tdata.FPKM.sample.info <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_phenotypes.RData"))

tdata.FPKM <- readRDS(here("Data","20190406_RNAseq_B6_4wk_2DG_counts_numeric.RData"))

log.tdata.FPKM <- log(tdata.FPKM + 1)
log.tdata.FPKM <- as.data.frame(log.tdata.FPKM)

log.tdata.FPKM.sample.info <- cbind(log.tdata.FPKM, tdata.FPKM.sample.info[,27238:27240])

log.tdata.FPKM.sample.info <- log.tdata.FPKM.sample.info %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.subset <- log.tdata.FPKM[,colMeans(log.tdata.FPKM != 0) > 0.5] 

log.tdata.FPKM.sample.info.subset <- cbind(log.tdata.FPKM.subset,tdata.FPKM.sample.info[,27238:27240])
log.tdata.FPKM.sample.info.subset <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(rowname != "A113") %>% column_to_rownames()

log.tdata.FPKM.sample.info.subset.heart <- log.tdata.FPKM.sample.info.subset %>% rownames_to_column() %>% filter(Tissue == "Heart") %>% column_to_rownames()

module.labels <- readRDS(here("Data","Heart","log.tdata.FPKM.sample.info.subset.heart.WGCNA.module.labels.RData"))

modules <- readRDS(here("Data","Heart","log.tdata.FPKM.sample.info.subset.heart.WGCNA.module.membership.RData"))

net.deg <- readRDS(here("Data","Heart","Chang_2DG_BL6_connectivity_heart.RData"))

ensembl.location <- readRDS(here("Data","Ensembl_gene_id_and_location.RData"))

Hub Genes

Hub genes are genes in the module network that have the highest connectivity. For instance, if the gene significance of a particular module is associated with treatment. The hub genes in this module are likely associated with this trait.

hub.genes.list <- hub.genes(net.deg,module.labels,modules,ensembl.location)

Plum1 Module

DT.table.hub(hub.genes.list[[1]])

Brown Module

DT.table.hub(hub.genes.list[[2]])

Darkred Module

DT.table.hub(hub.genes.list[[3]])

Cyan Module

DT.table.hub(hub.genes.list[[4]])

Black Module

DT.table.hub(hub.genes.list[[5]])

Royalblue Module

DT.table.hub(hub.genes.list[[6]])

Pink Module

DT.table.hub(hub.genes.list[[7]])

Lightgreen Module

DT.table.hub(hub.genes.list[[8]])

Darkturquoise Module

DT.table.hub(hub.genes.list[[9]])

Lightyellow Module

DT.table.hub(hub.genes.list[[10]])

Darkmagenta Module

DT.table.hub(hub.genes.list[[11]])

Darkgreen Module

DT.table.hub(hub.genes.list[[12]])

Darkgrey Module

DT.table.hub(hub.genes.list[[13]])

Darkorange Module

DT.table.hub(hub.genes.list[[14]])

Skyblue Module

DT.table.hub(hub.genes.list[[15]])

Saddlebrown Module

DT.table.hub(hub.genes.list[[16]])

Steelblue Module

DT.table.hub(hub.genes.list[[17]])

Paleturquoise Module

DT.table.hub(hub.genes.list[[18]])

Violet Module

DT.table.hub(hub.genes.list[[19]])

Sienna3 Module

DT.table.hub(hub.genes.list[[20]])

Yellowgreen Module

DT.table.hub(hub.genes.list[[21]])

Skyblue3 Module

DT.table.hub(hub.genes.list[[22]])

Mediumpurple3 Module

DT.table.hub(hub.genes.list[[23]])

Lightsteelblue1 Module

DT.table.hub(hub.genes.list[[24]])

Lightcyan1 Module

DT.table.hub(hub.genes.list[[25]])

ANOVA

To perform analysis of variance Aligned Rank Transformation was performed, which is designed to handle non-parametric multi-factorial experiments. P-value was adjusted using Benjamini-hochberg procedure.

log.tdata.FPKM.sample.info.subset.heart$Time <- as.factor(log.tdata.FPKM.sample.info.subset.heart$Time)
log.tdata.FPKM.sample.info.subset.heart$Treatment <- as.factor(log.tdata.FPKM.sample.info.subset.heart$Treatment)

for(m in module.labels) {
    name <- str_split(m,"_")[[1]][2]
    hub.met <- net.deg[modules$Gene,] %>%
      dplyr::mutate(Gene=modules$Gene) %>%
      dplyr::filter(modules$Module == m) %>%
      dplyr::arrange(desc(kWithin)) %>%
      dplyr::select(Gene, kWithin)
    gene <- ensembl.location$external_gene_name[match(hub.met$Gene,ensembl.location$ensembl_gene_id)]
    hub.met <- cbind(gene,hub.met)
    cat("\n###",name, "{.tabset .tabset-fade .tabset-pills}","\n")
          for(i in 1:10){
             cat("\n####",hub.met$gene[i],"\n")
             m <- art(data = log.tdata.FPKM.sample.info.subset.heart, log.tdata.FPKM.sample.info.subset.heart[,hub.met$Gene[i]] ~ Time*Treatment)
             model <- anova(m)
             adjust <- p.adjust(model$`Pr(>F)`, method = "BH")
             print(knitr::kable(cbind(model,adjust)) %>% 
                      column_spec(8, color = "white", background = spec_color(adjust, end = 0.05, scale_from = c(0,0.05))) %>% kable_styling(bootstrap_options = c("striped", "hover", "responsive")))
             cat("\n \n")
             }
          cat("\n \n")
          }

plum1

Emc10

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 225.00 113.0 23.893805 0.0003734 0.0011201
Treatment Treatment 1 12 12.25 327.5 0.448855 0.5155648 0.5155648
Time:Treatment Time:Treatment 1 12 30.25 306.5 1.184339 0.2978486 0.4467730

Myo1c

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 225.00 112.5 24.000000 0.0003666 0.0010997
Treatment Treatment 1 12 1.00 338.0 0.035503 0.8536945 0.8536945
Time:Treatment Time:Treatment 1 12 72.25 263.5 3.290323 0.0947559 0.1421338

St3gal2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 210.25 129.5 19.482626 0.0008445 0.0025336
Treatment Treatment 1 12 0.00 339.0 0.000000 1.0000000 1.0000000
Time:Treatment Time:Treatment 1 12 42.25 297.5 1.704202 0.2162143 0.3243215

Flywch1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 225.00 114.5 23.580786 0.0003942 0.0011826
Treatment Treatment 1 12 25.00 314.0 0.955414 0.3476395 0.3476395
Time:Treatment Time:Treatment 1 12 56.25 283.5 2.380952 0.1487723 0.2231584

Tbc1d9b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 196 143.5 16.390244 0.0016147 0.0048441
Treatment Treatment 1 12 1 338.0 0.035503 0.8536945 0.8536945
Time:Treatment Time:Treatment 1 12 49 291.0 2.020619 0.1806405 0.2709608

Nomo1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 196 140.0 16.8000000 0.0014756 0.0044267
Treatment Treatment 1 12 1 332.5 0.0360902 0.8525050 0.8525050
Time:Treatment Time:Treatment 1 12 16 321.5 0.5972006 0.4546008 0.6819012

9530068E07Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 182.25 155.5 14.0643087 0.0027698 0.0083093
Treatment Treatment 1 12 1.00 336.5 0.0356612 0.8533730 0.8533730
Time:Treatment Time:Treatment 1 12 36.00 301.5 1.4328358 0.2544148 0.3816222

Eif3b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 210.25 129.5 19.4826255 0.0008445 0.0025336
Treatment Treatment 1 12 6.25 332.5 0.2255639 0.6433598 0.6433598
Time:Treatment Time:Treatment 1 12 36.00 303.0 1.4257426 0.2555303 0.3832955

Lmf2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 144.00 196.0 8.8163265 0.0117179 0.0351538
Treatment Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504
Time:Treatment Time:Treatment 1 12 30.25 308.5 1.1766613 0.2993491 0.4490236

Abcd1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 196 144.0 16.3333333 0.0016352 0.0049057
Treatment Treatment 1 12 9 330.5 0.3267776 0.5781134 0.5781134
Time:Treatment Time:Treatment 1 12 64 275.5 2.7876588 0.1208505 0.1812758

brown

Rplp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 334.0 0.0359281 0.8528323 0.9265504
Treatment Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504
Time:Treatment Time:Treatment 1 12 56.25 274.5 2.4590164 0.1428309 0.4284927

Atox1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 337.5 0.0088889 0.9264420 0.9264420
Treatment Treatment 1 12 0.25 335.5 0.0089419 0.9262238 0.9264420
Time:Treatment Time:Treatment 1 12 90.25 242.5 4.4659794 0.0562022 0.1686066

Uqcr10

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1 336.5 0.0356612 0.8533730 0.8533730
Treatment Treatment 1 12 4 334.0 0.1437126 0.7112404 0.8533730
Time:Treatment Time:Treatment 1 12 36 300.0 1.4400000 0.2532947 0.7598842

2410015M20Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 334.5 0.0807175 0.7811702 0.9265504
Treatment Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504
Time:Treatment Time:Treatment 1 12 49.00 288.5 2.0381282 0.1789011 0.5367034

Rpl36a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 319.5 0.7605634 0.4002654 0.6003981
Treatment Treatment 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583
Time:Treatment Time:Treatment 1 12 64.00 275.5 2.7876588 0.1208505 0.3625516

Rpl31-ps8

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232
Treatment Treatment 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583
Time:Treatment Time:Treatment 1 12 56.25 277.5 2.4324324 0.1448201 0.4344602

Rps20

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 334.0 0.1437126 0.7112404 0.8536945
Treatment Treatment 1 12 1.00 338.0 0.0355030 0.8536945 0.8536945
Time:Treatment Time:Treatment 1 12 30.25 298.5 1.2160804 0.2917562 0.8536945

Siva1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 334.0 0.1437126 0.7112404 1.0000000
Treatment Treatment 1 12 0.00 338.0 0.0000000 1.0000000 1.0000000
Time:Treatment Time:Treatment 1 12 42.25 291.5 1.7392796 0.2118446 0.6355337

Tomm7

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 331.0 0.1450151 0.7100011 0.71165
Treatment Treatment 1 12 4 335.0 0.1432836 0.7116500 0.71165
Time:Treatment Time:Treatment 1 12 25 300.5 0.9983361 0.3374358 0.71165

Rpl37a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 330.0 0.3272727 0.5778293 0.866744
Treatment Treatment 1 12 0.00 339.0 0.0000000 1.0000000 1.000000
Time:Treatment Time:Treatment 1 12 30.25 302.5 1.2000000 0.2948207 0.866744

darkred

Fras1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 239.0 0.4518828 0.5141774 0.6580135
Treatment Treatment 1 12 4.00 233.0 0.2060086 0.6580135 0.6580135
Time:Treatment Time:Treatment 1 12 30.25 201.5 1.8014888 0.2043753 0.6131260

Cilp2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 235.0 0.2042553 0.6593682 0.6593682
Treatment Treatment 1 12 4 234.5 0.2046908 0.6590310 0.6593682
Time:Treatment Time:Treatment 1 12 16 191.0 1.0052356 0.3358364 0.6593682

Rxfp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 234.5 0.2046908 0.6590310 0.659031
Treatment Treatment 1 12 4 234.5 0.2046908 0.6590310 0.659031
Time:Treatment Time:Treatment 1 12 16 194.0 0.9896907 0.3394556 0.659031

Irf6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 249.0 0.7710843 0.3971232 0.3971232
Treatment Treatment 1 12 20.25 242.5 1.0020619 0.3365707 0.3971232
Time:Treatment Time:Treatment 1 12 56.25 272.5 2.4770642 0.1415000 0.3971232

Bmx

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 268.5 0.4022346 0.5378403 0.8067604
Treatment Treatment 1 12 1.00 286.0 0.0419580 0.8411331 0.8411331
Time:Treatment Time:Treatment 1 12 56.25 272.5 2.4770642 0.1415000 0.4245001

Fgf12

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 235.0 0.2042553 0.6593682 0.6593682
Treatment Treatment 1 12 4 235.0 0.2042553 0.6593682 0.6593682
Time:Treatment Time:Treatment 1 12 16 194.5 0.9871465 0.3400533 0.6593682

Bmp3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 231 0.2077922 0.6566425 0.6566425
Treatment Treatment 1 12 4 231 0.2077922 0.6566425 0.6566425
Time:Treatment Time:Treatment 1 12 16 183 1.0491803 0.3259019 0.6566425

Plagl1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 292.5 0.0923077 0.7664673 1.0000000
Treatment Treatment 1 12 0.00 315.0 0.0000000 1.0000000 1.0000000
Time:Treatment Time:Treatment 1 12 90.25 242.5 4.4659794 0.0562022 0.1686066

Adamts19

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 277.5 0.3891892 0.5444029 0.6848242
Treatment Treatment 1 12 4 277.5 0.1729730 0.6848242 0.6848242
Time:Treatment Time:Treatment 1 12 49 265.5 2.2146893 0.1625039 0.4875118

Tmem163

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 240.0 0.450000 0.5150393 0.5150393
Treatment Treatment 1 12 9.00 240.0 0.450000 0.5150393 0.5150393
Time:Treatment Time:Treatment 1 12 56.25 202.5 3.333333 0.0928617 0.2785850

cyan

Tmem176b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 335.5 0.0804769 0.7814873 0.7814873
Treatment Treatment 1 12 36.00 303.5 1.4233937 0.2559012 0.3838518
Time:Treatment Time:Treatment 1 12 256.00 83.5 36.7904192 0.0000562 0.0001687

Cfl1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 326.0 0.3312883 0.5755362 0.5755362
Treatment Treatment 1 12 110.25 228.5 5.7899344 0.0331400 0.0497101
Time:Treatment Time:Treatment 1 12 210.25 114.5 22.0349345 0.0005195 0.0015585

Anxa5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029
Treatment Treatment 1 12 121.00 217.0 6.6912442 0.0238003 0.0357004
Time:Treatment Time:Treatment 1 12 196.00 140.0 16.8000000 0.0014756 0.0044267

Rab8b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504
Treatment Treatment 1 12 81.00 258.5 3.7601547 0.0763620 0.1145429
Time:Treatment Time:Treatment 1 12 132.25 206.5 7.6852300 0.0168921 0.0506763

Ifitm2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 339.5 0.0088365 0.9266583 0.9266583
Treatment Treatment 1 12 72.25 257.5 3.3669903 0.0914117 0.1371175
Time:Treatment Time:Treatment 1 12 225.00 114.0 23.6842105 0.0003872 0.0011615

Pmp22

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 336.5 0.0356612 0.8533730 0.8533730
Treatment Treatment 1 12 49.00 291.0 2.0206186 0.1806405 0.2709608
Time:Treatment Time:Treatment 1 12 210.25 129.5 19.4826255 0.0008445 0.0025336

Ifngr1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 338.5 0.0354505 0.8538013 0.8538013
Treatment Treatment 1 12 56.25 282.5 2.3893805 0.1481160 0.2221740
Time:Treatment Time:Treatment 1 12 156.25 183.5 10.2179837 0.0076814 0.0230443

Pi16

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 316.5 0.7677725 0.3981082 0.3981082
Treatment Treatment 1 12 25.00 314.0 0.9554140 0.3476395 0.3981082
Time:Treatment Time:Treatment 1 12 256.00 83.0 37.0120482 0.0000547 0.0001641

Trps1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 338 0.0088757 0.9264962 0.9264962
Treatment Treatment 1 12 156.25 180 10.4166667 0.0072530 0.0108796
Time:Treatment Time:Treatment 1 12 210.25 128 19.7109375 0.0008073 0.0024218

Ddr2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 315.5 0.6085578 0.4504449 0.4504449
Treatment Treatment 1 12 100 240.0 5.0000000 0.0451154 0.0676730
Time:Treatment Time:Treatment 1 12 169 168.5 12.0356083 0.0046375 0.0139124

black

Srp19

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 308.5 1.176661 0.2993491 0.2993491
Treatment Treatment 1 12 110.25 226.5 5.841060 0.0325051 0.0975154
Time:Treatment Time:Treatment 1 12 42.25 294.5 1.721562 0.2140371 0.2993491

Vps35

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 331.5 0.2262443 0.6428643 0.6428643
Treatment Treatment 1 12 64.00 273.5 2.8080439 0.1196311 0.3066375
Time:Treatment Time:Treatment 1 12 42.25 281.5 1.8010657 0.2044250 0.3066375

Sdcbp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 316.5 0.3412322 0.5699374 0.5699374
Treatment Treatment 1 12 110.25 214.5 6.1678322 0.0287723 0.0863169
Time:Treatment Time:Treatment 1 12 81.00 258.0 3.7674419 0.0761128 0.1141692

Acp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 297.5 1.704202 0.2162143 0.2162143
Treatment Treatment 1 12 64.00 271.5 2.828729 0.1184093 0.1776139
Time:Treatment Time:Treatment 1 12 72.25 266.5 3.253283 0.0964252 0.1776139

Serinc1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 322.5 0.2325581 0.6383100 0.6383100
Treatment Treatment 1 12 100.00 239.5 5.0104384 0.0449263 0.0849569
Time:Treatment Time:Treatment 1 12 90.25 243.5 4.4476386 0.0566379 0.0849569

Tmco1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 323.0 0.5944272 0.4556254 0.4556254
Treatment Treatment 1 12 121 216.5 6.7066975 0.0236697 0.0651292
Time:Treatment Time:Treatment 1 12 100 235.5 5.0955414 0.0434195 0.0651292

Rpsa

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 110.25 228.5 5.789934 0.0331400 0.0994201
Treatment Treatment 1 12 64.00 275.5 2.787659 0.1208505 0.1487723
Time:Treatment Time:Treatment 1 12 56.25 283.5 2.380952 0.1487723 0.1487723

Exosc9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 309.5 1.172859 0.3000959 0.3000959
Treatment Treatment 1 12 100.00 238.0 5.042017 0.0443600 0.1330799
Time:Treatment Time:Treatment 1 12 42.25 297.5 1.704202 0.2162143 0.3000959

Sugt1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 331.5 0.1447964 0.7102088 0.7102088
Treatment Treatment 1 12 9.00 326.0 0.3312883 0.5755362 0.7102088
Time:Treatment Time:Treatment 1 12 90.25 248.5 4.3581489 0.0588233 0.1764698

Cdc42

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 296.5 1.709949 0.2154903 0.2154903
Treatment Treatment 1 12 49.00 286.0 2.055944 0.1771533 0.2154903
Time:Treatment Time:Treatment 1 12 72.25 252.5 3.433663 0.0886202 0.2154903

royalblue

Dmxl1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 282.5 2.389381 0.1481160 0.2111103
Treatment Treatment 1 12 81.00 256.5 3.789474 0.0753654 0.2111103
Time:Treatment Time:Treatment 1 12 42.25 290.5 1.745267 0.2111103 0.2111103

Cul5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 81.00 256.5 3.7894737 0.0753654 0.1130482
Treatment Treatment 1 12 110.25 228.5 5.7899344 0.0331400 0.0994201
Time:Treatment Time:Treatment 1 12 16.00 311.5 0.6163724 0.4476219 0.4476219

Pds5b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 277.5 2.432432 0.1448201 0.1448201
Treatment Treatment 1 12 72.25 266.5 3.253283 0.0964252 0.1446378
Time:Treatment Time:Treatment 1 12 240.25 98.5 29.269036 0.0001575 0.0004725

Pcnp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 264.5 3.277883 0.0953126 0.1347893
Treatment Treatment 1 12 110.25 229.5 5.764706 0.0334588 0.1003764
Time:Treatment Time:Treatment 1 12 56.25 262.5 2.571429 0.1347893 0.1347893

Gm10040

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49.00 289.0 2.034602 0.1792497 0.1792497
Treatment Treatment 1 12 132.25 206.5 7.685230 0.0168921 0.0506763
Time:Treatment Time:Treatment 1 12 81.00 250.0 3.888000 0.0721303 0.1081955

Galnt1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 277.5 2.432432 0.1448201 0.2172301
Treatment Treatment 1 12 72.25 258.5 3.353965 0.0919695 0.2172301
Time:Treatment Time:Treatment 1 12 36.00 263.0 1.642586 0.2241816 0.2241816

Nars

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 303.5 1.196046 0.2955811 0.2955811
Treatment Treatment 1 12 144.00 195.0 8.861538 0.0115535 0.0346606
Time:Treatment Time:Treatment 1 12 49.00 283.0 2.077739 0.1750448 0.2625672

Eea1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 254.0 3.4133858 0.0894580 0.2524320
Treatment Treatment 1 12 49.00 273.5 2.1499086 0.1682880 0.2524320
Time:Treatment Time:Treatment 1 12 20.25 316.0 0.7689873 0.3977464 0.3977464

Idi1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 132.25 207.5 7.648193 0.0171028 0.0256542
Treatment Treatment 1 12 144.00 193.5 8.930233 0.0113089 0.0256542
Time:Treatment Time:Treatment 1 12 100.00 215.0 5.581395 0.0358879 0.0358879

Atp6v1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 323.5 0.5935085 0.4559656 0.4559656
Treatment Treatment 1 12 110.25 226.5 5.8410596 0.0325051 0.0975154
Time:Treatment Time:Treatment 1 12 81.00 254.0 3.8267717 0.0741204 0.1111807

pink

Cps1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 288 0.2604167 0.6190904 0.9167102
Treatment Treatment 1 12 0.25 263 0.0114068 0.9167102 0.9167102
Time:Treatment Time:Treatment 1 12 2.25 279 0.0967742 0.7610733 0.9167102

Plg

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 269.5 0.0111317 0.9177167 0.9177167
Treatment Treatment 1 12 2.25 239.5 0.1127349 0.7428493 0.9177167
Time:Treatment Time:Treatment 1 12 1.00 275.5 0.0435572 0.8381803 0.9177167

Cml2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 273.0 0.0109890 0.9182437 1
Treatment Treatment 1 12 2.25 265.0 0.1018868 0.7550651 1
Time:Treatment Time:Treatment 1 12 0.00 265.5 0.0000000 1.0000000 1

Saa4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 281 0.1708185 0.6866753 0.9157476
Treatment Treatment 1 12 0.25 254 0.0118110 0.9152536 0.9157476
Time:Treatment Time:Treatment 1 12 0.25 257 0.0116732 0.9157476 0.9157476

Mat1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 263.5 0.0000000 1.0000000 1
Treatment Treatment 1 12 0.25 258.5 0.0116054 0.9159914 1
Time:Treatment Time:Treatment 1 12 1.00 278.5 0.0430880 0.8390407 1

Bhmt

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 284.0 0.1690141 0.6882363 0.9167889
Treatment Treatment 1 12 4.00 236.0 0.2033898 0.6600396 0.9167889
Time:Treatment Time:Treatment 1 12 0.25 263.5 0.0113852 0.9167889 0.9167889

Ambp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 289.5 1.0362694 0.3287762 0.7581251
Treatment Treatment 1 12 6.25 239.0 0.3138075 0.5856593 0.7581251
Time:Treatment Time:Treatment 1 12 2.25 272.0 0.0992647 0.7581251 0.7581251

Elovl3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 261 0.1839080 0.6756337 0.7589786
Treatment Treatment 1 12 12.25 249 0.5903614 0.4571344 0.7589786
Time:Treatment Time:Treatment 1 12 2.25 274 0.0985401 0.7589786 0.7589786

Cyp3a11

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 282.5 0.0955752 0.7625075 0.8353619
Treatment Treatment 1 12 1.00 266.0 0.0451128 0.8353619 0.8353619
Time:Treatment Time:Treatment 1 12 4.00 284.0 0.1690141 0.6882363 0.8353619

Itih1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 215 0.5023256 0.4920199 0.7456384
Treatment Treatment 1 12 4.00 236 0.2033898 0.6600396 0.7456384
Time:Treatment Time:Treatment 1 12 2.25 245 0.1102041 0.7456384 0.7456384

lightgreen

Abca13

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Chrne

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Stxbp5l

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Dnaaf1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

5730559C18Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

4930426D05Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ccdc79

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm16044

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm16548

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

A330033J07Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

darkturquoise

Aire

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

1600016N20Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cntnap3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Foxj1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Rsph4a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slco4c1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gldn

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Hmga2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Caln1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Sorcs3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

lightyellow

Lama1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Brinp3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Capsl

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slc47a2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Zan

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm15910

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Trpm1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 177.0 1.0847458 0.3181679 0.6524285
Treatment Treatment 1 12 6.25 214.5 0.3496503 0.5652838 0.6524285
Time:Treatment Time:Treatment 1 12 4.00 225.0 0.2133333 0.6524285 0.6524285

Vwa5b2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16.00 178.5 1.0756303 0.3201249 0.5981233
Treatment Treatment 1 12 4.00 228.0 0.2105263 0.6545547 0.6545547
Time:Treatment Time:Treatment 1 12 12.25 192.0 0.7656250 0.3987489 0.5981233

Gm15892

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 214.5 0.3496503 0.5652838 0.8479257
Treatment Treatment 1 12 0.00 249.0 0.0000000 1.0000000 1.0000000
Time:Treatment Time:Treatment 1 12 6.25 214.5 0.3496503 0.5652838 0.8479257

Cntnap4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 222 0.2162162 0.6502627 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 16 150 1.2800000 0.2800026 0.6502627

darkmagenta

Serbp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 318.5 0.3390895 0.5711345 0.5711345
Treatment Treatment 1 12 132.25 207.5 7.6481928 0.0171028 0.0513084
Time:Treatment Time:Treatment 1 12 12.25 324.5 0.4530046 0.5136651 0.5711345

Nemf

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 36 303.0 1.425743 0.2555303 0.3832955
Treatment Treatment 1 12 49 284.5 2.066784 0.1761006 0.3832955
Time:Treatment Time:Treatment 1 12 4 333.5 0.143928 0.7110350 0.7110350

Capza2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25.00 305.0 0.9836066 0.3408876 0.3476395
Treatment Treatment 1 12 110.25 227.5 5.8153846 0.0328221 0.0984664
Time:Treatment Time:Treatment 1 12 25.00 314.0 0.9554140 0.3476395 0.3476395

Pdcl

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 273.5 2.808044 0.1196311 0.1794466
Treatment Treatment 1 12 144 194.0 8.907217 0.0113902 0.0341706
Time:Treatment Time:Treatment 1 12 4 335.5 0.143070 0.7118542 0.7118542

Gtf2h1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 291.5 1.7392796 0.2118446 0.3177669
Treatment Treatment 1 12 81.00 251.0 3.8725100 0.0726276 0.2178829
Time:Treatment Time:Treatment 1 12 4.00 321.5 0.1493002 0.7059689 0.7059689

Ccdc47

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 324.5 0.0832049 0.7779222 0.7779222
Treatment Treatment 1 12 100.00 238.0 5.0420168 0.0443600 0.1330799
Time:Treatment Time:Treatment 1 12 16.00 322.0 0.5962733 0.4549430 0.6824144

Ik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 81 258.0 3.7674419 0.0761128 0.2283384
Treatment Treatment 1 12 49 288.5 2.0381282 0.1789011 0.2683517
Time:Treatment Time:Treatment 1 12 1 334.5 0.0358744 0.8529409 0.8529409

Ddx3x

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 328.5 0.3287671 0.5769737 0.7102088
Treatment Treatment 1 12 169 171.0 11.8596491 0.0048604 0.0145812
Time:Treatment Time:Treatment 1 12 4 331.5 0.1447964 0.7102088 0.7102088

Mfap1b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 296.5 1.7099494 0.2154903 0.3232354
Treatment Treatment 1 12 49.00 288.5 2.0381282 0.1789011 0.3232354
Time:Treatment Time:Treatment 1 12 6.25 330.5 0.2269289 0.6423668 0.6423668

Morf4l2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 49 281.0 2.0925267 0.1736324 0.2604487
Treatment Treatment 1 12 144 195.5 8.8388747 0.0116356 0.0349068
Time:Treatment Time:Treatment 1 12 4 323.0 0.1486068 0.7066168 0.7066168

darkgreen

Tmem82

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 110.25 228.5 5.7899344 0.0331400 0.0497101
Treatment Treatment 1 12 256.00 83.5 36.7904192 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 1.00 338.5 0.0354505 0.8538013 0.8538013

Fbxo32

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 248.5 4.3581489 0.0588233 0.0882349
Treatment Treatment 1 12 256.00 83.5 36.7904192 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 6.25 327.5 0.2290076 0.6408615 0.6408615

Pdk4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 100.00 239.5 5.0104384 0.0449263 0.0673894
Treatment Treatment 1 12 256.00 83.5 36.7904192 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 0.25 330.5 0.0090772 0.9256696 0.9256696

Ucp3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 121.00 217.0 6.6912442 0.0238003 0.0357004
Treatment Treatment 1 12 256.00 83.5 36.7904192 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 20.25 313.5 0.7751196 0.3959282 0.3959282

Asb4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 332.5 0.2255639 0.6433598 0.8533730
Treatment Treatment 1 12 225.00 112.5 24.0000000 0.0003666 0.0010997
Time:Treatment Time:Treatment 1 12 1.00 336.5 0.0356612 0.8533730 0.8533730

Agpat9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 81 249 3.903615 0.0716332 0.1074499
Treatment Treatment 1 12 256 83 37.012048 0.0000547 0.0001641
Time:Treatment Time:Treatment 1 12 4 327 0.146789 0.7083237 0.7083237

Tfdp2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 281.5 2.3978686 0.1474588 0.2211881
Treatment Treatment 1 12 225.00 114.0 23.6842105 0.0003872 0.0011615
Time:Treatment Time:Treatment 1 12 12.25 326.5 0.4502297 0.5149340 0.5149340

Gsta1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 280.5 2.4064171 0.1468005 0.2202008
Treatment Treatment 1 12 256.00 83.5 36.7904192 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 2.25 335.5 0.0804769 0.7814873 0.7814873

Mrpl32

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 121.00 214.0 6.7850467 0.0230208 0.0345312
Treatment Treatment 1 12 210.25 126.5 19.9446640 0.0007711 0.0023133
Time:Treatment Time:Treatment 1 12 2.25 336.5 0.0802377 0.7818029 0.7818029

Rgs5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 337.5 0.080000 0.7821172 0.7821172
Treatment Treatment 1 12 256.00 83.0 37.012048 0.0000547 0.0001641
Time:Treatment Time:Treatment 1 12 30.25 307.5 1.180488 0.2986000 0.4479000

darkgrey

Tubb1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 336.0 0.0803571 0.7816453 0.7816453
Treatment Treatment 1 12 121.00 217.5 6.6758621 0.0239310 0.0717931
Time:Treatment Time:Treatment 1 12 4.00 331.0 0.1450151 0.7100011 0.7816453

Draxin

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 42.25 283 1.7915194 0.2055489 0.3083234
Treatment Treatment 1 12 144.00 190 9.0947368 0.0107475 0.0322425
Time:Treatment Time:Treatment 1 12 25.00 305 0.9836066 0.3408876 0.3408876

Treml2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 290.0 0.6620690 0.4316801 0.4366418
Treatment Treatment 1 12 144 192.5 8.9766234 0.0111472 0.0334415
Time:Treatment Time:Treatment 1 12 16 296.5 0.6475548 0.4366418 0.4366418

Gp9

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 320.5 0.4586583 0.5110972 0.7666459
Treatment Treatment 1 12 182.25 156.5 13.9744409 0.0028310 0.0084931
Time:Treatment Time:Treatment 1 12 0.25 338.5 0.0088626 0.9265504 0.9265504

Cd19

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.25 331.5 0.0090498 0.9257814 0.9257814
Treatment Treatment 1 12 156.25 172.5 10.8695652 0.0063772 0.0191317
Time:Treatment Time:Treatment 1 12 1.00 331.5 0.0361991 0.8522856 0.9257814

AU023871

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 319 0.0846395 0.7760730 0.9256135
Treatment Treatment 1 12 110.25 226 5.8539823 0.0323469 0.0970408
Time:Treatment Time:Treatment 1 12 0.25 330 0.0090909 0.9256135 0.9256135

Slc6a4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 330.0 0.0818182 0.7797264 0.8527234
Treatment Treatment 1 12 210.25 129.0 19.5581395 0.0008320 0.0024960
Time:Treatment Time:Treatment 1 12 1.00 333.5 0.0359820 0.8527234 0.8527234

Cd79a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 331.5 0.0814480 0.7802108 0.8533730
Treatment Treatment 1 12 121.00 218.5 6.6453089 0.0241934 0.0725801
Time:Treatment Time:Treatment 1 12 1.00 336.5 0.0356612 0.8533730 0.8533730

Nrgn

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 25 306.0 0.9803922 0.3416477 0.5124715
Treatment Treatment 1 12 169 166.5 12.1801802 0.0044633 0.0133898
Time:Treatment Time:Treatment 1 12 4 329.5 0.1456753 0.7093755 0.7093755

Cxcr5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9.00 312.5 0.3456000 0.5675132 0.5675132
Treatment Treatment 1 12 121.00 204.5 7.1002445 0.0206144 0.0618431
Time:Treatment Time:Treatment 1 12 20.25 297.0 0.8181818 0.3835129 0.5675132

darkorange

Nmrk2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 144 187.0 9.240642 0.0102769 0.0102769
Treatment Treatment 1 12 256 81.5 37.693252 0.0000503 0.0001508
Time:Treatment Time:Treatment 1 12 196 142.0 16.563380 0.0015541 0.0023312

Sh3bgr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 210.25 128.5 19.634241 0.0008196 0.0012294
Treatment Treatment 1 12 256.00 83.0 37.012048 0.0000547 0.0001641
Time:Treatment Time:Treatment 1 12 42.25 287.5 1.763478 0.2088974 0.2088974

Ccrn4l

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 275.5 2.787659 0.1208505 0.1208505
Treatment Treatment 1 12 225 114.5 23.580786 0.0003942 0.0011826
Time:Treatment Time:Treatment 1 12 144 196.0 8.816327 0.0117179 0.0175769

Klhl38

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 304.5 0.7980296 0.3892475 0.3892475
Treatment Treatment 1 12 256.00 83.0 37.0120482 0.0000547 0.0001641
Time:Treatment Time:Treatment 1 12 36.00 291.0 1.4845361 0.2464790 0.3697184

Me2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 283 2.385159 0.1484443 0.1484443
Treatment Treatment 1 12 256.00 83 37.012048 0.0000547 0.0000820
Time:Treatment Time:Treatment 1 12 256.00 83 37.012048 0.0000547 0.0000820

Ugp2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 182.25 156.5 13.974441 0.0028310 0.0042466
Treatment Treatment 1 12 225.00 113.0 23.893805 0.0003734 0.0011201
Time:Treatment Time:Treatment 1 12 72.25 266.5 3.253283 0.0964252 0.0964252

4933421O10Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 156.25 183.5 10.21798 0.0076814 0.0076814
Treatment Treatment 1 12 256.00 83.5 36.79042 0.0000562 0.0000844
Time:Treatment Time:Treatment 1 12 256.00 82.0 37.46341 0.0000517 0.0000844

Gimap8

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 169.00 170.5 11.894428 0.0048154 0.0072230
Treatment Treatment 1 12 225.00 114.5 23.580786 0.0003942 0.0011826
Time:Treatment Time:Treatment 1 12 56.25 283.5 2.380952 0.1487723 0.1487723

Rnf125

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 132.25 201.5 7.87593 0.0158547 0.0237820
Treatment Treatment 1 12 256.00 83.5 36.79042 0.0000562 0.0001687
Time:Treatment Time:Treatment 1 12 42.25 291.5 1.73928 0.2118446 0.2118446

Adam17

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 169 170 11.929412 0.0047706 0.0071558
Treatment Treatment 1 12 256 83 37.012048 0.0000547 0.0001641
Time:Treatment Time:Treatment 1 12 121 218 6.660551 0.0240621 0.0240621

skyblue

Th

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 174 1.103448 0.3142057 0.3142057
Treatment Treatment 1 12 16 174 1.103448 0.3142057 0.3142057
Time:Treatment Time:Treatment 1 12 16 150 1.280000 0.2800026 0.3142057

4933427G17Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4.00 228.0 0.2105263 0.6545547 0.6545547
Treatment Treatment 1 12 6.25 218.0 0.3440367 0.5683785 0.6545547
Time:Treatment Time:Treatment 1 12 16.00 178.5 1.0756303 0.3201249 0.6545547

Tdrd6

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 191.5 1.002611 0.3364435 0.3364435
Treatment Treatment 1 12 16 191.5 1.002611 0.3364435 0.3364435
Time:Treatment Time:Treatment 1 12 16 185.5 1.035040 0.3290517 0.3364435

Dapl1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Fermt1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Pnmal1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Dao

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Casr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm9990

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Insm1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

saddlebrown

Clvs2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ly6h

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Sctr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Arhgef38

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Als2cr12

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slitrk3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Fank1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Mansc4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Fam155a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Trim71

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

steelblue

Gabrg1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Fam184b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Csmd3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Hs3st2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

A630023P12Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Trim15

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Rgs13

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Nanp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Klhdc7b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Nhlrc4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 185.5 1.035040 0.3290517 0.3315416
Treatment Treatment 1 12 16 179.5 1.069638 0.3214208 0.3315416
Time:Treatment Time:Treatment 1 12 16 187.5 1.024000 0.3315416 0.3315416

paleturquoise

Asic2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cbln2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Elf5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cldn14

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Myt1l

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ptgdr

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Lrrtm2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Grem1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

AI847159

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

B230206H07Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

violet

Dach2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ccdc60

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Scn9a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

C430042M11Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Chek1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 253.5 0.0473373 0.8314187 0.9180191
Treatment Treatment 1 12 20.25 226.5 1.0728477 0.3207257 0.9180191
Time:Treatment Time:Treatment 1 12 0.25 271.5 0.0110497 0.9180191 0.9180191

Ttc16

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 237.0 0.2025316 0.6607070 0.6607070
Treatment Treatment 1 12 49 229.5 2.5620915 0.1354353 0.2031529
Time:Treatment Time:Treatment 1 12 121 176.0 8.2500000 0.0140302 0.0420907

Car1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 218.0 3.522936 0.0850439 0.0850439
Treatment Treatment 1 12 64 218.0 3.522936 0.0850439 0.0850439
Time:Treatment Time:Treatment 1 12 64 186.5 4.117962 0.0652115 0.0850439

Lmtk3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 30.25 203.0 1.7881773 0.2059443 0.5154686
Treatment Treatment 1 12 9.00 240.5 0.4490644 0.5154686 0.5154686
Time:Treatment Time:Treatment 1 12 9.00 240.5 0.4490644 0.5154686 0.5154686

Svop

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 4 222 0.2162162 0.6502627 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 16 150 1.2800000 0.2800026 0.6502627

E430024P14Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 0.00 290.0 0.0000000 1.0000000 1.0000000
Treatment Treatment 1 12 12.25 299.5 0.4908180 0.4969224 0.8089845
Time:Treatment Time:Treatment 1 12 9.00 270.5 0.3992606 0.5393230 0.8089845

sienna3

Lhx2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Syt14

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Grp

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Klb

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Alox12b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

St18

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slc39a5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Pkhd1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ranbp3l

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Il31ra

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

yellowgreen

Atp8b5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 9 209 0.5167464 0.4859957 0.4859957
Treatment Treatment 1 12 16 186 1.0322581 0.3296766 0.4859957
Time:Treatment Time:Treatment 1 12 9 209 0.5167464 0.4859957 0.4859957

Amn

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

4933407L21Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Cdh15

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Sstr2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm14137

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Gm26614

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Dusp15

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 64 161 4.7701863 0.0495309 0.1485928
Treatment Treatment 1 12 9 235 0.4595745 0.5106834 0.5106834
Time:Treatment Time:Treatment 1 12 9 235 0.4595745 0.5106834 0.5106834

Sectm1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 150 1.2800000 0.2800026 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627

Slc10a4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 271.0 0.0442804 0.8368634 0.9171016
Treatment Treatment 1 12 4.00 223.0 0.2152466 0.6509891 0.9171016
Time:Treatment Time:Treatment 1 12 0.25 265.5 0.0112994 0.9171016 0.9171016

skyblue3

Slc6a3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Mfi2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Padi1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Tac2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Lmx1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Kif12

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ttc21a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Bmp8a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Actrt3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Lhfpl1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

mediumpurple3

Tceal1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 121.00 218.5 6.6453089 0.0241934 0.0725801
Treatment Treatment 1 12 2.25 333.5 0.0809595 0.7808518 0.8529409
Time:Treatment Time:Treatment 1 12 1.00 334.5 0.0358744 0.8529409 0.8529409

Hnmt

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 249.5 4.3406814 0.0592616 0.1777848
Treatment Treatment 1 12 2.25 321.5 0.0839813 0.7769193 0.7769193
Time:Treatment Time:Treatment 1 12 2.25 319.5 0.0845070 0.7762430 0.7769193

Pyroxd1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 20.25 309.5 0.7851373 0.3929854 0.9256696
Treatment Treatment 1 12 1.00 334.0 0.0359281 0.8528323 0.9256696
Time:Treatment Time:Treatment 1 12 0.25 330.5 0.0090772 0.9256696 0.9256696

Gm7336

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 248.5 4.3581489 0.0588233 0.1764698
Treatment Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.7811702
Time:Treatment Time:Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232

Gm10359

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 248.5 4.3581489 0.0588233 0.1764698
Treatment Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.7811702
Time:Treatment Time:Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232

Gm12671

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 90.25 248.5 4.3581489 0.0588233 0.1764698
Treatment Treatment 1 12 2.25 334.5 0.0807175 0.7811702 0.7811702
Time:Treatment Time:Treatment 1 12 20.25 318.5 0.7629513 0.3995488 0.5993232

Gpbp1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 56.25 277.5 2.4324324 0.1448201 0.4344602
Treatment Treatment 1 12 0.25 332.5 0.0090226 0.9258928 0.9258928
Time:Treatment Time:Treatment 1 12 1.00 329.0 0.0364742 0.8517327 0.9258928

Art3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 72.25 265.5 3.2655367 0.0958690 0.2876070
Treatment Treatment 1 12 36.00 294.0 1.4693878 0.2487692 0.3731538
Time:Treatment Time:Treatment 1 12 20.25 310.5 0.7826087 0.3937250 0.3937250

Plekhs1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 6.25 271.5 0.2762431 0.6087497 0.690787
Treatment Treatment 1 12 4.00 289.0 0.1660900 0.6907870 0.690787
Time:Treatment Time:Treatment 1 12 4.00 279.0 0.1720430 0.6856215 0.690787

Zfp110

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 169.00 164.5 12.328268 0.0042927 0.0128781
Treatment Treatment 1 12 1.00 338.0 0.035503 0.8536945 0.8536945
Time:Treatment Time:Treatment 1 12 2.25 337.5 0.080000 0.7821172 0.8536945

lightsteelblue1

Trp73

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

P2rx2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Dcx

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

March4

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Foxp3

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Golt1a

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Drc1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Smlr1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

1700019L03Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 182.5 1.052055 0.3252668 0.3327767
Treatment Treatment 1 12 16 188.5 1.018568 0.3327767 0.3327767
Time:Treatment Time:Treatment 1 12 16 188.5 1.018568 0.3327767 0.3327767

Erich2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 178.5 1.075630 0.3201249 0.3302999
Treatment Treatment 1 12 16 186.5 1.029491 0.3302999 0.3302999
Time:Treatment Time:Treatment 1 12 16 184.5 1.040650 0.3277968 0.3302999

lightcyan1

Fut1

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slc25a48

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Ak8

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

2810032G03Rik

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Mogat2

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Slc4a5

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 147 1.306122 0.2753873 0.2753873
Treatment Treatment 1 12 16 147 1.306122 0.2753873 0.2753873
Time:Treatment Time:Treatment 1 12 16 147 1.306122 0.2753873 0.2753873

Myo3b

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 16 150 1.2800000 0.2800026 0.6502627
Treatment Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627
Time:Treatment Time:Treatment 1 12 4 222 0.2162162 0.6502627 0.6502627

Gm21887

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 2.25 231 0.1168831 0.7383527 0.7623042
Treatment Treatment 1 12 30.25 246 1.4756098 0.2478251 0.7434752
Time:Treatment Time:Treatment 1 12 2.25 282 0.0957447 0.7623042 0.7623042

Rab25

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 12.25 228.5 0.6433260 0.4381049 0.6571573
Treatment Treatment 1 12 1.00 268.5 0.0446927 0.8361178 0.8361178
Time:Treatment Time:Treatment 1 12 42.25 220.5 2.2993197 0.1553226 0.4659679

Ccdc40

Term Df Df.res Sum Sq Sum Sq.res F value Pr(>F) adjust
Time Time 1 12 1.00 286 0.0419580 0.8411331 0.8411331
Treatment Treatment 1 12 2.25 268 0.1007463 0.7563907 0.8411331
Time:Treatment Time:Treatment 1 12 9.00 286 0.3776224 0.5503525 0.8411331

Analysis performed by Ann Wells

The Carter Lab The Jackson Laboratory 2023

ann.wells@jax.org