Ssna1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	300.0	1.4400000	0.2532947	0.3799421
Treatment	Treatment	1	12	64	255.5	3.0058708	0.1085543	0.3256630
Time:Treatment	Time:Treatment	1	12	1	338.5	0.0354505	0.8538013	0.8538013

Rpl37a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	277.5	2.4324324	0.1448201	0.2577891
Treatment	Treatment	1	12	49.00	278.5	2.1113106	0.1718594	0.2577891
Time:Treatment	Time:Treatment	1	12	9.00	326.0	0.3312883	0.5755362	0.5755362

Rpl38

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313.5	0.7751196	0.3959282	0.5938923
Treatment	Treatment	1	12	49.00	276.5	2.1265823	0.1704349	0.5113046
Time:Treatment	Time:Treatment	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238

Aurkaip1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	326.0	0.1472393	0.7078997	0.8520652
Treatment	Treatment	1	12	56.25	277.5	2.4324324	0.1448201	0.4344602
Time:Treatment	Time:Treatment	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652

Ndufs6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	308.5	0.9724473	0.3435370	0.5153056
Treatment	Treatment	1	12	56.25	258.5	2.6112186	0.1320794	0.3962381
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.0814480	0.7802108	0.7802108

Gm9843

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	297.5	1.4521008	0.2514180	0.3771269
Treatment	Treatment	1	12	42.25	281.5	1.8010657	0.2044250	0.3771269
Time:Treatment	Time:Treatment	1	12	4.00	323.5	0.1483771	0.7068318	0.7068318

D8Ertd738e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	303.5	1.1960461	0.2955811	0.4433717
Treatment	Treatment	1	12	49.00	264.5	2.2230624	0.1617749	0.4433717
Time:Treatment	Time:Treatment	1	12	2.25	324.5	0.0832049	0.7779222	0.7779222

deepskyblue4

Atp5h

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	291.5	0.0926244	0.7660802	0.7660802
Treatment	Treatment	1	12	49.00	230.0	2.5565217	0.1358225	0.4074674
Time:Treatment	Time:Treatment	1	12	16.00	263.0	0.7300380	0.4096046	0.6144069

Ndufb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	267.5	0.0112150	0.9174109	0.9174109
Treatment	Treatment	1	12	30.25	243.5	1.4907598	0.2455462	0.5997939
Time:Treatment	Time:Treatment	1	12	16.00	252.0	0.7619048	0.3998626	0.5997939

Timmdc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	227.0	0.8458150	0.3758563	0.3758563
Treatment	Treatment	1	12	30.25	261.5	1.3881453	0.2615552	0.3758563
Time:Treatment	Time:Treatment	1	12	20.25	253.5	0.9585799	0.3468716	0.3758563

Exosc9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	278.0	0.0431655	0.8388983	0.8388983
Treatment	Treatment	1	12	9.00	259.0	0.4169884	0.5305982	0.7958973
Time:Treatment	Time:Treatment	1	12	20.25	241.5	1.0062112	0.3356111	0.7958973

Tcp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	230.5	2.1995662	0.1638313	0.4914939
Treatment	Treatment	1	12	9.00	268.5	0.4022346	0.5378403	0.5378403
Time:Treatment	Time:Treatment	1	12	12.25	261.5	0.5621415	0.4678438	0.5378403

Snurf

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	312.5	0.3456000	0.5675132	0.5675132
Treatment	Treatment	1	12	72.25	221.5	3.9142212	0.0712979	0.2138938
Time:Treatment	Time:Treatment	1	12	20.25	271.5	0.8950276	0.3627798	0.5441697

Mrpl13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	277.5	0.2702703	0.6126063	0.6834817
Treatment	Treatment	1	12	49.00	230.0	2.5565217	0.1358225	0.4074674
Time:Treatment	Time:Treatment	1	12	4.00	275.0	0.1745455	0.6834817	0.6834817

1810037I17Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	297.5	0.2521008	0.6246855	0.6246855
Treatment	Treatment	1	12	30.25	228.5	1.5886214	0.2314811	0.4990624
Time:Treatment	Time:Treatment	1	12	20.25	238.5	1.0188679	0.3327083	0.4990624

Iscu

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	287.0	0.0418118	0.8414059	0.8414059
Treatment	Treatment	1	12	36.00	232.0	1.8620690	0.1974285	0.3683193
Time:Treatment	Time:Treatment	1	12	30.25	243.5	1.4907598	0.2455462	0.3683193

Trnau1ap

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	264.5	1.372401	0.2641356	0.3196994
Treatment	Treatment	1	12	30.25	203.5	1.783784	0.2064656	0.3196994
Time:Treatment	Time:Treatment	1	12	20.25	225.5	1.077605	0.3196994	0.3196994

coral1

Ogfod2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	275.0	2.138182	0.1693629	0.2540444
Treatment	Treatment	1	12	100	239.0	5.020920	0.0447373	0.1342120
Time:Treatment	Time:Treatment	1	12	0	317.5	0.000000	1.0000000	1.0000000

Cox4i1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	281.5	1.8010657	0.2044250	0.3066375
Treatment	Treatment	1	12	81.00	255.0	3.8117647	0.0746183	0.2238550
Time:Treatment	Time:Treatment	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238

Cyhr1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	284.5	2.0667838	0.1761006	0.2641509
Treatment	Treatment	1	12	81.00	256.5	3.7894737	0.0753654	0.2260963
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331

Nap1l4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	267.5	1.8953271	0.1937450	0.2906175
Treatment	Treatment	1	12	72.25	265.5	3.2655367	0.0958690	0.2876070
Time:Treatment	Time:Treatment	1	12	0.25	309.5	0.0096931	0.9231978	0.9231978

Ndufs2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	308.5	0.7876823	0.3922431	0.5883647
Treatment	Treatment	1	12	64.00	269.5	2.8497217	0.1171851	0.3515552
Time:Treatment	Time:Treatment	1	12	0.25	326.5	0.0091884	0.9252172	0.9252172

Copz1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	238.5	4.0754717	0.0664272	0.0996409
Treatment	Treatment	1	12	110.25	229.5	5.7647059	0.0334588	0.0996409
Time:Treatment	Time:Treatment	1	12	0.25	319.5	0.0093897	0.9244051	0.9244051

Timm13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	291.5	1.739280	0.2118446	0.3177669
Treatment	Treatment	1	12	81.00	259.0	3.752896	0.0766112	0.2298335
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.081448	0.7802108	0.7802108

Phpt1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	300.5	0.9983361	0.3374358	0.5061537
Treatment	Treatment	1	12	110.25	227.5	5.8153846	0.0328221	0.0984664
Time:Treatment	Time:Treatment	1	12	1.00	324.5	0.0369800	0.8507217	0.8507217

Tsfm

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	299.0	0.6421405	0.4385165	0.6577747
Treatment	Treatment	1	12	121	215.0	6.7534884	0.0232796	0.0698388
Time:Treatment	Time:Treatment	1	12	1	324.5	0.0369800	0.8507217	0.8507217

Ndufa8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	295.0	1.4644068	0.2495286	0.3742928
Treatment	Treatment	1	12	56.25	281.5	2.3978686	0.1474588	0.3742928
Time:Treatment	Time:Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500

turquoise

Cdh3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	286.5	1.0471204	0.3263580	0.7612497
Treatment	Treatment	1	12	12.25	315.0	0.4666667	0.5074998	0.7612497
Time:Treatment	Time:Treatment	1	12	2.25	325.0	0.0830769	0.7780881	0.7780881

Scara5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	275.0	1.5709091	0.2339456	0.7018368
Treatment	Treatment	1	12	6.25	326.5	0.2297090	0.6403555	0.8520652
Time:Treatment	Time:Treatment	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652

Tmem184a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	301.5	0.4875622	0.4983252	0.7798882
Treatment	Treatment	1	12	4.00	327.0	0.1467890	0.7083237	0.7798882
Time:Treatment	Time:Treatment	1	12	2.25	330.5	0.0816944	0.7798882	0.7798882

Baiap2l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25	288.5	1.0398614	0.3279729	0.7083237
Treatment	Treatment	1	12	9	318.0	0.3396226	0.5708361	0.7083237
Time:Treatment	Time:Treatment	1	12	4	327.0	0.1467890	0.7083237	0.7083237

Cab39l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	296.5	1.0118044	0.3343238	0.7087458
Treatment	Treatment	1	12	4.00	328.0	0.1463415	0.7087458	0.7087458
Time:Treatment	Time:Treatment	1	12	6.25	318.5	0.2354788	0.6362293	0.7087458

Itpripl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	313.5	0.2392344	0.6335773	0.8520652
Treatment	Treatment	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Time:Treatment	Time:Treatment	1	12	9.00	326.0	0.3312883	0.5755362	0.8520652

Slc2a12

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	273.5	1.5795247	0.2327425	0.6982274
Treatment	Treatment	1	12	12.25	317.5	0.4629921	0.5091447	0.7637171
Time:Treatment	Time:Treatment	1	12	2.25	327.5	0.0824427	0.7789118	0.7789118

Sult1c2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	302.5	0.4859504	0.4990223	0.7789118
Treatment	Treatment	1	12	4.00	327.5	0.1465649	0.7085349	0.7789118
Time:Treatment	Time:Treatment	1	12	2.25	327.5	0.0824427	0.7789118	0.7789118

Nid2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	321.5	0.4572317	0.5117430	0.7102088
Treatment	Treatment	1	12	6.25	327.5	0.2290076	0.6408615	0.7102088
Time:Treatment	Time:Treatment	1	12	4.00	331.5	0.1447964	0.7102088	0.7102088

Sgms2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	294.5	1.7215620	0.2140371	0.6421112
Treatment	Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7808518
Time:Treatment	Time:Treatment	1	12	4.00	332.0	0.1445783	0.7104160	0.7808518

darkseagreen2

Rangap1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	309.5	0.2423263	0.6314136	0.6314136
Treatment	Treatment	1	12	64.00	273.5	2.8080439	0.1196311	0.3588933
Time:Treatment	Time:Treatment	1	12	12.25	317.5	0.4629921	0.5091447	0.6314136

Spryd3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	311	0.1543408	0.7013107	0.7053168
Treatment	Treatment	1	12	64	271	2.8339483	0.1181034	0.3543103
Time:Treatment	Time:Treatment	1	12	4	320	0.1500000	0.7053168	0.7053168

Pkm

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	328.5	0.0091324	0.9254444	0.9254444
Treatment	Treatment	1	12	25.00	310.0	0.9677419	0.3446632	0.9254444
Time:Treatment	Time:Treatment	1	12	4.00	331.0	0.1450151	0.7100011	0.9254444

Sult4a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	312.5	0.3456000	0.5675132	0.5769737
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Time:Treatment	Time:Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.5769737

Uqcrc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	309.5	0.2423263	0.6314136	0.8479213
Treatment	Treatment	1	12	64.00	272.0	2.8235294	0.1187149	0.3561448
Time:Treatment	Time:Treatment	1	12	1.00	312.5	0.0384000	0.8479213	0.8479213

Pld3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	330.5	0.0090772	0.9256696	0.9256696
Treatment	Treatment	1	12	64.00	275.0	2.7927273	0.1205459	0.3616377
Time:Treatment	Time:Treatment	1	12	25.00	306.0	0.9803922	0.3416477	0.5124715

Aldoa

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	317.5	0.1511811	0.7042202	0.7042202
Treatment	Treatment	1	12	49.00	286.0	2.0559441	0.1771533	0.5314599
Time:Treatment	Time:Treatment	1	12	12.25	317.5	0.4629921	0.5091447	0.7042202

Gnl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	309.5	0.4749596	0.5038225	0.5038225
Treatment	Treatment	1	12	64.00	275.5	2.7876588	0.1208505	0.3625516
Time:Treatment	Time:Treatment	1	12	16.00	311.0	0.6173633	0.4472660	0.5038225

Uchl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	313.5	0.0861244	0.7741768	0.7741768
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Time:Treatment	Time:Treatment	1	12	20.25	310.5	0.7826087	0.3937250	0.5905875

Rnf187

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	331.5	0.0814480	0.7802108	0.8529409
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Time:Treatment	Time:Treatment	1	12	1.00	334.5	0.0358744	0.8529409	0.8529409

chocolate3

Csrp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	300.5	0.9983361	0.3374358	0.3929854
Treatment	Treatment	1	12	49.00	286.0	2.0559441	0.1771533	0.3929854
Time:Treatment	Time:Treatment	1	12	20.25	309.5	0.7851373	0.3929854	0.3929854

Etfa

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	230.0	5.2173913	0.0413660	0.0843033
Treatment	Treatment	1	12	90.25	242.5	4.4659794	0.0562022	0.0843033
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Odc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	276.5	1.8336347	0.2006502	0.4329816
Treatment	Treatment	1	12	30.25	294.5	1.2325976	0.2886544	0.4329816
Time:Treatment	Time:Treatment	1	12	16.00	315.5	0.6085578	0.4504449	0.4504449

Mcee

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	257.5	3.366990	0.0914117	0.1371175
Treatment	Treatment	1	12	72.25	251.5	3.447316	0.0880616	0.1371175
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.143928	0.7110350	0.7110350

Cd63

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	299.5	1.2120200	0.2925258	0.3385921
Treatment	Treatment	1	12	25.00	302.0	0.9933775	0.3385921	0.3385921
Time:Treatment	Time:Treatment	1	12	25.00	302.0	0.9933775	0.3385921	0.3385921

Hemk1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	287.5	1.763478	0.2088974	0.2925258
Treatment	Treatment	1	12	132.25	197.5	8.035443	0.0150444	0.0451331
Time:Treatment	Time:Treatment	1	12	30.25	299.5	1.212020	0.2925258	0.2925258

Npc2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	261.5	3.3154876	0.0936419	0.2809258
Treatment	Treatment	1	12	30.25	302.5	1.2000000	0.2948207	0.4422311
Time:Treatment	Time:Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7112404

Bsg

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	290.5	1.745267	0.2111103	0.2917562
Treatment	Treatment	1	12	30.25	287.5	1.262609	0.2831347	0.2917562
Time:Treatment	Time:Treatment	1	12	30.25	298.5	1.216080	0.2917562	0.2917562

Rbp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	271.5	2.828729	0.1184093	0.2162370
Treatment	Treatment	1	12	56.25	276.5	2.441230	0.1441580	0.2162370
Time:Treatment	Time:Treatment	1	12	25.00	296.5	1.011804	0.3343238	0.3343238

Acaa2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	291.0	1.4845361	0.2464790	0.3697184
Treatment	Treatment	1	12	49.00	274.0	2.1459854	0.1686467	0.3697184
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.5117430

darkgrey

8030462N17Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	293.5	0.1635434	0.6930299	0.6930299
Treatment	Treatment	1	12	110.25	216.5	6.1108545	0.0293849	0.0881546
Time:Treatment	Time:Treatment	1	12	49.00	258.5	2.2746615	0.1573727	0.2360591

Arhgap5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	291.5	0.0926244	0.7660802	0.7660802
Treatment	Treatment	1	12	72.25	263.5	3.2903226	0.0947559	0.2842677
Time:Treatment	Time:Treatment	1	12	20.25	263.5	0.9222011	0.3558485	0.5337728

Fam126b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	278.5	1.303411	0.2758614	0.2758614
Treatment	Treatment	1	12	169.00	158.0	12.835443	0.0037638	0.0112915
Time:Treatment	Time:Treatment	1	12	49.00	240.5	2.444906	0.1438824	0.2158236

Snx13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	311.5	0.0096308	0.9234439	0.9234439
Treatment	Treatment	1	12	196.00	124.0	18.9677419	0.0009362	0.0028087
Time:Treatment	Time:Treatment	1	12	36.00	263.5	1.6394687	0.2245948	0.3368922

Dmxl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	274.5	1.5737705	0.2335451	0.3503176
Treatment	Treatment	1	12	110.25	225.0	5.8800000	0.0320312	0.0960937
Time:Treatment	Time:Treatment	1	12	4.00	303.0	0.1584158	0.6976092	0.6976092

Braf

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	231.5	1.049676	0.3257922	0.3257922
Treatment	Treatment	1	12	210.25	128.5	19.634241	0.0008196	0.0024587
Time:Treatment	Time:Treatment	1	12	64.00	199.5	3.849624	0.0733700	0.1100550

Clock

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	278.5	1.077199	0.3197868	0.3197868
Treatment	Treatment	1	12	182.25	156.5	13.974441	0.0028310	0.0084931
Time:Treatment	Time:Treatment	1	12	72.25	221.5	3.914221	0.0712979	0.1069469

Hdgfrp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	308.5	0.0875203	0.7724106	0.7724106
Treatment	Treatment	1	12	169.00	156.5	12.9584665	0.0036473	0.0109420
Time:Treatment	Time:Treatment	1	12	56.25	227.5	2.9670330	0.1106254	0.1659381

Nfat5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	300.5	0.0099834	0.9220603	0.9220603
Treatment	Treatment	1	12	56.25	277.5	2.4324324	0.1448201	0.4344602
Time:Treatment	Time:Treatment	1	12	20.25	271.5	0.8950276	0.3627798	0.5441697

Cacna2d1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	286.0	1.048951	0.3259526	0.3259526
Treatment	Treatment	1	12	132.25	201.5	7.875930	0.0158547	0.0475640
Time:Treatment	Time:Treatment	1	12	30.25	273.5	1.327239	0.2717323	0.3259526

brown1

Gm9846

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	295.5	1.715736	0.2147645	0.346528
Treatment	Treatment	1	12	36.00	299.0	1.444816	0.2525455	0.346528
Time:Treatment	Time:Treatment	1	12	25.00	312.5	0.960000	0.3465280	0.346528

Tpm3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	322.0	0.5962733	0.4549430	0.6824144
Treatment	Treatment	1	12	1.00	322.0	0.0372671	0.8501511	0.8501511
Time:Treatment	Time:Treatment	1	12	30.25	305.5	1.1882160	0.2970951	0.6824144

Ndufa3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	328.5	0.3287671	0.5769737	0.6388247
Treatment	Treatment	1	12	6.25	323.5	0.2318393	0.6388247	0.6388247
Time:Treatment	Time:Treatment	1	12	20.25	317.5	0.7653543	0.3988298	0.6388247

Lamtor5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	300.0	1.440000	0.2532947	0.3884918
Treatment	Treatment	1	12	20.25	303.5	0.800659	0.3884918	0.3884918
Time:Treatment	Time:Treatment	1	12	30.25	307.5	1.180488	0.2986000	0.3884918

Rpl15-ps3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	323.0	0.1486068	0.7066168	0.7066168
Treatment	Treatment	1	12	6.25	323.5	0.2318393	0.6388247	0.7066168
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.7066168

mt-Nd3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.6532621
Treatment	Treatment	1	12	1.00	313.0	0.0383387	0.8480412	0.8480412
Time:Treatment	Time:Treatment	1	12	16.00	295.0	0.6508475	0.4355081	0.6532621

Tacc2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	330.5	0.2269289	0.6423668	0.7068318
Treatment	Treatment	1	12	6.25	318.5	0.2354788	0.6362293	0.7068318
Time:Treatment	Time:Treatment	1	12	4.00	323.5	0.1483771	0.7068318	0.7068318

Cox7a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	297.5	1.4521008	0.2514180	0.4476219
Treatment	Treatment	1	12	25	302.5	0.9917355	0.3389763	0.4476219
Time:Treatment	Time:Treatment	1	12	16	311.5	0.6163724	0.4476219	0.4476219

Rpl31-ps8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Treatment	Treatment	1	12	12.25	323.5	0.4544049	0.5130269	0.7695403
Time:Treatment	Time:Treatment	1	12	16.00	319.5	0.6009390	0.4532258	0.7695403

Sec13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	314.0	0.6114650	0.4493913	0.4518406
Treatment	Treatment	1	12	25	302.5	0.9917355	0.3389763	0.4518406
Time:Treatment	Time:Treatment	1	12	16	317.5	0.6047244	0.4518406	0.4518406

pink1

Rusc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	323	0.5944272	0.4556254	0.4556254
Treatment	Treatment	1	12	81	257	3.7821012	0.0756145	0.2268436
Time:Treatment	Time:Treatment	1	12	36	302	1.4304636	0.2547871	0.3821807

Stx1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Treatment	Treatment	1	12	56.25	283.5	2.3809524	0.1487723	0.2231584
Time:Treatment	Time:Treatment	1	12	81.00	257.0	3.7821012	0.0756145	0.2231584

Kcnf1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Treatment	Treatment	1	12	110.25	225.5	5.8669623	0.0321890	0.0482835
Time:Treatment	Time:Treatment	1	12	132.25	207.5	7.6481928	0.0171028	0.0482835

Chd5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	323.0	0.5944272	0.4556254	0.4556254
Treatment	Treatment	1	12	81.00	258.5	3.7601547	0.0763620	0.1438035
Time:Treatment	Time:Treatment	1	12	72.25	265.5	3.2655367	0.0958690	0.1438035

Dio3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	290.5	1.745267	0.2111103	0.2111103
Treatment	Treatment	1	12	81.00	258.0	3.767442	0.0761128	0.1446378
Time:Treatment	Time:Treatment	1	12	72.25	266.5	3.253283	0.0964252	0.1446378

Hrh3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.5	2.787659	0.1208505	0.1812758
Treatment	Treatment	1	12	42.25	297.5	1.704202	0.2162143	0.2162143
Time:Treatment	Time:Treatment	1	12	100.00	237.5	5.052632	0.0441715	0.1325146

Timp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	297.5	1.220168	0.2909843	0.2909843
Treatment	Treatment	1	12	81.00	249.0	3.903615	0.0716332	0.1074499
Time:Treatment	Time:Treatment	1	12	121.00	216.5	6.706697	0.0236697	0.0710091

Camk2n2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	309.5	1.172859	0.3000959	0.3000959
Treatment	Treatment	1	12	110.25	229.5	5.764706	0.0334588	0.0501882
Time:Treatment	Time:Treatment	1	12	110.25	225.5	5.866962	0.0321890	0.0501882

Fxyd6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	315.0	0.952381	0.3483776	0.3483776
Treatment	Treatment	1	12	144.00	195.0	8.861538	0.0115535	0.0346606
Time:Treatment	Time:Treatment	1	12	90.25	249.5	4.340681	0.0592616	0.0888924

Grem2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598
Treatment	Treatment	1	12	30.25	303.5	1.1960461	0.2955811	0.4433717
Time:Treatment	Time:Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757

indianred1

AI504432

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	290.5	1.0327022	0.3295767	0.7724010
Treatment	Treatment	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.7724010

Cit

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	254.0	3.8267717	0.0741204	0.1446378
Treatment	Treatment	1	12	9.00	322.0	0.3354037	0.5732055	0.5732055
Time:Treatment	Time:Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.1446378

Leng8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	227.0	5.2863436	0.0402555	0.1207664
Treatment	Treatment	1	12	0.25	328.5	0.0091324	0.9254444	0.9254444
Time:Treatment	Time:Treatment	1	12	1.00	326.0	0.0368098	0.8510610	0.9254444

Zmym3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	183.5	9.4168937	0.0097404	0.0292211
Treatment	Treatment	1	12	0.25	324.5	0.0092450	0.9249878	0.9249878
Time:Treatment	Time:Treatment	1	12	9.00	318.0	0.3396226	0.5708361	0.8562542

Ocrl

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	239.5	4.5219207	0.0548979	0.1646938
Treatment	Treatment	1	12	1.00	326.5	0.0367534	0.8511736	0.8511736
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.7724010

Sept11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	317.5	0.6047244	0.4518406	0.6777609
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.4443480

Unc13c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	312	0.9615385	0.3461562	0.3977464
Treatment	Treatment	1	12	20.25	316	0.7689873	0.3977464	0.3977464
Time:Treatment	Time:Treatment	1	12	72.25	266	3.2593985	0.0961472	0.2884415

Necab1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	291.0	2.0206186	0.1806405	0.2709608
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	64.00	273.5	2.8080439	0.1196311	0.2709608

Farp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	299.0	1.4448161	0.2525455	0.3838518
Treatment	Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.7811702
Time:Treatment	Time:Treatment	1	12	36.00	303.5	1.4233937	0.2559012	0.3838518

Gria4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	295.5	1.7157360	0.2147645	0.3221468
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	121.00	218.5	6.6453089	0.0241934	0.0725801

tan4

Secisbp2l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	334.5	0.0358744	0.8529409	0.8529409
Treatment	Treatment	1	12	110.25	220.5	6.0000000	0.0306218	0.0628858
Time:Treatment	Time:Treatment	1	12	100.00	231.5	5.1835853	0.0419238	0.0628858

Tmem88b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	323.0	0.5944272	0.4556254	0.4556254
Treatment	Treatment	1	12	64.00	271.0	2.8339483	0.1181034	0.2221740
Time:Treatment	Time:Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.2221740

Spg20

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	313.0	0.9584665	0.3468991	0.3468991
Treatment	Treatment	1	12	110.25	223.5	5.9194631	0.0315594	0.0946781
Time:Treatment	Time:Treatment	1	12	42.25	296.5	1.7099494	0.2154903	0.3232354

Kif13b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Treatment	Treatment	1	12	56.25	277.5	2.4324324	0.1448201	0.3639306
Time:Treatment	Time:Treatment	1	12	36.00	286.0	1.5104895	0.2426204	0.3639306

Plekhh1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	301.5	1.432836	0.2544148	0.2544148
Treatment	Treatment	1	12	90.25	248.5	4.358149	0.0588233	0.0882349
Time:Treatment	Time:Treatment	1	12	90.25	247.5	4.375758	0.0583853	0.0882349

Pde8a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598
Treatment	Treatment	1	12	100.00	237.5	5.0526316	0.0441715	0.1325146
Time:Treatment	Time:Treatment	1	12	72.25	267.5	3.2411215	0.0969812	0.1454718

Prr18

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	309.5	1.172859	0.3000959	0.3000959
Treatment	Treatment	1	12	81.00	259.0	3.752896	0.0766112	0.2298335
Time:Treatment	Time:Treatment	1	12	49.00	290.5	2.024096	0.1802933	0.2704400

Trp53inp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	328.5	0.3287671	0.5769737	0.5769737
Treatment	Treatment	1	12	25.00	311.0	0.9646302	0.3454109	0.5769737
Time:Treatment	Time:Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.5769737

Gatm

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Treatment	Treatment	1	12	121.00	217.0	6.6912442	0.0238003	0.0714008
Time:Treatment	Time:Treatment	1	12	64.00	271.0	2.8339483	0.1181034	0.1771551

Scrib

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.5	0.3267776	0.5781134	0.5781134
Treatment	Treatment	1	12	132.25	194.5	8.1593830	0.0144484	0.0216726
Time:Treatment	Time:Treatment	1	12	144.00	176.0	9.8181818	0.0086372	0.0216726

dodgerblue1

Psap

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	272.5	2.1577982	0.1675697	0.2513545
Treatment	Treatment	1	12	90.25	249.5	4.3406814	0.0592616	0.1777848
Time:Treatment	Time:Treatment	1	12	0.25	333.5	0.0089955	0.9260036	0.9260036

Slc20a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	271.5	2.8287293	0.1184093	0.1776139
Treatment	Treatment	1	12	72.25	267.5	3.2411215	0.0969812	0.1776139
Time:Treatment	Time:Treatment	1	12	12.25	325.5	0.4516129	0.5143008	0.5143008

Lrp10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	305.5	1.1882160	0.2970951	0.4456426
Treatment	Treatment	1	12	49.00	289.0	2.0346021	0.1792497	0.4456426
Time:Treatment	Time:Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013

Bcam

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	239.5	5.0104384	0.0449263	0.0673894
Treatment	Treatment	1	12	110.25	223.5	5.9194631	0.0315594	0.0673894
Time:Treatment	Time:Treatment	1	12	6.25	331.5	0.2262443	0.6428643	0.6428643

Akirin2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	246.5	2.7383367	0.1238655	0.1857983
Treatment	Treatment	1	12	110.25	226.5	5.8410596	0.0325051	0.0975154
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331

Ube2z

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	257.5	3.3669903	0.0914117	0.1371175
Treatment	Treatment	1	12	90.25	245.5	4.4114053	0.0575108	0.1371175
Time:Treatment	Time:Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323

Tmem106c

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	246.5	3.9432049	0.0703913	0.1055870
Treatment	Treatment	1	12	90.25	246.5	4.3935091	0.0579478	0.1055870
Time:Treatment	Time:Treatment	1	12	2.25	300.5	0.0898502	0.7694964	0.7694964

Man2b1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	257.5	3.3669903	0.0914117	0.1371175
Treatment	Treatment	1	12	132.25	201.5	7.8759305	0.0158547	0.0475640
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Gas6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	308.5	1.176661	0.2993491	0.3000959
Treatment	Treatment	1	12	30.25	309.5	1.172859	0.3000959	0.3000959
Time:Treatment	Time:Treatment	1	12	30.25	309.5	1.172859	0.3000959	0.3000959

Ddb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	268.5	1.8882682	0.1945193	0.2917789
Treatment	Treatment	1	12	100.00	237.5	5.0526316	0.0441715	0.1325146
Time:Treatment	Time:Treatment	1	12	12.25	300.5	0.4891847	0.4976252	0.4976252

green

C3ar1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	196	144.0	16.33333	0.0016352	0.0016352
Treatment	Treatment	1	12	256	82.0	37.46341	0.0000517	0.0000776
Time:Treatment	Time:Treatment	1	12	256	81.5	37.69325	0.0000503	0.0000776

Ifi204

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	204.5	7.760391	0.0164739	0.0164739
Treatment	Treatment	1	12	256.00	81.5	37.693252	0.0000503	0.0001508
Time:Treatment	Time:Treatment	1	12	240.25	99.5	28.974874	0.0001646	0.0002469

Tmem119

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	157.5	13.88571	0.0028931	0.0028931
Treatment	Treatment	1	12	256.00	83.5	36.79042	0.0000562	0.0001687
Time:Treatment	Time:Treatment	1	12	196.00	144.0	16.33333	0.0016352	0.0024528

Aoah

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144	193.5	8.930233	0.0113089	0.0113089
Treatment	Treatment	1	12	256	83.0	37.012048	0.0000547	0.0001641
Time:Treatment	Time:Treatment	1	12	196	141.0	16.680851	0.0015145	0.0022718

Gpr65

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	195.0	8.861538	0.0115535	0.0115535
Treatment	Treatment	1	12	256.00	83.5	36.790419	0.0000562	0.0001687
Time:Treatment	Time:Treatment	1	12	182.25	155.5	14.064309	0.0027698	0.0041546

AI607873

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	256	83.5	36.79042	5.62e-05	5.78e-05
Treatment	Treatment	1	12	256	84.0	36.57143	5.78e-05	5.78e-05
Time:Treatment	Time:Treatment	1	12	256	84.0	36.57143	5.78e-05	5.78e-05

Fcer1g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	210.25	128.5	19.634241	0.0008196	0.0012294
Treatment	Treatment	1	12	256.00	83.5	36.790419	0.0000562	0.0001687
Time:Treatment	Time:Treatment	1	12	144.00	195.0	8.861538	0.0115535	0.0115535

Clec4a3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	257.0	3.782101	0.0756145	0.1134218
Treatment	Treatment	1	12	256.00	83.5	36.790419	0.0000562	0.0001687
Time:Treatment	Time:Treatment	1	12	56.25	281.5	2.397869	0.1474588	0.1474588

C5ar1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	256	84.0	36.57143	5.78e-05	5.78e-05
Treatment	Treatment	1	12	256	83.0	37.01205	5.47e-05	5.78e-05
Time:Treatment	Time:Treatment	1	12	256	83.5	36.79042	5.62e-05	5.78e-05

Bcl2a1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	306.5	0.9787928	0.3420268	0.3420268
Treatment	Treatment	1	12	256.00	77.5	39.6387097	0.0000397	0.0001192
Time:Treatment	Time:Treatment	1	12	90.25	239.5	4.5219207	0.0548979	0.0823469

darkslateblue

Atp2b1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	309.5	1.172859	0.3000959	0.3000959
Treatment	Treatment	1	12	196.00	143.0	16.447552	0.0015944	0.0043397
Time:Treatment	Time:Treatment	1	12	182.25	157.5	13.885714	0.0028931	0.0043397

Epha3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	327.5	0.2290076	0.6408615	0.6408615
Treatment	Treatment	1	12	156.25	183.5	10.2179837	0.0076814	0.0115222
Time:Treatment	Time:Treatment	1	12	169.00	166.0	12.2168675	0.0044203	0.0115222

Cdh8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.5	2.024096	0.1802933	0.1802933
Treatment	Treatment	1	12	210.25	129.5	19.482626	0.0008445	0.0025336
Time:Treatment	Time:Treatment	1	12	182.25	157.5	13.885714	0.0028931	0.0043397

Zbtb20

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500
Treatment	Treatment	1	12	169.00	169.0	12.0000000	0.0046816	0.0070224
Time:Treatment	Time:Treatment	1	12	182.25	154.5	14.1553398	0.0027092	0.0070224

Dhx33

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	316.5	0.7677725	0.3981082	0.3981082
Treatment	Treatment	1	12	169.00	169.0	12.0000000	0.0046816	0.0070224
Time:Treatment	Time:Treatment	1	12	182.25	151.5	14.4356436	0.0025324	0.0070224

Trim2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	329.5	0.0091047	0.9255573	0.9255573
Treatment	Treatment	1	12	169.00	164.5	12.3282675	0.0042927	0.0128781
Time:Treatment	Time:Treatment	1	12	121.00	216.5	6.7066975	0.0236697	0.0355046

Slc24a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	314.5	0.9538951	0.3480088	0.3480088
Treatment	Treatment	1	12	210.25	127.5	19.7882353	0.0007951	0.0023853
Time:Treatment	Time:Treatment	1	12	110.25	222.5	5.9460674	0.0312459	0.0468689

Jhdm1d

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	334.5	0.0358744	0.8529409	0.8529409
Treatment	Treatment	1	12	210.25	129.5	19.4826255	0.0008445	0.0012668
Time:Treatment	Time:Treatment	1	12	210.25	128.5	19.6342412	0.0008196	0.0012668

Camk1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	339.0	0.0353982	0.8539077	0.8539077
Treatment	Treatment	1	12	144	193.5	8.9302326	0.0113089	0.0169634
Time:Treatment	Time:Treatment	1	12	169	166.5	12.1801802	0.0044633	0.0133898

Rasgrp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Treatment	Treatment	1	12	210.25	128.5	19.6342412	0.0008196	0.0024587
Time:Treatment	Time:Treatment	1	12	132.25	205.5	7.7226277	0.0166825	0.0250237

grey

Pitx2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm14492

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	224	0.8571429	0.3727843	0.5591764
Treatment	Treatment	1	12	16	222	0.8648649	0.3707118	0.5591764
Time:Treatment	Time:Treatment	1	12	1	252	0.0476190	0.8309262	0.8309262

2610528J11Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Ces3b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Sec22a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	308.5	0.0097245	0.9230739	0.9230739
Treatment	Treatment	1	12	9.00	298.5	0.3618090	0.5586958	0.8380437
Time:Treatment	Time:Treatment	1	12	20.25	304.5	0.7980296	0.3892475	0.8380437

Tfpi2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	190.5	3.543307	0.0842527	0.2527580
Treatment	Treatment	1	12	36.00	232.5	1.858065	0.1978782	0.2887597
Time:Treatment	Time:Treatment	1	12	25.00	243.5	1.232033	0.2887597	0.2887597

Marco

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	150	1.2800000	0.2800026	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Tex14

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	309.0	0.1553398	0.7003981	0.9237482
Treatment	Treatment	1	12	0.25	314.0	0.0095541	0.9237482	0.9237482
Time:Treatment	Time:Treatment	1	12	9.00	329.5	0.3277693	0.5775447	0.9237482

Cyp4a12a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	267	0.0112360	0.9173339	0.9173339
Treatment	Treatment	1	12	2.25	234	0.1153846	0.7399665	0.9173339
Time:Treatment	Time:Treatment	1	12	2.25	276	0.0978261	0.7598230	0.9173339

Timd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627

lavenderblush2

Sirpb1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

1010001N08Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Cckar

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	175	1.097143	0.3155336	0.3309216
Treatment	Treatment	1	12	16	187	1.026738	0.3309216	0.3309216
Time:Treatment	Time:Treatment	1	12	16	187	1.026738	0.3309216	0.3309216

Susd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	309.5	0.0872375	0.7727672	0.7727672
Treatment	Treatment	1	12	72.25	238.5	3.6352201	0.0807923	0.1220275
Time:Treatment	Time:Treatment	1	12	72.25	239.5	3.6200418	0.0813517	0.1220275

Fbxo40

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	194.5	0.9871465	0.3400533	0.4153283
Treatment	Treatment	1	12	16.00	225.0	0.8533333	0.3738131	0.4153283
Time:Treatment	Time:Treatment	1	12	12.25	206.5	0.7118644	0.4153283	0.4153283

Arhgap6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	327.5	0.0091603	0.9253311	0.9253311
Treatment	Treatment	1	12	49.00	283.0	2.0777385	0.1750448	0.2625672
Time:Treatment	Time:Treatment	1	12	90.25	247.5	4.3757576	0.0583853	0.1751560

Ecel1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	189.5	6.332454	0.0270858	0.0270858
Treatment	Treatment	1	12	132.25	178.5	8.890756	0.0114487	0.0270858
Time:Treatment	Time:Treatment	1	12	110.25	190.5	6.944882	0.0217612	0.0270858

Casr

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	224.0	0.3348214	0.5735341	0.8310909
Treatment	Treatment	1	12	20.25	198.0	1.2272727	0.2896494	0.8310909
Time:Treatment	Time:Treatment	1	12	1.00	252.5	0.0475248	0.8310909	0.8310909

Gm13154

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	280	0.1714286	0.6861498	0.6861498
Treatment	Treatment	1	12	42.25	251	2.0199203	0.1807104	0.5421311
Time:Treatment	Time:Treatment	1	12	12.25	278	0.5287770	0.4810680	0.6861498

Lurap1l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	328.5	0.3287671	0.5769737	0.5769737
Treatment	Treatment	1	12	42.25	281.5	1.8010657	0.2044250	0.3771269
Time:Treatment	Time:Treatment	1	12	36.00	297.5	1.4521008	0.2514180	0.3771269

indianred4

Rnf220

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Treatment	Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	333.5	0.0809595	0.7808518	0.7818029

Gm4540

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945
Treatment	Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.6819012
Time:Treatment	Time:Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.6819012

Fpgt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Treatment	Treatment	1	12	42.25	294.5	1.7215620	0.2140371	0.3771269
Time:Treatment	Time:Treatment	1	12	36.00	297.5	1.4521008	0.2514180	0.3771269

Slc6a17

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	331.5	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	36.00	303.5	1.423394	0.2559012	0.5960761
Time:Treatment	Time:Treatment	1	12	20.25	315.5	0.770206	0.3973841	0.5960761

Zfp81

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	316.5	0.464455	0.5084887	0.5084887
Treatment	Treatment	1	12	110.25	228.5	5.789934	0.0331400	0.0994201
Time:Treatment	Time:Treatment	1	12	56.25	274.5	2.459016	0.1428309	0.2142464

Zmym2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	308.5	0.350081	0.5650477	0.5650477
Treatment	Treatment	1	12	144	191.0	9.047120	0.0109066	0.0327197
Time:Treatment	Time:Treatment	1	12	36	303.0	1.425743	0.2555303	0.3832955

Yme1l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.3832955
Time:Treatment	Time:Treatment	1	12	36.00	303.0	1.4257426	0.2555303	0.3832955

Scyl1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	325.5	0.4516129	0.5143008	0.5143008
Treatment	Treatment	1	12	64.00	275.5	2.7876588	0.1208505	0.3625516
Time:Treatment	Time:Treatment	1	12	36.00	303.0	1.4257426	0.2555303	0.3832955

Ddx54

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.9265504
Treatment	Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.9265504
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Arap2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	329.0	0.0364742	0.8517327	0.8517327
Treatment	Treatment	1	12	110.25	226.5	5.8410596	0.0325051	0.0975154
Time:Treatment	Time:Treatment	1	12	4.00	331.0	0.1450151	0.7100011	0.8517327

tomato

Lct

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	327.5	0.1465649	0.7085349	0.7085349
Treatment	Treatment	1	12	36.00	303.5	1.4233937	0.2559012	0.3838518
Time:Treatment	Time:Treatment	1	12	210.25	129.5	19.4826255	0.0008445	0.0025336

Plekha2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Treatment	Treatment	1	12	49.00	290.5	2.0240964	0.1802933	0.2704400
Time:Treatment	Time:Treatment	1	12	156.25	183.5	10.2179837	0.0076814	0.0230443

Stxbp6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	330.5	0.0090772	0.9256696	0.9256696
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.2221740
Time:Treatment	Time:Treatment	1	12	225.00	114.0	23.6842105	0.0003872	0.0011615

Sema5a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Treatment	Treatment	1	12	90.25	249.5	4.3406814	0.0592616	0.0888924
Time:Treatment	Time:Treatment	1	12	225.00	114.5	23.5807860	0.0003942	0.0011826

Pla2g2f

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	303.5	1.423394	0.2559012	0.2559012
Treatment	Treatment	1	12	56.25	282.5	2.389381	0.1481160	0.2221740
Time:Treatment	Time:Treatment	1	12	196.00	142.0	16.563380	0.0015541	0.0046624

Epha7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	335.0	0.1432836	0.7116500	0.7116500
Treatment	Treatment	1	12	144	189.5	9.1187335	0.0106684	0.0160026
Time:Treatment	Time:Treatment	1	12	196	141.5	16.6219081	0.0015343	0.0046028

Sema4a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81	258.5	3.760155	0.0763620	0.0763620
Treatment	Treatment	1	12	81	258.5	3.760155	0.0763620	0.0763620
Time:Treatment	Time:Treatment	1	12	225	114.5	23.580786	0.0003942	0.0011826

Anxa11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	332.0	0.2259036	0.6431123	0.6431123
Treatment	Treatment	1	12	36.00	301.5	1.4328358	0.2544148	0.3816222
Time:Treatment	Time:Treatment	1	12	182.25	157.0	13.9299363	0.0028620	0.0085859

Dsp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.5	0.3267776	0.5781134	0.5781134
Treatment	Treatment	1	12	42.25	294.5	1.7215620	0.2140371	0.3210556
Time:Treatment	Time:Treatment	1	12	156.25	182.5	10.2739726	0.0075578	0.0226734

Foxn2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Treatment	Treatment	1	12	90.25	249.5	4.3406814	0.0592616	0.0888924
Time:Treatment	Time:Treatment	1	12	210.25	128.5	19.6342412	0.0008196	0.0024587

pink4

Fat1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.8538013
Time:Treatment	Time:Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.8538013

Prelp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.1430700	0.7118542	1
Treatment	Treatment	1	12	0.00	339.0	0.0000000	1.0000000	1
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	1

Slc16a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Treatment	Treatment	1	12	1.00	338.5	0.0354505	0.8538013	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9266583

Phactr2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	337.5	0.0088889	0.926442	1
Treatment	Treatment	1	12	0.00	337.5	0.0000000	1.000000	1
Time:Treatment	Time:Treatment	1	12	9.00	327.0	0.3302752	0.576113	1

Atp2b3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	339.0	0.0353982	0.8539077	0.9265504
Treatment	Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.9265504
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Polr1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	339.5	0.0000000	1.0000000	1
Treatment	Treatment	1	12	9.00	330.5	0.3267776	0.5781134	1
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	1

Stxbp4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	335.0	0.1432836	0.7116500	0.71165
Treatment	Treatment	1	12	4	323.5	0.1483771	0.7068318	0.71165
Time:Treatment	Time:Treatment	1	12	9	322.0	0.3354037	0.5732055	0.71165

Rhbdd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	335.5	0.0089419	0.9262238	0.9262238
Treatment	Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.9262238
Time:Treatment	Time:Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.9262238

Mapk4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.5	0.1430700	0.7118542	0.9260036
Treatment	Treatment	1	12	0.25	333.5	0.0089955	0.9260036	0.9260036
Time:Treatment	Time:Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.9260036

Zfp521

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	331.5	0.2262443	0.6428643	0.7818029
Treatment	Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

slateblue1

Pcdh10

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	281.5	1.801066	0.2044250	0.3122344
Treatment	Treatment	1	12	25.00	295.0	1.016949	0.3331460	0.3331460
Time:Treatment	Time:Treatment	1	12	42.25	286.5	1.769634	0.2081563	0.3122344

Zfp385a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	287.5	1.7634783	0.2088974	0.3133461
Treatment	Treatment	1	12	1.00	316.5	0.0379147	0.8488722	0.8488722
Time:Treatment	Time:Treatment	1	12	56.25	283.5	2.3809524	0.1487723	0.3133461

Ptprt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	245.5	4.4114053	0.0575108	0.1446378
Treatment	Treatment	1	12	25.00	307.0	0.9771987	0.3424053	0.3424053
Time:Treatment	Time:Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.1446378

Kcnn3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	233.5	5.1391863	0.0426702	0.1280106
Treatment	Treatment	1	12	9.00	302.0	0.3576159	0.5609503	0.5609503
Time:Treatment	Time:Treatment	1	12	30.25	302.5	1.2000000	0.2948207	0.4422311

Tox2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	273.0	2.1538462	0.1679290	0.2688745
Treatment	Treatment	1	12	6.25	331.5	0.2262443	0.6428643	0.6428643
Time:Treatment	Time:Treatment	1	12	49.00	289.0	2.0346021	0.1792497	0.2688745

Atat1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	268.0	2.8656716	0.1162654	0.2688745
Treatment	Treatment	1	12	12.25	302.5	0.4859504	0.4990223	0.4990223
Time:Treatment	Time:Treatment	1	12	49.00	289.0	2.0346021	0.1792497	0.2688745

Atn1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	245.5	4.411405	0.0575108	0.1725323
Treatment	Treatment	1	12	42.25	281.5	1.801066	0.2044250	0.3066375
Time:Treatment	Time:Treatment	1	12	25.00	312.5	0.960000	0.3465280	0.3465280

Tdp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	272.5	2.4770642	0.1415000	0.4245001
Treatment	Treatment	1	12	30.25	287.5	1.2626087	0.2831347	0.4247020
Time:Treatment	Time:Treatment	1	12	16.00	315.5	0.6085578	0.4504449	0.4504449

Glo1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	276.5	2.4412297	0.1441580	0.4324739
Treatment	Treatment	1	12	30.25	306.5	1.1843393	0.2978486	0.4467730
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Nr1d1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	226.5	5.8410596	0.0325051	0.0975154
Treatment	Treatment	1	12	0.00	338.0	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.6819012

blue3

Aldh1a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	308.5	1.176661	0.2993491	0.2993491
Treatment	Treatment	1	12	81.00	254.0	3.826772	0.0741204	0.1757776
Time:Treatment	Time:Treatment	1	12	64.00	269.5	2.849722	0.1171851	0.1757776

Slc22a6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	314.5	0.9538951	0.3480088	0.3480088
Treatment	Treatment	1	12	100.00	237.5	5.0526316	0.0441715	0.1325146
Time:Treatment	Time:Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.2221740

Cdh1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	328.5	0.3287671	0.5769737	0.5769737
Treatment	Treatment	1	12	81.00	252.5	3.8495050	0.0733739	0.1100608
Time:Treatment	Time:Treatment	1	12	90.25	237.5	4.5600000	0.0540309	0.1100608

Slc6a13

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	239.0	5.020920	0.0447373	0.0671060
Treatment	Treatment	1	12	132.25	204.5	7.760391	0.0164739	0.0494217
Time:Treatment	Time:Treatment	1	12	49.00	278.0	2.115108	0.1715037	0.1715037

Slc22a8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	290.0	2.0275862	0.1799458	0.2699187
Treatment	Treatment	1	12	100.00	240.0	5.0000000	0.0451154	0.1353461
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Thbd

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	289.0	2.034602	0.1792497	0.2688745
Treatment	Treatment	1	12	64	275.5	2.787659	0.1208505	0.2688745
Time:Treatment	Time:Treatment	1	12	25	292.5	1.025641	0.3311698	0.3311698

Kank2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	217.5	6.675862	0.0239310	0.0358966
Treatment	Treatment	1	12	144.00	195.5	8.838875	0.0116356	0.0349068
Time:Treatment	Time:Treatment	1	12	90.25	243.0	4.456790	0.0564200	0.0564200

Ptgds

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	226.5	5.841060	0.0325051	0.0426702
Treatment	Treatment	1	12	132.25	206.5	7.685230	0.0168921	0.0426702
Time:Treatment	Time:Treatment	1	12	100.00	233.5	5.139186	0.0426702	0.0426702

F13a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	314.5	0.9538951	0.3480088	0.3480088
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.2221740
Time:Treatment	Time:Treatment	1	12	56.25	277.5	2.4324324	0.1448201	0.2221740

Slc47a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	291.0	2.020619	0.1806405	0.1806405
Treatment	Treatment	1	12	64	276.0	2.782609	0.1211550	0.1806405
Time:Treatment	Time:Treatment	1	12	121	212.5	6.832941	0.0226345	0.0679034

blanchedalmond

Tgfb2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	333.5	0.2248876	0.6438533	0.7818029
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Time:Treatment	Time:Treatment	1	12	6.25	333.5	0.2248876	0.6438533	0.7818029

Gm20878

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	333.5	0.1439280	0.7110350	0.711035
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.711035
Time:Treatment	Time:Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.711035

Gm11992

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	330.5	0.1452345	0.7097930	0.709793
Treatment	Treatment	1	12	9	325.5	0.3317972	0.5752469	0.709793
Time:Treatment	Time:Treatment	1	12	9	318.0	0.3396226	0.5708361	0.709793

1110008P14Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	321.5	0.5972006	0.4546008	0.8620000
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Time:Treatment	Time:Treatment	1	12	9.00	324.5	0.3328197	0.5746666	0.8620000

Itpk1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	339.5	0.0000000	1.0000000	1
Treatment	Treatment	1	12	2.25	337.5	0.0800000	0.7821172	1
Time:Treatment	Time:Treatment	1	12	20.25	317.5	0.7653543	0.3988298	1

Synm

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	303.0	1.4257426	0.2555303	0.6844579
Treatment	Treatment	1	12	16	324.0	0.5925926	0.4563052	0.6844579
Time:Treatment	Time:Treatment	1	12	0	339.5	0.0000000	1.0000000	1.0000000

Sdccag3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.0	0.3272727	0.5778293	0.7818029
Treatment	Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.7818029
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Cat

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	321.0	0.5981308	0.4542580	0.6813870
Treatment	Treatment	1	12	0.25	338.0	0.0088757	0.9264962	0.9264962
Time:Treatment	Time:Treatment	1	12	16.00	319.5	0.6009390	0.4532258	0.6813870

Cdhr3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	332.5	0.2255639	0.6433598	0.8534804
Treatment	Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.8534804
Time:Treatment	Time:Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.8534804

Ddr1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	316.5	0.7677725	0.3981082	0.9266583
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

darkolivegreen

Gpr162

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	334.0	0.0359281	0.8528323	0.9258928
Treatment	Treatment	1	12	56.25	277.5	2.4324324	0.1448201	0.4344602
Time:Treatment	Time:Treatment	1	12	0.25	332.5	0.0090226	0.9258928	0.9258928

Adcy3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	318.0	0.3396226	0.5708361	0.8517327
Treatment	Treatment	1	12	72.25	264.5	3.2778828	0.0953126	0.2859377
Time:Treatment	Time:Treatment	1	12	1.00	329.0	0.0364742	0.8517327	0.8517327

Katnb1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	317.5	0.0094488	0.9241682	0.9241682
Treatment	Treatment	1	12	81.00	258.5	3.7601547	0.0763620	0.2290859
Time:Treatment	Time:Treatment	1	12	6.25	315.5	0.2377179	0.6346451	0.9241682

Smc6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	333.5	0.143928	0.7110350	1
Treatment	Treatment	1	12	20.25	315.5	0.770206	0.3973841	1
Time:Treatment	Time:Treatment	1	12	0.00	338.0	0.000000	1.0000000	1

4931428F04Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	321.5	0.5972006	0.4546008	0.6819012
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Time:Treatment	Time:Treatment	1	12	2.25	335.5	0.0804769	0.7814873	0.7814873

Rab11fip5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	321.5	0.1493002	0.7059689	0.8520652
Treatment	Treatment	1	12	25	312.5	0.9600000	0.3465280	0.8520652
Time:Treatment	Time:Treatment	1	12	1	330.5	0.0363086	0.8520652	0.8520652

Kiss1r

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	330.0	0.2272727	0.6421172	0.7118542
Treatment	Treatment	1	12	16.00	323.0	0.5944272	0.4556254	0.7118542
Time:Treatment	Time:Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.7118542

Smc3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	326.0	0.3312883	0.5755362	0.8530493
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.4443480
Time:Treatment	Time:Treatment	1	12	1.00	335.0	0.0358209	0.8530493	0.8530493

Tubb5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	306.5	0.3523654	0.5637992	0.6330400
Treatment	Treatment	1	12	56.25	273.5	2.4680073	0.1421660	0.4264979
Time:Treatment	Time:Treatment	1	12	6.25	312.5	0.2400000	0.6330400	0.6330400

Tspyl4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	326.0	0.0368098	0.8510610	0.851061
Treatment	Treatment	1	12	25	306.5	0.9787928	0.3420268	0.851061
Time:Treatment	Time:Treatment	1	12	9	318.0	0.3396226	0.5708361	0.851061

green3

Dync1i1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	308.5	0.2431118	0.6308667	0.9463
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.9463
Time:Treatment	Time:Treatment	1	12	0.00	319.5	0.0000000	1.0000000	1.0000

Syt3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	308.5	0.2431118	0.6308667	0.6308667
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.4443480
Time:Treatment	Time:Treatment	1	12	20.25	307.5	0.7902439	0.3914982	0.5872473

Cd2ap

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	328.5	0.0821918	0.7792387	0.8536945
Treatment	Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.8536945
Time:Treatment	Time:Treatment	1	12	16.00	317.5	0.6047244	0.4518406	0.8536945

Cpne6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	330.5	0.0816944	0.7798882	0.7798882
Treatment	Treatment	1	12	4.00	327.0	0.1467890	0.7083237	0.7798882
Time:Treatment	Time:Treatment	1	12	4.00	318.0	0.1509434	0.7044405	0.7798882

Spata2l

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	330.5	0.0363086	0.8520652	0.8520652
Treatment	Treatment	1	12	2.25	331.5	0.0814480	0.7802108	0.8520652
Time:Treatment	Time:Treatment	1	12	12.25	311.5	0.4719101	0.5051691	0.8520652

Fbxo31

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	288.5	1.2582322	0.2839304	0.4258957
Treatment	Treatment	1	12	64.00	276.0	2.7826087	0.1211550	0.3634650
Time:Treatment	Time:Treatment	1	12	16.00	298.0	0.6442953	0.4377688	0.4377688

Strn4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	328.5	0.3287671	0.5769737	0.8511736
Treatment	Treatment	1	12	4	329.5	0.1456753	0.7093755	0.8511736
Time:Treatment	Time:Treatment	1	12	1	326.5	0.0367534	0.8511736	0.8511736

Fibcd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	281.5	0.6820604	0.4249935	0.7704976
Treatment	Treatment	1	12	12.25	324.5	0.4530046	0.5136651	0.7704976
Time:Treatment	Time:Treatment	1	12	0.25	314.5	0.0095390	0.9238087	0.9238087

Zap70

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	330.5	0.0090772	0.9256696	0.9256696
Treatment	Treatment	1	12	16.00	324.0	0.5925926	0.4563052	0.9256696
Time:Treatment	Time:Treatment	1	12	4.00	329.5	0.1456753	0.7093755	0.9256696

Npy4r

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	244.5	0.0122699	0.9136300	1
Treatment	Treatment	1	12	1.00	235.5	0.0509554	0.8252079	1
Time:Treatment	Time:Treatment	1	12	0.00	249.0	0.0000000	1.0000000	1

dodgerblue3

Tmem145

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	307.5	1.180488	0.2986000	0.2986000
Treatment	Treatment	1	12	64.00	272.0	2.823529	0.1187149	0.1780724
Time:Treatment	Time:Treatment	1	12	121.00	218.5	6.645309	0.0241934	0.0725801

Cd109

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	310.0	0.9677419	0.3446632	0.3446632
Treatment	Treatment	1	12	42.25	291.0	1.7422680	0.2114777	0.3172165
Time:Treatment	Time:Treatment	1	12	81.00	254.5	3.8192534	0.0743694	0.2231081

Ankrd24

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	333.5	0.2248876	0.6438533	0.6438533
Treatment	Treatment	1	12	36.00	304.0	1.4210526	0.2562716	0.3844073
Time:Treatment	Time:Treatment	1	12	132.25	207.5	7.6481928	0.0171028	0.0513084

Inha

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	330.5	0.2269289	0.6423668	0.6423668
Treatment	Treatment	1	12	81.00	252.5	3.8495050	0.0733739	0.2201216
Time:Treatment	Time:Treatment	1	12	42.25	296.5	1.7099494	0.2154903	0.3232354

Podn

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49.00	291.0	2.020619	0.1806405	0.2162143
Treatment	Treatment	1	12	42.25	297.5	1.704202	0.2162143	0.2162143
Time:Treatment	Time:Treatment	1	12	110.25	228.5	5.789934	0.0331400	0.0994201

Ptpn3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	335.0	0.1432836	0.7116500	0.7116500
Treatment	Treatment	1	12	30.25	305.5	1.1882160	0.2970951	0.4456426
Time:Treatment	Time:Treatment	1	12	72.25	263.5	3.2903226	0.0947559	0.2842677

Arpp21

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	303.5	1.423394	0.2559012	0.2559012
Treatment	Treatment	1	12	56.25	282.5	2.389381	0.1481160	0.2221740
Time:Treatment	Time:Treatment	1	12	121.00	219.0	6.630137	0.0243249	0.0729747

Rnf207

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	321.5	0.5972006	0.4546008	0.4546008
Treatment	Treatment	1	12	56.25	276.5	2.4412297	0.1441580	0.2162370
Time:Treatment	Time:Treatment	1	12	64.00	275.0	2.7927273	0.1205459	0.2162370

Iyd

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	323.5	0.4544049	0.5130269	0.5130269
Treatment	Treatment	1	12	90.25	249.5	4.3406814	0.0592616	0.0888924
Time:Treatment	Time:Treatment	1	12	100.00	240.0	5.0000000	0.0451154	0.0888924

Vill

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	273.5	2.808044	0.1196311	0.1196311
Treatment	Treatment	1	12	100	239.5	5.010438	0.0449263	0.0673894
Time:Treatment	Time:Treatment	1	12	121	214.0	6.785047	0.0230208	0.0673894

chocolate2

Carhsp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	295.5	1.715736	0.2147645	0.3221468
Treatment	Treatment	1	12	20.25	315.5	0.770206	0.3973841	0.3973841
Time:Treatment	Time:Treatment	1	12	64.00	274.0	2.802920	0.1199362	0.3221468

A230050P20Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	246.5	3.9432049	0.0703913	0.2111740
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Time:Treatment	Time:Treatment	1	12	36.00	296.0	1.4594595	0.2502858	0.3754288

Pcgf2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	267.5	3.2411215	0.0969812	0.1454718
Treatment	Treatment	1	12	25.00	313.0	0.9584665	0.3468991	0.3468991
Time:Treatment	Time:Treatment	1	12	90.25	248.5	4.3581489	0.0588233	0.1454718

Cnp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	229.5	5.764706	0.0334588	0.1003764
Treatment	Treatment	1	12	25.00	314.0	0.955414	0.3476395	0.3476395
Time:Treatment	Time:Treatment	1	12	72.25	267.5	3.241122	0.0969812	0.1454718

Gjc2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	229.5	5.7647059	0.0334588	0.1003764
Treatment	Treatment	1	12	9.00	326.0	0.3312883	0.5755362	0.5755362
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.4490236

Mag

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	248.5	4.358149	0.0588233	0.1454718
Treatment	Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.2993491
Time:Treatment	Time:Treatment	1	12	72.25	267.5	3.241122	0.0969812	0.1454718

Ado

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	214.0	6.7850467	0.0230208	0.0690623
Treatment	Treatment	1	12	20.25	299.5	0.8113523	0.3854418	0.3854418
Time:Treatment	Time:Treatment	1	12	90.25	248.5	4.3581489	0.0588233	0.0882349

Frmd8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	212.5	6.8329412	0.0226345	0.0679034
Treatment	Treatment	1	12	6.25	327.5	0.2290076	0.6408615	0.6408615
Time:Treatment	Time:Treatment	1	12	49.00	288.5	2.0381282	0.1789011	0.2683517

Tspan15

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	301.5	1.432836	0.2544148	0.3816222
Treatment	Treatment	1	12	6.25	326.5	0.229709	0.6403555	0.6403555
Time:Treatment	Time:Treatment	1	12	81.00	258.5	3.760155	0.0763620	0.2290859

Rasd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	316.5	0.7677725	0.3981082	0.3995488
Treatment	Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.3995488
Time:Treatment	Time:Treatment	1	12	110.25	228.5	5.7899344	0.0331400	0.0994201

lavenderblush3

mt-Co2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	329.0	0.3282675	0.5772595	0.9265504
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	1.00	338.0	0.0355030	0.8536945	0.9265504

Trank1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	326.5	0.3307810	0.5758249	0.8637373
Treatment	Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.8637373
Time:Treatment	Time:Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331

2810403A07Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	319.5	0.6009390	0.4532258	0.9263331
Treatment	Treatment	1	12	0.25	336.5	0.0089153	0.9263331	0.9263331
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.9263331

Rac1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	319.5	0.7605634	0.4002654	0.9265504
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.9265504

Terf2ip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	320.0	0.6000000	0.4535705	0.9266583
Treatment	Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Ubqln1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	327.5	0.4488550	0.5155648	0.853373
Treatment	Treatment	1	12	4.00	335.5	0.1430700	0.7118542	0.853373
Time:Treatment	Time:Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.853373

Hsp90ab1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	324.5	0.4530046	0.5136651	0.853373
Treatment	Treatment	1	12	6.25	329.5	0.2276176	0.6418671	0.853373
Time:Treatment	Time:Treatment	1	12	1.00	336.5	0.0356612	0.8533730	0.853373

Cyb5r3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	321.0	0.0373832	0.8499210	0.849921
Treatment	Treatment	1	12	16.00	314.0	0.6114650	0.4493913	0.849921
Time:Treatment	Time:Treatment	1	12	2.25	331.5	0.0814480	0.7802108	0.849921

Bcl2l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	330.5	0.0816944	0.7798882	0.8534804
Treatment	Treatment	1	12	12.25	325.5	0.4516129	0.5143008	0.8534804
Time:Treatment	Time:Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.8534804

Cdc42se1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	327.5	0.1465649	0.7085349	0.8534804
Treatment	Treatment	1	12	1	334.0	0.0359281	0.8528323	0.8534804
Time:Treatment	Time:Treatment	1	12	1	337.0	0.0356083	0.8534804	0.8534804

chocolate

Eif4a-ps4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	264.0	3.284091	0.0950343	0.0950343
Treatment	Treatment	1	12	81.00	250.5	3.880240	0.0723790	0.0950343
Time:Treatment	Time:Treatment	1	12	81.00	256.5	3.789474	0.0753654	0.0950343

Nudt11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	265.5	3.265537	0.0958690	0.1438035
Treatment	Treatment	1	12	90.25	247.5	4.375758	0.0583853	0.1438035
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.2993491

Tbc1d20

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	252.5	3.433663	0.0886202	0.0886202
Treatment	Treatment	1	12	90.25	247.5	4.375758	0.0583853	0.0886202
Time:Treatment	Time:Treatment	1	12	81.00	258.0	3.767442	0.0761128	0.0886202

Srp54a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	296.0	1.4594595	0.2502858	0.3754288
Treatment	Treatment	1	12	56.25	280.5	2.4064171	0.1468005	0.3754288
Time:Treatment	Time:Treatment	1	12	4.00	334.0	0.1437126	0.7112404	0.7112404

Pdxdc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	296.5	1.709949	0.2154903	0.2547871
Treatment	Treatment	1	12	36.00	302.0	1.430464	0.2547871	0.2547871
Time:Treatment	Time:Treatment	1	12	49.00	290.5	2.024096	0.1802933	0.2547871

Fam133b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	284.5	2.0667838	0.1761006	0.2641509
Treatment	Treatment	1	12	64	275.5	2.7876588	0.1208505	0.2641509
Time:Treatment	Time:Treatment	1	12	16	315.0	0.6095238	0.4500944	0.4500944

Aph1a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	314.5	0.9538951	0.3480088	0.3480088
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.2221740
Time:Treatment	Time:Treatment	1	12	56.25	279.5	2.4150268	0.1461414	0.2221740

Gpr37l1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	339.0	0.0353982	0.8539077	0.8539077
Treatment	Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.5220133
Time:Treatment	Time:Treatment	1	12	25.00	314.5	0.9538951	0.3480088	0.5220133

Snrnp48

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	272.0	2.8235294	0.1187149	0.1780724
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.1780724
Time:Treatment	Time:Treatment	1	12	12.25	311.5	0.4719101	0.5051691	0.5051691

Hist3h2ba

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	321.5	0.5972006	0.4546008	0.4546008
Treatment	Treatment	1	12	49	290.5	2.0240964	0.1802933	0.4546008
Time:Treatment	Time:Treatment	1	12	25	314.5	0.9538951	0.3480088	0.4546008

orangered1

Hoxb3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm15051

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Casc5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	195.0	0.9846154	0.3406495	0.3406495
Treatment	Treatment	1	12	20.25	198.5	1.2241814	0.2902292	0.3406495
Time:Treatment	Time:Treatment	1	12	16.00	193.0	0.9948187	0.3382554	0.3406495

Slc6a4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	277.5	0.0972973	0.7604506	0.8302629
Treatment	Treatment	1	12	1.00	250.0	0.0480000	0.8302629	0.8302629
Time:Treatment	Time:Treatment	1	12	9.00	286.5	0.3769634	0.5506953	0.8302629

Mmp8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	290.5	1.032702	0.3295767	0.3295767
Treatment	Treatment	1	12	72.25	242.0	3.582645	0.0827500	0.2482500
Time:Treatment	Time:Treatment	1	12	25.00	290.5	1.032702	0.3295767	0.3295767

RP24-242F4.8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	196.5	3.908397	0.0714818	0.0714818
Treatment	Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818
Time:Treatment	Time:Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818

Sirpb1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Ngp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	272.5	2.477064	0.1415000	0.1415000
Treatment	Treatment	1	12	210.25	122.5	20.595918	0.0006799	0.0020396
Time:Treatment	Time:Treatment	1	12	144.00	183.5	9.416894	0.0097404	0.0146106

Hnf4g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	322.0	0.2329193	0.6380519	0.6380519
Treatment	Treatment	1	12	49.00	284.5	2.0667838	0.1761006	0.4997190
Time:Treatment	Time:Treatment	1	12	25.00	295.0	1.0169492	0.3331460	0.4997190

Padi1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	229.5	0.0522876	0.8229799	0.8229799
Treatment	Treatment	1	12	1	229.5	0.0522876	0.8229799	0.8229799
Time:Treatment	Time:Treatment	1	12	1	229.5	0.0522876	0.8229799	0.8229799

firebrick3

Hoxa4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Habp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Akr1c19

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm15433

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121	162	8.962963	0.0111945	0.0111945
Treatment	Treatment	1	12	144	120	14.400000	0.0025542	0.0076625
Time:Treatment	Time:Treatment	1	12	121	162	8.962963	0.0111945	0.0111945

Saa4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	196.5	3.908397	0.0714818	0.0714818
Treatment	Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818
Time:Treatment	Time:Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818

Esco2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	229.5	3.777778	0.0757611	0.1136416
Treatment	Treatment	1	12	156.25	175.5	10.683761	0.0067206	0.0201618
Time:Treatment	Time:Treatment	1	12	36.00	279.5	1.545617	0.2375257	0.2375257

Gm4955

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	211.5	5.673759	0.0346386	0.0346386
Treatment	Treatment	1	12	110.25	221.0	5.986425	0.0307775	0.0346386
Time:Treatment	Time:Treatment	1	12	144.00	191.5	9.023499	0.0109865	0.0329595

Clec12b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	252.5	2.328713	0.1529229	0.1529229
Treatment	Treatment	1	12	49	246.5	2.385396	0.1484258	0.1529229
Time:Treatment	Time:Treatment	1	12	49	252.5	2.328713	0.1529229	0.1529229

Cd300a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	274.5	1.092896	0.3164325	0.3164325
Treatment	Treatment	1	12	210.25	114.5	22.034934	0.0005195	0.0015585
Time:Treatment	Time:Treatment	1	12	72.25	249.5	3.474950	0.0869439	0.1304158

Trim15

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81	222	4.378378	0.0583205	0.0583205
Treatment	Treatment	1	12	81	222	4.378378	0.0583205	0.0583205
Time:Treatment	Time:Treatment	1	12	144	150	11.520000	0.0053274	0.0159821

deeppink

Mmrn2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	293.5	1.7274276	0.2133079	0.4546008
Treatment	Treatment	1	12	25.00	312.5	0.9600000	0.3465280	0.4546008
Time:Treatment	Time:Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.4546008

Ets1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Treatment	Treatment	1	12	64.00	275.5	2.7876588	0.1208505	0.3625516
Time:Treatment	Time:Treatment	1	12	4.00	332.0	0.1445783	0.7104160	0.9266583

Podxl

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	328.5	0.3287671	0.5769737	0.9266583
Treatment	Treatment	1	12	4.00	335.0	0.1432836	0.7116500	0.9266583
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

Kdr

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	313.0	0.9584665	0.3468991	0.5203486
Treatment	Treatment	1	12	49.00	288.5	2.0381282	0.1789011	0.5203486
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.6433598

Bsdc1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	335.5	0.0000000	1.0000000	1
Treatment	Treatment	1	12	9	322.5	0.3348837	0.5734989	1
Time:Treatment	Time:Treatment	1	12	1	334.0	0.0359281	0.8528323	1

Robo4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.5	0.0354505	0.8538013	0.8538013
Treatment	Treatment	1	12	56.25	282.5	2.3893805	0.1481160	0.4443480
Time:Treatment	Time:Treatment	1	12	9.00	327.0	0.3302752	0.5761130	0.8538013

Sema3g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	313.0	0.9584665	0.3468991	0.926442
Treatment	Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.926442
Time:Treatment	Time:Treatment	1	12	0.25	337.5	0.0088889	0.9264420	0.926442

Tie1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.8501511
Treatment	Treatment	1	12	100.00	235.0	5.1063830	0.0432319	0.1296957
Time:Treatment	Time:Treatment	1	12	1.00	322.0	0.0372671	0.8501511	0.8501511

Slc35e4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	330.5	0.0090772	0.9256696	0.9256696
Treatment	Treatment	1	12	25.00	313.0	0.9584665	0.3468991	0.9256696
Time:Treatment	Time:Treatment	1	12	1.00	337.0	0.0356083	0.8534804	0.9256696

Rif1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	321.0	0.0373832	0.8499210	0.8499210
Treatment	Treatment	1	12	49.00	272.5	2.1577982	0.1675697	0.5027091
Time:Treatment	Time:Treatment	1	12	12.25	306.5	0.4796085	0.5017821	0.7526731

salmon1

Fbp2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	150	1.2800000	0.2800026	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Gm9783

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

3830408C21Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	312.5	0.4704000	0.5058384	0.7741768
Treatment	Treatment	1	12	2.25	313.5	0.0861244	0.7741768	0.7741768
Time:Treatment	Time:Treatment	1	12	6.25	318.5	0.2354788	0.6362293	0.7741768

Fam132b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	216.0	0.3472222	0.5666182	0.8525677
Treatment	Treatment	1	12	6.25	218.0	0.3440367	0.5683785	0.8525677
Time:Treatment	Time:Treatment	1	12	0.00	256.5	0.0000000	1.0000000	1.0000000

Cma1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	212.5	5.6470588	0.0349944	0.1049831
Treatment	Treatment	1	12	2.25	309.0	0.0873786	0.7725891	0.7725891
Time:Treatment	Time:Treatment	1	12	25.00	262.5	1.1428571	0.3060827	0.4591241

Malat1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	322.5	0.2325581	0.6383100	1
Treatment	Treatment	1	12	0.25	310.5	0.0096618	0.9233212	1
Time:Treatment	Time:Treatment	1	12	0.00	322.0	0.0000000	1.0000000	1

2410131K14Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36.00	287.0	1.5052265	0.2433963	0.7301889
Treatment	Treatment	1	12	9.00	290.0	0.3724138	0.5530733	0.7641154
Time:Treatment	Time:Treatment	1	12	2.25	286.5	0.0942408	0.7641154	0.7641154

Mfsd9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	303.0	1.1980198	0.2952012	0.849341
Treatment	Treatment	1	12	2.25	322.0	0.0838509	0.7770874	0.849341
Time:Treatment	Time:Treatment	1	12	1.00	318.5	0.0376766	0.8493410	0.849341

Tmem54

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	191	4.020942	0.0680279	0.2040837
Treatment	Treatment	1	12	30.25	275	1.320000	0.2729778	0.2729778
Time:Treatment	Time:Treatment	1	12	30.25	275	1.320000	0.2729778	0.2729778

Lilra6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	214.5	3.1468531	0.1014270	0.3042811
Treatment	Treatment	1	12	4.00	285.5	0.1681261	0.6890081	0.6890081
Time:Treatment	Time:Treatment	1	12	4.00	237.5	0.2021053	0.6610393	0.6890081

lavenderblush1

Tnfrsf18

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Hoxd8

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	174	1.103448	0.3142057	0.3142057
Treatment	Treatment	1	12	16	150	1.280000	0.2800026	0.3142057
Time:Treatment	Time:Treatment	1	12	16	174	1.103448	0.3142057	0.3142057

Mroh2a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	249.0	0.0481928	0.8299282	0.8299282
Treatment	Treatment	1	12	9	211.5	0.5106383	0.4885314	0.8299282
Time:Treatment	Time:Treatment	1	12	4	228.5	0.2100656	0.6549053	0.8299282

Slc4a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	236.0	0.6228814	0.4452927	0.8349033
Treatment	Treatment	1	12	1.00	264.5	0.0453686	0.8349033	0.8349033
Time:Treatment	Time:Treatment	1	12	2.25	258.0	0.1046512	0.7518860	0.8349033

Slc7a9

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	287.5	0.3756522	0.5513786	0.5513786
Treatment	Treatment	1	12	30.25	215.0	1.6883721	0.2182251	0.5513786
Time:Treatment	Time:Treatment	1	12	9.00	287.5	0.3756522	0.5513786	0.5513786

Tmem174

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	297.5	0.3630252	0.5580452	0.8416774
Treatment	Treatment	1	12	2.25	291.5	0.0926244	0.7660802	0.8416774
Time:Treatment	Time:Treatment	1	12	1.00	288.0	0.0416667	0.8416774	0.8416774

Fam83f

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	313	0.0383387	0.8480412	0.8480412
Treatment	Treatment	1	12	9	303	0.3564356	0.5615882	0.8442835
Time:Treatment	Time:Treatment	1	12	9	305	0.3540984	0.5628557	0.8442835

AI847159

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9	288.5	0.3743501	0.5520588	0.8280882
Treatment	Treatment	1	12	64	258.5	2.9709865	0.1104124	0.3312371
Time:Treatment	Time:Treatment	1	12	1	315.0	0.0380952	0.8485177	0.8485177

Bmp8a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	196.5	3.908397	0.0714818	0.0714818
Treatment	Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818
Time:Treatment	Time:Treatment	1	12	64	196.5	3.908397	0.0714818	0.0714818

BC021785

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	304.0	0.7993421	0.3888700	0.4504449
Treatment	Treatment	1	12	81.00	234.0	4.1538462	0.0642057	0.1926171
Time:Treatment	Time:Treatment	1	12	16.00	315.5	0.6085578	0.4504449	0.4504449

firebrick2

Oit3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	194.0	0.9896907	0.3394556	0.3394556
Treatment	Treatment	1	12	16	193.5	0.9922481	0.3388563	0.3394556
Time:Treatment	Time:Treatment	1	12	16	194.0	0.9896907	0.3394556	0.3394556

2810007J24Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	241.0	1.506224	0.2432490	0.2432490
Treatment	Treatment	1	12	64.00	159.5	4.815047	0.0486296	0.1458889
Time:Treatment	Time:Treatment	1	12	30.25	241.0	1.506224	0.2432490	0.2432490

Sucnr1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	241.0	1.506224	0.2432490	0.2432490
Treatment	Treatment	1	12	64.00	159.5	4.815047	0.0486296	0.1458889
Time:Treatment	Time:Treatment	1	12	30.25	241.0	1.506224	0.2432490	0.2432490

Fam151a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627

Aunip

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	304.0	0.2467105	0.6283750	0.7725891
Treatment	Treatment	1	12	25.00	249.5	1.2024048	0.2943596	0.7725891
Time:Treatment	Time:Treatment	1	12	2.25	309.0	0.0873786	0.7725891	0.7725891

Gm26670

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	254.5	0.7544204	0.4021179	0.8022477
Treatment	Treatment	1	12	9	264.5	0.4083176	0.5348318	0.8022477
Time:Treatment	Time:Treatment	1	12	1	283.0	0.0424028	0.8403060	0.8403060

Miox

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	275.0	0.0000000	1.0000000	1
Treatment	Treatment	1	12	20.25	264.0	0.9204545	0.3562881	1
Time:Treatment	Time:Treatment	1	12	1.00	284.5	0.0421793	0.8407211	1

Mefv

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Fbxo5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	306.0	0.3529412	0.5634854	0.8498055
Treatment	Treatment	1	12	1.00	320.5	0.0374415	0.8498055	0.8498055
Time:Treatment	Time:Treatment	1	12	2.25	316.5	0.0853081	0.7752171	0.8498055

Urah

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	312.5	0.4704000	0.5058384	0.7587576
Treatment	Treatment	1	12	16.00	291.5	0.6586621	0.4328365	0.7587576
Time:Treatment	Time:Treatment	1	12	1.00	314.0	0.0382166	0.8482800	0.8482800

indianred2

Gcsam

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Gm10548

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	195.5	0.9820972	0.3412442	0.3418373
Treatment	Treatment	1	12	16	195.5	0.9820972	0.3412442	0.3418373
Time:Treatment	Time:Treatment	1	12	16	196.0	0.9795918	0.3418373	0.3418373

Klri2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	150	1.2800000	0.2800026	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Gja5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64	204.0	3.7647059	0.0762062	0.2286187
Treatment	Treatment	1	12	25	242.5	1.2371134	0.2878144	0.4317216
Time:Treatment	Time:Treatment	1	12	1	296.5	0.0404722	0.8439299	0.8439299

D230002A01Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	240.5	0.0498960	0.8270016	0.8270016
Treatment	Treatment	1	12	6.25	216.0	0.3472222	0.5666182	0.8270016
Time:Treatment	Time:Treatment	1	12	4.00	276.5	0.1735986	0.6842893	0.8270016

Lgals7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	191	4.020942	0.0680279	0.2040837
Treatment	Treatment	1	12	30.25	241	1.506224	0.2432490	0.2432490
Time:Treatment	Time:Treatment	1	12	30.25	241	1.506224	0.2432490	0.2432490

Upk3b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	260.5	1.6583493	0.2221069	0.3331603
Treatment	Treatment	1	12	36	260.5	1.6583493	0.2221069	0.3331603
Time:Treatment	Time:Treatment	1	12	9	273.0	0.3956044	0.5411565	0.5411565

Ctla4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	298.5	1.0050251	0.3358850	0.9233212
Treatment	Treatment	1	12	6.25	315.5	0.2377179	0.6346451	0.9233212
Time:Treatment	Time:Treatment	1	12	0.25	310.5	0.0096618	0.9233212	0.9233212

Akr1c6

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	247.5	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	16	151.5	1.267327	0.2822802	0.8468407
Time:Treatment	Time:Treatment	1	12	0	247.5	0.000000	1.0000000	1.0000000

A430093F15Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	311	0.2411576	0.6322295	0.7746987
Treatment	Treatment	1	12	2.25	315	0.0857143	0.7746987	0.7746987
Time:Treatment	Time:Treatment	1	12	56.25	228	2.9605263	0.1109771	0.3329314

blue1

Ola1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	339.5	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	72.25	258.5	3.3539652	0.0919695	0.2759085
Time:Treatment	Time:Treatment	1	12	4.00	336.0	0.1428571	0.7120579	1.0000000

Pan2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	337.5	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	56.25	274.5	2.4590164	0.1428309	0.4284927
Time:Treatment	Time:Treatment	1	12	12.25	323.5	0.4544049	0.5130269	0.7695403

Krba1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	335.5	0.0804769	0.7814873	0.7814873
Treatment	Treatment	1	12	100.00	235.5	5.0955414	0.0434195	0.1302584
Time:Treatment	Time:Treatment	1	12	6.25	332.5	0.2255639	0.6433598	0.7814873

Dusp5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	324.5	0.0369800	0.8507217	0.8507217
Treatment	Treatment	1	12	90.25	242.5	4.4659794	0.0562022	0.1686066
Time:Treatment	Time:Treatment	1	12	6.25	317.5	0.2362205	0.6357035	0.8507217

Naa40

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Treatment	Treatment	1	12	42.25	294.5	1.7215620	0.2140371	0.6421112
Time:Treatment	Time:Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583

BC030499

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.5	0.0354505	0.8538013	0.9265504
Treatment	Treatment	1	12	49.00	290.5	2.0240964	0.1802933	0.5408800
Time:Treatment	Time:Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504

Agtpbp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	316.5	0.4644550	0.5084887	0.7100011
Treatment	Treatment	1	12	72.25	246.5	3.5172414	0.0852667	0.2558001
Time:Treatment	Time:Treatment	1	12	4.00	331.0	0.1450151	0.7100011	0.7100011

Gm13199

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	323.0	0.5944272	0.4556254	0.6834380
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.2892757
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029

Exd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.0	0.035503	0.8536945	1.0000000
Treatment	Treatment	1	12	30.25	308.5	1.176661	0.2993491	0.8980472
Time:Treatment	Time:Treatment	1	12	0.00	340.0	0.000000	1.0000000	1.0000000

Plcxd1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	338.0	0.035503	0.8536945	0.8536945
Treatment	Treatment	1	12	156.25	181.5	10.330578	0.0074351	0.0223054
Time:Treatment	Time:Treatment	1	12	4.00	335.5	0.143070	0.7118542	0.8536945

darkgoldenrod4

Ctsz

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	273.5	2.4680073	0.1421660	0.2577891
Treatment	Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.3981082
Time:Treatment	Time:Treatment	1	12	49.00	278.5	2.1113106	0.1718594	0.2577891

Hspa5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16.00	315.5	0.6085578	0.4504449	0.5149340
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.5149340
Time:Treatment	Time:Treatment	1	12	90.25	246.5	4.3935091	0.0579478	0.1738435

Ctsd

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	276.5	1.8336347	0.2006502	0.4329816
Treatment	Treatment	1	12	6.25	330.5	0.2269289	0.6423668	0.6423668
Time:Treatment	Time:Treatment	1	12	30.25	294.5	1.2325976	0.2886544	0.4329816

Clic1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	245.5	4.4114053	0.0575108	0.0862661
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	90.25	243.5	4.4476386	0.0566379	0.0862661

Dnase2a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	291.5	1.7392796	0.2118446	0.4535705
Treatment	Treatment	1	12	16.00	320.0	0.6000000	0.4535705	0.4535705
Time:Treatment	Time:Treatment	1	12	25.00	308.5	0.9724473	0.3435370	0.4535705

2810004N23Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	240.5	4.503119	0.0553322	0.1659966
Treatment	Treatment	1	12	1.00	338.0	0.035503	0.8536945	0.8536945
Time:Treatment	Time:Treatment	1	12	56.25	280.5	2.406417	0.1468005	0.2202008

Ptchd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	293.5	1.7274276	0.2133079	0.3199619
Treatment	Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.5781134
Time:Treatment	Time:Treatment	1	12	49.00	282.5	2.0814159	0.1746922	0.3199619

Ifi30

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	235.0	5.1063830	0.0432319	0.1296957
Treatment	Treatment	1	12	25	310.5	0.9661836	0.3450374	0.3450374
Time:Treatment	Time:Treatment	1	12	64	269.5	2.8497217	0.1171851	0.1757776

Rbks

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	121.00	218.5	6.6453089	0.0241934	0.0725801
Treatment	Treatment	1	12	20.25	313.5	0.7751196	0.3959282	0.5149340
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.5149340

Tigd2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4.00	332.0	0.1445783	0.7104160	0.7104160
Treatment	Treatment	1	12	72.25	264.5	3.2778828	0.0953126	0.1446378
Time:Treatment	Time:Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.1446378

antiquewhite

Gbp2b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Meox2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Nfe2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	253.5	0.7573964	0.4012188	0.4065552
Treatment	Treatment	1	12	16	259.5	0.7398844	0.4065552	0.4065552
Time:Treatment	Time:Treatment	1	12	16	259.5	0.7398844	0.4065552	0.4065552

Il18r1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627

Slc34a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	280.5	0.5240642	0.4829879	0.7244819
Treatment	Treatment	1	12	0.25	302.5	0.0099174	0.9223174	0.9223174
Time:Treatment	Time:Treatment	1	12	12.25	280.5	0.5240642	0.4829879	0.7244819

Tmed2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	144.00	193.5	8.9302326	0.0113089	0.0339267
Treatment	Treatment	1	12	9.00	288.5	0.3743501	0.5520588	0.6229453
Time:Treatment	Time:Treatment	1	12	6.25	294.5	0.2546689	0.6229453	0.6229453

Gm8935

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	303	0.8019802	0.3881130	0.5821694
Treatment	Treatment	1	12	2.25	312	0.0865385	0.7736513	0.7736513
Time:Treatment	Time:Treatment	1	12	36.00	278	1.5539568	0.2363372	0.5821694

Golga7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	225.00	106.5	25.352113	0.0002917	0.0008751
Treatment	Treatment	1	12	72.25	239.5	3.620042	0.0813517	0.1220275
Time:Treatment	Time:Treatment	1	12	36.00	279.5	1.545617	0.2375257	0.2375257

Ptp4a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81	234.5	4.1449893	0.0644522	0.0966783
Treatment	Treatment	1	12	100	215.5	5.5684455	0.0360674	0.0966783
Time:Treatment	Time:Treatment	1	12	9	311.0	0.3472669	0.5665936	0.5665936

Tmpo

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	327.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	90.25	239.0	4.5313808	0.0546810	0.1640429
Time:Treatment	Time:Treatment	1	12	4.00	306.5	0.1566069	0.6992454	1.0000000

orange3

Mmp3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Vsig4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

A530099J19Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Hoxa3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Aknad1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	262.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	12.25	216.5	0.6789838	0.4260117	0.6512362
Time:Treatment	Time:Treatment	1	12	12.25	224.5	0.6547884	0.4341574	0.6512362

Gm15326

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	173	6.936416	0.0218258	0.0218258
Treatment	Treatment	1	12	121	165	8.800000	0.0117780	0.0176670
Time:Treatment	Time:Treatment	1	12	121	165	8.800000	0.0117780	0.0176670

Cidec

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	222	0.2162162	0.6502627	0.6502627
Treatment	Treatment	1	12	16	150	1.2800000	0.2800026	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Il9r

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	150	1.2800000	0.2800026	0.6502627
Treatment	Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627
Time:Treatment	Time:Treatment	1	12	4	222	0.2162162	0.6502627	0.6502627

Ces1e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	247.5	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	16	151.5	1.267327	0.2822802	0.8468407
Time:Treatment	Time:Treatment	1	12	0	247.5	0.000000	1.0000000	1.0000000

Dio1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	271	1.339483	0.2696436	0.4044654
Treatment	Treatment	1	12	42.25	257	1.972763	0.1855068	0.4044654
Time:Treatment	Time:Treatment	1	12	9.00	301	0.358804	0.5603097	0.5603097

tan1

Cebpg

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	333.5	0.0089955	0.9260036	0.9260036
Treatment	Treatment	1	12	100.00	239.0	5.0209205	0.0447373	0.1342120
Time:Treatment	Time:Treatment	1	12	1.00	326.5	0.0367534	0.8511736	0.9260036

Atp13a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Treatment	Treatment	1	12	90.25	248.5	4.3581489	0.0588233	0.1764698
Time:Treatment	Time:Treatment	1	12	6.25	326.5	0.2297090	0.6403555	0.9265504

Tmem25

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	333.5	0.2248876	0.6438533	0.711035
Treatment	Treatment	1	12	30.25	309.5	1.1728595	0.3000959	0.711035
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.711035

Dpm2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	331.0	0.0362538	0.8521755	0.8521755
Treatment	Treatment	1	12	49.00	288.5	2.0381282	0.1789011	0.4387887
Time:Treatment	Time:Treatment	1	12	30.25	299.5	1.2120200	0.2925258	0.4387887

Slu7

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323
Treatment	Treatment	1	12	90.25	248.5	4.3581489	0.0588233	0.1764698
Time:Treatment	Time:Treatment	1	12	4.00	332.0	0.1445783	0.7104160	0.8528323

Serbp1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	30.25	300.5	1.2079867	0.2932931	0.4399396
Treatment	Treatment	1	12	100.00	240.0	5.0000000	0.0451154	0.1353461
Time:Treatment	Time:Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323

Smarca5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	322.0	0.5962733	0.4549430	0.6824144
Treatment	Treatment	1	12	81	258.5	3.7601547	0.0763620	0.2290859
Time:Treatment	Time:Treatment	1	12	1	330.5	0.0363086	0.8520652	0.8520652

Ube2k

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Treatment	Treatment	1	12	90.25	248.5	4.3581489	0.0588233	0.1764698
Time:Treatment	Time:Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.7818029

Ccdc174

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	12.25	323.5	0.4544049	0.5130269	0.5149340
Treatment	Treatment	1	12	72.25	267.5	3.2411215	0.0969812	0.2909436
Time:Treatment	Time:Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.5149340

Dgkq

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	9.00	330.0	0.3272727	0.5778293	0.7104160
Treatment	Treatment	1	12	72.25	264.5	3.2778828	0.0953126	0.2859377
Time:Treatment	Time:Treatment	1	12	4.00	332.0	0.1445783	0.7104160	0.7104160

darkgoldenrod1

Ces1g

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	16	147	1.306122	0.2753873	0.2753873
Treatment	Treatment	1	12	16	147	1.306122	0.2753873	0.2753873
Time:Treatment	Time:Treatment	1	12	16	147	1.306122	0.2753873	0.2753873

Slc16a5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0	247.5	0.000000	1.0000000	1.0000000
Treatment	Treatment	1	12	0	247.5	0.000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	16	151.5	1.267327	0.2822802	0.8468407

Muc4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	263.0	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	6.25	225.5	0.3325942	0.5747945	0.8621918
Time:Treatment	Time:Treatment	1	12	9.00	215.5	0.5011601	0.4925125	0.8621918

Clec4e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	4	276	0.1739130	0.6840208	0.8268247
Treatment	Treatment	1	12	4	226	0.2123894	0.6531416	0.8268247
Time:Treatment	Time:Treatment	1	12	1	240	0.0500000	0.8268247	0.8268247

Afp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	6.25	280.5	0.2673797	0.6144925	0.6144925
Treatment	Treatment	1	12	42.25	241.5	2.0993789	0.1729829	0.3710562
Time:Treatment	Time:Treatment	1	12	30.25	245.5	1.4786151	0.2473708	0.3710562

Lmod3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	257.0	1.972763	0.1855068	0.3331603
Treatment	Treatment	1	12	36.00	260.5	1.658349	0.2221069	0.3331603
Time:Treatment	Time:Treatment	1	12	9.00	301.0	0.358804	0.5603097	0.5603097

Pacsin2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.0	2.792727	0.1205459	0.3616377
Treatment	Treatment	1	12	20.25	312.5	0.777600	0.3951964	0.3951964
Time:Treatment	Time:Treatment	1	12	36.00	300.0	1.440000	0.2532947	0.3799421

B4galt3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	1	320.5	0.0374415	0.8498055	0.8503801
Treatment	Treatment	1	12	1	323.0	0.0371517	0.8503801	0.8503801
Time:Treatment	Time:Treatment	1	12	9	326.0	0.3312883	0.5755362	0.8503801

Rbm11

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	198.5	7.9949622	0.0152453	0.0457358
Treatment	Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323
Time:Treatment	Time:Treatment	1	12	16.00	319.0	0.6018809	0.4528805	0.6793207

Fam220a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	0.00	331.5	0.0000000	1.0000000	1.0000000
Treatment	Treatment	1	12	12.25	314.5	0.4674086	0.5071688	0.7607533
Time:Treatment	Time:Treatment	1	12	16.00	316.0	0.6075949	0.4507948	0.7607533

rosybrown3

Tshz2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	267.5	3.2411215	0.0969812	0.2909436
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Time:Treatment	Time:Treatment	1	12	36.00	303.0	1.4257426	0.2555303	0.3832955

Sowahb

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	313	0.7763578	0.3955626	0.5933439
Treatment	Treatment	1	12	0.25	338	0.0088757	0.9264962	0.9264962
Time:Treatment	Time:Treatment	1	12	30.25	305	1.1901639	0.2967174	0.5933439

Dsc3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	280.5	2.4064171	0.1468005	0.4404016
Treatment	Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.7818029
Time:Treatment	Time:Treatment	1	12	30.25	308.5	1.1766613	0.2993491	0.4490236

Nxph3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	297.5	1.704202	0.2162143	0.2495286
Treatment	Treatment	1	12	36.00	295.0	1.464407	0.2495286	0.2495286
Time:Treatment	Time:Treatment	1	12	49.00	288.5	2.038128	0.1789011	0.2495286

Gm2694

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	296.5	1.7099494	0.2154903	0.6464708
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	2.25	336.5	0.0802377	0.7818029	0.9266583

Rims4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	42.25	296.5	1.7099494	0.2154903	0.3232354
Treatment	Treatment	1	12	0.25	338.5	0.0088626	0.9265504	0.9265504
Time:Treatment	Time:Treatment	1	12	49.00	290.0	2.0275862	0.1799458	0.3232354

Ly6g6e

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	250.5	3.8802395	0.0723790	0.1085684
Treatment	Treatment	1	12	12.25	326.5	0.4502297	0.5149340	0.5149340
Time:Treatment	Time:Treatment	1	12	90.25	249.5	4.3406814	0.0592616	0.1085684

Kcnk3

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	25.00	307.0	0.9771987	0.3424053	0.5136079
Treatment	Treatment	1	12	0.25	339.5	0.0088365	0.9266583	0.9266583
Time:Treatment	Time:Treatment	1	12	56.25	281.5	2.3978686	0.1474588	0.4423763

Dkk2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	36	303.5	1.4233937	0.2559012	0.7677036
Treatment	Treatment	1	12	1	338.0	0.0355030	0.8536945	0.8536945
Time:Treatment	Time:Treatment	1	12	1	337.0	0.0356083	0.8534804	0.8536945

Medag

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	132.25	201.5	7.8759305	0.0158547	0.0475640
Treatment	Treatment	1	12	9.00	328.5	0.3287671	0.5769737	0.5769737
Time:Treatment	Time:Treatment	1	12	36.00	303.0	1.4257426	0.2555303	0.3832955

khaki3

Scaf4

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100.00	240.0	5.0000000	0.0451154	0.1353461
Treatment	Treatment	1	12	20.25	317.5	0.7653543	0.3988298	0.5781134
Time:Treatment	Time:Treatment	1	12	9.00	330.5	0.3267776	0.5781134	0.5781134

Eif1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	100	239.0	5.0209205	0.0447373	0.1342120
Treatment	Treatment	1	12	36	303.5	1.4233937	0.2559012	0.3838518
Time:Treatment	Time:Treatment	1	12	9	328.5	0.3287671	0.5769737	0.5769737

Slc25a33

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.5	3.7601547	0.0763620	0.2202008
Treatment	Treatment	1	12	56.25	280.5	2.4064171	0.1468005	0.2202008
Time:Treatment	Time:Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.4546008

2610005L07Rik

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	271.5	2.8287293	0.1184093	0.3552278
Treatment	Treatment	1	12	20.25	316.5	0.7677725	0.3981082	0.5971623
Time:Treatment	Time:Treatment	1	12	0.00	339.0	0.0000000	1.0000000	1.0000000

Kmt2b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	274.0	2.802920	0.1199362	0.3476395
Treatment	Treatment	1	12	30.25	309.5	1.172859	0.3000959	0.3476395
Time:Treatment	Time:Treatment	1	12	25.00	314.0	0.955414	0.3476395	0.3476395

Cstf2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	81.00	258.0	3.7674419	0.0761128	0.2231584
Treatment	Treatment	1	12	16.00	321.5	0.5972006	0.4546008	0.4546008
Time:Treatment	Time:Treatment	1	12	56.25	283.5	2.3809524	0.1487723	0.2231584

Slc25a15

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	182.25	156.5	13.9744409	0.0028310	0.0084931
Treatment	Treatment	1	12	72.25	266.5	3.2532833	0.0964252	0.1446378
Time:Treatment	Time:Treatment	1	12	1.00	339.0	0.0353982	0.8539077	0.8539077

Dazap1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	271.5	2.8287293	0.1184093	0.3552278
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.4002654
Time:Treatment	Time:Treatment	1	12	20.25	318.5	0.7629513	0.3995488	0.4002654

Mgea5

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	227.5	5.815385	0.0328221	0.0662573
Treatment	Treatment	1	12	30.25	306.5	1.184339	0.2978486	0.2978486
Time:Treatment	Time:Treatment	1	12	100.00	237.5	5.052632	0.0441715	0.0662573

Cacna1b

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	245.5	4.4114053	0.0575108	0.1725323
Treatment	Treatment	1	12	49.00	284.5	2.0667838	0.1761006	0.2641509
Time:Treatment	Time:Treatment	1	12	16.00	322.0	0.5962733	0.4549430	0.4549430

bisque2

Hbb-bs

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	275.5	2.7876588	0.1208505	0.3625516
Treatment	Treatment	1	12	12.25	320.5	0.4586583	0.5110972	0.7666459
Time:Treatment	Time:Treatment	1	12	0.25	333.5	0.0089955	0.9260036	0.9260036

Hba-a1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	110.25	227.5	5.8153846	0.0328221	0.0984664
Treatment	Treatment	1	12	9.00	324.5	0.3328197	0.5746666	0.8620000
Time:Treatment	Time:Treatment	1	12	0.00	335.0	0.0000000	1.0000000	1.0000000

Hba-a2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	263.5	3.2903226	0.0947559	0.2842677
Treatment	Treatment	1	12	9.00	322.5	0.3348837	0.5734989	0.8602484
Time:Treatment	Time:Treatment	1	12	0.00	330.0	0.0000000	1.0000000	1.0000000

Hbb-bt

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	90.25	249.5	4.3406814	0.0592616	0.1777848
Treatment	Treatment	1	12	25.00	308.5	0.9724473	0.3435370	0.5153056
Time:Treatment	Time:Treatment	1	12	4.00	333.5	0.1439280	0.7110350	0.7110350

Alas2

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	72.25	243.5	3.5605749	0.0835890	0.2507669
Treatment	Treatment	1	12	20.25	310.5	0.7826087	0.3937250	0.5905875
Time:Treatment	Time:Treatment	1	12	4.00	316.0	0.1518987	0.7035563	0.7035563

Tmem165

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	56.25	279.5	2.4150268	0.1461414	0.4384241
Treatment	Treatment	1	12	0.00	333.5	0.0000000	1.0000000	1.0000000
Time:Treatment	Time:Treatment	1	12	12.25	321.5	0.4572317	0.5117430	0.7676145

Camk2n1

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	317.5	0.7653543	0.3988298	0.6003981
Treatment	Treatment	1	12	20.25	319.5	0.7605634	0.4002654	0.6003981
Time:Treatment	Time:Treatment	1	12	1.00	334.0	0.0359281	0.8528323	0.8528323

Prkcdbp

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	20.25	318.5	0.7629513	0.3995488	0.7811702
Treatment	Treatment	1	12	2.25	334.5	0.0807175	0.7811702	0.7811702
Time:Treatment	Time:Treatment	1	12	9.00	329.0	0.3282675	0.5772595	0.7811702

Zfp953

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	49	286	2.055944	0.1771533	0.5314599
Treatment	Treatment	1	12	4	327	0.146789	0.7083237	0.8506081
Time:Treatment	Time:Treatment	1	12	1	324	0.037037	0.8506081	0.8506081

Clec12a

	Term	Df	Df.res	Sum Sq	Sum Sq.res	F value	Pr(>F)	adjust
Time	Time	1	12	64.00	273.5	2.8080439	0.1196311	0.3588933
Treatment	Treatment	1	12	4.00	323.0	0.1486068	0.7066168	0.7066168
Time:Treatment	Time:Treatment	1	12	6.25	327.0	0.2293578	0.6406088	0.7066168

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Analysis performed by Ann Wells

The Carter Lab The Jackson Laboratory 2023

ann.wells@jax.org